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There are 10 ways to get from Manhattan to Buffalo Depew Station by train, plane, subway, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Train to Newark, fly to Buffalo

  1. Take the train from New York Penn Station to Newark Airport Railroad Station
  2. Fly from Newark (EWR) to Buffalo (BUF)

Cheapest option

Bus

  1. Take the bus from New York Midtown to Buffalo

8 alternative options

Subway to New York JFK, fly to Buffalo

  1. Take the subway from Lexington Av/53 St to Sutphin Blvd-Archer Av-JFK Airport
  2. Fly from New York JFK (JFK) to Buffalo (BUF)

Subway to New York La Guardia, fly to Buffalo

  1. Take the subway from Lexington Av/63 St to Jackson Hts-Roosevelt Av
  2. Fly from New York La Guardia (LGA) to Buffalo (BUF)

Fly Newark to Rochester, train

  1. Fly from Newark (EWR) to Rochester (ROC)
  2. Take the train from Rochester to Buffalo Depew Station

Fly New York La Guardia to Rochester, train

  1. Fly from New York La Guardia (LGA) to Rochester (ROC)
  2. Take the train from Rochester to Buffalo Depew Station

Fly New York JFK to Rochester, train

  1. Fly from New York JFK (JFK) to Rochester (ROC)
  2. Take the train from Rochester to Buffalo Depew Station

Train

  1. Take the train from NY Moynihan Train Hall at Penn Station to Buffalo Depew Station

Bus via 86 St

  1. Take the bus from New York to Buffalo

Drive

  1. Drive from Manhattan to Buffalo Depew Station
Manhattan → Buffalo Depew Station
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Rules to follow in United States

2m

Recommended

Recommended

Travel within United States

Nationwide control measures in place

COVID-19 help in United States

If you need help, visit the national COVID-19 website or call the COVID-19 Helpline 800-232-4636

Frequently Asked Questions


Yes, travel within United States is currently allowed.

Explore travel options

Domestic travel is not restricted, but some conditions may apply

  • Face masks are recommended
  • There is a social distancing requirement of 2 metres
  • Nationwide control measures in place

Explore travel options

The national COVID-19 helpline number in Buffalo Depew Station is 800-232-4636.

Wearing a face mask on public transport in Buffalo Depew Station is recommended.

The social distance requirement in Buffalo Depew Station is 2 metres.

Make yourself known to an official member of staff and/or call the national coronavirus helpline number on 800-232-4636.

Last updated: 3 Aug 2022
Exceptions may apply, for full details: Centers for Disease control and prevention (CDC).

We're working around the clock to bring you the latest COVID-19 travel updates.
This information is compiled from official sources. To the best of our knowledge, it is correct as of the last update.
Visit Rome2rio travel advice for general help.

Questions & Answers

The cheapest way to get from Manhattan to Buffalo Depew Station is to bus which costs $30 - $70 and takes 9h 43m.

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The quickest way to get from Manhattan to Buffalo Depew Station is to train and fly which costs $110 - $700 and takes 4h 22m.

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No, there is no direct bus from Manhattan to Buffalo Depew Station. However, there are services departing from New York Midtown and arriving at Walden Ave & 2929 Walden via Ellicott St & North Division St and Walden Ave & Thruway Transit Center. The journey, including transfers, takes approximately 9h 43m.

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Yes, there is a direct train departing from NY Moynihan Train Hall at Penn Station station and arriving at Buffalo Depew Station station. Services depart every four hours, and operate every day. The journey takes approximately 8h 49m.

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The distance between Manhattan and Buffalo Depew Station is 287 miles. The road distance is 373.7 miles.

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The best way to get from Manhattan to Buffalo Depew Station without a car is to train which takes 8h 49m and costs $100 - $250.

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It takes approximately 4h 22m to get from Manhattan to Buffalo Depew Station, including transfers.

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Manhattan to Buffalo Depew Station bus services, operated by Flixbus USA, depart from New York Midtown station.

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Manhattan to Buffalo Depew Station train services, operated by Amtrak, depart from NY Moynihan Train Hall at Penn Station.

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The best way to get from Manhattan to Buffalo Depew Station is to train which takes 8h 49m and costs $100 - $250. Alternatively, you can bus, which costs $30 - $70 and takes 9h 43m.

Mode details

Map of how to get from Manhattan to Buffalo Depew Station.
Launch map view
  • Distance: 287.2 miles
  • Duration: 4h 22m

What companies run services between Manhattan, NY, USA and Buffalo Depew Station, NY, USA?

Amtrak operates a train from NY Moynihan Train Hall at Penn Station to Buffalo Depew Station 5 times a day. Tickets cost $55 - $80 and the journey takes 8h 49m. VIA Rail also services this route once daily. Alternatively, Flixbus USA operates a bus from New York Midtown to Buffalo twice daily. Tickets cost $29 - $65 and the journey takes 7h 50m.

Airlines
United Airlines
Website
united.com
Flights from Newark to Buffalo
Ave. Duration
1h 28m
When
Every day
Estimated price
$120 - $1,300
Flights from Newark to Buffalo via Washington Dulles
Ave. Duration
3h 38m
When
Every day
Estimated price
$120 - $1,300
Flights from New York La Guardia to Buffalo via Washington Dulles
Ave. Duration
3h 44m
When
Every day
Estimated price
$130 - $1,100
Flights from Newark to Rochester
Ave. Duration
1h 18m
When
Every day
Estimated price
$110 - $450
Delta
Website
delta.com
Flights from New York JFK to Buffalo
Ave. Duration
1h 42m
When
Every day
Estimated price
$120 - $350
Flights from New York La Guardia to Buffalo
Ave. Duration
1h 31m
When
Every day
Estimated price
$120 - $350
Flights from New York La Guardia to Rochester
Ave. Duration
1h 23m
When
Every day
Estimated price
$110 - $330
Flights from New York JFK to Rochester
Ave. Duration
1h 37m
When
Every day
Estimated price
$110 - $320
American Airlines
Website
aa.com
Flights from New York JFK to Buffalo
Ave. Duration
1h 34m
When
Every day
Estimated price
$130 - $700
Flights from New York JFK to Buffalo via Boston
Ave. Duration
3h 36m
When
Every day
Estimated price
$130 - $700
Flights from New York La Guardia to Buffalo via Reagan Washington
Ave. Duration
3h 30m
When
Monday to Friday
Estimated price
$130 - $750
Flights from New York JFK to Rochester
Ave. Duration
1h 27m
When
Every day
Estimated price
$110 - $470
JetBlue Airways
Website
jetblue.com
Flights from New York JFK to Buffalo
Ave. Duration
1h 34m
When
Every day
Estimated price
$130 - $700
Flights from New York JFK to Buffalo via Boston
Ave. Duration
3h 36m
When
Every day
Estimated price
$130 - $700
Flights from New York JFK to Rochester
Ave. Duration
1h 27m
When
Every day
Estimated price
$110 - $470
Southwest Airlines
Website
southwest.com
Flights from New York La Guardia to Buffalo via Baltimore
Ave. Duration
3h 55m
When
Saturday
Estimated price
$170 - $650
Flights from New York La Guardia to Rochester via Baltimore
Ave. Duration
3h 20m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $430
Train operators
NJ Transit
Phone
+1 973-275-5555
Website
njtransit.com
Train from New York Penn Station to Newark Airport Railroad Station
Ave. Duration
24 min
Frequency
Every 20 minutes
Estimated price
$13 - $17
Schedules at
njtransit.com
MTA

The New York City Subway consists of 27 underground lines that serve Manhattan, the Bronx, Brooklyn and Queens. Lines are identified by a number or letter as well as a colour. Subway passes (called MetroCards) are available for purchase from ticket machines and desks in subway stations (choose from Pay-Per-Ride or 7/30-Day Unlimited), and a new contactless payment system called OMNY is currently being rolled out. The subway runs 24 hours a day, 365 days a year.

Contact Details
Website
mta.info
Subway from Lexington Av/53 St to Sutphin Blvd-Archer Av-JFK Airport
Ave. Duration
26 min
Frequency
Every 10 minutes
Estimated price
$1 - $3
Website
mta.info
Seniors 65+ and Concession
$2
Standard
$3
Subway from Lexington Av/63 St to Jackson Hts-Roosevelt Av
Ave. Duration
11 min
Frequency
Every 10 minutes
Estimated price
$1 - $3
Website
mta.info
Seniors 65+ and Concession
$2
Standard
$3
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 800-872-7245
Website
amtrak.com
Train from Rochester to Buffalo Depew Station
Ave. Duration
1h
Frequency
Every 4 hours
Estimated price
$25 - $35
Website
Amtrak
Coach Seat
$25 - $35
Premium
$180 - $260
Flexi Coach Seat
$35 - $55
Business Seat
$30 - $50
Train from NY Moynihan Train Hall at Penn Station to Buffalo Depew Station
Ave. Duration
8h 49m
Frequency
5 times a day
Estimated price
$55 - $80
Website
Amtrak
Coach Seat
$55 - $80
Premium
$240 - $330
Flexi Coach Seat
$100 - $150
Business Seat
$100 - $150
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Rochester to Buffalo
Ave. Duration
1h 9m
Frequency
Once daily
Estimated price
$35 - $60
Website
VIA Rail
Escape
$17 - $28
Business
$64 - $66
Economy
$37 - $38
EconomyPlus
$40 - $60
Train from New York Penn Station to Buffalo
Ave. Duration
7h 56m
Frequency
Once daily
Estimated price
$100 - $250
Website
VIA Rail
Escape
$70 - $90
Business
$120 - $170
Economy
$100 - $120
EconomyPlus
$170 - $250
Bus operators
Flixbus USA
Phone
(855) 626-8585
Website
flixbus.com
Bus from New York Midtown to Buffalo
Ave. Duration
7h 50m
Frequency
Twice daily
Estimated price
$29 - $65
Schedules at
flixbus.com
Adult Standard Purchase
$30 - $65
Adult Advance Purchase
$29 - $45
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from New York to Buffalo
Ave. Duration
8h 55m
Frequency
3 times a day
Estimated price
$45 - $65
Website
greyhound.com
Economy
$45 - $65
Flexible
$75 - $110
Trailways
Phone
+1 800-858-8555
Website
trailways.com
Bus from New York, Ny to Buffalo, Ny
Ave. Duration
8h 20m
Frequency
4 times a week
Estimated price
$95 - $140
Schedules at
trailways.com

Want to know more about travelling around United States

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More Questions & Answers

The quickest flight from Newark Airport to Buffalo Airport is the direct flight which takes 1h 21m.

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Manhattan to Buffalo Depew Station bus services, operated by Flixbus USA, arrive at Buffalo station.

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Manhattan to Buffalo Depew Station train services, operated by Amtrak, arrive at Buffalo Depew Station.

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Yes, the driving distance between Manhattan to Buffalo Depew Station is 374 miles. It takes approximately 6h 45m to drive from Manhattan to Buffalo Depew Station.

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United Airlines offers flights from Newark Airport to Buffalo Airport.

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Book your Manhattan to Buffalo Depew Station train tickets online with Omio.

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There are 120+ hotels available in Buffalo Depew Station. Prices start at $100 USD per night.

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