There are 9 ways to get from Messina to Isernia by ferry, train, bus, car, plane, or train (Trenitalia)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Ferry, train
best- Take the ferry from Messina Marittima to Villa S.Giovanniferry M1 / ...
- Take the train from Villa S.Giovanni to Napoli Afragolatrain Fr
- Take the train from Napoli Afragola to Iserniatrain Re
8h 4mBus via Caserta
cheapest- Take the bus from Messina Centrale Station to Caserta pzza Garibaldibus Autoservizi Salemi S202
- Take the bus from Caserta Terminal Bus to Iserniabus 433
8h 49m€27–76Ferry, drive
- Take the ferry from Messina Marittima to Villa San Giovanniferry
- Drive from Villa San Giovanni to Iserniacar
6h 5m€87–132Train to Catania–Fontanarossa Airport, fly to Naples Airport, train
- Take the train from Messina Centrale to Catania Centraletrain
- Fly from Catania–Fontanarossa Airport (CTA) to Naples Airport (NAP)plane CTA - NAP
- Take the train from Caserta to Iserniatrain
8h 23m€49–206Train (Trenitalia)
- Take the train from Messina Centrale to Napoli Centraletrain Ic
- Take the train from Napoli Centrale to Iserniatrain Re
9h 5m€64–122Bus
- Take the bus from Messina to Salernobus N592 / ...
- Take the bus from Salerno to Iserniabus 433
10h 59m€45–73Train to Catania–Fontanarossa Airport, fly to Fiumicino International Airport, train
- Take the train from Messina Centrale to Catania Centraletrain
- Fly from Catania–Fontanarossa Airport (CTA) to Fiumicino International Airport (FCO)plane CTA - FCO
- Take the train from Roma Termini to Iserniatrain
8h 33m€60–181Train to Palermo Airport, fly to Naples Airport, train
- Take the train from Messina Centrale to Palermo Centraletrain
- Fly from Palermo Airport (PMO) to Naples Airport (NAP)plane PMO - NAP
- Take the train from Caserta to Iserniatrain
9h 49m€64–239Train to Catania–Fontanarossa Airport, fly to Abruzzo Airport, bus
- Take the train from Messina Centrale to Catania Centraletrain
- Fly from Catania–Fontanarossa Airport (CTA) to Abruzzo Airport (PSR)plane CTA - PSR
- Take the bus from Pescara to Iserniabus
9h 54m€54–214
Catania–Fontanarossa Airport (CTA) to Naples Airport (NAP) flights
Questions & Answers
The cheapest way to get from Messina to Isernia is to bus via Caserta which costs €27 - €80 and takes 8h 49m.
The fastest way to get from Messina to Isernia is to ferry and drive which takes 6h 5m and costs €85 - €140.
No, there is no direct bus from Messina station to Isernia. However, there are services departing from Messina Centrale Station and arriving at Isernia via Caserta Terminal Bus. The journey, including transfers, takes approximately 8h 49m.
No, there is no direct train from Messina to Isernia. However, there are services departing from Messina Centrale and arriving at Isernia via Napoli Centrale. The journey, including transfers, takes approximately 9h 5m.
The distance between Messina and Isernia is 547 km.
The best way to get from Messina to Isernia without a car is to ferry and train which takes 8h 4m and costs .
It takes approximately 8h 4m to get from Messina to Isernia, including transfers.
Messina to Isernia bus services, operated by Autoservizi Salemi Srl, depart from Messina Centrale Station.
Messina to Isernia train services, operated by Trenitalia Intercity, depart from Messina Centrale station.
The best way to get from Messina to Isernia is to bus via Caserta which takes 8h 49m and costs €27 - €80. Alternatively, you can train, which costs €60 - €130 and takes 9h 5m.
What companies run services between Messina, Italy and Isernia, Italy?
You can take a bus from Messina Centrale Station to Isernia via Caserta pzza Garibaldi and Caserta Terminal Bus in around 8h 49m. Alternatively, you can take a train from Messina Centrale to Isernia via Napoli Centrale in around 9h 5m.
- Website
- ryanair.com
Flights from Catania–Fontanarossa Airport to Naples Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €25–140
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €23–80
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport via Bari
- Ave. Duration
- 2h 45m
- When
- Saturday
- Estimated price
- €23–80
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport via Malta
- Ave. Duration
- 3h 15m
- When
- Sunday
- Estimated price
- €23–80
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 1h
- When
- Every day
- Estimated price
- €26–190
Flights from Catania–Fontanarossa Airport to Abruzzo Airport
- Ave. Duration
- 1h 25m
- When
- Saturday, Sunday, Wednesday, Tuesday, and Thursday
- Estimated price
- €30–150
- Phone
- +39 06 68475475
- Website
- Trenitalia Frecce
Train from Villa S.Giovanni to Napoli Afragola
- Ave. Duration
- 4h 5m
- Frequency
- Hourly
- Estimated price
- €60–130
- Schedules at
- Trenitalia Frecce
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Messina Centrale Station to Caserta pzza Garibaldi
- Ave. Duration
- 6h 35m
- Frequency
- Twice daily
- Estimated price
- €21–30
- Schedules at
- autoservizisalemi.it
- Phone
- +39.06.5210550
- Website
- Trenitalia
Ferry from Messina Marittima to Villa S.Giovanni
- Ave. Duration
- 20 min
- Frequency
- Hourly
- Website
- Trenitalia
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More Questions & Answers
Messina to Isernia bus services, operated by Autoservizi Salemi Srl, arrive at Caserta pzza Garibaldi station.
Messina to Isernia train services, operated by Trenitalia Intercity, arrive at Napoli Centrale station.
Book your Messina to Isernia train tickets online with Omio.
Book your Messina to Isernia bus tickets online with Omio.
There are 468+ hotels available in Isernia.







