There are 8 ways to get from Manitowoc to Des Moines by taxi, plane, bus (Amtrak, Greyhound, Flixbus), car, bus, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Taxi to Appleton International Airport, fly
best- Take the taxi from Manitowoc to Appleton International Airport (ATW)
- Fly from Appleton International Airport (ATW) to Des Moines (DSM)ATW - DSM
5h 12m$233–809Drive 400.4 mi
cheapest- Drive from Manitowoc to Des Moines400.4 mi
7h 48m$74–106Bus
- Take the bus from Manitowoc Amtrak Bus Stop to Milwaukee
- Take the bus from Milwaukee Intermodal Station to Chicago Bus Station
- Take the bus from Chicago Bus Station to Des Moines
12h 7m$86–209Bus to Green Bay, fly
- Take the bus from Manitowoc, WI to Green Bay, WI
- Fly from Green Bay (GRB) to Des Moines (DSM)GRB - DSM
5h 42m$177–748Bus to General Mitchell International Airport, fly
- Take the bus from Manitowoc Amtrak Bus Stop to Milwaukee
- Fly from General Mitchell International Airport (MKE) to Des Moines (DSM)MKE - DSM
6h 55m$190–1,160Bus, bus to Chicago O'Hare International Airport, fly
- Take the bus from Manitowoc Amtrak Bus Stop to Milwaukee
- Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departures
- Fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM)ORD - DSM
7h 5m$153–668Bus via Des Moines
- Take the bus from Manitowoc Amtrak Bus Stop to Milwaukee
- Take the bus from Milwaukee Intermodal Station to Chicago Bus Station
- Take the bus from Chicago to Des Moines
12h 43m$96–279Bus, train
- Take the bus from Manitowoc Amtrak Bus Stop to Milwaukee
- Take the train from Milwaukee to Chicago Union Station
- Take the train from Chicago Union Station to Galesburg Amtrak Station
- Take the bus from Galesburg to Burlington
- Take the bus from Burlington to Des Moines
14h 3m$136–314
Appleton International Airport (ATW) to Des Moines (DSM) flights
Questions & Answers
The cheapest way to get from Manitowoc to Des Moines is to drive which costs $70 - $110 and takes 7h 48m.
The fastest way to get from Manitowoc to Des Moines is to taxi and fly which takes 5h 12m and costs $230 - $850.
The distance between Manitowoc and Des Moines is 379 miles. The road distance is 402.7 miles.
The best way to get from Manitowoc to Des Moines without a car is to bus which takes 12h 7m and costs $85 - $210.
It takes approximately 5h 12m to get from Manitowoc to Des Moines, including transfers.
Yes, the driving distance between Manitowoc to Des Moines is 403 miles. It takes approximately 7h 48m to drive from Manitowoc to Des Moines.
There are 223+ hotels available in Des Moines.
What companies run services between Manitowoc, WI, USA and Des Moines, IA, USA?
You can take a vehicle from Manitowoc to Des Moines via Manitowoc Amtrak Bus Stop, Milwaukee, Milwaukee Intermodal Station, and Chicago Bus Station in around 12h 7m.
Transport is disrupted due to the Russia-Ukraine war. Read more
- Website
- united.com
Flights from Appleton International Airport to Des Moines via Chicago O'Hare International Airport
- Ave. Duration
- 4h 45m
- When
- Every day
- Estimated price
- $100–650
Flights from Appleton International Airport to Des Moines via Denver
- Ave. Duration
- 7h 37m
- When
- Every day
- Estimated price
- $220–1,000
Flights from Green Bay to Des Moines via Chicago O'Hare International Airport
- Ave. Duration
- 3h 56m
- When
- Every day
- Estimated price
- $110–650
Flights from General Mitchell International Airport to Des Moines via Chicago O'Hare International Airport
- Ave. Duration
- 4h 3m
- When
- Every day
- Estimated price
- $150–1,000
Flights from General Mitchell International Airport to Des Moines via Denver
- Ave. Duration
- 5h 25m
- When
- Tuesday to Thursday
- Estimated price
- $350–1,600
Flights from Chicago O'Hare International Airport to Des Moines
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $80–550
- Website
- aa.com
Flights from Appleton International Airport to Des Moines via Chicago O'Hare International Airport
- Ave. Duration
- 4h 59m
- When
- Thursday to Sunday
- Estimated price
- $100–650
Flights from Appleton International Airport to Des Moines via Charlotte
- Ave. Duration
- 7h 29m
- When
- Monday, Tuesday, Wednesday, Friday, Saturday, and Sunday
- Estimated price
- $230–1,100
Flights from Green Bay to Des Moines via Chicago O'Hare International Airport
- Ave. Duration
- 5h 12m
- When
- Every day
- Estimated price
- $110–650
Flights from General Mitchell International Airport to Des Moines via Chicago O'Hare International Airport
- Ave. Duration
- 4h 24m
- When
- Thursday to Sunday
- Estimated price
- $150–1,000
Flights from Chicago O'Hare International Airport to Des Moines
- Ave. Duration
- 1h 28m
- When
- Every day
- Estimated price
- $80–550
- Website
- delta.com
Flights from Appleton International Airport to Des Moines via Minneapolis
- Ave. Duration
- 4h 40m
- When
- Every day
- Estimated price
- $100–650
Flights from Appleton International Airport to Des Moines via Detroit
- Ave. Duration
- 5h 11m
- When
- Every day
- Estimated price
- $150–800
Flights from Appleton International Airport to Des Moines via Atlanta
- Ave. Duration
- 8h 8m
- When
- Every day
- Estimated price
- $220–1,000
Flights from Green Bay to Des Moines via Minneapolis
- Ave. Duration
- 4h 36m
- When
- Every day
- Estimated price
- $110–650
Flights from Green Bay to Des Moines via Detroit
- Ave. Duration
- 5h 9m
- When
- Every day
- Estimated price
- $140–800
Flights from General Mitchell International Airport to Des Moines via Minneapolis
- Ave. Duration
- 4h 52m
- When
- Every day
- Estimated price
- $180–1,100
Flights from General Mitchell International Airport to Des Moines via Atlanta
- Ave. Duration
- 6h 1m
- When
- Every day
- Estimated price
- $340–1,600
Flights from General Mitchell International Airport to Des Moines via Detroit
- Ave. Duration
- 7h 9m
- When
- Every day
- Estimated price
- $230–1,200
- Website
- southwest.com
Flights from General Mitchell International Airport to Des Moines via St. Louis
- Ave. Duration
- 4h 30m
- When
- Monday to Friday
- Estimated price
- $190–1,100
Flights from General Mitchell International Airport to Des Moines via Denver
- Ave. Duration
- 6h 11m
- When
- Monday, Tuesday, Wednesday, Thursday, and Sunday
- Estimated price
- $350–1,600
Flights from General Mitchell International Airport to Des Moines via Chicago Midway
- Ave. Duration
- 6h 20m
- When
- Monday, Thursday, and Friday
- Estimated price
- $160–1,000
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Milwaukee to Chicago Union Station
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $23–40
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Galesburg Amtrak Station
- Ave. Duration
- 2h 36m
- Frequency
- 4 times a day
- Estimated price
- $27–85
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Manitowoc Amtrak Bus Stop to Milwaukee
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Website
- https://www.amtrak.com/home.html
Bus from Manitowoc, WI to Green Bay, WI
- Ave. Duration
- 55 min
- Frequency
- Once daily
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 989-725-5105
- Website
- indiantrails.com
Bus from Manitowoc Amtrak Bus Stop to Milwaukee
- Ave. Duration
- 1h 45m
- Frequency
- Once daily
- Estimated price
- $14–35
- Website
- https://indiantrails.com
Bus from Manitowoc, WI to Green Bay, WI
- Ave. Duration
- 40 min
- Frequency
- Once daily
- Estimated price
- $7–23
- Website
- https://indiantrails.com
- Phone
- +1 800-236-1240
- Website
- golamers.com
Bus from Manitowoc Amtrak Bus Stop to Milwaukee
- Ave. Duration
- 2h
- Frequency
- Twice a week
- Estimated price
- $21–50
- Website
- https://www.golamers.com/
- Schedules at
- https://www.golamers.com/
Bus from Manitowoc, WI to Green Bay, WI
- Ave. Duration
- 55 min
- Frequency
- Twice a week
- Estimated price
- $14–23
- Website
- https://www.golamers.com/
- Schedules at
- https://www.golamers.com/
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Milwaukee Intermodal Station to Chicago Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- 3 times a day
- Estimated price
- $20–60
- Website
- https://www.greyhound.com/
Bus from Chicago Bus Station to Des Moines
- Ave. Duration
- 6h 34m
- Frequency
- 3 times a day
- Estimated price
- $45–90
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Milwaukee Intermodal Station to Chicago Bus Station
- Ave. Duration
- 2h 15m
- Frequency
- 3 times a day
- Estimated price
- $20–28
- Schedules at
- flixbus.com
- Phone
- (866) 912 6224
- questions@coachusa.com
- Website
- coachusa.com
Bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departures
- Ave. Duration
- 1h 50m
- Frequency
- Every 2 hours
- Estimated price
- $35–38
- Schedules at
- coachusa.com
- Phone
- +1 (319) 753-2864
- info@burlingtontrailways.com
- Website
- burlingtontrailways.com
Bus from Chicago to Des Moines
- Ave. Duration
- 7h 10m
- Frequency
- Twice daily
- Estimated price
- $55–160
- Website
- https://burlingtontrailways.com
- Saver Fares
- $65–95
- Flexible Fares
- $90–130
- Saver Fare
- $55–110
- Flex Fare
- $75–160
Bus from Galesburg to Burlington
- Ave. Duration
- 1h 10m
- Frequency
- Once daily
- Estimated price
- $25–50
- Website
- https://burlingtontrailways.com
- Saver Fares
- $25–40
- Flexible Fares
- $30–50
Bus from Burlington to Des Moines
- Ave. Duration
- 3h 5m
- Frequency
- Once daily
- Estimated price
- $40–80
- Website
- https://burlingtontrailways.com
- Saver Fares
- $40–60
- Flexible Fares
- $50–80
- Ave. Duration
- 1h 15m
- Estimated price
- $110–140
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