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How to get fromMattoon to Buffaloby train, plane, bus, train (Amtrak), or car

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There are 8 ways to get from Mattoon to Buffalo by train, plane, bus, train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to University Of Illinois Willard Airport, fly

    best
    1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain train
    2. Fly from University Of Illinois Willard Airport (CMI) to Buffalo Niagara International Airport (BUF)plane plane CMI - BUF
    7h 16m
    $134–680

  2. Train, bus

    cheapest
    1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis, IN to Toledobus bus
    4. Take the bus from Toledo to Clevelandbus bus
    5. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    15h 46m
    $81–234

  3. Train (Amtrak)

    1. Take the train from Mattoon Amtrak Station to Chicago Union Stationtrain train Saluki / ...
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    16h 11m
    $215–591

  4. Drive 625.2 mi

    1. Drive from Mattoon to Buffalocar car 625.2 mi
    11h 20m
    $115–165

  5. Train to Chicago O'Hare International Airport, fly

    1. Take the train from Mattoon Amtrak Station to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF)plane plane ORD - BUF
    8h 4m
    $227–445

  6. Train to Chicago Midway International Airport, fly

    1. Take the train from Mattoon Amtrak Station to Homewoodtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)plane plane MDW - BUF
    7h 55m
    $214–506

  7. Train, bus to Decatur Airport, fly

    1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Decatur Downtown Transportation Centerbus bus
    3. Fly from Decatur Airport (DEC) to Buffalo Niagara International Airport (BUF)plane plane DEC - BUF
    11h 33m
    $137–687

  8. Train, bus via Chicago

    1. Take the train from Mattoon Amtrak Station to Champaign-Urbanatrain train
    2. Take the bus from Champaign Intermodal Trans Ctr to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus
    4. Take the bus from Cleveland Bus Station to Buffalobus bus
    17h 1m
    $138–249

Mattoon to Buffalo by train and bus

Calendar7Weekly Services
Duration15h 46mAverage Duration
Ticket$81Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mattoon to Buffalo.ExpandLaunch map view
  • Distance: 596.7 mi
  • Duration: 7h 16m

What companies run services between Mattoon, IL, USA and Buffalo, NY, USA?

You can take a train from Mattoon Amtrak Station to Buffalo via Chicago Union Station and Buffalo Depew Station in around 16h 11m.

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Bus operators

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