There are 6 ways to get from Medellín to Guayaquil by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  6 h 22 min

  1. Fly from Medellin Jose Marie Cordova (MDE) to Guayaquil (GYE) MDE - GYE

$266 - $521

Cheapest option

Bus Expreso Internacional Ormeño  •  31 h 1 min

  1. Take the bus from Medellín to Buga
  2. Take the bus from Buga to Cali
  3. Take the bus from Cali to Guayaquil

$89 - $134

4 alternative options

Lo Nuestro, Class plus, bus  •  32 h 3 min

  1. Take the Lo Nuestro, Class plus from Medellín to Remolinos
  2. Take the bus from Cartago to Cali
  3. Take the bus from Cali to Guayaquil

$111 - $174

Bus via Quito  •  40 h 46 min

  1. Take the bus from Medellín to Pereira
  2. Take the bus from Pereira to Buga
  3. Take the bus from Buga to Quito
  4. Take the bus from Quito - Terminal Quitumbe to Santo Domingo de los Tsáchilas
  5. Take the bus from Santo Domingo de los Colorados to Guayaquil

$113 - $201

Bus via Quito #2  •  43 h 4 min

  1. Take the bus from Medellín to Pereira
  2. Take the bus from Pereira to Buga
  3. Take the bus from Buga to Quito
  4. Take the bus from Quito Terminal Quitumbe to Guayaquil

$114 - $197

Drive  •  26 h 22 min

  1. Drive from Medellín to Guayaquil 1028.6 miles

$100 - $160

Questions & Answers

The cheapest way to get from Medellín to Guayaquil is to bus which costs $85 - $140 and takes 31 h 1 min.

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The quickest way to get from Medellín to Guayaquil is to fly which costs $260 - $550 and takes 6 h 22 min.

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No, there is no direct bus from Medellín to Guayaquil. However, there are services departing from Medellín and arriving at Guayaquil via Pereira, Buga, Quito - Terminal Quitumbe and Santo Domingo de los Colorados. The journey, including transfers, takes approximately 40 h 46 min.

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The distance between Medellín and Guayaquil is 1057 km. The road distance is 1645.8 km.

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The best way to get from Medellín to Guayaquil without a car is to bus which takes 31 h 1 min and costs $85 - $140.

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It takes approximately 6 h 22 min to get from Medellín to Guayaquil, including transfers.

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Medellín to Guayaquil bus services, operated by Flota Ospina, depart from Medellín station.

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The best way to get from Medellín to Guayaquil is to fly which takes 6 h 22 min and costs $260 - $550. Alternatively, you can bus, which costs $85 - $140 and takes 31 h 1 min.

Mode details

There is no direct flight from Medellin Jose Marie Cordova Airport to Guayaquil Airport. The quickest flight takes 3 h 26 min and has one stopover.

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Medellín to Guayaquil bus services, operated by Cooperativa de Transportes Zaracay, arrive at Guayaquil station.

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Map of how to get from Medellín to Guayaquil.
Launch map view
  • Distance: 660.6 miles
  • Duration: 6 h 22 min

What companies run services between Medellín, Colombia and Guayaquil, Ecuador?

Avianca - Aerovías del Continente Americano S.A., Copa Airlines and three other airlines fly from Medellín to Guayaquil hourly. Alternatively, you can take a bus from Medellín to Guayaquil via Buga, Cali, and Guayaquil in around 31 h 1 min.

Airlines
Avianca - Aerovías del Continente Americano S.A.
Website
avianca.com
Flights from Medellin Jose Marie Cordova to Guayaquil via Cali
Ave. Duration
3 h 26 min
When
Every day
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Bogota
Ave. Duration
4 h 4 min
When
Every day
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Bogota, Quito
Ave. Duration
5 h 27 min
When
Thursday, Friday and Sunday
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Bogota, Cali
Ave. Duration
5 h 43 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Barranquilla, Bogota
Ave. Duration
6 h 54 min
When
Wednesday and Saturday
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Cali, Bogota
Ave. Duration
6 h 58 min
When
Monday, Tuesday, Thursday, Friday and Saturday
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Santa Marta, Bogota
Ave. Duration
7 h 26 min
When
Saturday and Sunday
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Cartagena, Cali
Ave. Duration
7 h 36 min
When
Every day
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Cartagena, Bogota
Ave. Duration
7 h 49 min
When
Every day
Estimated price
$430 - $800
Copa Airlines
Website
copaair.com
Flights from Medellin Jose Marie Cordova to Guayaquil via Panama City
Ave. Duration
4 h 50 min
When
Every day
Estimated price
$480 - $1,200
Bus operators
Empresa Arauca
Phone
018000 42 37 87
Email
contacto@empresaarauca.com.co
Website
empresaarauca.com.co
Bus from Medellín to Buga
Ave. Duration
6 h 30 min
Frequency
Every 3 hours
Estimated price
$15 - $35
Schedules at
empresaarauca.com.co
Cooperativa Ciudad Señora
Phone
0057 (2) 6687964
Email
cooperativa@cootrancise.com
Bus from Buga to Cali
Ave. Duration
1 h 10 min
Frequency
Every 15 minutes
Estimated price
$3
Schedules at
terminalcali.com
Bus from Cartago to Cali
Ave. Duration
2 h 10 min
Frequency
Once daily
Estimated price
$6
Schedules at
terminalcali.com
Expreso Palmira
Website
expresopalmira.com.co
Bus from Pereira to Buga
Ave. Duration
2 h 45 min
Frequency
Every 30 minutes
Estimated price
$7 - $18
Schedules at
expresopalmira.com.co
Regular With WiFi (Mettro)
$7 - $11
Premium (S26)
$16 - $18
De Occidente
Website
deoccidente.com
Bus from Pereira to Buga
Ave. Duration
2 h 30 min
Frequency
4 times a day
Estimated price
$7
Schedules at
deoccidente.com
Panamericana Internacional
Phone
+593 (2) 2557133 / 2557134
Email
info@panamericana.ec
Website
panamericana.ec
Bus from Quito - Terminal Quitumbe to Santo Domingo de los Tsáchilas
Ave. Duration
2 h 7 min
Frequency
Hourly
Estimated price
$6 - $9
Schedules at
panamericana.ec
Transportes Occidentales
Phone
+593 2-303-4291
Email
sistemas@transportesoccidentales.com
Website
transportesoccidentales.com.ec
Bus from Quito - Terminal Quitumbe to Santo Domingo de los Tsáchilas
Ave. Duration
2 h 17 min
Frequency
5 times a day
Estimated price
$11
Schedules at
transportesoccidentales.com.ec
Book at
andestransit.com
Reina del Camino
Phone
042130757 - 042130030, 023824850 - 023824875
Email
denuncias@reinadelcamino.ec
Website
facebook.com
Bus from Quito Terminal Quitumbe to Santo Domingo
Ave. Duration
2 h 22 min
Frequency
3 times a day
Estimated price
$9
Schedules at
busbud.com
Cooperativa de Transportes Zaracay
Phone
(+593)-0236547894
Website
transporteszaracay.com.ec
Bus from Santo Domingo de los Colorados to Guayaquil
Ave. Duration
5 h
Frequency
Every 30 minutes
Estimated price
$7
Schedules at
transporteszaracay.com.ec
Book at
andestransit.com
Cooperativa de Transportes Aerotaxi
Phone
593 99 195 2081
Email
transportesaerotaxi@yahoo.com
Website
coop_transporte_aerotaxi.amawebs.com
Bus from Quito Terminal Quitumbe to Guayaquil
Ave. Duration
9 h 10 min
Frequency
Every 4 hours
Estimated price
$14
Schedules at
coop_transporte_aerotaxi.amawebs.com
Book at
andestransit.com

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More Questions & Answers

Yes, the driving distance between Medellín to Guayaquil is 1646 km. It takes approximately 26 h 22 min to drive from Medellín to Guayaquil.

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Copa Airlines and Avianca - Aerovías del Continente Americano S.A. offer flights from Medellin Jose Marie Cordova Airport to Guayaquil Airport.

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There are 291+ hotels available in Guayaquil. Prices start at $25 USD per night.

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The best way to get from Medellín to Medellin Jose Marie Cordova Airport is to shuttle which takes 45 min and costs $27.

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