From Milton Keynes Central train to Euston Bus Station, line 18 bus to London Marylebone, then train to High Wycombe. 1 h 34 min £52. From Central Milton Keynes, The Point (Central Milton Keynes The Point H3) bus to Aylesbury, Bus Station (Bus Stn Bay 7) then bus to High Wycombe, Frogmoor (viaduct). 2 h 11 min £6. From Milton Keynes taxi to High Wycombe. 50 min £116. From Milton Keynes drive to High Wycombe. 50 min £7.