Rome2Rio

How to get fromManitowoc to Mayo Clinicby bus (Amtrak), car, bus, plane, bus (Flixbus) or taxi

Find Transport to Mayo Clinic

See all options

There are 8 ways to get from Manitowoc to Mayo Clinic by bus (Amtrak), car, bus, plane, bus (Flixbus), or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Manitowoc Amtrak Bus Stop to MilwaukeebusAmtrak Thruway Connecting Service
    2. Take the bus from Milwaukee to RochesterbusJefferson 966
    8h 32m
    $48–179

  2. Drive 270.8 mi

    1. Drive from Manitowoc to Mayo Cliniccar270.8 mi
    5h 28m
    $50–72

  3. Bus to Green Bay, fly to Rochester

    1. Take the bus from Manitowoc, WI to Green Bay, WIbus
    2. Fly from Green Bay (GRB) to Rochester (RST)planeGRB - RST
    7h 12m
    $96–417

  4. Bus via Madison

    1. Take the bus from Manitowoc, WI to Milwaukeebus103
    2. Take the bus from Mitchell Airport to Madison, WI-Lake St.bus
    3. Take the bus from Madison to Rochesterbus
    11h 2m
    $69–219

  5. Taxi to Appleton International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the taxi from Manitowoc to Appleton International Airport (ATW)taxi
    2. Fly from Appleton International Airport (ATW) to Minneapolis–Saint Paul International Airport (MSP)planeATW - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus
    5h 29m
    $192–541

  6. Bus to Green Bay, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Manitowoc, WI to Green Bay, WIbus
    2. Fly from Green Bay (GRB) to Minneapolis–Saint Paul International Airport (MSP)planeGRB - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus
    6h 14m
    $126–480

  7. Bus to General Mitchell International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Manitowoc Amtrak Bus Stop to Milwaukeebus
    2. Fly from General Mitchell International Airport (MKE) to Minneapolis–Saint Paul International Airport (MSP)planeMKE - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus
    7h 29m
    $344–762

  8. Bus, bus to Chicago O'Hare International Airport, fly to Rochester

    1. Take the bus from Manitowoc Amtrak Bus Stop to Milwaukeebus
    2. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus
    3. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)planeORD - RST
    8h 13m
    $97–407

Green Bay (GRB) to Rochester (RST) flights

Calendar36Weekly Planes
Duration5h 18mAverage Duration
Ticket$47Cheapest Price
See schedules

Questions & Answers

What companies run services between Manitowoc, WI, USA and Mayo Clinic, MN, USA?

You can take a vehicle from Manitowoc to Mayo Clinic via Manitowoc Amtrak Bus Stop, Milwaukee, and Rochester in around 8h 32m.

Transport is disrupted due to the Russia-Ukraine war. Read more

Airlines
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Trips from Manitowoc

Trips to Mayo Clinic

Popular routes