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How to get fromMiddlesboro to Roanokeby car, plane, bus or train

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There are 7 ways to get from Middlesboro to Roanoke by car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Mcghee Tyson Airport, fly

    best
    1. Drive from Middlesboro to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Roanoke Regional Airport-Woodrum Field (ROA)plane plane TYS - ROA
    6h 24m
    $87–524

  2. Drive 242.5 mi

    cheapest
    1. Drive from Middlesboro to Roanokecar car 242.5 mi
    4h 31m
    $45–64

  3. Drive, bus, train

    1. Drive from Middlesboro to Londoncar car
    2. Take the bus from London to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Charlotte Bus Stationbus bus
    4. Take the train from Charlotte Amtrak Station to Lynchburgtrain train
    5. Take the train from Lynchburg to Roanoketrain train
    20h 21m
    $141–510

  4. Drive, bus, train via Indianapolis

    1. Drive from Middlesboro to Londoncar car
    2. Take the bus from London to Cincinnati Bus Stationbus bus
    3. Take the bus from Greyhound Station Cincinnati to Indianapolis, INbus bus
    4. Take the train from Indianapolis to Charlottesvilletrain train
    5. Take the train from Charlottesville to Roanoketrain train
    28h 14m
    $194–669

  5. Drive to Tri-Cities Regional Tn/Va Airport, fly

    1. Drive from Middlesboro to Tri-Cities-Regional-Airport-TRIcar car
    2. Fly from Tri-Cities Regional Tn/Va Airport (TRI) to Roanoke Regional Airport-Woodrum Field (ROA)plane plane TRI - ROA
    6h 23m
    $81–460

  6. Drive, bus via Nashville (Greyhound)

    1. Drive from Middlesboro to Londoncar car
    2. Take the bus from London to Cincinnati Bus Stationbus bus
    3. Take the bus from Cincinnati Bus Station to Nashville Bus Stationbus bus
    4. Take the bus from Nashville Bus Station to Roanoke Bus Stopbus bus
    20h 46m
    $151–299

  7. Drive, bus

    1. Drive from Middlesboro to Londoncar car
    2. Take the bus from London to Cincinnati Bus Stationbus bus
    3. Take the bus from Cincinnati, OH to N Wilson Rd & Ferrell Pl - Columbusbus bus
    4. Take the bus from Columbus - Mound St to Wythevillebus bus
    5. Take the bus from Wytheville Rural King Parking Lot to Christiansburgbus bus
    6. Take the bus from Exit 118 - Park and Ride to 3rd St Station Slip Dbus bus Swb
    20h 56m
    $114–269

Mcghee Tyson Airport (TYS) to Roanoke Regional Airport-Woodrum Field (ROA) flights

Calendar59Weekly Planes
Duration4h 57mAverage Duration
Ticket$73Cheapest Price
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Questions & Answers

What companies run services between Middlesboro, KY, USA and Roanoke, VA, USA?

There is no direct connection from Middlesboro to Roanoke. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to Roanoke Regional Airport-Woodrum Field (ROA), walk to Airport, then take the bus to 3rd St Station Slip D. Alternatively, you can take a vehicle from Middlesboro to Roanoke via London, Atlanta Bus Station, Charlotte Bus Station, Trade St & Graham St, Transit Center- Bay A, Transit Center- Bay O, Tryon St & 23rd St, Charlotte Amtrak Station, and Lynchburg in around 20h 21m.

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