There are 8 ways to get from Manitowoc to St. Louis by bus, train, bus (Greyhound, Flixbus), car, taxi, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, train
best- Take the bus from Manitowoc to Chicago Bus Stationbus Greyhound US0150S
- Take the train from Chicago Union Station to St. Louistrain Lincoln Service / ...
9h 54m$77–299Bus
- Take the bus from Manitowoc to Chicago Bus Stationbus Greyhound US0150S
- Take the bus from Chicago Bus Station to St Louis Bus Stationbus FlixBus N2521 / ...
11h 9m$77–149Drive 450.7 mi
- Drive from Manitowoc to St. Louiscar 450.7 mi
7h 36m$83–119Taxi to Appleton International Airport, fly
- Take the taxi from Manitowoc to Appleton International Airport (ATW)taxi
- Fly from Appleton International Airport (ATW) to Lambert–St. Louis International Airport (STL)plane ATW - STL
6h 10m$205–691Bus, train via Bloomington
- Take the bus from Manitowoc, WI to Milwaukeebus 103
- Take the bus from Mitchell Airport to O'Hare International Airport - Terminal 2 Departuresbus
- Take the bus from Multi-Modal Facility to Uptown Stationbus
- Take the train from Bloomington-Normal to St. Louistrain
13h 51m$126–232Bus to General Mitchell International Airport, fly
- Take the bus from Manitowoc to Milwaukee Intermodal Stationbus
- Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane MKE - STL
5h 21m$146–952Bus to Green Bay, fly
- Take the bus from Manitowoc, WI to Green Bay, WIbus
- Fly from Green Bay (GRB) to Lambert–St. Louis International Airport (STL)plane GRB - STL
6h 25m$138–630Bus, bus to Chicago O'Hare International Airport, fly
- Take the bus from Manitowoc to Milwaukee Intermodal Stationbus
- Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus
- Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane ORD - STL
7h 40m$259–600
Appleton International Airport (ATW) to Lambert–St. Louis International Airport (STL) flights
Questions & Answers
The cheapest way to get from Manitowoc to St. Louis is to drive which costs $80 - $120 and takes 7h 36m.
The fastest way to get from Manitowoc to St. Louis is to bus and fly which takes 5h 21m and costs $140 - $950.
The distance between Manitowoc and St. Louis is 455 miles. The road distance is 453.3 miles.
The best way to get from Manitowoc to St. Louis without a car is to bus and train which takes 9h 54m and costs $75 - $300.
It takes approximately 9h 54m to get from Manitowoc to St. Louis, including transfers.
Yes, the driving distance between Manitowoc to St. Louis is 453 miles. It takes approximately 7h 36m to drive from Manitowoc to St. Louis.
There are 428+ hotels available in St. Louis.
What companies run services between Manitowoc, WI, USA and St. Louis, MO, USA?
You can take a vehicle from Manitowoc to St Louis Bus Station via Manitowoc and Chicago Bus Station in around 11h 9m.
- Website
- united.com
Flights from Appleton International Airport to Lambert–St. Louis International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 5h 2m
- When
- Every day
- Estimated price
- $85–550
Flights from Green Bay to Lambert–St. Louis International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 4h 4m
- When
- Every day
- Estimated price
- $85–550
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 31m
- When
- Every day
- Estimated price
- $65–420
- Website
- aa.com
Flights from Appleton International Airport to Lambert–St. Louis International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 5h 35m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $85–550
Flights from Appleton International Airport to Lambert–St. Louis International Airport via Dallas/Ft.Worth
- Ave. Duration
- 8h 11m
- When
- Saturday
- Estimated price
- $180–850
Flights from Appleton International Airport to Lambert–St. Louis International Airport via Charlotte
- Ave. Duration
- 9h 4m
- When
- Every day
- Estimated price
- $160–800
Flights from General Mitchell International Airport to Lambert–St. Louis International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 3h 36m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $120–800
Flights from Green Bay to Lambert–St. Louis International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 5h 11m
- When
- Every day
- Estimated price
- $85–550
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 26m
- When
- Every day
- Estimated price
- $65–420
- Website
- delta.com
Flights from Appleton International Airport to Lambert–St. Louis International Airport via Minneapolis
- Ave. Duration
- 5h 26m
- When
- Every day
- Estimated price
- $110–600
Flights from Appleton International Airport to Lambert–St. Louis International Airport via Detroit
- Ave. Duration
- 5h 34m
- When
- Every day
- Estimated price
- $110–650
Flights from Appleton International Airport to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 5h 42m
- When
- Every day
- Estimated price
- $160–800
Flights from Green Bay to Lambert–St. Louis International Airport via Minneapolis
- Ave. Duration
- 5h 25m
- When
- Every day
- Estimated price
- $110–600
Flights from Green Bay to Lambert–St. Louis International Airport via Detroit
- Ave. Duration
- 5h 22m
- When
- Every day
- Estimated price
- $110–650
Flights from Green Bay to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 5h 38m
- When
- Every day
- Estimated price
- $160–800
- Website
- southwest.com
Flights from General Mitchell International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 31m
- When
- Every day
- Estimated price
- $120–800
- Website
- gojetairlines.com
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 28m
- When
- Every day
- Estimated price
- $65–420
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to St. Louis
- Ave. Duration
- 4h 46m
- Frequency
- 5 times a day
- Estimated price
- $35–220
- Website
- https://www.amtrak.com/home.html
Train from Bloomington-Normal to St. Louis
- Ave. Duration
- 2h 45m
- Frequency
- 5 times a day
- Estimated price
- $17–60
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Manitowoc to Chicago Bus Station
- Ave. Duration
- 3h 55m
- Frequency
- Once daily
- Estimated price
- $35–70
- Website
- https://www.greyhound.com/
Bus from Manitowoc to Milwaukee Intermodal Station
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Estimated price
- $27–60
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Chicago Bus Station to St Louis Bus Station
- Ave. Duration
- 6h 10m
- Frequency
- 3 times a day
- Estimated price
- $35–70
- Schedules at
- flixbus.com
- Phone
- +1 800-236-1240
- Website
- golamers.com
Bus from Manitowoc, WI to Milwaukee
- Ave. Duration
- 2h 30m
- Frequency
- Twice a week
- Estimated price
- $22–60
- Website
- https://www.golamers.com/
- Schedules at
- https://www.golamers.com/
Bus from Manitowoc to Milwaukee Intermodal Station
- Ave. Duration
- 2h
- Frequency
- Twice a week
- Estimated price
- $21–50
- Website
- https://www.golamers.com/
- Schedules at
- https://www.golamers.com/
Bus from Manitowoc, WI to Green Bay, WI
- Ave. Duration
- 55 min
- Frequency
- Twice a week
- Estimated price
- $14–23
- Website
- https://www.golamers.com/
- Schedules at
- https://www.golamers.com/
- Phone
- (866) 912 6224
- questions@coachusa.com
- Website
- coachusa.com
Bus from Mitchell Airport to O'Hare International Airport - Terminal 2 Departures
- Ave. Duration
- 1h 30m
- Frequency
- Every 2 hours
- Estimated price
- $32–35
- Schedules at
- coachusa.com
Bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departures
- Ave. Duration
- 1h 50m
- Frequency
- Every 2 hours
- Estimated price
- $35–38
- Schedules at
- coachusa.com
- Phone
- +1 800-448-0572
- ticketsales@peoriacharter.com
- Website
- peoriacharter.com
Bus from Multi-Modal Facility to Uptown Station
- Ave. Duration
- 3h 20m
- Frequency
- Twice daily
- Estimated price
- $45–60
- Schedules at
- peoriacharter.com
- cash
- $60
- online
- $45
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Manitowoc to Milwaukee Intermodal Station
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Website
- https://www.amtrak.com/home.html
Bus from Manitowoc, WI to Green Bay, WI
- Ave. Duration
- 55 min
- Frequency
- Once daily
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 989-725-5105
- Website
- indiantrails.com
Bus from Manitowoc to Milwaukee Intermodal Station
- Ave. Duration
- 1h 45m
- Frequency
- Once daily
- Estimated price
- $14–35
- Website
- https://indiantrails.com
Bus from Manitowoc, WI to Green Bay, WI
- Ave. Duration
- 40 min
- Frequency
- Once daily
- Estimated price
- $7–23
- Website
- https://indiantrails.com
- Ave. Duration
- 1h 16m
- Estimated price
- $110–140
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide













