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How to get fromMattoon to Des Moinesby train, bus, car, or plane

Find Transport to Des Moines

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There are 7 ways to get from Mattoon to Des Moines by train, bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain train Saluki / ...
    2. Take the bus from Champaign Intermodal Trans Ctr to Des Moinesbus bus Greyhound US0157S
    9h 36m
    $64–129

  2. Drive 381.7 mi

    1. Drive from Mattoon to Des Moinescar car 381.7 mi
    7h 4m
    $70–101

  3. Train to University Of Illinois Willard Airport, fly

    1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain train
    2. Fly from University Of Illinois Willard Airport (CMI) to Des Moines (DSM)plane plane CMI - DSM
    6h 4m
    $144–622

  4. Train to Chicago O'Hare International Airport, fly

    1. Take the train from Mattoon Amtrak Station to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM)plane plane ORD - DSM
    7h 8m
    $149–629

  5. Train to Chicago Midway International Airport, fly

    1. Take the train from Mattoon Amtrak Station to Homewoodtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Des Moines (DSM)plane plane MDW - DSM
    7h 7m
    $166–780

  6. Train, bus to Central Illinois Regional Airport At Bloomington-Normal, fly

    1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Bloomington-Normalbus bus
    3. Fly from Central Illinois Regional Airport At Bloomington-Normal (BMI) to Des Moines (DSM)plane plane BMI - DSM
    9h 26m
    $129–616

  7. Train, bus to Decatur Airport, fly

    1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Decatur Downtown Transportation Centerbus bus
    3. Fly from Decatur Airport (DEC) to Des Moines (DSM)plane plane DEC - DSM
    9h 10m
    $147–680

Mattoon to Des Moines by train and bus

Calendar7Weekly Services
Duration9h 36mAverage Duration
Ticket$64Cheapest Price
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Questions & Answers

Map of how to get from Mattoon to Des Moines.ExpandLaunch map view
  • Distance: 386.4 mi
  • Duration: 9h 36m

What companies run services between Mattoon, IL, USA and Des Moines, IA, USA?

There is no direct connection from Mattoon to Des Moines. However, you can take the train to Champaign-Urbana, walk to Champaign Intermodal Trans Ctr, then take the bus to Des Moines. Alternatively, you can drive from Mattoon to Des Moines in around 7h 4m.

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