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There are 8 ways to get from Medellín to Guayaquil by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Medellin Jose Marie Cordova  •  6h 22m

  1. Fly from Medellin Jose Marie Cordova (MDE) to Guayaquil (GYE) MDE - GYE

$249 - $504

Cheapest option

Bus Tiseca  •  31h 18m

  1. Take the bus from Medellín to Buga
  2. Take the bus from Buga to Cali
  3. Take the bus from Cali to Guayaquil

$84 - $199

6 alternative options

Fly from Medellin Enrique Olaya Herrera  •  4h 8m

  1. Fly from Medellin Enrique Olaya Herrera (EOH) to Guayaquil (GYE) EOH - GYE

$213 - $729

Bus via Chinchiná  •  30h 59m

  1. Take the bus from Medellín to Remolinos
  2. Take the bus from Cartago to Cali
  3. Take the bus from Cali to Guayaquil

$107 - $157

Bus  •  30h 35m

  1. Take the bus from Medellín to Buga
  2. Take the bus from Buga to Cali
  3. Take the bus from Cali to Guayaquil

$85 - $130

Bus Tiseca #2  •  33h 14m

  1. Take the bus from Medellín to Pereira
  2. Take the bus from Pereira to Cali
  3. Take the bus from Cali to Guayaquil

$90 - $191

Bus via Quito Terminal Quitumbe  •  41h 52m

  1. Take the bus from Medellín to Pereira
  2. Take the bus from Pereira to Cali
  3. Take the bus from Cali to Quito Terminal Quitumbe
  4. Take the bus from Quito Terminal Quitumbe to Guayaquil

$139 - $191

Drive  •  26h 22m

  1. Drive from Medellín to Guayaquil 1028.6 miles

$100 - $160

Questions & Answers

The cheapest way to get from Medellín to Guayaquil is to bus which costs $85 - $130 and takes 30h 35m.

More details

The quickest way to get from Medellín to Guayaquil is to fly which costs $210 - $750 and takes 4h 8m.

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No, there is no direct bus from Medellín to Guayaquil. However, there are services departing from Medellín and arriving at Guayaquil via Pereira, Terminal, Cali and Quito Terminal Quitumbe. The journey, including transfers, takes approximately 41h 52m.

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The distance between Medellín and Guayaquil is 1057 km. The road distance is 1645.8 km.

Get driving directions

The best way to get from Medellín to Guayaquil without a car is to bus which takes 30h 59m and costs $100 - $160.

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It takes approximately 6h 22m to get from Medellín to Guayaquil, including transfers.

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Medellín to Guayaquil bus services, operated by Flota Ospina, depart from Medellín station.

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The best way to get from Medellín to Guayaquil is to fly which takes 6h 22m and costs $240 - $550. Alternatively, you can bus, which costs $100 - $160 and takes 30h 59m.

Mode details

There is no direct flight from Medellin Jose Marie Cordova Airport to Guayaquil Airport. The quickest flight takes 3h 26m and has one stopover.

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Medellín to Guayaquil bus services, operated by Cooperativa de Transportes Aerotaxi, arrive at Guayaquil station.

More details

Map of how to get from Medellín to Guayaquil.
Launch map view
  • Distance: 660.6 miles
  • Duration: 6h 22m

What companies run services between Medellín, Colombia and Guayaquil, Ecuador?

Avianca - Aerovías del Continente Americano S.A., Copa Airlines and two other airlines fly from Medellín to Guayaquil hourly. Alternatively, you can take a bus from Medellín to Guayaquil via Remolinos, Chinchiná, Pereira, Cartago, Cali, Clinica Uribe, Cali, and Guayaquil in around 30h 59m.

Airlines
Avianca - Aerovías del Continente Americano S.A.
Website
avianca.com
Flights from Medellin Jose Marie Cordova to Guayaquil via Cali
Ave. Duration
3h 26m
When
Every day
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Bogota
Ave. Duration
4h 10m
When
Every day
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Bogota, Cali
Ave. Duration
6h 2m
When
Every day
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Bogota, Quito
Ave. Duration
6h 30m
When
Every day
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Cartagena, Bogota
Ave. Duration
7h 3m
When
Every day
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Cali, Bogota
Ave. Duration
7h 11m
When
Every day
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Barranquilla, Bogota
Ave. Duration
7h 21m
When
Every day
Estimated price
$430 - $800
Flights from Medellin Jose Marie Cordova to Guayaquil via Cartagena, Cali
Ave. Duration
7h 36m
When
Every day
Estimated price
$430 - $800
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Bogota
Ave. Duration
5h 21m
When
Every day
Estimated price
$190 - $700
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Pereira, Bogota
Ave. Duration
5h 35m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $750
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Quibdo, Bogota
Ave. Duration
6h 47m
When
Every day
Estimated price
$200 - $750
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Bogota, Cali
Ave. Duration
5h 55m
When
Monday, Tuesday, Thursday, Friday, Saturday and Sunday
Estimated price
$190 - $750
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Cucuta, Bogota
Ave. Duration
7h
When
Every day
Estimated price
$230 - $800
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Bogota, Quito
Ave. Duration
7h 3m
When
Tuesday, Wednesday and Saturday
Estimated price
$190 - $700
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Armenia, Bogota
Ave. Duration
7h 25m
When
Monday to Friday
Estimated price
$200 - $750
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Ibague, Bogota
Ave. Duration
7h 25m
When
Every day
Estimated price
$200 - $750
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Monteria, Bogota
Ave. Duration
8h 5m
When
Every day
Estimated price
$230 - $800
Copa Airlines
Website
copaair.com
Flights from Medellin Jose Marie Cordova to Guayaquil via Panama City
Ave. Duration
4h 39m
When
Every day
Estimated price
$480 - $1,200
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Pereira, Panama City
Ave. Duration
6h 18m
When
Monday, Tuesday, Friday and Sunday
Estimated price
$210 - $900
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Bogota, Panama City
Ave. Duration
8h 7m
When
Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$230 - $950
TAME
Website
tame.com.ec
Flights from Medellin Enrique Olaya Herrera to Guayaquil via Bogota
Ave. Duration
3h 51m
When
Saturday
Estimated price
$360 - $750
Bus operators
Cooperativa Ciudad Señora
Phone
0057 (2) 6687964
Email
cooperativa@cootrancise.com
Bus from Cartago to Cali
Ave. Duration
2h 10m
Frequency
Once daily
Estimated price
$6
Schedules at
terminalcali.com
Bus from Buga to Cali
Ave. Duration
1h 10m
Frequency
Every 15 minutes
Estimated price
$3
Schedules at
terminalcali.com
Empresa Arauca
Tiseca
Phone
+58 276 7713091
Website
tiseca.com.ve
Bus from Cali to Guayaquil
Ave. Duration
23h
Frequency
Hourly
Estimated price
$133
Schedules at
tiseca.com.ve
Conexiones Siglo 21
Phone
+57 311 357 5623
Email
ayuda@conexionesiglo21.com
Website
conexionesiglo21.com
Bus from Cali to Guayaquil
Ave. Duration
23h
Frequency
Every 4 hours
Estimated price
$129
Schedules at
conexionesiglo21.com
Alianza Internacional del Sur
Website
facebook.com
Bus from Cali to Guayaquil
Ave. Duration
22h
Frequency
6 times a week
Schedules at
venezuelatravelinternational.com
Book at
venezuelatravelinternational.com
Cruz del Sur
Phone
+51 1 311-5050
Website
cruzdelsur.com.pe
Bus from Cali to Quito Terminal Quitumbe
Ave. Duration
20h 30m
Frequency
Once a week
Estimated price
$100 - $150
Schedules at
cruzdelsur.com.pe
Book at
cruzdelsur.com.pe
Cooperativa de Transportes Aerotaxi
Phone
593 99 195 2081
Email
transportesaerotaxi@yahoo.com
Website
coop_transporte_aerotaxi.amawebs.com
Bus from Quito Terminal Quitumbe to Guayaquil
Ave. Duration
9h 10m
Frequency
Every 4 hours
Estimated price
$14
Schedules at
coop_transporte_aerotaxi.amawebs.com
Book at
andestransit.com

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More Questions & Answers

Yes, the driving distance between Medellín to Guayaquil is 1646 km. It takes approximately 26h 22m to drive from Medellín to Guayaquil.

Get driving directions

Copa Airlines and Avianca - Aerovías del Continente Americano S.A. offer flights from Medellin Jose Marie Cordova Airport to Guayaquil Airport.

Search flights

There are 300+ hotels available in Guayaquil. Prices start at $25 USD per night.

More details

The best way to get from Medellín to Medellin Jose Marie Cordova Airport is to shuttle which takes 45m and costs $10.

More details