There are 8 ways to get from Messina to Isernia by bus, ferry, train, car, plane, or train (Trenitalia)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus via Caserta
best- Take the bus from Messina Piazza della Repubblica to Caserta Viale Vittorio Venetobus Autoservizi Salemi S202
- Take the bus from Caserta Terminal Bus to Iserniabus 433
8h 49m€24–37Ferry, train (Trenitalia)
- Take the ferry from Messina Marittima to Villa S.Giovanniferry M1 / ...
- Take the train from Villa S.Giovanni to Napoli Centraletrain Ic
- Take the train from Napoli Centrale to Iserniatrain Re
8h 51mFerry, drive
- Take the ferry from Messina Marittima to Villa San Giovanniferry
- Drive from Villa San Giovanni to Iserniacar
6h 5m€87–132Train to Catania–Fontanarossa Airport, fly to Naples Airport, train
- Take the train from Messina Centrale to Catania Centraletrain
- Fly from Catania–Fontanarossa Airport (CTA) to Naples Airport (NAP)plane CTA - NAP
- Take the train from Napoli Centrale to Iserniatrain
7h 30m€39–153Train (Trenitalia)
- Take the train from Messina Centrale to Casertatrain Ic
- Take the train from Caserta to Iserniatrain Re
8h 56m€52–114Bus
- Take the bus from Messina to Salernobus N592 / ...
- Take the bus from Salerno to Iserniabus 433
10h 59m€37–64Train to Catania–Fontanarossa Airport, fly to Fiumicino International Airport, train
- Take the train from Messina Centrale to Catania Centraletrain
- Fly from Catania–Fontanarossa Airport (CTA) to Fiumicino International Airport (FCO)plane CTA - FCO
- Take the train from Roma Termini to Iserniatrain
8h 15m€52–188Train to Palermo Airport, fly to Naples Airport, train
- Take the train from Messina Centrale to Palermo Centraletrain
- Fly from Palermo Airport (PMO) to Naples Airport (NAP)plane PMO - NAP
- Take the train from Napoli Centrale to Iserniatrain
9h 32m€48–183
Messina to Isernia by bus
Questions & Answers
The cheapest way to get from Messina to Isernia is to bus via Caserta which costs €24 - €40 and takes 8h 49m.
The fastest way to get from Messina to Isernia is to ferry and drive which takes 6h 5m and costs €85 - €140.
No, there is no direct bus from Messina to Isernia. However, there are services departing from Messina Piazza della Repubblica and arriving at Isernia via Caserta Terminal Bus. The journey, including transfers, takes approximately 8h 49m.
No, there is no direct train from Messina to Isernia. However, there are services departing from Messina Centrale and arriving at Isernia via Caserta. The journey, including transfers, takes approximately 8h 56m.
The distance between Messina and Isernia is 560 km.
The best way to get from Messina to Isernia without a car is to bus via Caserta which takes 8h 49m and costs €24 - €40.
It takes approximately 8h 49m to get from Messina to Isernia, including transfers.
Messina to Isernia bus services, operated by Autoservizi Salemi Srl, depart from Messina Piazza della Repubblica station.
Messina to Isernia train services, operated by Trenitalia Intercity, depart from Messina Centrale station.
The best way to get from Messina to Isernia is to bus via Caserta which takes 8h 49m and costs €24 - €40. Alternatively, you can train, which costs €50 - €120 and takes 8h 56m.
What companies run services between Messina, Italy and Isernia, Italy?
You can take a bus from Messina Piazza della Repubblica to Isernia via Caserta Viale Vittorio Veneto and Caserta Terminal Bus in around 8h 49m. Alternatively, you can take a train from Messina Centrale to Isernia via Caserta in around 8h 56m.
- Website
- ryanair.com
Flights from Catania–Fontanarossa Airport to Naples Airport
- Ave. Duration
- 1h 10m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €26–110
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €24–130
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport via Malta
- Ave. Duration
- 3h 30m
- When
- Monday and Saturday
- Estimated price
- €24–130
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 1h
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €40–110
- Website
- easyjet.com
Flights from Catania–Fontanarossa Airport to Naples Airport
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- €21–100
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 54 min
- When
- Every day
- Estimated price
- €20–95
- Website
- ita-airways.com
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €35–130
- Website
- aeroitalia.com
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €30–140
- Website
- flexflight.dk
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €30–140
- Website
- neosair.it
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 20m
- When
- Sunday
- Estimated price
- €140–400
- Website
- volotea.com
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 1h
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- €20–90
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Villa S.Giovanni to Napoli Centrale
- Ave. Duration
- 4h 28m
- Frequency
- Every 4 hours
- Estimated price
- €40–95
- Website
- https://www.trenitalia.com/en.html
Train from Messina Centrale to Catania Centrale
- Ave. Duration
- 1h 19m
- Frequency
- Twice daily
- Estimated price
- €9–21
- Website
- https://www.trenitalia.com/en.html
Train from Messina Centrale to Caserta
- Ave. Duration
- 6h 38m
- Frequency
- Once daily
- Estimated price
- €45–110
- Website
- https://www.trenitalia.com/en.html
Train from Messina Centrale to Palermo Centrale
- Ave. Duration
- 3h 10m
- Frequency
- Twice daily
- Estimated price
- €21–50
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Villa S.Giovanni to Napoli Centrale
- Ave. Duration
- 4h 12m
- Frequency
- Twice daily
- Estimated price
- €60–120
- Schedules at
- trenitalia.com
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Napoli Centrale to Isernia
- Ave. Duration
- 2h 3m
- Frequency
- 4 times a day
- Estimated price
- €8–13
- Website
- https://www.trenitalia.com/en.html
Train from Messina Centrale to Catania Centrale
- Ave. Duration
- 1h 48m
- Frequency
- Every 3 hours
- Estimated price
- €7–10
- Website
- https://www.trenitalia.com/en.html
Train from Caserta to Isernia
- Ave. Duration
- 1h 18m
- Frequency
- 4 times a day
- Estimated price
- €6–10
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €11–17
- Website
- https://www.trenitalia.com/en.html
Train from Messina Centrale to Palermo Centrale
- Ave. Duration
- 2h 54m
- Frequency
- Every 4 hours
- Estimated price
- €13–20
- Website
- https://www.trenitalia.com/en.html
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Messina Piazza della Repubblica to Caserta Viale Vittorio Veneto
- Ave. Duration
- 6h 35m
- Frequency
- Once daily
- Estimated price
- €20–29
- Schedules at
- autoservizisalemi.it
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Caserta Terminal Bus to Isernia
- Ave. Duration
- 1h 14m
- Frequency
- Once daily
- Estimated price
- €4–9
- Website
- https://www.flixbus.co.uk
Bus from Messina to Salerno
- Ave. Duration
- 6h 25m
- Frequency
- Twice daily
- Estimated price
- €27–50
- Website
- https://www.flixbus.co.uk
Bus from Salerno to Isernia
- Ave. Duration
- 3h 34m
- Frequency
- Once daily
- Estimated price
- €10–18
- Website
- https://www.flixbus.co.uk
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Ferry from Messina Marittima to Villa S.Giovanni
- Ave. Duration
- 20 min
- Frequency
- Hourly
- Website
- https://www.trenitalia.com/en.html
- Phone
- 3409848540
- info@blujetlines.it
- Website
- blujetlines.it
Ferry from Messina Marittima to Villa San Giovanni
- Ave. Duration
- 20 min
- Frequency
- Hourly
- Estimated price
- €2–3
- Schedules at
- blujetlines.it
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More Questions & Answers
Messina to Isernia bus services, operated by Autoservizi Salemi Srl, arrive at Caserta Viale Vittorio Veneto station.
Messina to Isernia train services, operated by Trenitalia Intercity, arrive at Caserta station.
Book your Messina to Isernia train tickets online with Omio.
Book your Messina to Isernia bus tickets online with Omio.
There are 435+ hotels available in Isernia.














