There are 4 ways to get from Mexico City to Panama City by plane, bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Benito Juárez International Airport
best- Fly from Benito Juárez International Airport (MEX) to Tocumen International Airport (PTY)plane MEX - PTY
6h 37m$378–790Bus
cheapest- Take the bus from México City to Tapachulabus
- Take the bus from Tapachula to Guatemana Aguilar Batresbus
- Take the bus from Guatemala Aguilar Batres to Terminal San Carlos - Ticabusbus
- Take the bus from Terminal Tica Bus San Salvador to Terminal Tica Bus San Josébus
- Take the bus from Terminal Tica Bus San José to Terminal Tica Bus Panamábus
2d 20h$201–290Drive 3,152.7 km
- Drive from Mexico City to Panama Citycar 3,152.7 km
44h 56m$429–619Fly from Felipe Ángeles International Airport
- Fly from Felipe Ángeles International Airport (NLU) to Tocumen International Airport (PTY)plane NLU - PTY
10h 23m$591–1,249
Benito Juárez International Airport (MEX) to Tocumen International Airport (PTY) flights
Comparing Your Travel Options
The cheapest way to get from Mexico City to Panama City is to bus which costs $200 - $290 and takes 2 days 20h.
The fastest way to get from Mexico City to Panama City is to fly which takes 6h 37m and costs $370 - $800.
No, there is no direct bus from Mexico City to Panama City. However, there are services departing from México City and arriving at Terminal Tica Bus Panamá via Tapachula, Guatemala Aguilar Batres, Terminal Tica Bus San Salvador and Terminal Tica Bus San José. The journey, including transfers, takes approximately 2 days 20h.
The distance between Mexico City and Panama City is 2441 km. The road distance is 3152.7 km.
The best way to get from Mexico City to Panama City without a car is to bus which takes 2 days 20h and costs $200 - $290.
It takes approximately 6h 37m to get from Mexico City to Panama City, including transfers.
Mexico City to Panama City bus services, operated by Autobuses Titanium, depart from México City station.
The best way to get from Mexico City to Panama City is to fly which takes 6h 37m and costs $370 - $800. Alternatively, you can bus, which costs $200 - $290 and takes 2 days 20h.
Mexico City to Panama City bus services, operated by Autobuses Titanium, arrive at Tapachula station.
Panama City is 1h ahead of Mexico City. It is currently 4:10 AM in Mexico City and 5:10 AM in Panama City.
What companies run services between Mexico City, Mexico and Panama City, Panama?
Aeroméxico, Copa Airlines, and Avianca - Aerovías del Continente Americano S.A. fly from Benito Juárez International Airport (MEX) to Tocumen International Airport (PTY) every 4 hours. Alternatively, you can take a bus from México City to Terminal Tica Bus Panamá via Tapachula, Guatemala Aguilar Batres, Terminal San Carlos - Ticabus, Terminal Tica Bus San Salvador, and Terminal Tica Bus San José in around 2d 20h.
- Website
- copaair.com
Flights from Benito Juárez International Airport to Tocumen International Airport
- Ave. Duration
- 3h 48m
- When
- Every day
- Estimated price
- $100–490
Flights from Felipe Ángeles International Airport to Tocumen International Airport via Cancun
- Ave. Duration
- 7h 17m
- When
- Every day
- Estimated price
- $100–470
Flights from Felipe Ángeles International Airport to Tocumen International Airport via Guadalajara
- Ave. Duration
- 8h 57m
- When
- Every day
- Estimated price
- $120–550
Flights from Felipe Ángeles International Airport to Tocumen International Airport via Havana
- Ave. Duration
- 7h 8m
- When
- Tuesday, Thursday, and Saturday
- Estimated price
- $340–950
Flights from Felipe Ángeles International Airport to Tocumen International Airport via Monterrey
- Ave. Duration
- 7h 34m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $120–550
- Website
- avianca.com
Flights from Benito Juárez International Airport to Tocumen International Airport via San Salvador
- Ave. Duration
- 8h 15m
- When
- Every day
- Estimated price
- $340–800
Flights from Felipe Ángeles International Airport to Tocumen International Airport via Bogota
- Ave. Duration
- 10h 1m
- When
- Every day
- Estimated price
- $220–1,000
- Website
- vivaaerobus.com
Flights from Felipe Ángeles International Airport to Tocumen International Airport via Bogota
- Ave. Duration
- 10h 1m
- When
- Every day
- Estimated price
- $220–1,000
- Website
- aeromexico.com
Flights from Benito Juárez International Airport to Tocumen International Airport
- Ave. Duration
- 3h 56m
- When
- Every day
- Estimated price
- $100–490
- Phone
- +52 961 638 5018
- info@autobusestitanium.com
- Website
- autobusestitanium.com
Bus from México City to Tapachula
- Ave. Duration
- 15h
- Frequency
- 3 times a day
- Estimated price
- $45–65
- Schedules at
- autobusestitanium.com
- Book at
- autobusestitanium.com
- Delux
- $45–65
- First Class
- $50–60
Bus from Tapachula to Guatemana Aguilar Batres
- Ave. Duration
- 8h
- Frequency
- Twice daily
- Estimated price
- $21–30
- Schedules at
- Cristóbal Colón Autobuses (Línea Dorada y Trans Galgos Inter)
- Road
- $21–30
Bus from Guatemala Aguilar Batres to Terminal San Carlos - Ticabus
- Ave. Duration
- 6h 10m
- Frequency
- 4 times a day
- Estimated price
- $19–28
- Schedules at
- Cristóbal Colón Autobuses (Línea Dorada y Trans Galgos Inter)
- Road
- $19–28
- Phone
- +52 962 625 2435
- info@ticabus.com
- Website
- Tica Bus
Bus from Terminal Tica Bus San Salvador to Terminal Tica Bus San José
- Ave. Duration
- 19h 30m
- Frequency
- 3 times a week
- Estimated price
- $60–90
- Website
- Tica Bus
Bus from Terminal Tica Bus San José to Terminal Tica Bus Panamá
- Ave. Duration
- 16h 10m
- Frequency
- Once daily
- Estimated price
- $55–80
- Website
- Tica Bus
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Booking & Getting There
Yes, the driving distance between Mexico City to Panama City is 3153 km. It takes approximately 44h 56m to drive from Mexico City to Panama City.
There are 904+ hotels available in Panama City.