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How to get fromMiddlesex to Chicagoby train, plane, bus (Flixbus), train (Amtrak), car, bus or bus (Greyhound)

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There are 10 ways to get from Middlesex to Chicago by train, plane, bus (Flixbus), train (Amtrak), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Newark Liberty International Airport, fly to Chicago O'Hare International Airport

    best
    1. Take the train from Dunellen to Newark Penn Stationtrain
    2. Fly from Newark Liberty International Airport (EWR) to Chicago O'Hare International Airport (ORD)planeEWR - ORD
    6h 1m
    $93–316

  2. Bus to Laguardia Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the bus from Boundbrook Rd At 4Th St to Port Authority Bus Terminalbus
    2. Fly from Laguardia Airport (LGA) to Chicago O'Hare International Airport (ORD)planeLGA - ORD
    6h 48m
    $68–298

  3. Bus (Flixbus)

    1. Take the bus from Newark Penn Station to Chicago Bus StationbusFlixBus N2640
    22h 51m
    $99–196

  4. Train via Ossining (Amtrak)

    1. Take the train from Ny Moynihan Train Hall At Penn Station to Croton-Harmon Amtrak StationtrainEmpire Service / ...
    2. Take the train from Croton-Harmon Amtrak Station to Chicago Union StationtrainLake Shore Limited
    23h 28m
    $163–1,516

  5. Drive 762.7 mi

    1. Drive from Middlesex to Chicagocar762.7 mi
    12h 55m
    $140–202

  6. Bus to Laguardia Airport, fly to Chicago Midway International Airport

    1. Take the bus from Boundbrook Rd At 4Th St to Port Authority Bus Terminalbus
    2. Fly from Laguardia Airport (LGA) to Chicago Midway International Airport (MDW)planeLGA - MDW
    6h 36m
    $113–348

  7. Train, train to John F. Kennedy International Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Dunellen to Newark Penn Stationtrain
    2. Take the train from Newark Penn Station to New York Penn Stationtrain
    3. Take the train from New York Penn Station to Jamaicatrain
    4. Fly from John F. Kennedy International Airport (JFK) to Chicago O'Hare International Airport (ORD)planeJFK - ORD
    7h 4m
    $110–901

  8. Train to Philadelphia International Airport, fly to Chicago Midway International Airport

    1. Take the train from Newark Penn Station to 30th Street Stationtrain
    2. Fly from Philadelphia International Airport (PHL) to Chicago Midway International Airport (MDW)planePHL - MDW
    7h 26m
    $126–981

  9. Bus via Baltimore

    1. Take the bus from Boundbrook Rd At 4Th St to Port Authority Bus Terminalbus114
    2. Take the bus from Port Authority Bus Terminal to Baltimore Downtown Bus Stationbus
    3. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus
    25h 14m
    $116–278

  10. Train (Amtrak)

    1. Take the train from Newark Penn Station to Chicago Union StationtrainCardinal
    30h 21m
    $163–496

Middlesex to Chicago by bus (Flixbus)

Calendar13Weekly Buses
Duration22h 51mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

What companies run services between Middlesex, NJ, USA and Chicago, IL, USA?

Flixbus USA operates a bus from Newark Penn Station to Chicago Bus Station twice daily. Tickets cost $95–180 and the journey takes 19h 40m. Alternatively, you can take a bus from Boundbrook Rd At 1St St to Chicago Union Station via S Washington Ave At New Market Rd, Dunellen, Newark Penn Station, Ny Moynihan Train Hall At Penn Station, and Croton-Harmon Amtrak Station in around 23h 28m.

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