There are 5 ways to get from Matlacha to Key West by ferry, bus (Flixbus, Greyhound), car, bus, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Ferry
best- Take the ferry from Fort Myers Beach, FL to Key West, FLferry Fort Myers Beach
4h 35m$179–188Drive 287.2 mi
cheapest- Drive from Matlacha to Key Westcar 287.2 mi
6h 13m$53–76Bus
- Take the bus from Fort Myers Bus Stop to Miami Airport Stationbus
- Take the bus from Miami Airport Station to Big Pine Keybus
- Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus Lks
10h 18m$80–136Bus to Miami International Airport, fly
- Take the bus from Fort Myers 7-11 to Miami Airportbus
- Fly from Miami International Airport (MIA) to Key West International Airport (EYW)plane MIA - EYW
5h 32m$224–801Bus to Tampa, fly
- Take the bus from Fort Myers 7-11 to Tampa International Airportbus
- Fly from Tampa (TPA) to Key West International Airport (EYW)plane TPA - EYW
5h 11m$174–581
Miami International Airport (MIA) to Key West International Airport (EYW) flights
Questions & Answers
The cheapest way to get from Matlacha to Key West is to drive which costs $50 - $80 and takes 6h 13m.
The fastest way to get from Matlacha to Key West is to ferry which takes 4h 35m and costs $175 - $190.
The distance between Matlacha and Key West is 161 miles. The road distance is 288.8 miles.
The best way to get from Matlacha to Key West without a car is to ferry which takes 4h 35m and costs $175 - $190.
It takes approximately 4h 35m to get from Matlacha to Key West, including transfers.
Yes, the driving distance between Matlacha to Key West is 289 miles. It takes approximately 6h 13m to drive from Matlacha to Key West.
There are 805+ hotels available in Key West.
What companies run services between Matlacha, FL, USA and Key West, FL, USA?
Key West Express operates a ferry from Fort Myers Beach, FL to Key West, FL once daily. Tickets cost $130 and the journey takes 4h. Alternatively, you can take a vehicle from Matlacha to N Roosevelt & 3rd Street via Fort Myers Bus Stop, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 10h 18m.
- Website
- aa.com
Flights from Miami International Airport to Key West International Airport
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- $40–300
Flights from Tampa to Key West International Airport via Miami International Airport
- Ave. Duration
- 3h 7m
- When
- Saturday
- Estimated price
- $55–350
- Website
- flybreeze.com
Flights from Tampa to Key West International Airport
- Ave. Duration
- 1h 9m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $110–440
- Website
- spirit.com
Flights from Tampa to Key West International Airport via Fort Lauderdale
- Ave. Duration
- 3h 18m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $85–320
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Fort Myers Bus Stop to Miami Airport Station
- Ave. Duration
- 3h 5m
- Frequency
- 4 times a day
- Estimated price
- $25–55
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 35m
- Frequency
- 3 times a day
- Estimated price
- $22–40
- Website
- https://www.greyhound.com/
- Phone
- +1 305-809-3700
- Website
- cityofkeywest-fl.gov
Bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Street
- Ave. Duration
- 1h 9m
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- https://www.cityofkeywest-fl.gov/595/Schedules-and-Route-Maps
- Phone
- +1 877 733 0724
- Website
- redcoachusa.com
Bus from Fort Myers 7-11 to Miami Airport
- Ave. Duration
- 2h 55m
- Frequency
- 3 times a day
- Estimated price
- $23–140
- Website
- https://www.redcoachusa.com
- Web
- $23–140
Bus from Fort Myers 7-11 to Tampa International Airport
- Ave. Duration
- 2h 20m
- Frequency
- 5 times a week
- Estimated price
- $23–140
- Website
- https://www.redcoachusa.com
- Web
- $23–140
- Phone
- +1 239-463-5733
- Website
- keywestexpress.net
Ferry from Fort Myers Beach, FL to Key West, FL
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $130
- Website
- https://www.keywestexpress.net
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