There are 9 ways to get from Mainz to Siena by plane, train, bus, night train, train (Trenitalia), car, or car train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Florence Peretola Airport, train
best- Fly from Frankfurt (FRA) to Florence Peretola Airport (FLR)plane FRA - FLR
- Take the train from Firenze S.M.N. to Sienatrain
6h 42m€119–344Bus
cheapest- Take the bus from Frankfurt central train station to Florence Villa Constanza Bus Stationbus N77 / ...
- Take the bus from Florence Villa Constanza Bus Station to Sienabus N528 / ...
20h 10m€71–132Train, bus
- Take the train from Mainz Hbf to Zürich HBtrain
- Take the train from Zürich HB to Luganotrain Ec / ...
- Take the train from Lugano to Milano Centraletrain
- Take the train from Milano Centrale to Florence Santa Maria Novellatrain
- Take the bus from Firenze Autostazione to Siena-Via Tozzibus 131
15h 20m€175–460Train, night train, bus
- Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain S5 / ...
- Take the train from Mannheim, Hauptbahnhof to Hauptbahnhoftrain 22 / ...
- Take the night train from Stuttgart Hbf to Venezia Mestrenighttrain Nj
- Take the train from Venezia Mestre to Firenze S.M.N.train Fr
- Take the bus from Firenze Autostazione to Siena-Via Tozzibus 131
19h 33m€110–412Fly to Bologna Guglielmo Marconi Airport, train
- Fly from Frankfurt (FRA) to Bologna Guglielmo Marconi Airport (BLQ)plane FRA - BLQ
- Take the train from Bologna Centrale to Firenze S.M.N.train
- Take the train from Firenze S.M.N. to Sienatrain
7h 11m€126–372Train via Basel
- Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain S5 / ...
- Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain 20 / ...
- Take the train from Basel SBB to Domodossolatrain Ec
- Take the train from Domodossola to Milano Centraletrain
- Take the train from Milano Centrale to Firenze S.M.N.train Fr
- Take the train from Firenze S.M.N. to Sienatrain Re
15h 29m€174–497Train
- Take the train from Frankfurt to München Hbftrain 41 / ...
- Take the train from München Hbf to Verona Porta Nuovatrain 89
- Take the train from Verona Porta Nuova to Firenze S.M.N.train Fr
- Take the train from Firenze S.M.N. to Sienatrain Re
15h 39m€160–437Drive 1,023.3 km
- Drive from Mainz to Sienacar 1,023.3 km
9h 48m€160–231Drive, car train
- Drive from Mainz to Fuldacar
- Take the car train from Fulda to München Ostcartrain
- Drive from München Ost to Sienacar
10h 32m€215–299
Mainz to Siena by train and bus
Questions & Answers
The cheapest way to get from Mainz to Siena is to bus which costs €70 - €140 and takes 20h 10m.
The fastest way to get from Mainz to Siena is to fly and train which takes 6h 42m and costs €110 - €350.
No, there is no direct bus from Mainz station to Siena. However, there are services departing from Mainz central train station and arriving at Siena via Frankfurt central train station and Florence Villa Constanza Bus Station. The journey, including transfers, takes approximately 20h 10m.
No, there is no direct train from Mainz to Siena. However, there are services departing from Mainz, Römisches Theater and arriving at Siena via Mannheim, Hauptbahnhof, Basel SBB, Domodossola, Milano Centrale and Firenze S.M.N.. The journey, including transfers, takes approximately 15h 29m.
The distance between Mainz and Siena is 847 km. The road distance is 1023.3 km.
The best way to get from Mainz to Siena without a car is to train and bus which takes 15h 20m and costs €170 - €460.
It takes approximately 6h 42m to get from Mainz to Siena, including transfers.
Mainz to Siena bus services, operated by FlixBus, depart from Frankfurt central train station.
Mainz to Siena train services, operated by Deutsche Bahn Regio (DB Regional), depart from Mainz, Römisches Theater station.
The best way to get from Mainz to Siena is to bus which takes 20h 10m and costs €70 - €140. Alternatively, you can train via Basel, which costs €170 - €500 and takes 15h 29m.
What companies run services between Mainz, Germany and Siena, Italy?
You can take a bus from Mainz central train station to Siena via Frankfurt central train station and Florence Villa Constanza Bus Station in around 20h 10m. Alternatively, you can take a train from Mainz, Römisches Theater to Siena via Mannheim, Hauptbahnhof, Basel SBB, Domodossola, Milano Centrale, and Firenze S.M.N. in around 15h 29m.
- Website
- lufthansa.com
Flights from Frankfurt to Florence Peretola Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €110–400
Flights from Frankfurt to Florence Peretola Airport via Munich
- Ave. Duration
- 3h 18m
- When
- Every day
- Estimated price
- €110–400
Flights from Frankfurt to Bologna Guglielmo Marconi Airport
- Ave. Duration
- 1h 23m
- When
- Every day
- Estimated price
- €90–480
Flights from Frankfurt to Bologna Guglielmo Marconi Airport via Munich
- Ave. Duration
- 3h 16m
- When
- Every day
- Estimated price
- €110–550
- Website
- airdolomiti.it
Flights from Frankfurt to Florence Peretola Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €110–400
Flights from Frankfurt to Bologna Guglielmo Marconi Airport
- Ave. Duration
- 1h 23m
- When
- Every day
- Estimated price
- €100–480
- Website
- swiss.com
Flights from Frankfurt to Florence Peretola Airport via Zurich
- Ave. Duration
- 3h 48m
- When
- Every day
- Estimated price
- €120–210
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Firenze S.M.N. to Siena
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €11–20
- Website
- https://www.trenitalia.com/en.html
Train from Bologna Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 35m
- Frequency
- Twice daily
- Estimated price
- €11–20
- Website
- https://www.trenitalia.com/en.html
- Phone
- +31 30 751 5155
- Website
- ns.nl
Train from Mainz Hbf to Zürich HB
- Ave. Duration
- 6h 22m
- Frequency
- Once daily
- Estimated price
- €45–120
- Website
- https://www.ns.nl/en
Train from Mannheim, Hauptbahnhof to Hauptbahnhof
- Ave. Duration
- 37 min
- Frequency
- 3 times a day
- Estimated price
- €11–27
- Website
- https://www.ns.nl/en
Train from Mannheim, Hauptbahnhof to Basel SBB
- Ave. Duration
- 2h 50m
- Frequency
- Once daily
- Estimated price
- €26–65
- Website
- https://www.ns.nl/en
Train from Frankfurt to München Hbf
- Ave. Duration
- 3h 19m
- Frequency
- 3 times a day
- Estimated price
- €40–110
- Website
- https://www.ns.nl/en
- Phone
- +41 848 446 688
- Website
- sbb.ch
Train from Zürich HB to Lugano
- Ave. Duration
- 1h 55m
- Frequency
- Hourly
- Estimated price
- €60–180
- Website
- https://www.sbb.ch/en
Train from Lugano to Milano Centrale
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Estimated price
- €27–80
- Website
- https://www.sbb.ch/en
Train from Basel SBB to Domodossola
- Ave. Duration
- 2h 42m
- Frequency
- Once a week
- Estimated price
- €85–250
- Website
- https://www.sbb.ch/en
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Milano Centrale to Florence Santa Maria Novella
- Ave. Duration
- 1h 55m
- Frequency
- 5 times a day
- Estimated price
- €35–80
- Website
- https://www.italotreno.it/en
Train from Venezia Mestre to Firenze S.M.N.
- Ave. Duration
- 2h 11m
- Frequency
- Once a week
- Estimated price
- €30–65
- Website
- https://www.italotreno.it/en
Train from Bologna Centrale to Firenze S.M.N.
- Ave. Duration
- 46 min
- Frequency
- Once a week
- Estimated price
- €11–23
- Website
- https://www.italotreno.it/en
- Phone
- +49 30 2970
- Website
- bahn.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 1h 17m
- Frequency
- Hourly
- Estimated price
- €14–21
- Website
- https://int.bahn.de/en
- Phone
- 0621 8301200
- Website
- suewex.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 53 min
- Frequency
- Once daily
- Estimated price
- €14–20
- Schedules at
- suewex.de
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from Mannheim, Hauptbahnhof to Hauptbahnhof
- Ave. Duration
- 38 min
- Frequency
- Every 30 minutes
- Estimated price
- €18–45
- Website
- https://int.bahn.de/en
Train from Mannheim, Hauptbahnhof to Basel SBB
- Ave. Duration
- 2h 21m
- Frequency
- Hourly
- Estimated price
- €40–110
- Website
- https://int.bahn.de/en
Train from Frankfurt to München Hbf
- Ave. Duration
- 3h 31m
- Frequency
- Every 30 minutes
- Estimated price
- €70–170
- Website
- https://int.bahn.de/en
Train from München Hbf to Verona Porta Nuova
- Ave. Duration
- 5h 31m
- Frequency
- Every 4 hours
- Estimated price
- €75–180
- Website
- https://int.bahn.de/en
- Phone
- +43 51717
- Website
- nightjet.com
Night train from Stuttgart Hbf to Venezia Mestre
- Ave. Duration
- 11h 54m
- Frequency
- Once daily
- Estimated price
- €50–270
- Website
- https://www.nightjet.com/en/#/home
- Sleeper Carriage
- €260–270
- Couchette Carriage
- €150–180
- Seating Carriage
- €50–75
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Venezia Mestre to Firenze S.M.N.
- Ave. Duration
- 2h 1m
- Frequency
- Hourly
- Estimated price
- €30–70
- Schedules at
- trenitalia.com
Train from Bologna Centrale to Firenze S.M.N.
- Ave. Duration
- 37 min
- Frequency
- Every 30 minutes
- Estimated price
- €13–25
- Schedules at
- trenitalia.com
Train from Milano Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 54m
- Frequency
- Hourly
- Estimated price
- €40–85
- Schedules at
- trenitalia.com
Train from Verona Porta Nuova to Firenze S.M.N.
- Ave. Duration
- 1h 32m
- Frequency
- Every 4 hours
- Estimated price
- €29–60
- Schedules at
- trenitalia.com
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Bologna Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 16m
- Frequency
- Once daily
- Estimated price
- €9–21
- Website
- https://www.trenitalia.com/en.html
Train from Milano Centrale to Firenze S.M.N.
- Ave. Duration
- 3h 42m
- Frequency
- Once daily
- Estimated price
- €30–70
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- ufficiogruppi@trenitalia.it
- Website
- trenitalia.com
Train from Bologna Centrale to Firenze S.M.N.
- Ave. Duration
- 59 min
- Frequency
- Once a week
- Estimated price
- €27–70
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €45–70
- 2nd Class
- €27–40
- Phone
- +43 5 1717
- Website
- oebb.at
Train from Mannheim, Hauptbahnhof to Basel SBB
- Ave. Duration
- 2h 59m
- Frequency
- 3 times a week
- Estimated price
- €50–90
- Website
- https://www.oebb.at/en/reiseplanung-services/im-zug/unsere-zuege/eurocity-intercity
- Website
- https://shop.oebbtickets.at/en/ticket
- Phone
- +39 02 7249 4494
- my-link@trenord.it
- Website
- trenord.it
Train from Domodossola to Milano Centrale
- Ave. Duration
- 1h 42m
- Frequency
- Every 2 hours
- Estimated price
- €8–11
- Website
- https://www.trenord.it/en/
- Phone
- +49 (0) 221 800 20 820
- info@urlaubs-express.de
- Website
- urlaubs-express.de
Car train from Fulda to München Ost
- Ave. Duration
- 2h 11m
- Frequency
- Once daily
- Estimated price
- €95–110
- Website
- https://urlaubs-express.de/?lang=en
- Phone
- +39 800 142 424
- numeroverdetpl@regione.toscana.it
- Website
- at-bus.it
Bus from Firenze Autostazione to Siena-Via Tozzi
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Estimated price
- €5–6
- Website
- https://www.at-bus.it/en
- Schedules at
- https://www.at-bus.it/en/lines-and-timetables
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Frankfurt central train station to Florence Villa Constanza Bus Station
- Ave. Duration
- 16h 40m
- Frequency
- Twice daily
- Estimated price
- €65–120
- Website
- https://www.flixbus.co.uk
Bus from Florence Villa Constanza Bus Station to Siena
- Ave. Duration
- 50 min
- Frequency
- Every 2 hours
- Estimated price
- €4–8
- Website
- https://www.flixbus.co.uk
Want to know more about travelling around Italy
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italy Travel Guides
Read the travel guide
Heading to Europe? Read this before you buy a Eurail Pass
Read the travel guide
5 incredible day trips from Florence by train
Read the travel guide
More Questions & Answers
Mainz to Siena bus services, operated by FlixBus, arrive at Florence Villa Constanza Bus Station.
Mainz to Siena train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Mannheim, Hauptbahnhof station.
Yes, the driving distance between Mainz to Siena is 1023 km. It takes approximately 9h 48m to drive from Mainz to Siena.
Book your Mainz to Siena train tickets online with Omio.
Book your Mainz to Siena bus tickets online with FlixBus.
There are 2374+ hotels available in Siena.
































































