There are 7 ways to get from Medellín to Guayaquil by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Medellin Jose Marie Cordova  •  6 h 22 min

  1. Fly from Medellin Jose Marie Cordova (MDE) to Guayaquil (GYE) MDE - GYE

$261 - $514

Cheapest option

Bus  •  24 h 18 min

  1. Take the bus from Medellín to Córdoba
  2. Take the bus from Ipiales to Guayaquil

$82 - $138

5 alternative options

Fly from Medellin Enrique Olaya Herrera  •  4 h 24 min

  1. Fly from Medellin Enrique Olaya Herrera (EOH) to Guayaquil (GYE) EOH - GYE

$207 - $721

Bus via Santo Domingo de los Colorados  •  22 h 27 min

  1. Take the bus from Medellín to Córdoba
  2. Take the bus from Rumichaca to Quito
  3. Take the bus from Quito - Terminal Quitumbe to Santo Domingo de los Colorados
  4. Take the bus from Santo Domingo de los Colorados to Guayaquil

$121 - $183

Bus Expreso Internacional Ormeño Perú  •  37 h 40 min

  1. Take the bus from Medellín to Pereira
  2. Take the bus from Pereira to Cali
  3. Take the bus from Cali to Guayaquil Terminal, Avenida Benjamín Rosales, La Garzota, Tarqui, Guayaquil, Guayas, Ecuador

Bus via Buga  •  43 h 34 min

  1. Take the bus from Medellín to Pereira
  2. Take the bus from Pereira to Buga
  3. Take the bus from Buga to Quito
  4. Take the bus from Quito Terminal Quitumbe to Guayaquil

$120 - $198

Drive  •  26 h 22 min

  1. Drive from Medellín to Guayaquil 1028.6 miles

$100 - $160

What companies run services between Medellín, Colombia and Guayaquil, Ecuador?

Avianca - Aerovías del Continente Americano S.A., Copa Airlines and two other airlines fly from Medellín to Guayaquil hourly. Alternatively, you can take a bus from Medellín to Guayaquil via Córdoba, Rumichaca, Quito, Quito - Terminal Quitumbe, Santo Domingo de los Colorados, and Santo Domingo de los Colorados in around 22 h 27 min.

Airlines
Avianca - Aerovías del Continente Americano S.A.
Website
avianca.com
Flights from Medellin Jose Marie Cordova to Guayaquil via Cali
Ave. Duration
3 h 26 min
When
Every day
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Bogota
Ave. Duration
4 h 4 min
When
Every day
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Bogota, Cali
Ave. Duration
5 h 43 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Cali, Bogota
Ave. Duration
6 h 58 min
When
Every day
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Santa Marta, Bogota
Ave. Duration
7 h 26 min
When
Saturday and Sunday
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Bogota, Quito
Ave. Duration
7 h 37 min
When
Monday, Tuesday, Wednesday and Thursday
Estimated price
$430 - $800
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Bogota
Ave. Duration
5 h 4 min
When
Monday, Tuesday, Wednesday, Saturday and Sunday
Estimated price
$190 - $700
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Quibdo, Bogota
Ave. Duration
6 h 19 min
When
Monday to Friday
Estimated price
$200 - $750
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Bogota, Cali
Ave. Duration
5 h 50 min
When
Monday, Tuesday, Wednesday and Sunday
Estimated price
$190 - $750
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Pereira, Bogota
Ave. Duration
7 h 29 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $750
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Monteria, Bogota
Ave. Duration
7 h
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$230 - $800
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Bogota, Quito
Ave. Duration
7 h 18 min
When
Tuesday and Wednesday
Estimated price
$190 - $700
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Cucuta, Bogota
Ave. Duration
8 h 34 min
When
Every day
Estimated price
$230 - $800
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Ibague, Bogota
Ave. Duration
8 h 34 min
When
Every day
Estimated price
$200 - $750
Copa Airlines
Website
copaair.com
Flights from Medellin Jose Marie Cordova to Guayaquil via Panama City
Ave. Duration
5 h 2 min
When
Every day
Estimated price
$480 - $1,200
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Pereira, Panama City
Ave. Duration
6 h 27 min
When
Tuesday, Wednesday and Friday
Estimated price
$210 - $900
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Bogota, Panama City
Ave. Duration
7 h 54 min
When
Tuesday, Wednesday, Saturday and Sunday
Estimated price
$230 - $950
LATAM Chile
Website
latam.com
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Bogota, Lima
Ave. Duration
8 h 44 min
When
Tuesday and Saturday
Estimated price
$360 - $1,400
Bus operators
Rutas De America
Phone
+57 (2) 641 0936 Colombia / +58 (424) 7017720 / (276) 415 78 01 Venezuela / (212) 762 94 06 Caracas
Email
reservas@rutasdeamerica.com.co
Website
rutasdeamerica.com.co
Bus from Rumichaca to Quito
Ave. Duration
5 h
Frequency
Every 4 hours
Estimated price
$70 - $95
Schedules at
rutasdeamerica.com.co
Bus from Buga to Quito
Ave. Duration
24 h
Frequency
Every 4 hours
Estimated price
$85 - $150
Schedules at
rutasdeamerica.com.co
Panamericana Internacional
Phone
+593 (2) 2557133 / 2557134
Email
info@panamericana.ec
Website
panamericana.ec
Bus from Quito - Terminal Quitumbe to Santo Domingo de los Colorados
Ave. Duration
1 h 44 min
Frequency
Every 10 minutes
Estimated price
$6 - $10
Schedules at
panamericana.ec
Cooperativa de Transportes Zaracay
Phone
(+593)-0236547894
Website
transporteszaracay.com.ec
Bus from Santo Domingo de los Colorados to Guayaquil
Ave. Duration
5 h
Frequency
Every 30 minutes
Estimated price
$7
Schedules at
transporteszaracay.com.ec
Book at
andestransit.com
Expreso Trejos
Expreso Internacional Ormeño Perú
Website
grupo-ormeno.com.co
Bus from Cali to Guayaquil Terminal, Avenida Benjamín Rosales, La Garzota, Tarqui, Guayaquil, Guayas, Ecuador
Ave. Duration
26 h
Frequency
3 times a week
Schedules at
es-la.facebook.com
Expreso Palmira
Website
expresopalmira.com.co
Bus from Pereira to Buga
Ave. Duration
2 h 45 min
Frequency
Every 30 minutes
Estimated price
$7 - $19
Schedules at
expresopalmira.com.co
Regular With WiFi (Mettro)
$8 - $12
Premium (S26)
$16 - $19
De Occidente
Website
deoccidente.com
Bus from Pereira to Buga
Ave. Duration
2 h 30 min
Frequency
4 times a day
Schedules at
deoccidente.com
Cooperativa de Transportes Aerotaxi
Phone
593 99 195 2081
Email
transportesaerotaxi@yahoo.com
Website
coop_transporte_aerotaxi.amawebs.com
Bus from Quito Terminal Quitumbe to Guayaquil
Ave. Duration
9 h 10 min
Frequency
Every 4 hours
Estimated price
$14
Schedules at
coop_transporte_aerotaxi.amawebs.com
Book at
andestransit.com

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Questions & Answers

The distance between Medellín and Guayaquil is 1057 km. The road distance is 1646 km.

The cheapest way to get from Medellín to Guayaquil is to bus which costs $80 - $140 and takes 24 h 18 min.

The quickest way to get from Medellín to Guayaquil is to fly which takes 4 h 24 min and costs $200 - $750.

No, there is no direct bus from Medellín to Guayaquil. However, there are services departing from Medellín and arriving at Guayaquil via Pereira, Buga and Quito Terminal Quitumbe. The journey, including transfers, takes approximately 43 h 34 min.

It takes approximately 6 h 22 min to get from Medellín to Guayaquil, including transfers.