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How to get fromMannheim to Sienaby train, plane, train (Trenitalia), bus, night train or car

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There are 8 ways to get from Mannheim to Siena by train, plane, train (Trenitalia), bus, night train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Frankfurt, fly to Florence Peretola Airport, train

    best
    1. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Florence Peretola Airport (FLR)plane plane FRA - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    6h 53m
    €126–310
  2. Bus via Milan

    cheapest
    1. Take the bus from Mannheim Central Bus Station to Milanbus bus MarinoBus 254 / ...
    2. Take the bus from Milan to Siena Central Train Stationbus bus Itabus
    18h 20m
    €45–99
  3. Train

    1. Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain train 20 / ...
    2. Take the train from Basel SBB to Luganotrain train Ec
    3. Take the train from Lugano to Milano Centraletrain train
    4. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    5. Take the train from Firenze S.M.N. to Sienatrain train Re
    13h 7m
    €101–383
  4. Bus

    1. Take the bus from Mannheim central bus station to Florence Villa Constanza Bus Stationbus bus N77
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus N528 / ...
    16h 57m
    €54–93
  5. Train, night train, bus

    1. Take the train from Mannheim, Hauptbahnhof to Hauptbahnhoftrain train 22 / ...
    2. Take the night train from Stuttgart Hbf to Venezia Mestrenighttrain night train Nj
    3. Take the train from Venezia Mestre to Firenze S.M.N.train train Fr
    4. Take the bus from Firenze Autostazione to Siena-Via Tozzibus bus 131
    17h 58m
  6. Train to Frankfurt, fly to Bologna Guglielmo Marconi Airport, train

    1. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Bologna Guglielmo Marconi Airport (BLQ)plane plane FRA - BLQ
    3. Take the train from Bologna Centrale to Florence Santa Maria Novellatrain train
    4. Take the train from Firenze S.M.N. to Sienatrain train
    7h 29m
    €144–352
  7. Train, train to Zurich Airport, fly to Florence Peretola Airport

    1. Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain train
    2. Take the train from Basel SBB to Zürich HBtrain train
    3. Fly from Zurich Airport (ZRH) to Florence Peretola Airport (FLR)plane plane ZRH - FLR
    4. Take the train from Firenze S.M.N. to Sienatrain train
    9h 53m
    €144–424
  8. Drive 952.5 km

    1. Drive from Mannheim to Sienacar car 952.5 km
    9h 18m
    €147–212

Mannheim to Siena by train

Calendar76Weekly Trains
Duration13h 7mAverage Duration
Ticket€101Cheapest Price
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Questions & Answers

What companies run services between Mannheim, Germany and Siena, Italy?

You can take a train from Mannheim, Hauptbahnhof to Siena via Basel SBB, Lugano, Milano Centrale, and Firenze S.M.N. in around 13h 7m. Alternatively, you can take a bus from Mannheim central bus station to Siena via Florence Villa Constanza Bus Station in around 16h 57m.

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