There are 8 ways to get from Manitowoc to Florida Keys by taxi, plane, bus (Greyhound, Flixbus), bus, train, shuttle, car, or ferry
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Taxi to Appleton International Airport, fly to Key West International Airport
best- Take the taxi from Manitowoc to Appleton International Airport (ATW)taxi
- Fly from Appleton International Airport (ATW) to Key West International Airport (EYW)plane ATW - EYW
10h 25m$304–857Bus
cheapest- Take the bus from Manitowoc to Chicago Bus Stationbus
- Take the bus from Chicago Bus Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Miami Airport Stationbus
- Take the bus from Miami Airport Station to Big Pine Keybus
40h 34m$208–528Bus, train, shuttle
- Take the bus from Manitowoc to Chicago Bus Stationbus
- Take the train from Chicago Union Station to Miami Amtrak Stationtrain
- Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine Lab
2d 9h$401–946Drive 1,621.2 mi
- Drive from Manitowoc to Florida Keyscar 1,621.2 mi
29h 41m$296–428Bus to Green Bay, fly to Key West International Airport
- Take the bus from Manitowoc, WI to Green Bay, WIbus
- Fly from Green Bay (GRB) to Key West International Airport (EYW)plane GRB - EYW
11h 6m$237–796Bus to General Mitchell International Airport, fly to Key West International Airport
- Take the bus from Manitowoc to Milwaukee Intermodal Stationbus
- Fly from General Mitchell International Airport (MKE) to Key West International Airport (EYW)plane MKE - EYW
11h 9m$280–1,218Bus, bus to Chicago O'Hare International Airport, fly to Key West International Airport
- Take the bus from Manitowoc to Milwaukee Intermodal Stationbus
- Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus
- Fly from Chicago O'Hare International Airport (ORD) to Key West International Airport (EYW)plane ORD - EYW
11h 42m$243–776Taxi to Appleton International Airport, fly to Ft. Myers, ferry
- Take the taxi from Manitowoc to Appleton International Airport (ATW)taxi
- Fly from Appleton International Airport (ATW) to Ft. Myers (RSW)plane ATW - RSW
- Take the ferry from Fort Myers Beach, FL to Key West, FLferry
13h 4m$404–954
Appleton International Airport (ATW) to Key West International Airport (EYW) flights
Questions & Answers
The cheapest way to get from Manitowoc to Florida Keys is to bus which costs $200 - $550 and takes 40h 34m.
The fastest way to get from Manitowoc to Florida Keys is to taxi and fly which takes 10h 25m and costs $300 - $900.
The distance between Manitowoc and Florida Keys is 1493 miles. The road distance is 1630.7 miles.
The best way to get from Manitowoc to Florida Keys without a car is to bus which takes 40h 34m and costs $200 - $550.
It takes approximately 10h 25m to get from Manitowoc to Florida Keys, including transfers.
Yes, the driving distance between Manitowoc to Florida Keys is 1631 miles. It takes approximately 29h 41m to drive from Manitowoc to Florida Keys.
There are 797+ hotels available in Florida Keys.
What companies run services between Manitowoc, WI, USA and Florida Keys, FL, USA?
You can take a vehicle from Manitowoc to Florida Keys via Manitowoc, Chicago Bus Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 40h 34m.
- Website
- delta.com
Flights from Appleton International Airport to Key West International Airport via Atlanta
- Ave. Duration
- 7h 28m
- When
- Every day
- Estimated price
- $140–650
Flights from Green Bay to Key West International Airport via Atlanta
- Ave. Duration
- 7h 24m
- When
- Every day
- Estimated price
- $140–650
Flights from Green Bay to Key West International Airport via Detroit, Atlanta
- Ave. Duration
- 9h 11m
- When
- Every day
- Estimated price
- $140–700
Flights from General Mitchell International Airport to Key West International Airport via Atlanta
- Ave. Duration
- 5h 48m
- When
- Every day
- Estimated price
- $210–1,000
Flights from Chicago O'Hare International Airport to Key West International Airport via Atlanta
- Ave. Duration
- 5h 12m
- When
- Every day
- Estimated price
- $110–550
Flights from Appleton International Airport to Ft. Myers via Atlanta
- Ave. Duration
- 5h 36m
- When
- Every day
- Estimated price
- $130–650
Flights from Appleton International Airport to Ft. Myers via Detroit
- Ave. Duration
- 5h 48m
- When
- Every day
- Estimated price
- $140–650
Flights from Appleton International Airport to Ft. Myers via Minneapolis
- Ave. Duration
- 5h 52m
- When
- Every day
- Estimated price
- $150–700
- Website
- aa.com
Flights from Appleton International Airport to Key West International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 6h 47m
- When
- Every day
- Estimated price
- $140–650
Flights from Appleton International Airport to Key West International Airport via Charlotte
- Ave. Duration
- 7h 54m
- When
- Every day
- Estimated price
- $140–650
Flights from Green Bay to Key West International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 7h 25m
- When
- Every day
- Estimated price
- $140–650
Flights from General Mitchell International Airport to Key West International Airport via Miami
- Ave. Duration
- 5h 33m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $220–1,000
Flights from General Mitchell International Airport to Key West International Airport via Charlotte
- Ave. Duration
- 5h 36m
- When
- Every day
- Estimated price
- $220–1,000
Flights from General Mitchell International Airport to Key West International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 6h 53m
- When
- Every day
- Estimated price
- $210–1,000
Flights from Chicago O'Hare International Airport to Key West International Airport
- Ave. Duration
- 3h 28m
- When
- Every day
- Estimated price
- $110–550
Flights from Appleton International Airport to Ft. Myers via Charlotte
- Ave. Duration
- 7h 17m
- When
- Every day
- Estimated price
- $130–650
- Website
- united.com
Flights from Appleton International Airport to Key West International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 6h 39m
- When
- Every day
- Estimated price
- $140–650
Flights from Green Bay to Key West International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 7h 17m
- When
- Every day
- Estimated price
- $140–650
Flights from General Mitchell International Airport to Key West International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 5h 44m
- When
- Every day
- Estimated price
- $210–1,000
Flights from Chicago O'Hare International Airport to Key West International Airport
- Ave. Duration
- 3h 21m
- When
- Every day
- Estimated price
- $110–550
Flights from Appleton International Airport to Ft. Myers via Chicago O'Hare International Airport
- Ave. Duration
- 6h 12m
- When
- Every day
- Estimated price
- $130–650
- Website
- spirit.com
Flights from Chicago O'Hare International Airport to Key West International Airport via Fort Lauderdale
- Ave. Duration
- 5h 41m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $140–600
- Website
- allegiantair.com
Flights from Appleton International Airport to Ft. Myers
- Ave. Duration
- 3h 15m
- When
- Monday and Friday
- Estimated price
- $130–650
- Website
- suncountry.com
Flights from Appleton International Airport to Ft. Myers
- Ave. Duration
- 3h 29m
- When
- Monday and Friday
- Estimated price
- $130–650
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to Miami Amtrak Station
- Ave. Duration
- 46h 29m
- Frequency
- Once daily
- Estimated price
- $200–650
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Manitowoc to Chicago Bus Station
- Ave. Duration
- 3h 55m
- Frequency
- Once daily
- Estimated price
- $35–70
- Website
- https://www.greyhound.com/
Bus from Chicago Bus Station to Atlanta Bus Station
- Ave. Duration
- 16h 15m
- Frequency
- 4 times a day
- Estimated price
- $75–190
- Website
- https://www.greyhound.com/
Bus from Atlanta Bus Station to Miami Airport Station
- Ave. Duration
- 14h 5m
- Frequency
- Once daily
- Estimated price
- $65–210
- Website
- https://www.greyhound.com/
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 35m
- Frequency
- 3 times a day
- Estimated price
- $24–45
- Website
- https://www.greyhound.com/
Bus from Manitowoc to Milwaukee Intermodal Station
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Estimated price
- $27–60
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Chicago Bus Station to Atlanta Bus Station
- Ave. Duration
- 14h 25m
- Frequency
- 3 times a day
- Estimated price
- $80–180
- Schedules at
- flixbus.com
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- keysshuttle.com
Shuttle from Miami, FL - International Airport to Summerland Key - Mote Marine Lab
- Ave. Duration
- 3h 30m
- Frequency
- 4 times a day
- Estimated price
- $130–180
- Website
- https://www.keysshuttle.com
- Phone
- +1 989-725-5105
- Website
- indiantrails.com
Bus from Manitowoc, WI to Green Bay, WI
- Ave. Duration
- 40 min
- Frequency
- Once daily
- Estimated price
- $7–23
- Website
- https://indiantrails.com
Bus from Manitowoc to Milwaukee Intermodal Station
- Ave. Duration
- 1h 45m
- Frequency
- Once daily
- Estimated price
- $14–35
- Website
- https://indiantrails.com
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Manitowoc, WI to Green Bay, WI
- Ave. Duration
- 55 min
- Frequency
- Once daily
- Website
- https://www.amtrak.com/home.html
Bus from Manitowoc to Milwaukee Intermodal Station
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 800-236-1240
- Website
- golamers.com
Bus from Manitowoc, WI to Green Bay, WI
- Ave. Duration
- 55 min
- Frequency
- Twice a week
- Estimated price
- $14–23
- Website
- https://www.golamers.com/
- Schedules at
- https://www.golamers.com/
Bus from Manitowoc to Milwaukee Intermodal Station
- Ave. Duration
- 2h
- Frequency
- Twice a week
- Estimated price
- $21–50
- Website
- https://www.golamers.com/
- Schedules at
- https://www.golamers.com/
- Phone
- (866) 912 6224
- questions@coachusa.com
- Website
- coachusa.com
Bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departures
- Ave. Duration
- 1h 50m
- Frequency
- Every 2 hours
- Estimated price
- $35–38
- Schedules at
- coachusa.com
- Phone
- +1 239-463-5733
- Website
- keywestexpress.net
Ferry from Fort Myers Beach, FL to Key West, FL
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $130
- Website
- https://www.keywestexpress.net
- Ave. Duration
- 1h 16m
- Estimated price
- $110–140
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide














