There are 8 ways to get from Manitowoc to Mayo Clinic by bus, train, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus, train  •  9 h 4 min

  1. Take the bus from Manitowoc, WI to Milwaukee 915 / ...
  2. Take the train from Milwaukee Intermodal Station to Winona Amtrak
  3. Take the bus from Winona, MN to Rochester, MN

$102 - $195

Cheapest option

Bus  •  9 h 6 min

  1. Take the bus from Manitowoc, WI to Milwaukee 915 / ...
  2. Take the bus from Milwaukee to Rochester, MN 966

$82 - $130

6 alternative options

Drive  •  5 h 24 min

  1. Drive from Manitowoc to Mayo Clinic 299.1 miles

$29 - $45

Bus to Green Bay, fly to Rochester  •  7 h 33 min

  1. Take the bus from Manitowoc, WI to Green Bay, WI
  2. Fly from Green Bay (GRB) to Rochester (RST) GRB - RST

$223 - $981

Bus to Green Bay, fly to Minneapolis, bus  •  5 h 37 min

  1. Take the bus from Manitowoc, WI to Green Bay, WI
  2. Fly from Green Bay (GRB) to Minneapolis (MSP) GRB - MSP
  3. Take the bus from Minneapolis-St Paul Airport, MN to Rochester, MN

$198 - $805

Bus to Milwaukee, fly to Minneapolis, bus  •  7 h 11 min

  1. Take the bus from Manitowoc, WI to Milwaukee
  2. Fly from Milwaukee (MKE) to Minneapolis (MSP) MKE - MSP
  3. Take the bus from Minneapolis-St Paul Airport, MN to Rochester, MN

$161 - $430

Bus, bus to Chicago O'Hare, fly to Rochester  •  7 h 22 min

  1. Take the bus from Manitowoc, WI to Milwaukee
  2. Take the bus from Milwaukee, WI - Amtrak to Chicago, IL - O'Hare International Airport
  3. Fly from Chicago O'Hare (ORD) to Rochester (RST) ORD - RST

$205 - $796

Bus, bus to Appleton, fly to Minneapolis  •  7 h 24 min

  1. Take the bus from Manitowoc, WI to Green Bay, WI
  2. Take the bus from Green Bay, Wi to Appleton, Wi
  3. Fly from Appleton (ATW) to Minneapolis (MSP) ATW - MSP
  4. Take the bus from Minneapolis-St Paul Airport, MN to Rochester, MN

$240 - $1,018

Questions & Answers

The distance between Manitowoc and Mayo Clinic is 240 miles. The road distance is 299.1 miles.

Get driving directions

The best way to get from Manitowoc to Mayo Clinic without a car is to bus and train which takes 9 h 4 min and costs .

More details

It takes approximately 9 h 4 min to get from Manitowoc to Mayo Clinic, including transfers.

More details

There is no direct flight from Green Bay Airport to Rochester Airport. The quickest flight takes 4 h 21 min and has one stopover.

Search flights

Yes, the driving distance between Manitowoc to Mayo Clinic is 299 miles. It takes approximately 5 h 24 min to drive from Manitowoc to Mayo Clinic.

Get driving directions

American Airlines, United Airlines and Delta offer flights from Green Bay Airport to Rochester Airport.

Search flights

There are 56+ hotels available in Mayo Clinic. Prices start at $67 USD per night.

More details

Map of how to get from Manitowoc to Mayo Clinic.
Launch map view
  • Distance: 240.2 miles
  • Duration: 9 h 4 min

What companies run services between Manitowoc, WI, USA and Mayo Clinic, MN, USA?

You can take a bus from Manitowoc to Mayo Clinic via Manitowoc, WI, Milwaukee, and Rochester, MN in around 9 h 6 min.

Airlines
Delta
Website
delta.com
Flights from Green Bay to Rochester via Minneapolis
Ave. Duration
5 h 55 min
When
Every day
Estimated price
$160 - $900
Flights from Green Bay to Rochester via Detroit, Minneapolis
Ave. Duration
7 h 7 min
When
Every day
Estimated price
$200 - $1,000
Flights from Green Bay to Rochester via Atlanta
Ave. Duration
9 h 24 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$260 - $1,200
Flights from Green Bay to Rochester via Atlanta, Minneapolis
Ave. Duration
8 h 30 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$270 - $1,200
Flights from Green Bay to Rochester via Minneapolis, Atlanta
Ave. Duration
9 h 1 min
When
Every day
Estimated price
$290 - $1,300
Flights from Green Bay to Minneapolis
Ave. Duration
1 h 16 min
When
Every day
Estimated price
$120 - $700
Flights from Milwaukee to Minneapolis
Ave. Duration
1 h 20 min
When
Every day
Estimated price
$190 - $600
Flights from Chicago O'Hare to Rochester via Minneapolis
Ave. Duration
3 h 7 min
When
Monday to Friday
Estimated price
$320 - $750
Flights from Appleton to Minneapolis
Ave. Duration
1 h 18 min
When
Every day
Estimated price
$160 - $900
American Airlines
Website
aa.com
Flights from Green Bay to Rochester via Chicago O'Hare
Ave. Duration
4 h 33 min
When
Every day
Estimated price
$180 - $950
Flights from Milwaukee to Minneapolis via Chicago O'Hare
Ave. Duration
3 h 24 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $750
Flights from Chicago O'Hare to Rochester
Ave. Duration
1 h 11 min
When
Every day
Estimated price
$260 - $750
United Airlines
Website
united.com
Flights from Green Bay to Rochester via Chicago O'Hare
Ave. Duration
4 h 44 min
When
Every day
Estimated price
$200 - $1,000
Flights from Milwaukee to Minneapolis via Chicago O'Hare
Ave. Duration
3 h 23 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $750
Flights from Chicago O'Hare to Rochester
Ave. Duration
1 h 19 min
When
Every day
Estimated price
$150 - $750
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Milwaukee Intermodal Station to Winona Amtrak
Ave. Duration
3 h 49 min
Frequency
3 times a day
Estimated price
$40 - $110
Website
amtrak.com
Coach Seat
$40 - $65
Flexi Coach Seat
$75 - $110
Business Coach Seat
$75 - $110
Room
$210 - $290
Bus operators
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Manitowoc, WI to Milwaukee
Ave. Duration
1 h 45 min
Frequency
Every 3 hours
Estimated price
$22 - $35
Book at
jeffersonlines.com
Bus from Milwaukee to Rochester, MN
Ave. Duration
6 h 10 min
Frequency
Every 3 hours
Estimated price
$55 - $80
Book at
jeffersonlines.com
Bus from Manitowoc, WI to Green Bay, WI
Ave. Duration
45 min
Frequency
Every 3 hours
Estimated price
$16 - $22
Book at
jeffersonlines.com
Bus from Minneapolis-St Paul Airport, MN to Rochester, MN
Ave. Duration
1 h 20 min
Frequency
Every 3 hours
Estimated price
$22 - $35
Book at
jeffersonlines.com
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Bus from Manitowoc, WI to Milwaukee
Ave. Duration
1 h 45 min
Frequency
Twice daily
Website
amtrak.com
Bus from Manitowoc, WI to Green Bay, WI
Ave. Duration
1 h 4 min
Frequency
Once daily
Website
amtrak.com
Indian Trails
Phone
+1 800-292-3831
Website
indiantrails.com
Bus from Manitowoc, WI to Milwaukee
Ave. Duration
1 h 50 min
Frequency
Once daily
Estimated price
$14 - $19
Schedules at
indiantrails.com
Book at
webstore.indiantrails.com
Lamers Bus Lines
Phone
+1 800-236-1240
Website
golamers.com
Bus from Manitowoc, WI to Milwaukee, WI
Ave. Duration
2 h
Frequency
Twice a week
Estimated price
$20 - $25
Schedules at
golamers.com
Book at
webstore.golamers.com
Bus from Green Bay, WI - Metro to Appleton, WI
Ave. Duration
45 min
Frequency
Once daily
Estimated price
$12 - $16
Schedules at
golamers.com
Book at
webstore.golamers.com
Go Carefree Shuttle
Website
gocarefreeshuttle.com
Bus from Winona, MN to Rochester, MN
Ave. Duration
1 h 20 min
Frequency
Every 4 hours
Estimated price
$35
Schedules at
gocarefreeshuttle.com
Coach USA
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Green Bay, Wi to Appleton, Wi
Ave. Duration
45 min
Frequency
Hourly
Estimated price
$10 - $22
Website
greyhound.com
Economy
$10 - $14
Flexible
$17 - $22

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