There are 9 ways to get from Massachusetts to South Carolina by plane, bus, train, night bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Manchester to Charlotte  •  3 h 37 min

  1. Fly from Manchester (MHT) to Charlotte (CLT) MHT - CLT

$377 - $867

Cheapest option

Bus  •  17 h 47 min

  1. Take the bus from Boston, MA to New York
  2. Take the bus from New York, NY to Fayetteville, NC Nyc
  3. Take the bus from Fayetteville, Nc to Florence, Sc

$84 - $105

7 alternative options

Fly Boston to Charlotte  •  4 h 9 min

  1. Fly from Boston (BOS) to Charlotte (CLT) BOS - CLT

$163 - $513

Fly Boston to Charleston  •  4 h 50 min

  1. Fly from Boston (BOS) to Charleston (CHS) BOS - CHS

$125 - $466

Bus to Providence, fly to Charlotte  •  5 h 10 min

  1. Take the bus from New Bedford to Providence Downtown
  2. Fly from Providence (PVD) to Charlotte (CLT) PVD - CLT

$219 - $608

Bus to Hartford, fly to Charlotte  •  5 h 21 min

  1. Take the bus from Springfield, Ma to Hartford, Ct
  2. Fly from Hartford (BDL) to Charlotte (CLT) BDL - CLT

$226 - $544

Train  •  16 h 30 min

  1. Take the train from Boston South Station to New York Penn Station Acela Express / ...
  2. Take the train from New York Penn Station to Florence Amtrak Palmetto / ...

$219 - $600

Night bus, bus  •  20 h 20 min

  1. Take the night bus from Boston, Ma to New York, Ny
  2. Take the bus from New York, Ny to Fayetteville, Nc
  3. Take the bus from Fayetteville, Nc to Florence, Sc

$95 - $236

Drive  •  14 h 22 min

  1. Drive from Boston to Florence 848.7 miles

$80 - $120

Questions & Answers

The cheapest way to get from Massachusetts to South Carolina is to bus which costs $80 - $110 and takes 17 h 47 min.

More details

The quickest way to get from Massachusetts to South Carolina is to fly which costs $370 - $900 and takes 3 h 37 min.

More details

No, there is no direct bus from Massachusetts to South Carolina. However, there are services departing from Boston, MA and arriving at Florence, Sc via New York, NY and Fayetteville, Nc. The journey, including transfers, takes approximately 17 h 47 min.

More details

No, there is no direct train from Massachusetts station to South Carolina. However, there are services departing from Boston South Station and arriving at Florence Amtrak via New York Penn Station. The journey, including transfers, takes approximately 16 h 30 min.

More details

The distance between Massachusetts and South Carolina is 758 miles. The road distance is 848.7 miles.

Get driving directions

The best way to get from Massachusetts to South Carolina without a car is to train which takes 16 h 30 min and costs $210 - $600.

More details

It takes approximately 3 h 37 min to get from Massachusetts to South Carolina, including transfers.

More details

Massachusetts to South Carolina bus services, operated by Greyhound USA, depart from Boston, Ma station.

More details

Massachusetts to South Carolina train services, operated by Amtrak Acela Express, arrive at Boston South Station.

More details

The best way to get from Massachusetts to South Carolina is to fly which takes 3 h 37 min and costs $370 - $900. Alternatively, you can train, which costs $210 - $600 and takes 16 h 30 min, you could also bus, which costs $80 - $110 and takes 17 h 47 min.

Mode details

Map of how to get from Massachusetts to South Carolina.
Launch map view
  • Distance: 758.4 miles
  • Duration: 3 h 37 min

What companies run services between Massachusetts, USA and South Carolina, USA?

American Airlines, Southwest Airlines and two other airlines fly from Lowell to Rock Hill hourly. Alternatively, you can take a train from Boston to Florence via New York Penn Station in around 16 h 30 min.

Airlines
American Airlines
Website
aa.com
Flights from Manchester to Charlotte
Ave. Duration
2 h 31 min
When
Every day
Estimated price
$190 - $950
Flights from Manchester to Charlotte via Reagan Washington
Ave. Duration
4 h 40 min
When
Every day
Estimated price
$190 - $950
Flights from Manchester to Charlotte via Philadelphia
Ave. Duration
4 h 59 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $950
Flights from Boston to Charlotte
Ave. Duration
2 h 26 min
When
Every day
Estimated price
$95 - $900
Flights from Boston to Charleston via Charlotte
Ave. Duration
4 h 28 min
When
Every day
Estimated price
$150 - $1,100
Flights from Boston to Charleston via Reagan Washington
Ave. Duration
4 h 33 min
When
Monday to Friday
Estimated price
$150 - $1,100
Flights from Providence to Charlotte
Ave. Duration
2 h 16 min
When
Every day
Estimated price
$190 - $950
Flights from Providence to Charlotte via Reagan Washington
Ave. Duration
4 h 1 min
When
Monday to Saturday
Estimated price
$190 - $950
Flights from Providence to Charlotte via Philadelphia
Ave. Duration
4 h 6 min
When
Every day
Estimated price
$190 - $950
Flights from Hartford to Charlotte
Ave. Duration
2 h 11 min
When
Every day
Estimated price
$290 - $900
Flights from Hartford to Charlotte via Philadelphia
Ave. Duration
4 h 4 min
When
Every day
Estimated price
$290 - $900
Southwest Airlines
Website
southwest.com
Flights from Manchester to Charlotte via Baltimore
Ave. Duration
4 h 10 min
When
Monday to Saturday
Estimated price
$260 - $1,400
Flights from Boston to Charlotte via Baltimore
Ave. Duration
3 h 56 min
When
Monday to Saturday
Estimated price
$250 - $1,300
Flights from Boston to Charleston via Baltimore
Ave. Duration
4 h 11 min
When
Every day
Estimated price
$290 - $1,200
Flights from Providence to Charlotte via Baltimore
Ave. Duration
3 h 53 min
When
Monday to Saturday
Estimated price
$340 - $1,400
Flights from Hartford to Charlotte via Baltimore
Ave. Duration
3 h 56 min
When
Every day
Estimated price
$360 - $1,100
United Airlines
Website
united.com
Flights from Manchester to Charlotte via Newark
Ave. Duration
4 h 41 min
When
Every day
Estimated price
$180 - $1,400
Flights from Boston to Charlotte via Washington Dulles
Ave. Duration
4 h 2 min
When
Every day
Estimated price
$140 - $1,200
Flights from Boston to Charlotte via Newark
Ave. Duration
4 h 7 min
When
Monday to Friday
Estimated price
$140 - $1,200
Flights from Boston to Charleston via Washington Dulles
Ave. Duration
4 h 12 min
When
Every day
Estimated price
$190 - $1,200
Flights from Boston to Charleston via Newark
Ave. Duration
4 h 16 min
When
Every day
Estimated price
$190 - $1,200
Flights from Providence to Charlotte via Washington Dulles
Ave. Duration
4 h 2 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $1,800
Flights from Hartford to Charlotte via Washington Dulles
Ave. Duration
3 h 54 min
When
Every day
Estimated price
$290 - $900
JetBlue Airways
Website
jetblue.com
Flights from Boston to Charlotte
Ave. Duration
2 h 24 min
When
Every day
Estimated price
$140 - $1,000
Flights from Boston to Charlotte via New York JFK
Ave. Duration
3 h 53 min
When
Every day
Estimated price
$140 - $1,000
Flights from Boston to Charleston
Ave. Duration
2 h 28 min
When
Every day
Estimated price
$190 - $1,000
Flights from Boston to Charleston via Reagan Washington
Ave. Duration
4 h 16 min
When
Every day
Estimated price
$190 - $1,000
Delta
Website
delta.com
Flights from Manchester to Charlotte via Detroit
Ave. Duration
4 h 55 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$120 - $950
Flights from Boston to Charleston
Ave. Duration
2 h 25 min
When
Every day
Estimated price
$180 - $1,200
Frontier Airlines
Website
flyfrontier.com
Flights from Providence to Charlotte
Ave. Duration
2 h 16 min
When
Monday, Wednesday, Friday and Saturday
Estimated price
$90 - $420
Train operators
Amtrak Acela Express

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak Acela Express
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Boston South Station to New York Penn Station
Ave. Duration
3 h 40 min
Frequency
Every 4 hours
Estimated price
$120 - $340
Website
amtrak.com
Business Seat
$120 - $260
First Class Seat
$220 - $340
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from New York Penn Station to Florence Amtrak
Ave. Duration
11 h 50 min
Frequency
Twice daily
Estimated price
$90 - $260
Website
amtrak.com
Coach Seat
$90 - $140
Flexi Coach Seat
$160 - $230
Business Coach Seat
$180 - $260
Room
$370 - $550
Bus operators
Peter Pan Bus Lines
Phone
1-800-343-9999
Website
peterpanbus.com
Bus from New Bedford to Providence Downtown
Ave. Duration
40 min
Frequency
Twice daily
Estimated price
$12 - $17
Website
peterpanbus.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Springfield, Ma to Hartford, Ct
Ave. Duration
35 min
Frequency
Every 30 minutes
Estimated price
$9 - $20
Website
greyhound.com
Economy
$9 - $13
Flexible
$16 - $20
Bus from Fayetteville, Nc to Florence, Sc
Ave. Duration
1 h 35 min
Frequency
Every 30 minutes
Estimated price
$14 - $35
Website
greyhound.com
Economy
$14 - $22
Flexible
$26 - $35
Night bus from Boston, Ma to New York, Ny
Ave. Duration
4 h 20 min
Frequency
Hourly
Estimated price
$25 - $65
Website
greyhound.com
Economy
$25 - $40
Flexible
$45 - $65
Bus from New York, Ny to Fayetteville, Nc
Ave. Duration
13 h 45 min
Frequency
Hourly
Estimated price
$55 - $140
Website
greyhound.com
Economy
$55 - $90
Flexible
$100 - $140
Lucky Star Bus
Phone
(888) 881-0887 / (617) 269-5468
Email
info@luckystarbus.com
Website
luckystarbus.com
Bus from Boston, MA to New York
Ave. Duration
4 h 30 min
Frequency
Every 2 hours
Estimated price
$25
Schedules at
luckystarbus.com
Wanda Coach
Phone
6466307186
Email
help@wandacoach.com
Website
wandacoach.com
Bus from New York, NY to Fayetteville, NC
Ave. Duration
10 h 15 min
Frequency
5 times a day
Estimated price
$45
Schedules at
wandacoach.com

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

The quickest flight from Manchester Airport to Charlotte Airport is the direct flight which takes 2 h 27 min.

Search flights

Massachusetts to South Carolina bus services, operated by Greyhound USA, arrive at Florence, Sc station.

More details

Massachusetts to South Carolina train services, operated by Amtrak, arrive at Florence Amtrak station.

More details

Yes, the driving distance between Massachusetts to South Carolina is 849 miles. It takes approximately 14 h 22 min to drive from Massachusetts to South Carolina.

Get driving directions

Delta, Southwest Airlines, United Airlines and American Airlines offer flights from Manchester Airport to Charlotte Airport.

Search flights

Book your Massachusetts to South Carolina train tickets online with Rome2rio.

Search and book

Book your Massachusetts to South Carolina bus tickets online with Greyhound, Greyhound and Greyhound.

Search and book

There are 16+ hotels available in South Carolina. Prices start at $52 USD per night.

More details

The best way to get from Massachusetts to Manchester Airport is to taxi which takes 36 min and costs $190 - $230.

More details