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How to get fromMiddlesex to Chicagoby bus, plane, bus (Flixbus), train (Amtrak), car, train or bus (Greyhound)

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There are 11 ways to get from Middlesex to Chicago by bus, plane, bus (Flixbus), train (Amtrak), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Laguardia Airport, fly to Chicago O'Hare International Airport

    best
    1. Take the bus from Boundbrook Rd At 4Th St to Port Authority Bus Terminalbus bus
    2. Fly from Laguardia Airport (LGA) to Chicago O'Hare International Airport (ORD)plane plane LGA - ORD
    6h 47m
    $66–321

  2. Train, train to John F. Kennedy International Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the train from Dunellen to Newark Penn Stationtrain train
    2. Take the train from Newark Penn Station to New York Penn Stationtrain train
    3. Take the train from New York Penn Station to Jamaicatrain train
    4. Fly from John F. Kennedy International Airport (JFK) to Chicago O'Hare International Airport (ORD)plane plane JFK - ORD
    6h 59m
    $60–301

  3. Bus (Flixbus)

    1. Take the bus from Newark Penn Station to Chicago Bus Stationbus bus FlixBus N2640
    22h 51m
    $114–216

  4. Train via Ossining (Amtrak)

    1. Take the train from Ny Moynihan Train Hall At Penn Station to Croton-Harmon Amtrak Stationtrain train Empire Service / ...
    2. Take the train from Croton-Harmon Amtrak Station to Chicago Union Stationtrain train Lake Shore Limited
    23h 28m
    $263–591

  5. Drive 762.7 mi

    1. Drive from Middlesex to Chicagocar car 762.7 mi
    13h 4m
    $140–202

  6. Bus to Laguardia Airport, fly to Chicago Midway International Airport

    1. Take the bus from Boundbrook Rd At 4Th St to Port Authority Bus Terminalbus bus
    2. Fly from Laguardia Airport (LGA) to Chicago Midway International Airport (MDW)plane plane LGA - MDW
    6h 36m
    $106–541

  7. Train to Newark Liberty International Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Dunellen to Newark Penn Stationtrain train
    2. Fly from Newark Liberty International Airport (EWR) to Chicago O'Hare International Airport (ORD)plane plane EWR - ORD
    6h 2m
    $73–316

  8. Train to Philadelphia International Airport, fly to Chicago Midway International Airport

    1. Take the train from Newark Penn Station to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Chicago Midway International Airport (MDW)plane plane PHL - MDW
    7h 23m
    $114–1,174

  9. Bus to Lehigh Valley International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Newark Airport Terminal B to Lehigh Valley International Airport Trans Bridge Bus Stopbus bus
    2. Fly from Lehigh Valley International Airport (ABE) to Chicago O'Hare International Airport (ORD)plane plane ABE - ORD
    9h 6m
    $118–386

  10. Bus via Baltimore

    1. Take the bus from Boundbrook Rd At 4Th St to Port Authority Bus Terminalbus bus 114
    2. Take the bus from Port Authority Bus Terminal to Baltimore Downtown Bus Stationbus bus
    3. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus bus
    25h 16m
    $186–393

  11. Train (Amtrak)

    1. Take the train from Newark Penn Station to Chicago Union Stationtrain train Cardinal
    30h 21m
    $303–716

Middlesex to Chicago by bus (Flixbus)

Calendar7Weekly Buses
Duration22h 51mAverage Duration
Ticket$114Cheapest Price
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Questions & Answers

What companies run services between Middlesex, NJ, USA and Chicago, IL, USA?

Flixbus USA operates a bus from Newark Penn Station to Chicago Bus Station once daily. Tickets cost $110–200 and the journey takes 19h 40m. Alternatively, you can take a bus from Boundbrook Rd At 1St St to Chicago Union Station via S Washington Ave At New Market Rd, Dunellen, Newark Penn Station, Ny Moynihan Train Hall At Penn Station, and Croton-Harmon Amtrak Station in around 23h 28m.

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