There are 9 ways to get from Mainz to Siena by plane, train, bus, night train, train (Trenitalia), car, or car train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Florence Peretola Airport, train
best- Fly from Frankfurt (FRA) to Florence Peretola Airport (FLR)plane FRA - FLR
- Take the train from Firenze S.M.N. to Sienatrain
6h 42m€116–304Bus
cheapest- Take the bus from Frankfurt central train station to Florence Villa Constanza Bus Stationbus N77 / ...
- Take the bus from Florence Villa Constanza Bus Station to Sienabus N528 / ...
20h 10m€71–131Train, bus
- Take the train from Mainz Hbf to Zürich HBtrain
- Take the train from Zürich HB to Luganotrain Ec / ...
- Take the train from Lugano to Milano Centraletrain
- Take the train from Milano Centrale to Florence Santa Maria Novellatrain
- Take the bus from Firenze Autostazione to Siena-Via Tozzibus 131
15h 15mTrain, night train, bus
- Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain S5 / ...
- Take the train from Mannheim, Hauptbahnhof to Hauptbahnhoftrain 22 / ...
- Take the night train from Stuttgart Hbf to Venezia Mestrenighttrain Nj
- Take the train from Venezia Mestre to Firenze S.M.N.train Fr
- Take the bus from Firenze Autostazione to Siena-Via Tozzibus 131
19h 29mFly to Bologna Guglielmo Marconi Airport, train
- Fly from Frankfurt (FRA) to Bologna Guglielmo Marconi Airport (BLQ)plane FRA - BLQ
- Take the train from Bologna Centrale to Florence Santa Maria Novellatrain
- Take the train from Firenze S.M.N. to Sienatrain
7h 19m€142–332Train via Basel
- Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain S5 / ...
- Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain 20 / ...
- Take the train from Basel SBB to Domodossolatrain Ec
- Take the train from Domodossola to Milano Centraletrain
- Take the train from Milano Centrale to Firenze S.M.N.train Fr
- Take the train from Firenze S.M.N. to Sienatrain Re
15h 21m€179–416Train
- Take the train from Frankfurt to München Hbftrain 41 / ...
- Take the train from München Hbf to Verona Porta Nuovatrain 89
- Take the train from Verona Porta Nuova to Firenze S.M.N.train Fr
- Take the train from Firenze S.M.N. to Sienatrain Re
15h 39m€174–381Drive 1,023.3 km
- Drive from Mainz to Sienacar 1,023.3 km
9h 48m€158–228Drive, car train
- Drive from Mainz to Fuldacar
- Take the car train from Fulda to München Ostcartrain
- Drive from München Ost to Sienacar
10h 32m€215–299
Frankfurt (FRA) to Florence Peretola Airport (FLR) flights
Questions & Answers
The cheapest way to get from Mainz to Siena is to bus which costs €70 - €140 and takes 20h 10m.
The fastest way to get from Mainz to Siena is to fly and train which takes 6h 42m and costs €110 - €310.
No, there is no direct bus from Mainz station to Siena. However, there are services departing from Mainz central train station and arriving at Siena via Frankfurt central train station and Florence Villa Constanza Bus Station. The journey, including transfers, takes approximately 20h 10m.
No, there is no direct train from Mainz to Siena. However, there are services departing from Mainz, Römisches Theater and arriving at Siena via Mannheim, Hauptbahnhof, Basel SBB, Domodossola, Milano Centrale and Firenze S.M.N.. The journey, including transfers, takes approximately 15h 21m.
The distance between Mainz and Siena is 847 km. The road distance is 1023.3 km.
The best way to get from Mainz to Siena without a car is to train and bus which takes 15h 15m and costs .
It takes approximately 6h 42m to get from Mainz to Siena, including transfers.
Mainz to Siena bus services, operated by FlixBus, depart from Frankfurt central train station.
Mainz to Siena train services, operated by Deutsche Bahn Regio (DB Regional), depart from Mainz, Römisches Theater station.
The best way to get from Mainz to Siena is to bus which takes 20h 10m and costs €70 - €140. Alternatively, you can train via Basel, which costs €170 - €420 and takes 15h 21m.
What companies run services between Mainz, Germany and Siena, Italy?
You can take a bus from Mainz central train station to Siena via Frankfurt central train station and Florence Villa Constanza Bus Station in around 20h 10m. Alternatively, you can take a train from Mainz, Römisches Theater to Siena via Mannheim, Hauptbahnhof, Basel SBB, Domodossola, Milano Centrale, and Firenze S.M.N. in around 15h 21m.
- Website
- lufthansa.com
Flights from Frankfurt to Florence Peretola Airport
- Ave. Duration
- 1h 36m
- When
- Every day
- Estimated price
- €100–360
Flights from Frankfurt to Florence Peretola Airport via Munich
- Ave. Duration
- 3h 18m
- When
- Every day
- Estimated price
- €110–360
Flights from Frankfurt to Bologna Guglielmo Marconi Airport
- Ave. Duration
- 1h 23m
- When
- Every day
- Estimated price
- €90–370
Flights from Frankfurt to Bologna Guglielmo Marconi Airport via Munich
- Ave. Duration
- 3h 16m
- When
- Every day
- Estimated price
- €100–390
- Website
- airdolomiti.it
Flights from Frankfurt to Florence Peretola Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €110–360
Flights from Frankfurt to Bologna Guglielmo Marconi Airport
- Ave. Duration
- 1h 23m
- When
- Every day
- Estimated price
- €100–370
- Website
- swiss.com
Flights from Frankfurt to Florence Peretola Airport via Zurich
- Ave. Duration
- 3h 57m
- When
- Every day
- Estimated price
- €120–250
- Website
- luxair.lu
Flights from Frankfurt to Florence Peretola Airport via Luxembourg
- Ave. Duration
- 4h 5m
- When
- Sunday
- Estimated price
- €85–420
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Firenze S.M.N. to Siena
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €7–10
- Website
- https://www.trenitalia.com/en.html
- Phone
- +31 30 751 5155
- Website
- ns.nl
Train from Mainz Hbf to Zürich HB
- Ave. Duration
- 6h 22m
- Frequency
- Once daily
- Estimated price
- €70–240
- Website
- https://www.ns.nl/en
- 2nd Class
- €70–110
- 1st Class
- €140–240
Train from Mannheim, Hauptbahnhof to Hauptbahnhof
- Ave. Duration
- 37 min
- Frequency
- 3 times a day
- Estimated price
- €18–60
- Website
- https://www.ns.nl/en
- 2nd Class
- €18–27
- 1st Class
- €30–60
Train from Mannheim, Hauptbahnhof to Basel SBB
- Ave. Duration
- 2h 50m
- Frequency
- Once daily
- Estimated price
- €40–140
- Website
- https://www.ns.nl/en
- 2nd Class
- €40–60
- 1st Class
- €80–140
Train from Frankfurt to München Hbf
- Ave. Duration
- 3h 19m
- Frequency
- 3 times a day
- Estimated price
- €60–220
- Website
- https://www.ns.nl/en
- 2nd Class
- €60–95
- 1st Class
- €130–220
- Phone
- +41 848 446 688
- Website
- sbb.ch
Train from Zürich HB to Lugano
- Ave. Duration
- 1h 55m
- Frequency
- Hourly
- Estimated price
- €60–120
- Website
- https://www.sbb.ch/en
Train from Lugano to Milano Centrale
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Estimated price
- €24–45
- Website
- https://www.sbb.ch/en
Train from Basel SBB to Domodossola
- Ave. Duration
- 2h 42m
- Frequency
- Once a week
- Estimated price
- €80–150
- Website
- https://www.sbb.ch/en
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Milano Centrale to Florence Santa Maria Novella
- Ave. Duration
- 1h 55m
- Frequency
- Hourly
- Estimated price
- €45–65
- Website
- https://www.italotreno.it/en
- Smart Economy
- €45–65
- Smart Flex
- €50–65
Train from Venezia Mestre to Firenze S.M.N.
- Ave. Duration
- 2h 11m
- Frequency
- Once a week
- Estimated price
- €40–55
- Website
- https://www.italotreno.it/en
- Smart Economy
- €40–55
- Smart Flex
- €45–55
Train from Bologna Centrale to Florence Santa Maria Novella
- Ave. Duration
- 36 min
- Frequency
- Hourly
- Estimated price
- €28–40
- Website
- https://www.italotreno.it/en
- Smart Economy
- €28–40
- Smart Flex
- €29–40
- Phone
- +49 30 2970
- Website
- bahn.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 1h 17m
- Frequency
- Hourly
- Estimated price
- €13–19
- Website
- https://int.bahn.de/en
- Phone
- 0621 8301200
- Website
- suewex.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 53 min
- Frequency
- Once daily
- Estimated price
- €14–20
- Schedules at
- suewex.de
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from Mannheim, Hauptbahnhof to Hauptbahnhof
- Ave. Duration
- 38 min
- Frequency
- Every 30 minutes
- Estimated price
- €31–35
- Website
- https://int.bahn.de/en
Train from Mannheim, Hauptbahnhof to Basel SBB
- Ave. Duration
- 2h 21m
- Frequency
- Hourly
- Estimated price
- €49–54
- Website
- https://int.bahn.de/en
Train from Frankfurt to München Hbf
- Ave. Duration
- 3h 31m
- Frequency
- Every 30 minutes
- Estimated price
- €65–75
- Website
- https://int.bahn.de/en
Train from München Hbf to Verona Porta Nuova
- Ave. Duration
- 5h 31m
- Frequency
- Every 4 hours
- Estimated price
- €70–80
- Website
- https://int.bahn.de/en
- Phone
- +33 1 84 94 36 35
- Website
- sncf-connect.com
Train from Mannheim, Hauptbahnhof to Hauptbahnhof
- Ave. Duration
- 42 min
- Frequency
- Once daily
- Estimated price
- €25–60
- Website
- https://www.sncf-connect.com/en-en
- 2nd Class
- €25–35
- 1st Class
- €45–60
- Phone
- +43 51717
- Website
- nightjet.com
Night train from Stuttgart Hbf to Venezia Mestre
- Ave. Duration
- 11h 54m
- Frequency
- Once daily
- Estimated price
- €65–270
- Website
- https://www.nightjet.com/en/#/home
- Sleeper Carriage
- €260–270
- Couchette Carriage
- €150–180
- Seating Carriage
- €65–80
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Venezia Mestre to Firenze S.M.N.
- Ave. Duration
- 2h 1m
- Frequency
- Hourly
- Estimated price
- €35–70
- Schedules at
- trenitalia.com
Train from Milano Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 54m
- Frequency
- Hourly
- Estimated price
- €40–85
- Schedules at
- trenitalia.com
Train from Verona Porta Nuova to Firenze S.M.N.
- Ave. Duration
- 1h 32m
- Frequency
- Every 4 hours
- Estimated price
- €29–60
- Schedules at
- trenitalia.com
- Phone
- +43 5 1717
- Website
- oebb.at
Train from Mannheim, Hauptbahnhof to Basel SBB
- Ave. Duration
- 2h 59m
- Frequency
- 5 times a week
- Estimated price
- €45–65
- Website
- https://www.oebb.at/en/reiseplanung-services/im-zug/unsere-zuege/eurocity-intercity
- Website
- https://shop.oebbtickets.at/en/ticket
- Phone
- +39 02 7249 4494
- my-link@trenord.it
- Website
- trenord.it
Train from Domodossola to Milano Centrale
- Ave. Duration
- 1h 42m
- Frequency
- Every 2 hours
- Estimated price
- €8–11
- Website
- https://www.trenord.it/en/
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Milano Centrale to Firenze S.M.N.
- Ave. Duration
- 3h 42m
- Frequency
- Once daily
- Estimated price
- €30–70
- Website
- https://www.trenitalia.com/en.html
- Phone
- +49 (0) 221 800 20 820
- info@urlaubs-express.de
- Website
- urlaubs-express.de
Car train from Fulda to München Ost
- Ave. Duration
- 2h 11m
- Frequency
- Once daily
- Estimated price
- €95–110
- Website
- https://urlaubs-express.de/?lang=en
- Phone
- +39 055 849 0505
- servizioclienti@at-bus.it
- Website
- at-bus.it
Bus from Firenze Autostazione to Siena-Via Tozzi
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Website
- https://www.at-bus.it/en
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Frankfurt central train station to Florence Villa Constanza Bus Station
- Ave. Duration
- 16h 40m
- Frequency
- Twice daily
- Estimated price
- €65–120
- Website
- https://www.flixbus.co.uk
Bus from Florence Villa Constanza Bus Station to Siena
- Ave. Duration
- 50 min
- Frequency
- Every 2 hours
- Estimated price
- €4–7
- Website
- https://www.flixbus.co.uk
Want to know more about travelling around Italy
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More Questions & Answers
Mainz to Siena bus services, operated by FlixBus, arrive at Florence Villa Constanza Bus Station.
Mainz to Siena train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Mannheim, Hauptbahnhof station.
Yes, the driving distance between Mainz to Siena is 1023 km. It takes approximately 9h 48m to drive from Mainz to Siena.
Book your Mainz to Siena train tickets online with Omio.
Book your Mainz to Siena bus tickets online with FlixBus.
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