There are 8 ways to get from Mainz to Siena by plane, bus, train, night train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Florence Peretola Airport, bus
best- Fly from Frankfurt (FRA) to Florence Peretola Airport (FLR)plane FRA - FLR
- Take the bus from Firenze Autostazione to Siena-V Le V.Veneto N.5bus
6h 4m€132–350Bus
cheapest- Take the bus from Frankfurt central train station to Florence Villa Constanza Bus Stationbus N77 / ...
- Take the bus from Florence Villa Constanza Bus Station to Sienabus N528 / ...
20h 11m€81–142Train, bus
- Take the train from Frankfurt to Chiassotrain Ec
- Take the train from Chiasso to Milano Centraletrain S11
- Take the train from Milano Centrale to Firenze S.M.N.train Fr
- Take the bus from Firenze Autostazione to Siena-V Le V.Veneto N.5bus 131
13h 58m€280–815Train, bus via Zurich
- Take the train from Mainz Hbf to Zürich HBtrain
- Take the bus from Zürich Bus Station to San Donato Milanesebus 36
- Take the bus from Milan to Siena Central Train Stationbus
19h 52m€89–189Train, night train, bus
- Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain S5 / ...
- Take the train from Mannheim, Hauptbahnhof to Hauptbahnhoftrain 22 / ...
- Take the night train from Stuttgart Hbf to Verona Porta Nuovanighttrain Nj
- Take the train from Verona Porta Nuova to Firenze S.M.N.train Fr
- Take the bus from Firenze Autostazione to Siena-Via Tozzibus 131
19h 50m€105–266Fly to Bologna Guglielmo Marconi Airport, train, bus
- Fly from Frankfurt (FRA) to Bologna Guglielmo Marconi Airport (BLQ)plane FRA - BLQ
- Take the train from Bologna Centrale to Firenze S.M.N.train
- Take the bus from Firenze Autostazione to Siena-V Le V.Veneto N.5bus
6h 28m€119–358Fly to Pisa International Airport, train
- Fly from Frankfurt (FRA) to Pisa International Airport (PSA)plane FRA - PSA
- Take the train from Pisa Centrale to Empolitrain
- Take the train from Empoli to Sienatrain
6h 31m€134–292Drive 1,023.6 km
- Drive from Mainz to Sienacar 1,023.6 km
9h 48m€160–230
Mainz to Siena by train and bus
Questions & Answers
The cheapest way to get from Mainz to Siena is to bus which costs €80 - €150 and takes 20h 11m.
The fastest way to get from Mainz to Siena is to fly and bus which takes 6h 4m and costs €130 - €350.
No, there is no direct bus from Mainz station to Siena. However, there are services departing from Mainz central train station and arriving at Siena via Frankfurt central train station and Florence Villa Constanza Bus Station. The journey, including transfers, takes approximately 20h 11m.
The distance between Mainz and Siena is 824 km. The road distance is 1023.6 km.
The best way to get from Mainz to Siena without a car is to train and bus which takes 13h 58m and costs €280 - €850.
It takes approximately 6h 4m to get from Mainz to Siena, including transfers.
Mainz to Siena bus services, operated by FlixBus, depart from Frankfurt central train station.
Mainz to Siena bus services, operated by FlixBus, arrive at Florence Villa Constanza Bus Station.
Yes, the driving distance between Mainz to Siena is 1024 km. It takes approximately 9h 48m to drive from Mainz to Siena.
Book your Mainz to Siena bus tickets online with FlixBus.
What companies run services between Mainz, Germany and Siena, Italy?
You can take a bus from Mainz central train station to Siena via Frankfurt central train station and Florence Villa Constanza Bus Station in around 20h 11m.
- Website
- lufthansa.com
Flights from Frankfurt to Florence Peretola Airport
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- €110–400
Flights from Frankfurt to Florence Peretola Airport via Munich
- Ave. Duration
- 3h 15m
- When
- Every day
- Estimated price
- €130–400
Flights from Frankfurt to Bologna Guglielmo Marconi Airport
- Ave. Duration
- 1h 29m
- When
- Every day
- Estimated price
- €100–600
Flights from Frankfurt to Bologna Guglielmo Marconi Airport via Munich
- Ave. Duration
- 3h 25m
- When
- Every day
- Estimated price
- €140–650
Flights from Frankfurt to Pisa International Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €150–700
- Website
- airdolomiti.it
Flights from Frankfurt to Florence Peretola Airport
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- €130–400
Flights from Frankfurt to Bologna Guglielmo Marconi Airport
- Ave. Duration
- 1h 25m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €130–600
Flights from Frankfurt to Pisa International Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €150–700
- Website
- swiss.com
Flights from Frankfurt to Florence Peretola Airport via Zurich
- Ave. Duration
- 3h 32m
- When
- Every day
- Estimated price
- €120–490
Flights from Frankfurt to Bologna Guglielmo Marconi Airport via Zurich
- Ave. Duration
- 3h 5m
- When
- Monday, Tuesday, Thursday, Friday, and Sunday
- Estimated price
- €95–370
- Phone
- +41 848 446 688
- Website
- sbb.ch
Train from Frankfurt to Chiasso
- Ave. Duration
- 6h 49m
- Frequency
- 6 times a week
- Estimated price
- €220–650
- Website
- https://www.sbb.ch/en
Train from Chiasso to Milano Centrale
- Ave. Duration
- 46 min
- Frequency
- Hourly
- Estimated price
- €18–55
- Website
- https://www.sbb.ch/en
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Milano Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 54m
- Frequency
- Hourly
- Estimated price
- €45–90
- Schedules at
- trenitalia.com
Train from Verona Porta Nuova to Firenze S.M.N.
- Ave. Duration
- 1h 32m
- Frequency
- Every 4 hours
- Estimated price
- €30–60
- Schedules at
- trenitalia.com
Train from Bologna Centrale to Firenze S.M.N.
- Ave. Duration
- 37 min
- Frequency
- Every 30 minutes
- Estimated price
- €13–26
- Schedules at
- trenitalia.com
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Milano Centrale to Firenze S.M.N.
- Ave. Duration
- 2h 3m
- Frequency
- Twice daily
- Estimated price
- €40–80
- Website
- https://www.italotreno.it/en
Train from Bologna Centrale to Firenze S.M.N.
- Ave. Duration
- 46 min
- Frequency
- 3 times a day
- Estimated price
- €12–24
- Website
- https://www.italotreno.it/en
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Milano Centrale to Firenze S.M.N.
- Ave. Duration
- 3h 42m
- Frequency
- Once daily
- Estimated price
- €30–70
- Website
- https://www.trenitalia.com/en.html
Train from Bologna Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 16m
- Frequency
- Once daily
- Estimated price
- €9–21
- Website
- https://www.trenitalia.com/en.html
- Phone
- +31 30 751 5155
- Website
- ns.nl
Train from Mainz Hbf to Zürich HB
- Ave. Duration
- 6h 22m
- Frequency
- Once daily
- Estimated price
- €50–120
- Website
- https://www.ns.nl/en
Train from Mannheim, Hauptbahnhof to Hauptbahnhof
- Ave. Duration
- 37 min
- Frequency
- Twice daily
- Estimated price
- €11–27
- Website
- https://www.ns.nl/en
- Phone
- +49 30 2970
- Website
- bahn.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 1h 17m
- Frequency
- Hourly
- Estimated price
- €14–21
- Website
- https://int.bahn.de/en
- Phone
- 0621 8301200
- Website
- suewex.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 53 min
- Frequency
- Once daily
- Estimated price
- €14–20
- Schedules at
- suewex.de
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from Mannheim, Hauptbahnhof to Hauptbahnhof
- Ave. Duration
- 38 min
- Frequency
- Every 30 minutes
- Estimated price
- €19–50
- Website
- https://int.bahn.de/en
- Phone
- +43 51717
- Website
- nightjet.com
Night train from Stuttgart Hbf to Verona Porta Nuova
- Ave. Duration
- 12h 32m
- Frequency
- Once daily
- Estimated price
- €45–130
- Website
- https://www.nightjet.com/en/#/home
- Sleeper Carriage
- €100–130
- Couchette Carriage
- €75–90
- Seating Carriage
- €45–60
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Bologna Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 51m
- Frequency
- Twice daily
- Estimated price
- €11–19
- Website
- https://www.trenitalia.com/en.html
Train from Pisa Centrale to Empoli
- Ave. Duration
- 45 min
- Frequency
- Every 30 minutes
- Estimated price
- €5–10
- Website
- https://www.trenitalia.com/en.html
Train from Empoli to Siena
- Ave. Duration
- 56 min
- Frequency
- Hourly
- Estimated price
- €8–13
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- ufficiogruppi@trenitalia.it
- Website
- trenitalia.com
Train from Bologna Centrale to Firenze S.M.N.
- Ave. Duration
- 59 min
- Frequency
- Once daily
- Estimated price
- €27–70
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €45–70
- 2nd Class
- €27–40
- Phone
- +39 800 142 424
- numeroverdetpl@regione.toscana.it
- Website
- at-bus.it
Bus from Firenze Autostazione to Siena-V Le V.Veneto N.5
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Estimated price
- €4–6
- Website
- https://www.at-bus.it/en
- Schedules at
- https://www.at-bus.it/en/lines-and-timetables
Bus from Firenze Autostazione to Siena-Via Tozzi
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Estimated price
- €5–6
- Website
- https://www.at-bus.it/en
- Schedules at
- https://www.at-bus.it/en/lines-and-timetables
- Phone
- +39 06 88 93 82 32
- Website
- itabus.it
Bus from Zürich Bus Station to San Donato Milanese
- Ave. Duration
- 5h 50m
- Frequency
- Once daily
- Estimated price
- €17–35
- Website
- https://www.itabus.it/en/home
Bus from Milan to Siena Central Train Station
- Ave. Duration
- 5h 15m
- Frequency
- 4 times a week
- Estimated price
- €21–40
- Website
- https://www.itabus.it/en/home
Bus from Florence Villa Constanza Bus Station to Siena
- Ave. Duration
- 55 min
- Frequency
- Twice daily
- Estimated price
- €3–7
- Website
- https://www.itabus.it/en/home
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- https://www.flixbus.fr
Bus from Frankfurt central train station to Florence Villa Constanza Bus Station
- Ave. Duration
- 16h 40m
- Frequency
- Twice daily
- Estimated price
- €75–130
- Website
- https://www.flixbus.co.uk
Bus from Florence Villa Constanza Bus Station to Siena
- Ave. Duration
- 50 min
- Frequency
- Every 2 hours
- Estimated price
- €4–8
- Website
- https://www.flixbus.co.uk
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