There are 9 ways to get from Messina to Isernia by bus, ferry, train, car, plane, or train (Trenitalia)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus via Caserta
best- Take the bus from Messina Piazza della Repubblica to Caserta Viale Vittorio Venetobus Autoservizi Salemi S202
- Take the bus from Caserta Terminal Bus to Iserniabus 433
8h 49m€26–44Bus
cheapest- Take the bus from Messina Main Train Station to Caserta Terminal Busbus Itabus
- Take the bus from Caserta Terminal Bus to Iserniabus 433
10h 3m€25–42Ferry, train
- Take the ferry from Messina Marittima to Villa S.Giovanniferry M1 / ...
- Take the train from Villa S.Giovanni to Napoli Centraletrain Ic
- Take the train from Napoli Centrale to Iserniatrain Re
8h 53mFerry, drive
- Take the ferry from Messina Marittima to Villa San Giovanniferry
- Drive from Villa San Giovanni to Iserniacar
6h 5m€87–132Bus to Catania–Fontanarossa Airport, fly to Naples Airport, train
- Take the bus from Messina Viale Boccetta to Catania Fontanarossa Airport Departure Terminalbus
- Fly from Catania–Fontanarossa Airport (CTA) to Naples Airport (NAP)plane CTA - NAP
- Take the train from Napoli Centrale to Iserniatrain
6h 50m€40–157Train
- Take the train from Messina Centrale to Casertatrain Ic
- Take the train from Caserta to Iserniatrain Re
9h 14m€37–63Ferry to Reggio Calabria Airport, fly to Fiumicino International Airport, train
- Take the ferry from Messina Marittima to Reggio di Calabriaferry
- Fly from Reggio Calabria Airport (REG) to Fiumicino International Airport (FCO)plane REG - FCO
- Take the train from Roma Termini to Iserniatrain
7h 31m€70–221Bus to Catania–Fontanarossa Airport, fly to Fiumicino International Airport, train
- Take the bus from Messina Viale Boccetta to Catania Fontanarossa Airport Departure Terminalbus
- Fly from Catania–Fontanarossa Airport (CTA) to Fiumicino International Airport (FCO)plane CTA - FCO
- Take the train from Roma Termini to Iserniatrain
7h 35m€61–184Train to Palermo Airport, fly to Naples Airport, train
- Take the train from Messina Centrale to Palermo Centraletrain
- Fly from Palermo Airport (PMO) to Naples Airport (NAP)plane PMO - NAP
- Take the train from Napoli Centrale to Iserniatrain
9h 36m€52–170
Messina to Isernia by bus
Questions & Answers
The cheapest way to get from Messina to Isernia is to bus which costs €25 - €45 and takes 10h 3m.
The fastest way to get from Messina to Isernia is to ferry and drive which takes 6h 5m and costs €85 - €140.
No, there is no direct bus from Messina to Isernia. However, there are services departing from Messina Piazza della Repubblica and arriving at Isernia via Caserta Terminal Bus. The journey, including transfers, takes approximately 8h 49m.
No, there is no direct train from Messina to Isernia. However, there are services departing from Messina Centrale and arriving at Isernia via Caserta. The journey, including transfers, takes approximately 9h 14m.
The distance between Messina and Isernia is 560 km.
The best way to get from Messina to Isernia without a car is to bus via Caserta which takes 8h 49m and costs €26 - €45.
It takes approximately 8h 49m to get from Messina to Isernia, including transfers.
Messina to Isernia bus services, operated by Autoservizi Salemi Srl, depart from Messina Piazza della Repubblica station.
Messina to Isernia train services, operated by Trenitalia Intercity, depart from Messina Centrale station.
The best way to get from Messina to Isernia is to bus via Caserta which takes 8h 49m and costs €26 - €45. Alternatively, you can train, which costs €35 - €65 and takes 9h 14m.
What companies run services between Messina, Italy and Isernia, Italy?
You can take a bus from Messina Piazza della Repubblica to Isernia via Caserta Viale Vittorio Veneto and Caserta Terminal Bus in around 8h 49m. Alternatively, you can take a train from Messina Centrale to Isernia via Caserta in around 9h 14m.
- Website
- ryanair.com
Flights from Catania–Fontanarossa Airport to Naples Airport
- Ave. Duration
- 1h 10m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €30–150
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €28–140
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 1h
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €29–130
- Website
- ita-airways.com
Flights from Reggio Calabria Airport to Fiumicino International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €40–180
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €40–120
- Website
- easyjet.com
Flights from Catania–Fontanarossa Airport to Naples Airport
- Ave. Duration
- 1h 5m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €23–110
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 55 min
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €22–120
- Website
- aeroitalia.com
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €35–300
- Website
- flexflight.dk
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €35–300
- Website
- volotea.com
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 1h
- When
- Thursday
- Estimated price
- €22–100
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Villa S.Giovanni to Napoli Centrale
- Ave. Duration
- 4h 30m
- Frequency
- Every 4 hours
- Estimated price
- €30–50
- Website
- https://www.trenitalia.com/en.html
Train from Messina Centrale to Caserta
- Ave. Duration
- 6h 56m
- Frequency
- Twice a week
- Estimated price
- €30–55
- Website
- https://www.trenitalia.com/en.html
Train from Messina Centrale to Palermo Centrale
- Ave. Duration
- 3h 10m
- Frequency
- Twice daily
- Estimated price
- €17–26
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Villa S.Giovanni to Napoli Centrale
- Ave. Duration
- 4h 12m
- Frequency
- Twice daily
- Estimated price
- €40–90
- Schedules at
- trenitalia.com
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Napoli Centrale to Isernia
- Ave. Duration
- 2h 3m
- Frequency
- 4 times a day
- Estimated price
- €8–13
- Website
- https://www.trenitalia.com/en.html
Train from Caserta to Isernia
- Ave. Duration
- 1h 18m
- Frequency
- 4 times a day
- Estimated price
- €7–12
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €11–17
- Website
- https://www.trenitalia.com/en.html
Train from Messina Centrale to Palermo Centrale
- Ave. Duration
- 2h 53m
- Frequency
- Every 4 hours
- Estimated price
- €17
- Website
- https://www.trenitalia.com/en.html
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Messina Piazza della Repubblica to Caserta Viale Vittorio Veneto
- Ave. Duration
- 6h 35m
- Frequency
- Once daily
- Estimated price
- €20–29
- Schedules at
- autoservizisalemi.it
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Caserta Terminal Bus to Isernia
- Ave. Duration
- 1h 14m
- Frequency
- Twice daily
- Estimated price
- €6–16
- Website
- https://www.flixbus.co.uk
- Phone
- 800 21 10 20
- saisautolineeweb@gmail.com
- Website
- saisautolinee.it
Bus from Messina Viale Boccetta to Catania Fontanarossa Airport Departure Terminal
- Ave. Duration
- 1h 20m
- Frequency
- Every 4 hours
- Estimated price
- €6–9
- Schedules at
- saisautolinee.it
- Phone
- +39 06 88 93 82 32
- Website
- itabus.it
Bus from Messina Main Train Station to Caserta Terminal Bus
- Ave. Duration
- 7h 49m
- Frequency
- Once daily
- Estimated price
- €19–27
- Website
- https://www.itabus.it/en/home
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Ferry from Messina Marittima to Villa S.Giovanni
- Ave. Duration
- 20 min
- Frequency
- Hourly
- Website
- https://www.trenitalia.com/en.html
- Phone
- 342 32 55 869
- Website
- blujetlines.it
Ferry from Messina Marittima to Villa San Giovanni
- Ave. Duration
- 20 min
- Frequency
- Hourly
- Estimated price
- €2–3
- Schedules at
- blujetlines.it
- Phone
- 0923.873813
- callcenter@libertylines.it
- Website
- libertylines.it
Ferry from Messina Marittima to Reggio di Calabria
- Ave. Duration
- 30 min
- Frequency
- Hourly
- Estimated price
- €3–4
- Schedules at
- libertylines.it
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More Questions & Answers
Messina to Isernia bus services, operated by Autoservizi Salemi Srl, arrive at Caserta Viale Vittorio Veneto station.
Messina to Isernia train services, operated by Trenitalia Intercity, arrive at Caserta station.
Book your Messina to Isernia train tickets online with Omio.
Book your Messina to Isernia bus tickets online with Omio.
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