There are 8 ways to get from Manitowoc to Des Moines by taxi, plane, bus (Greyhound), car, bus, train, or bus (Amtrak)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Taxi to Appleton International Airport, fly
best- Take the taxi from Manitowoc to Appleton International Airport (ATW)
- Fly from Appleton International Airport (ATW) to Des Moines (DSM)ATW - DSM
5h 11m$229–759Drive 401.3 mi
cheapest- Drive from Manitowoc to Des Moines401.3 mi
7h 40m$74–106Bus
- Take the bus from Manitowoc to Chicago Bus StationGreyhound US0150S
- Take the bus from Chicago to Des MoinesChicago
12h 19m$97–239Bus to Green Bay, fly
- Take the bus from Manitowoc, WI to Green Bay, WI
- Fly from Green Bay (GRB) to Des Moines (DSM)GRB - DSM
5h 44m$167–698Bus to General Mitchell International Airport, fly
- Take the bus from Manitowoc Amtrak Bus Stop to Milwaukee
- Fly from General Mitchell International Airport (MKE) to Des Moines (DSM)MKE - DSM
6h 55m$180–1,070Bus, train
- Take the bus from Manitowoc Amtrak Bus Stop to Milwaukee
- Take the train from Milwaukee to Chicago Union Station
- Take the bus from Chicago to Des Moines
12h 31m$101–274Bus, train via Galesburg
- Take the bus from Manitowoc Amtrak Bus Stop to Milwaukee
- Take the train from Milwaukee to Chicago Union Station
- Take the train from Chicago Union Station to Galesburg Amtrak Station
- Take the bus from Galesburg to Burlington
- Take the bus from Burlington to Des Moines
14h 3m$141–329Bus via Saint Paul
- Take the bus from Manitowoc Amtrak Bus Stop to St. Paul-MinneapolisAmtrak Thruway Connecting Service
- Take the bus from MSP Airport to Des MoinesJefferson 803
14h 24m
Appleton International Airport (ATW) to Des Moines (DSM) flights
Questions & Answers
The cheapest way to get from Manitowoc to Des Moines is to drive which costs $70 - $110 and takes 7h 40m.
The fastest way to get from Manitowoc to Des Moines is to taxi and fly which takes 5h 11m and costs $220 - $800.
The distance between Manitowoc and Des Moines is 379 miles. The road distance is 403.6 miles.
The best way to get from Manitowoc to Des Moines without a car is to bus which takes 12h 19m and costs $95 - $240.
It takes approximately 5h 11m to get from Manitowoc to Des Moines, including transfers.
Yes, the driving distance between Manitowoc to Des Moines is 404 miles. It takes approximately 7h 40m to drive from Manitowoc to Des Moines.
There are 239+ hotels available in Des Moines.
What companies run services between Manitowoc, WI, USA and Des Moines, IA, USA?
You can take a vehicle from Manitowoc to Des Moines via Manitowoc and Chicago in around 12h 19m.
- Website
- delta.com
Flights from Appleton International Airport to Des Moines via Minneapolis
- Ave. Duration
- 4h 8m
- When
- Every day
- Estimated price
- $100–600
Flights from Appleton International Airport to Des Moines via Detroit
- Ave. Duration
- 5h 3m
- When
- Every day
- Estimated price
- $130–700
Flights from Appleton International Airport to Des Moines via Atlanta
- Ave. Duration
- 8h 6m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $200–900
Flights from Green Bay to Des Moines via Minneapolis
- Ave. Duration
- 4h 1m
- When
- Every day
- Estimated price
- $100–600
Flights from Green Bay to Des Moines via Detroit
- Ave. Duration
- 4h 45m
- When
- Every day
- Estimated price
- $130–700
Flights from General Mitchell International Airport to Des Moines via Minneapolis
- Ave. Duration
- 4h 22m
- When
- Every day
- Estimated price
- $170–1,000
Flights from General Mitchell International Airport to Des Moines via Atlanta
- Ave. Duration
- 6h 3m
- When
- Every day
- Estimated price
- $310–1,500
Flights from General Mitchell International Airport to Des Moines via Detroit
- Ave. Duration
- 7h 4m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $210–1,100
- Website
- united.com
Flights from Appleton International Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 4h 45m
- When
- Every day
- Estimated price
- $95–600
Flights from Appleton International Airport to Des Moines via Denver
- Ave. Duration
- 7h 56m
- When
- Every day
- Estimated price
- $200–900
Flights from Green Bay to Des Moines via Chicago O'Hare
- Ave. Duration
- 4h 3m
- When
- Every day
- Estimated price
- $100–600
Flights from General Mitchell International Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 4h 10m
- When
- Every day
- Estimated price
- $140–900
Flights from General Mitchell International Airport to Des Moines via Denver
- Ave. Duration
- 5h 33m
- When
- Tuesday to Thursday
- Estimated price
- $320–1,500
- Website
- aa.com
Flights from Appleton International Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 5h 59m
- When
- Every day
- Estimated price
- $95–600
Flights from Appleton International Airport to Des Moines via Charlotte
- Ave. Duration
- 8h 11m
- When
- Monday to Saturday
- Estimated price
- $210–950
Flights from Green Bay to Des Moines via Chicago O'Hare
- Ave. Duration
- 4h 57m
- When
- Every day
- Estimated price
- $100–600
Flights from General Mitchell International Airport to Des Moines via Chicago O'Hare
- Ave. Duration
- 4h 26m
- When
- Every day
- Estimated price
- $140–900
- Website
- southwest.com
Flights from General Mitchell International Airport to Des Moines via St. Louis
- Ave. Duration
- 3h 40m
- When
- Monday and Tuesday
- Estimated price
- $180–1,000
Flights from General Mitchell International Airport to Des Moines via Denver
- Ave. Duration
- 5h 38m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $320–1,500
Flights from General Mitchell International Airport to Des Moines via Chicago Midway
- Ave. Duration
- 6h 20m
- When
- Monday, Thursday, and Friday
- Estimated price
- $140–900
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Milwaukee to Chicago Union Station
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $25–45
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Galesburg Amtrak Station
- Ave. Duration
- 2h 36m
- Frequency
- 4 times a day
- Estimated price
- $30–85
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Manitowoc to Chicago Bus Station
- Ave. Duration
- 4h 5m
- Frequency
- Once daily
- Estimated price
- $35–70
- Website
- https://www.greyhound.com/
Bus from Manitowoc Amtrak Bus Stop to Milwaukee
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Estimated price
- $27–60
- Website
- https://www.greyhound.com/
- Phone
- +1 (319) 753-2864
- info@burlingtontrailways.com
- Website
- burlingtontrailways.com
Bus from Chicago to Des Moines
- Ave. Duration
- 7h 10m
- Frequency
- Twice daily
- Estimated price
- $55–160
- Website
- https://burlingtontrailways.com
- Saver Fares
- $65–95
- Flexible Fares
- $90–130
- Saver Fare
- $55–110
- Flex Fare
- $75–160
Bus from Galesburg to Burlington
- Ave. Duration
- 1h 10m
- Frequency
- Once daily
- Estimated price
- $25–50
- Website
- https://burlingtontrailways.com
- Saver Fares
- $25–40
- Flexible Fares
- $30–50
Bus from Burlington to Des Moines
- Ave. Duration
- 3h 5m
- Frequency
- Once daily
- Estimated price
- $40–80
- Website
- https://burlingtontrailways.com
- Saver Fares
- $40–60
- Flexible Fares
- $50–80
- Phone
- +1 989-725-5105
- Website
- indiantrails.com
Bus from Manitowoc, WI to Green Bay, WI
- Ave. Duration
- 40 min
- Frequency
- Once daily
- Estimated price
- $7–23
- Website
- https://indiantrails.com
Bus from Manitowoc Amtrak Bus Stop to Milwaukee
- Ave. Duration
- 1h 45m
- Frequency
- Once daily
- Estimated price
- $14–35
- Website
- https://indiantrails.com
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Manitowoc, WI to Green Bay, WI
- Ave. Duration
- 55 min
- Frequency
- Once daily
- Website
- https://www.amtrak.com/home.html
Bus from Manitowoc Amtrak Bus Stop to Milwaukee
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Website
- https://www.amtrak.com/home.html
Bus from Manitowoc Amtrak Bus Stop to St. Paul-Minneapolis
- Ave. Duration
- 6h 55m
- Frequency
- Once daily
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 800-236-1240
- Website
- golamers.com
Bus from Manitowoc, WI to Green Bay, WI
- Ave. Duration
- 55 min
- Frequency
- Twice a week
- Estimated price
- $14–23
- Website
- https://www.golamers.com/
- Schedules at
- https://www.golamers.com/
Bus from Manitowoc Amtrak Bus Stop to Milwaukee
- Ave. Duration
- 2h
- Frequency
- Twice a week
- Estimated price
- $21–50
- Website
- https://www.golamers.com/
- Schedules at
- https://www.golamers.com/
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from MSP Airport to Des Moines
- Ave. Duration
- 5h 35m
- Frequency
- Once daily
- Estimated price
- $23–110
- Book at
- https://www.jeffersonlines.com
- Ave. Duration
- 1h 15m
- Estimated price
- $110–140
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