From Milton Keynes Central train to Birmingham New Street then train to Cheltenham Spa. 1 h 48 min £78. From Central Milton Keynes, The Point (Central Milton Keynes The Point H3) bus to Buckingham, High Street (The Grand Junction PH), bus to Oxford City Centre, St Giles (o/s Ashmolean), then bus to Royal Well Bus Station. 4 h 12 min £22. From Milton Keynes drive to Cheltenham. 1 h 25 min £15.
Virgin West Coast Trains operates a train from Milton Keynes to Cheltenham hourly. Tickets cost $40 - $65 and the journey takes 51 min. CrossCountry also services this route every 30 minutes. Alternatively, Arriva UK operates a bus from Milton Keynes to Cheltenham every 30 minutes. Tickets cost $5 - $8 and the journey takes 28 min. 3 other operators also service this route.