There are 5 ways to get from Mayo Clinic to Des Moines by shuttle, bus, night bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Shuttle, bus  •  4 h 31 min

  1. Take a shuttle bus from Rochester to Albert Lea. MN
  2. Take the bus from Albert Lea, MN to Des Moines, IA 801 / ...

$44 - $80

4 alternative options

Bus, night bus  •  7 h 7 min

  1. Take the bus from Rochester, MN to Minneapolis, MN 966
  2. Take the night bus from Minneapolis, MN to Des Moines, IA 805

$69 - $103

Drive  •  3 h 28 min

  1. Drive from Mayo Clinic to Des Moines 211.1 miles

$20 - $30

Fly from Rochester  •  6 h 5 min

  1. Fly from Rochester (RST) to Des Moines (DSM) RST - DSM

$189 - $1,112

Bus to Minneapolis, fly  •  4 h 55 min

  1. Take the bus from Rochester, MN to Minneapolis-St Paul Airport, MN
  2. Fly from Minneapolis (MSP) to Des Moines (DSM) MSP - DSM

$224 - $352

Questions & Answers

The cheapest way to get from Mayo Clinic to Des Moines is to drive which costs $20 - $30 and takes 3 h 28 min.

More details

The quickest way to get from Mayo Clinic to Des Moines is to drive which costs $20 - $30 and takes 3 h 28 min.

More details

The distance between Mayo Clinic and Des Moines is 178 miles. The road distance is 211.1 miles.

Get driving directions

It takes approximately 4 h 31 min to get from Mayo Clinic to Des Moines, including transfers.

More details

No, there is no direct bus from Mayo Clinic to Des Moines. However, there are services departing from Rochester, MN and arriving at Des Moines, IA via Minneapolis, MN. The journey, including transfers, takes approximately 7 h 7 min.

More details

What companies run services between Mayo Clinic, MN, USA and Des Moines, IA, USA?

United Airlines, American Airlines and Delta fly from Mayo Clinic to Des Moines hourly.

Airlines
Delta
Website
delta.com
Flights from Rochester to Des Moines via Minneapolis
Ave. Duration
4 h 50 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $1,100
Flights from Rochester to Des Moines via Atlanta
Ave. Duration
7 h 39 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$300 - $1,300
Flights from Rochester to Des Moines via Minneapolis, Detroit
Ave. Duration
6 h 59 min
When
Saturday
Estimated price
$260 - $1,200
Flights from Minneapolis to Des Moines
Ave. Duration
1 h 11 min
When
Every day
Estimated price
$250 - $900
American Airlines
Website
aa.com
Flights from Rochester to Des Moines via Chicago O'Hare
Ave. Duration
5 h 21 min
When
Every day
Estimated price
$220 - $1,100
United Airlines
Website
united.com
Flights from Rochester to Des Moines via Chicago O'Hare
Ave. Duration
5 h 8 min
When
Every day
Estimated price
$240 - $1,200
Bus operators
Land to Air Express
Website
landtoairexpress.com
Shuttle from Rochester to Albert Lea. MN
Ave. Duration
1 h
Frequency
3 times a day
Estimated price
$8 - $30
Schedules at
landtoairexpress.com
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Albert Lea, MN to Des Moines, IA
Ave. Duration
2 h 55 min
Frequency
Hourly
Estimated price
$35 - $50
Schedules at
jeffersonlines.com
Bus from Rochester, MN to Minneapolis, MN
Ave. Duration
2 h
Frequency
Every 3 hours
Estimated price
$23 - $35
Schedules at
jeffersonlines.com
Night bus from Minneapolis, MN to Des Moines, IA
Ave. Duration
3 h 59 min
Frequency
Every 3 hours
Estimated price
$45 - $70
Schedules at
jeffersonlines.com
Bus from Rochester, MN to Minneapolis-St Paul Airport, MN
Ave. Duration
1 h 25 min
Frequency
Every 3 hours
Estimated price
$22 - $35
Schedules at
jeffersonlines.com

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