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There are 10 ways to get from Manitowoc to Mayo Clinic by bus, train, car, plane or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Amtrak Thruway, train, bus  •  8 h 42 min

  1. Take the Amtrak Thruway from Manitowoc, WI to Milwaukee 915 / ...
  2. Take the train from Milwaukee Intermodal Station to Winona Amtrak Station
  3. Take the bus from Winona Amtrak Station to Rochester, MN

$97 - $220

Cheapest option

Amtrak Thruway, bus  •  9 h 6 min

  1. Take the Amtrak Thruway from Manitowoc, WI to Milwaukee 8146 / ...
  2. Take the bus from Milwaukee to Rochester, MN 966

$82 - $130

8 alternative options

Bus  •  9 h 38 min

  1. Take the bus from Manitowoc, WI to Milwaukee, WI - UW 103
  2. Take the bus from Milwaukee to Rochester, MN 966

$91 - $123

Drive  •  5 h 24 min

  1. Drive from Manitowoc to Mayo Clinic 299.1 miles

$29 - $45

Drive to Appleton, fly to Minneapolis, shuttle  •  4 h 37 min

  1. Drive from Manitowoc to Appleton
  2. Fly from Appleton (ATW) to Minneapolis (MSP) ATW - MSP
  3. Take a shuttle bus from Terminal 2 MSP to 2nd Street Rochester

$199 - $958

Bus to Green Bay, fly to Minneapolis, shuttle  •  5 h 13 min

  1. Take the bus from Manitowoc, WI to Green Bay, WI - Transit
  2. Fly from Green Bay (GRB) to Minneapolis (MSP) GRB - MSP
  3. Take a shuttle bus from Terminal 2 MSP to 2nd Street Rochester

$200 - $815

Bus to Green Bay, fly to Rochester  •  6 h 19 min

  1. Take the bus from Manitowoc, WI to Green Bay, WI - Transit
  2. Fly from Green Bay (GRB) to Rochester (RST) GRB - RST

$215 - $978

Bus to Milwaukee, fly to Minneapolis, shuttle  •  7 h

  1. Take the bus from Manitowoc, WI to Milwaukee, WI - Airport
  2. Fly from Milwaukee (MKE) to Minneapolis (MSP) MKE - MSP
  3. Take a shuttle bus from Terminal 2 MSP to 2nd Street Rochester

$176 - $420

Amtrak Thruway, bus to Chicago O'Hare, fly to Rochester  •  7 h 25 min

  1. Take the Amtrak Thruway from Manitowoc, WI to Milwaukee
  2. Take the bus from Milwaukee, WI - Amtrak to Chicago, IL - O'Hare International Airport
  3. Fly from Chicago O'Hare (ORD) to Rochester (RST) ORD - RST

$205 - $796

Bus to Wausau/Marshfield, fly to Minneapolis, shuttle  •  7 h 42 min

  1. Take the bus from Manitowoc, WI to Wausau Transit, WI
  2. Fly from Wausau/Marshfield (CWA) to Minneapolis (MSP) CWA - MSP
  3. Take a shuttle bus from Terminal 2 MSP to 2nd Street Rochester

$278 - $1,136

Questions & Answers

The cheapest way to get from Manitowoc to Mayo Clinic is to drive which costs $29 - $45 and takes 5 h 24 min.

More details

The quickest way to get from Manitowoc to Mayo Clinic is to drive and fly and shuttle which costs $190 - $1,000 and takes 4 h 37 min.

More details

The distance between Manitowoc and Mayo Clinic is 240 miles. The road distance is 299.1 miles.

Get driving directions

The best way to get from Manitowoc to Mayo Clinic without a car is to Amtrak Thruway and train and bus which takes 8 h 42 min and costs $95 - $220.

More details

It takes approximately 8 h 42 min to get from Manitowoc to Mayo Clinic, including transfers.

More details

The quickest flight from Appleton Airport to Minneapolis Airport is the direct flight which takes 1 h 18 min.

Search flights

Yes, the driving distance between Manitowoc to Mayo Clinic is 299 miles. It takes approximately 5 h 24 min to drive from Manitowoc to Mayo Clinic.

Get driving directions

Delta offers flights from Appleton Airport to Minneapolis Airport.

Search flights

There are 57+ hotels available in Mayo Clinic. Prices start at $72 USD per night.

More details

Map of how to get from Manitowoc to Mayo Clinic.
Launch map view
  • Distance: 240.2 miles
  • Duration: 8 h 42 min

What companies run services between Manitowoc, WI, USA and Mayo Clinic, MN, USA?

You can take a bus from Manitowoc to Mayo Clinic via Manitowoc, WI, Milwaukee, and Rochester, MN in around 9 h 6 min.

Airlines
Delta
Website
delta.com
Flights from Appleton to Minneapolis
Ave. Duration
1 h 24 min
When
Every day
Estimated price
$160 - $900
Flights from Green Bay to Minneapolis
Ave. Duration
1 h 21 min
When
Every day
Estimated price
$120 - $700
Flights from Green Bay to Rochester via Minneapolis
Ave. Duration
4 h 42 min
When
Every day
Estimated price
$160 - $900
Flights from Green Bay to Rochester via Detroit, Minneapolis
Ave. Duration
7 h 34 min
When
Saturday and Sunday
Estimated price
$200 - $1,000
Flights from Milwaukee to Minneapolis
Ave. Duration
1 h 23 min
When
Every day
Estimated price
$190 - $600
Flights from Wausau/Marshfield to Minneapolis
Ave. Duration
1 h 15 min
When
Every day
Estimated price
$180 - $1,000
American Airlines
Website
aa.com
Flights from Green Bay to Rochester via Chicago O'Hare
Ave. Duration
4 h 31 min
When
Every day
Estimated price
$180 - $950
Flights from Milwaukee to Minneapolis via Chicago O'Hare
Ave. Duration
3 h 33 min
When
Every day
Estimated price
$220 - $750
Flights from Chicago O'Hare to Rochester
Ave. Duration
1 h 14 min
When
Every day
Estimated price
$260 - $750
United Airlines
Website
united.com
Flights from Green Bay to Rochester via Chicago O'Hare
Ave. Duration
4 h 39 min
When
Every day
Estimated price
$200 - $1,000
Flights from Milwaukee to Minneapolis via Chicago O'Hare
Ave. Duration
3 h 35 min
When
Every day
Estimated price
$200 - $750
Flights from Chicago O'Hare to Rochester
Ave. Duration
1 h 21 min
When
Every day
Estimated price
$150 - $750
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Milwaukee Intermodal Station to Winona Amtrak Station
Ave. Duration
3 h 49 min
Frequency
3 times a day
Estimated price
$40 - $110
Website
amtrak.com
Coach Seat
$40 - $65
Flexi Coach Seat
$75 - $110
Business Coach Seat
$75 - $110
Room
$210 - $290
Bus operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Bus from Manitowoc, WI to Milwaukee
Ave. Duration
1 h 45 min
Frequency
Twice daily
Website
amtrak.com
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Manitowoc, WI to Milwaukee
Ave. Duration
1 h 45 min
Frequency
Once daily
Estimated price
$22 - $35
Book at
jeffersonlines.com
Bus from Milwaukee to Rochester, MN
Ave. Duration
6 h 10 min
Frequency
Once daily
Estimated price
$55 - $80
Book at
jeffersonlines.com
Bus from Manitowoc, WI to Wausau Transit, WI
Ave. Duration
3 h
Frequency
Once daily
Estimated price
$30 - $45
Book at
jeffersonlines.com
Indian Trails
Phone
+1 800-292-3831
Website
indiantrails.com
Bus from Manitowoc, WI to Milwaukee
Ave. Duration
1 h 50 min
Frequency
Once daily
Estimated price
$14 - $19
Schedules at
indiantrails.com
Book at
webstore.indiantrails.com
Bus from Manitowoc, WI to Green Bay, WI - Transit
Ave. Duration
35 min
Frequency
Once daily
Estimated price
$8 - $11
Schedules at
indiantrails.com
Book at
webstore.indiantrails.com
Lamers Bus Lines
Phone
+1 800-236-1240
Website
golamers.com
Bus from Manitowoc, WI to Milwaukee, WI
Ave. Duration
2 h
Frequency
3 times a week
Estimated price
$20 - $25
Schedules at
golamers.com
Book at
webstore.golamers.com
Bus from Manitowoc, WI to Milwaukee, WI - UW
Ave. Duration
1 h 40 min
Frequency
3 times a week
Estimated price
$20 - $25
Schedules at
golamers.com
Book at
webstore.golamers.com
Bus from Manitowoc, WI to Green Bay, WI - Transit
Ave. Duration
45 min
Frequency
3 times a week
Estimated price
$13 - $17
Schedules at
golamers.com
Book at
webstore.golamers.com
Bus from Manitowoc, WI to Milwaukee, WI - Airport
Ave. Duration
2 h 30 min
Frequency
3 times a week
Estimated price
$21 - $27
Schedules at
golamers.com
Book at
webstore.golamers.com
Groome Transportation
Phone
(800) 280-9270
Website
groometransportation.com
Bus from Winona Amtrak Station to Rochester, MN
Ave. Duration
1 h 20 min
Frequency
Every 3 hours
Estimated price
$25 - $45
Schedules at
groometransportation.com
Shuttle from Terminal 2 MSP to 2nd Street Rochester
Ave. Duration
1 h 25 min
Frequency
Hourly
Estimated price
$30 - $45
Schedules at
groometransportation.com
Amtrak Thruway

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak Thruway
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Bus from Winona Amtrak Station to Rochester, MN
Ave. Duration
1 h 20 min
Frequency
Every 4 hours
Estimated price
$18 - $26
Website
amtrak.com
Coach USA
Phone
201-225-7500
Website
coachusa.com
Bus from Milwaukee, WI - Amtrak to Chicago, IL - O'Hare International Airport
Ave. Duration
1 h 50 min
Frequency
Hourly
Estimated price
$21 - $35
Schedules at
web.coachusa.com
Book at
coachusaairportexpress.com

Want to know more about travelling around United States

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