There are 4 ways to get from Mayo Clinic to Des Moines by shuttle, bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Shuttle, bus  •  4 h 36 min

  1. Take a shuttle bus from Rochester to Albert Lea. MN
  2. Take the bus from Albert Lea, MN to Des Moines, IA 801 / ...

$44 - $80

3 alternative options

Drive  •  3 h 28 min

  1. Drive from Mayo Clinic to Des Moines 211.1 miles

$20 - $30

Fly from Rochester  •  5 h 37 min

  1. Fly from Rochester (RST) to Des Moines (DSM) RST - DSM

$189 - $1,112

Bus to Minneapolis, fly  •  4 h 59 min

  1. Take the bus from Rochester, MN to Minneapolis-St Paul Airport, MN
  2. Fly from Minneapolis (MSP) to Des Moines (DSM) MSP - DSM

$224 - $352

Questions & Answers

The distance between Mayo Clinic and Des Moines is 178 miles. The road distance is 211.1 miles.

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The best way to get from Mayo Clinic to Des Moines without a car is to shuttle and bus which takes 4 h 36 min and costs .

More details

It takes approximately 4 h 36 min to get from Mayo Clinic to Des Moines, including transfers.

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There is no direct flight from Rochester Airport to Des Moines Airport. The quickest flight takes 3 h 6 min and has one stopover.

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Yes, the driving distance between Mayo Clinic to Des Moines is 211 miles. It takes approximately 3 h 28 min to drive from Mayo Clinic to Des Moines.

Get driving directions

Delta, United Airlines and American Airlines offer flights from Rochester Airport to Des Moines Airport.

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There are 106+ hotels available in Des Moines. Prices start at $75 USD per night.

More details

Map of how to get from Mayo Clinic to Des Moines.
Launch map view
  • Distance: 178.1 miles
  • Duration: 4 h 36 min

What companies run services between Mayo Clinic, MN, USA and Des Moines, IA, USA?

Delta, American Airlines and United Airlines fly from Mayo Clinic to Des Moines hourly.

Airlines
Delta
Website
delta.com
Flights from Rochester to Des Moines via Minneapolis
Ave. Duration
3 h 37 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $1,100
Flights from Minneapolis to Des Moines
Ave. Duration
1 h 15 min
When
Every day
Estimated price
$250 - $900
American Airlines
Website
aa.com
Flights from Rochester to Des Moines via Chicago O'Hare
Ave. Duration
4 h 43 min
When
Every day
Estimated price
$220 - $1,100
United Airlines
Website
united.com
Flights from Rochester to Des Moines via Chicago O'Hare
Ave. Duration
4 h 41 min
When
Every day
Estimated price
$240 - $1,200
Bus operators
Land to Air Express
Website
landtoairexpress.com
Shuttle from Rochester to Albert Lea. MN
Ave. Duration
1 h 5 min
Frequency
Every 4 hours
Estimated price
$8 - $30
Schedules at
landtoairexpress.com
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Albert Lea, MN to Des Moines, IA
Ave. Duration
2 h 55 min
Frequency
Hourly
Estimated price
$35 - $50
Book at
jeffersonlines.com
Bus from Rochester, MN to Minneapolis-St Paul Airport, MN
Ave. Duration
1 h 25 min
Frequency
Every 3 hours
Estimated price
$22 - $35
Book at
jeffersonlines.com

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