There are 10 ways to get from Manitowoc to Mayo Clinic by night bus, train, bus, car, plane or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Night bus, train, bus  •  8h 56m

  1. Take the night bus from Manitowoc Amtrak Bus Stop to Milwaukee Intermodal Station
  2. Take the train from Milwaukee Intermodal Station to Winona Amtrak Station
  3. Take the bus from Winona Amtrak Station to Rochester, MN

$74 - $111

9 alternative options

Bus, train  •  9h 1m

  1. Take the bus from Manitowoc, WI to Milwaukee 915 / ...
  2. Take the train from Milwaukee Intermodal Station to Winona Amtrak Station
  3. Take the bus from Winona Amtrak Station to Rochester, MN

$80 - $124

Bus  •  9h 6m

  1. Take the bus from Manitowoc, WI to Milwaukee 915 / ...
  2. Take the bus from Milwaukee to Rochester, MN 966

$83 - $124

Bus via Madison  •  10h 39m

  1. Take the bus from Manitowoc, WI to Milwaukee 103
  2. Take the bus from Milwaukee Mitchell Airport to UW Madison Langdon St 112
  3. Take the bus from UW Madison - Langdon St to Rochester - Mayo Clinic

$75 - $117

Drive  •  5h 21m

  1. Drive from Manitowoc to Mayo Clinic 300.9 miles

$29 - $45

Night bus to Green Bay, fly to Rochester  •  6h 10m

  1. Take the night bus from Manitowoc, WI to Green Bay, WI
  2. Fly from Green Bay (GRB) to Rochester (RST) GRB - RST

$179 - $679

Taxi to Appleton, fly to Minneapolis, bus  •  5h 15m

  1. Take a taxi from Manitowoc to Appleton
  2. Fly from Appleton (ATW) to Minneapolis (MSP) ATW - MSP
  3. Take the bus from MSP Airport to Rochester, MN

$331 - $772

Night bus to Green Bay, fly to Minneapolis, bus  •  5h 56m

  1. Take the night bus from Manitowoc, WI to Green Bay, WI
  2. Fly from Green Bay (GRB) to Minneapolis (MSP) GRB - MSP
  3. Take the bus from MSP Airport to Rochester, MN

$353 - $998

Night bus to Milwaukee, fly to Minneapolis, bus  •  7h 26m

  1. Take the night bus from Manitowoc Amtrak Bus Stop to Milwaukee Intermodal Station
  2. Fly from Milwaukee (MKE) to Minneapolis (MSP) MKE - MSP
  3. Take the bus from MSP Airport to Rochester, MN

$205 - $405

Night bus, bus to Chicago O'Hare, fly to Rochester  •  7h 59m

  1. Take the night bus from Manitowoc Amtrak Bus Stop to Milwaukee Intermodal Station
  2. Take the bus from Milwaukee, WI - Amtrak to O'Hare Term 1,2,3
  3. Fly from Chicago O'Hare (ORD) to Rochester (RST) ORD - RST

$144 - $367

Questions & Answers

Travel restrictions may apply and transportation services are subject to change. Please check before you travel.

Learn More.

The cheapest way to get from Manitowoc to Mayo Clinic is to drive which costs $29 - $45 and takes 5h 21m.

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The quickest way to get from Manitowoc to Mayo Clinic is to taxi and fly and bus which costs $330 - $800 and takes 5h 15m.

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The distance between Manitowoc and Mayo Clinic is 240 miles. The road distance is 300.9 miles.

Get driving directions

The best way to get from Manitowoc to Mayo Clinic without a car is to night bus and train and bus which takes 8h 56m and costs $70 - $120.

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It takes approximately 8h 56m to get from Manitowoc to Mayo Clinic, including transfers.

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There is no direct flight from Green Bay Airport to Rochester Airport. The quickest flight takes 3h 1m and has one stopover.

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Yes, the driving distance between Manitowoc to Mayo Clinic is 301 miles. It takes approximately 5h 21m to drive from Manitowoc to Mayo Clinic.

Get driving directions

United Airlines, American Airlines and Delta offer flights from Green Bay Airport to Rochester Airport.

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There are 66+ hotels available in Mayo Clinic. Prices start at $100 USD per night.

More details

What companies run services between Manitowoc, WI, USA and Mayo Clinic, MN, USA?

You can take a bus from Manitowoc to Mayo Clinic via Manitowoc, WI, Milwaukee, and Rochester, MN in around 9h 6m.

Airlines
Delta
Website
delta.com
Flights from Green Bay to Rochester via Minneapolis
Ave. Duration
4h 7m
When
Every day
Estimated price
$230 - $750
Flights from Green Bay to Rochester via Detroit, Minneapolis
Ave. Duration
6h 20m
When
Every day
Estimated price
$260 - $850
Flights from Appleton to Minneapolis
Ave. Duration
1h 20m
When
Every day
Estimated price
$190 - $600
Flights from Green Bay to Minneapolis
Ave. Duration
1h 18m
When
Every day
Estimated price
$280 - $900
Flights from Milwaukee to Minneapolis
Ave. Duration
1h 16m
When
Every day
Estimated price
$280 - $900
Flights from Chicago O'Hare to Rochester via Minneapolis
Ave. Duration
3h 10m
When
Monday to Saturday
Estimated price
$160 - $550
American Airlines
Website
aa.com
Flights from Green Bay to Rochester via Chicago O'Hare
Ave. Duration
4h 36m
When
Every day
Estimated price
$120 - $600
Flights from Chicago O'Hare to Rochester
Ave. Duration
1h 14m
When
Every day
Estimated price
$110 - $290
United Airlines
Website
united.com
Flights from Green Bay to Rochester via Chicago O'Hare
Ave. Duration
3h 48m
When
Every day
Estimated price
$170 - $700
Flights from Chicago O'Hare to Rochester
Ave. Duration
1h 21m
When
Every day
Estimated price
$260 - $290
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Milwaukee Intermodal Station to Winona Amtrak Station
Ave. Duration
3h 49m
Frequency
3 times a day
Estimated price
$35 - $55
Website
amtrak.com
Coach Seat
$35 - $55
Premium
$210 - $290
Flexi Coach Seat
$65 - $95
Business Seat
$65 - $95
Bus operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Night bus from Manitowoc Amtrak Bus Stop to Milwaukee Intermodal Station
Ave. Duration
1h 40m
Frequency
Once daily
Website
amtrak.com
Indian Trails
Phone
+1 800-292-3831
Website
indiantrails.com
Night bus from Manitowoc, WI to Milwaukee, WI
Ave. Duration
1h 40m
Frequency
Once daily
Estimated price
$15 - $22
Schedules at
indiantrails.com
Night bus from Manitowoc, WI to Green Bay, WI
Ave. Duration
40 min
Frequency
Once daily
Estimated price
$9 - $14
Schedules at
indiantrails.com
Amtrak Thruway

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak Thruway
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Bus from Winona Amtrak Station to Rochester, MN
Ave. Duration
1h 20m
Frequency
Every 4 hours
Estimated price
$17 - $25
Website
amtrak.com
Bus from MSP Airport to Rochester, MN
Ave. Duration
1h 45m
Frequency
Every 4 hours
Estimated price
$21 - $30
Website
amtrak.com
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Manitowoc, WI to Milwaukee
Ave. Duration
1h 45m
Frequency
Once daily
Estimated price
$22 - $35
Book at
jeffersonlines.com
Bus from Milwaukee to Rochester, MN
Ave. Duration
6h 10m
Frequency
Once daily
Estimated price
$55 - $80
Book at
jeffersonlines.com
Lamers Bus Lines
Phone
+1 800-236-1240
Website
golamers.com
Bus from Manitowoc, WI to Milwaukee, WI
Ave. Duration
2h
Frequency
Twice a week
Estimated price
$20 - $25
Schedules at
golamers.com
Bus from Milwaukee to Madison
Ave. Duration
2h 20m
Frequency
Once daily
Estimated price
$20 - $26
Schedules at
golamers.com
Badger Bus
Website
badgerbus.com
Bus from Milwaukee Mitchell Airport to UW Madison Langdon St
Ave. Duration
2h 5m
Frequency
Every 4 hours
Estimated price
$17 - $25
Schedules at
badgerbus.com
Book at
badgerbus.com
Bus from UW Madison - Langdon St to Rochester - Mayo Clinic
Ave. Duration
3h 45m
Frequency
Twice a week
Estimated price
$30 - $55
Schedules at
badgerbus.com
Book at
badgerbus.com
Wisconsin Coach Lines
Phone
+1 262-671-2538
Email
wisconsincoach@coachusa.com
Website
web.coachusa.com
Bus from Milwaukee, WI - Amtrak to O'Hare Term 1,2,3
Ave. Duration
1h 50m
Frequency
Every 4 hours
Estimated price
$5 - $35
Schedules at
coachusaairportexpress.com
Book at
coachusaairportexpress.com
Commuter and Intercity
$5 - $6
Other operators
Taxi from Manitowoc to Appleton
Ave. Duration
1h 12m
Estimated price
$120 - $150

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