There are 8 ways to get from Mainz to Siena by plane, train, bus, night train, car, or car train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Florence Peretola Airport, train
best- Fly from Frankfurt (FRA) to Florence Peretola Airport (FLR)FRA - FLR
- Take the train from Firenze S.M.N. to Siena
6h 49m€115–312Bus
cheapest- Take the bus from Frankfurt central train station to Florence Villa Constanza Bus StationN77 / ...
- Take the bus from Florence Villa Constanza Bus Station to SienaN528 / ...
19h 55m€63–144Train
- Take the train from Frankfurt to Basel SBB20 / ...
- Take the train from Basel SBB to Zürich HBIce / ...
- Take the train from Zürich HB to Milano CentraleEc
- Take the train from Milano Centrale to Florence Santa Maria Novella
- Take the train from Firenze S.M.N. to SienaRe
15h 23m€161–337Train, night train, bus
- Take the train from Mainz, Hauptbahnhof to Hauptbahnhof55 / ...
- Take the night train from Stuttgart Hbf to Venezia MestreNj
- Take the train from Venezia Mestre to Firenze S.M.N.Fr
- Take the bus from Firenze Autostazione to Siena-Via Tozzi131
18h 58mFly to Bologna Guglielmo Marconi Airport, train
- Fly from Frankfurt (FRA) to Bologna Guglielmo Marconi Airport (BLQ)FRA - BLQ
- Take the train from Bologna Centrale to Firenze S.M.N.
- Take the train from Firenze S.M.N. to Siena
7h 13m€126–329Train, bus
- Take the train from Mainz, Römisches Theater to Mannheim, HauptbahnhofS6
- Take the bus from Mannheim Central Bus Station to Milan
- Take the bus from Milan to Siena Central Train Station
20h 37m€64–155Drive 1,023.2 km
- Drive from Mainz to Siena1,023.2 km
9h 45m€160–231Drive, car train
- Drive from Mainz to Fulda
- Take the car train from Fulda to München Ost
- Drive from München Ost to Siena
10h 28m€215–299
Mainz to Siena by train
Questions & Answers
The cheapest way to get from Mainz to Siena is to bus which costs €60 - €150 and takes 19h 55m.
The fastest way to get from Mainz to Siena is to fly and train which takes 6h 49m and costs €110 - €320.
No, there is no direct bus from Mainz station to Siena. However, there are services departing from Mainz central train station and arriving at Siena via Frankfurt central train station and Florence Villa Constanza Bus Station. The journey, including transfers, takes approximately 19h 55m.
No, there is no direct train from Mainz to Siena. However, there are services departing from Mainz, Römisches Theater and arriving at Siena via Frankfurt, Basel SBB, Zürich HB, Milano Centrale and Firenze S.M.N.. The journey, including transfers, takes approximately 15h 23m.
The distance between Mainz and Siena is 847 km. The road distance is 1023.2 km.
The best way to get from Mainz to Siena without a car is to train which takes 15h 23m and costs €160 - €340.
It takes approximately 6h 49m to get from Mainz to Siena, including transfers.
Mainz to Siena bus services, operated by FlixBus, depart from Frankfurt central train station.
Mainz to Siena train services, operated by Deutsche Bahn Intercity (DB IC), depart from Frankfurt station.
The best way to get from Mainz to Siena is to train which takes 15h 23m and costs €160 - €340. Alternatively, you can bus, which costs €60 - €150 and takes 19h 55m.
What companies run services between Mainz, Germany and Siena, Italy?
You can take a train from Mainz, Römisches Theater to Siena via Frankfurt, Basel SBB, Zürich HB, Milano Centrale, and Firenze S.M.N. in around 15h 23m. Alternatively, you can take a bus from Mainz central train station to Siena via Frankfurt central train station and Florence Villa Constanza Bus Station in around 19h 55m.
- Website
- lufthansa.com
Flights from Frankfurt to Florence Peretola Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €100–250
Flights from Frankfurt to Florence Peretola Airport via Munich
- Ave. Duration
- 3h 18m
- When
- Every day
- Estimated price
- €100–250
Flights from Frankfurt to Bologna Guglielmo Marconi Airport
- Ave. Duration
- 1h 23m
- When
- Every day
- Estimated price
- €100–320
Flights from Frankfurt to Bologna Guglielmo Marconi Airport via Munich
- Ave. Duration
- 3h 16m
- When
- Every day
- Estimated price
- €100–330
- Website
- airdolomiti.it
Flights from Frankfurt to Florence Peretola Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €100–250
Flights from Frankfurt to Bologna Guglielmo Marconi Airport
- Ave. Duration
- 1h 23m
- When
- Every day
- Estimated price
- €100–320
- Website
- swiss.com
Flights from Frankfurt to Florence Peretola Airport via Zurich
- Ave. Duration
- 4h
- When
- Every day
- Estimated price
- €150–330
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Firenze S.M.N. to Siena
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €6–18
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €12–18
Train from Bologna Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 51m
- Frequency
- Twice daily
- Estimated price
- €6–17
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €12–17
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from Frankfurt to Basel SBB
- Ave. Duration
- 2h 50m
- Frequency
- Hourly
- Estimated price
- €40–85
- Website
- https://int.bahn.de/en
Train from Mainz, Hauptbahnhof to Hauptbahnhof
- Ave. Duration
- 1h 41m
- Frequency
- Every 3 hours
- Estimated price
- €24–75
- Website
- https://int.bahn.de/en
- Phone
- +41 848 446 688
- Website
- sbb.ch
Train from Basel SBB to Zürich HB
- Ave. Duration
- 1h 12m
- Frequency
- Every 20 minutes
- Estimated price
- €22–45
- Website
- https://www.sbb.ch/en
Train from Zürich HB to Milano Centrale
- Ave. Duration
- 3h 17m
- Frequency
- Once daily
- Estimated price
- €55–95
- Website
- https://www.sbb.ch/en
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Milano Centrale to Florence Santa Maria Novella
- Ave. Duration
- 1h 55m
- Frequency
- Every 2 hours
- Estimated price
- €29–80
- Website
- https://www.italotreno.it/en
Train from Venezia Mestre to Firenze S.M.N.
- Ave. Duration
- 2h 11m
- Frequency
- Once a week
- Estimated price
- €26–60
- Website
- https://www.italotreno.it/en
Train from Bologna Centrale to Firenze S.M.N.
- Ave. Duration
- 46 min
- Frequency
- Once a week
- Estimated price
- €15–40
- Website
- https://www.italotreno.it/en
- Phone
- +43 51717
- Website
- nightjet.com
Night train from Stuttgart Hbf to Venezia Mestre
- Ave. Duration
- 11h 54m
- Frequency
- Once daily
- Estimated price
- €65–270
- Website
- https://www.nightjet.com/en/#/home
- Sleeper Carriage
- €260–270
- Couchette Carriage
- €150–180
- Seating Carriage
- €65–80
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Venezia Mestre to Firenze S.M.N.
- Ave. Duration
- 2h 1m
- Frequency
- Hourly
- Estimated price
- €30–60
- Schedules at
- trenitalia.com
Train from Bologna Centrale to Firenze S.M.N.
- Ave. Duration
- 37 min
- Frequency
- Every 30 minutes
- Estimated price
- €17–35
- Schedules at
- trenitalia.com
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Bologna Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 16m
- Frequency
- Once daily
- Estimated price
- €9–13
- Website
- https://www.trenitalia.com/en.html
- Phone
- +49 30 2970
- Website
- bahn.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 1h 17m
- Frequency
- Hourly
- Estimated price
- €13–19
- Website
- https://int.bahn.de/en
- Phone
- 0621 8301200
- Website
- suewex.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 53 min
- Frequency
- Twice daily
- Estimated price
- €14–20
- Schedules at
- suewex.de
- Phone
- +49 (0) 221 800 20 820
- info@urlaubs-express.de
- Website
- urlaubs-express.de
Car train from Fulda to München Ost
- Ave. Duration
- 2h 11m
- Frequency
- Once daily
- Estimated price
- €95–110
- Website
- https://urlaubs-express.de/?lang=en
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Frankfurt central train station to Florence Villa Constanza Bus Station
- Ave. Duration
- 16h 40m
- Frequency
- Twice daily
- Estimated price
- €50–110
- Website
- https://www.flixbus.co.uk
Bus from Florence Villa Constanza Bus Station to Siena
- Ave. Duration
- 50 min
- Frequency
- Every 3 hours
- Estimated price
- €11–14
- Website
- https://www.flixbus.co.uk
- Phone
- +39 06 88 93 82 32
- Website
- itabus.it
Bus from Florence Villa Constanza Bus Station to Siena
- Ave. Duration
- 55 min
- Frequency
- 5 times a day
- Estimated price
- €12–26
- Website
- https://www.itabus.it/en/home
Bus from Milan to Siena Central Train Station
- Ave. Duration
- 5h 15m
- Frequency
- 4 times a day
- Estimated price
- €15–70
- Website
- https://www.itabus.it/en/home
- Phone
- +39 080 3112335
- info@marinobus.it
- Website
- marinobus.it
Bus from Florence Villa Constanza Bus Station to Siena
- Ave. Duration
- 1h
- Frequency
- 3 times a week
- Estimated price
- €7–14
- Website
- https://marinobus.it/en/
Bus from Mannheim Central Bus Station to Milan
- Ave. Duration
- 12h 5m
- Frequency
- Twice a week
- Estimated price
- €35–65
- Website
- https://marinobus.it/en/
- Phone
- +39 055 849 0505
- servizioclienti@at-bus.it
- Website
- at-bus.it
Bus from Firenze Autostazione to Siena-Via Tozzi
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Website
- https://www.at-bus.it/en
Want to know more about travelling around Italy
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italy Travel Guides
Read the travel guide
Heading to Europe? Read this before you buy a Eurail Pass
Read the travel guide
5 incredible day trips from Florence by train
Read the travel guide
More Questions & Answers
Mainz to Siena bus services, operated by FlixBus, arrive at Florence Villa Constanza Bus Station.
Mainz to Siena train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Basel SBB station.
Yes, the driving distance between Mainz to Siena is 1023 km. It takes approximately 9h 45m to drive from Mainz to Siena.
Book your Mainz to Siena bus tickets online with FlixBus.
There are 2213+ hotels available in Siena.

















































