Rome2Rio

How to get fromMebane to Lexingtonby bus, plane, car, or train

Find Transport to Lexington

See all options

There are 8 ways to get from Mebane to Lexington by bus, plane, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Raleigh-Durham International Airport, fly to Louisville International Airport, drive

    best
    1. Take the bus from E Washington St at S 5th St to Willard St at Durham Stationbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Louisville International Airport (SDF)plane plane RDU - SDF
    3. Drive from Louisville-Airport-SDF to Lexingtoncar car
    6h 33m
    $120–680

  2. Bus to Raleigh-Durham International Airport, fly to Blue Grass Airport

    cheapest
    1. Take the bus from E Washington St at S 5th St to Willard St at Durham Stationbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Blue Grass Airport (LEX)plane plane RDU - LEX
    9h 20m
    $68–380

  3. Bus, drive

    1. Take the bus from E Washington St at S 5th St to Willard St at Durham Stationbus bus Odx
    2. Take the bus from Durham to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Louisville Bus Stationbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    23h 18m
    $132–232

  4. Bus, train, drive

    1. Take the bus from E Washington St at S 5th St to Willard St at Durham Stationbus bus Odx
    2. Take the bus from Durham Station to Union Station - Bus Platform Abus bus Drx
    3. Take the train from Raleigh Union Station to Toledotrain train
    4. Take the bus from Toledo Bus Stop to Louisville Bus Stationbus bus
    5. Drive from Middletown Station @ Target to Lexingtoncar car
    33h 59m
    $274–584

  5. Drive  403.9 mi

    1. Drive from Mebane to Lexingtoncar car 403.9 mi
    7h 59m
    $74–107

  6. Bus to Raleigh-Durham International Airport, fly to Covington, drive

    1. Take the bus from E Washington St at S 5th St to Willard St at Durham Stationbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Covington (CVG)plane plane RDU - CVG
    3. Drive from Covington (CVG) to Lexingtoncar car
    6h 36m
    $116–630

  7. Bus to Piedmont Triad International Airport, fly to Blue Grass Airport

    1. Take the bus from Mebane Cone Health Park & Ride to Coble Transportation Centerbus bus
    2. Fly from Piedmont Triad International Airport (GSO) to Blue Grass Airport (LEX)plane plane GSO - LEX
    9h 29m
    $88–436

  8. Bus, drive via Greensboro

    1. Take the bus from Mebane Cone Health Park & Ride to Greensboro Depotbus bus 4
    2. Take the bus from Greensboro Bus Stop to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Louisville Bus Stationbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    23h 53m
    $124–224

Raleigh-Durham International Airport (RDU) to Louisville International Airport (SDF) flights

Calendar76Weekly Planes
Duration3h 39mAverage Duration
Ticket$106Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Mebane to Lexington.ExpandLaunch map view
  • Distance: 539.1 mi
  • Duration: 6h 33m

What companies run services between Mebane, NC, USA and Lexington, KY, USA?

There is no direct connection from Mebane to Lexington. However, you can take the bus to Willard St at Durham Station, walk to Durham Station, take the bus to Regional Transit Center, take the line 100 bus to RDU Airport at Terminal 1, walk to Raleigh-Durham-Airport-RDU airport, fly to Louisville International Airport (SDF), then drive to Lexington. Alternatively, you can take a bus from E Washington St at S 5th St to Lexington via Durham, Atlanta Bus Station, Louisville Bus Station, Chestnut @ 13th, Chestnut @ 8th, S 5th @ W Jefferson, and Middletown Station @ Target in around 23h 18m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound