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How to get fromMainz to Sienaby plane, train, train (Trenitalia), bus, night train, car or car train

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There are 8 ways to get from Mainz to Siena by plane, train, train (Trenitalia), bus, night train, car, or car train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Peretola Airport, train

    best
    1. Fly from Frankfurt (FRA) to Florence Peretola Airport (FLR)plane plane FRA - FLR
    2. Take the train from Firenze S.M.N. to Sienatrain train
    6h 42m
    €116–294
  2. Bus

    cheapest
    1. Take the bus from Frankfurt central train station to Florence Villa Constanza Bus Stationbus bus N77 / ...
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus N528 / ...
    19h 52m
    €57–161
  3. Train

    1. Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain train S5 / ...
    2. Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain train 20 / ...
    3. Take the train from Basel SBB to Zürich HBtrain train Ice / ...
    4. Take the train from Zürich HB to Milano Centraletrain train Ec
    5. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    6. Take the train from Firenze S.M.N. to Sienatrain train Re
    14h 36m
    €170–440
  4. Train, night train, bus

    1. Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain train S5 / ...
    2. Take the train from Mannheim, Hauptbahnhof to Hauptbahnhoftrain train 22 / ...
    3. Take the night train from Stuttgart Hbf to Venezia Mestrenighttrain night train Nj
    4. Take the train from Venezia Mestre to Firenze S.M.N.train train Fr
    5. Take the bus from Firenze Autostazione to Siena-Via Tozzibus bus 131
    19h 26m
  5. Fly to Bologna Guglielmo Marconi Airport, train

    1. Fly from Frankfurt (FRA) to Bologna Guglielmo Marconi Airport (BLQ)plane plane FRA - BLQ
    2. Take the train from Bologna Centrale to Florence Santa Maria Novellatrain train
    3. Take the train from Firenze S.M.N. to Sienatrain train
    7h 19m
    €135–316
  6. Train, bus

    1. Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain train S5 / ...
    2. Take the bus from Mannheim Central Bus Station to Milanbus bus
    3. Take the bus from Milan to Siena Central Train Stationbus bus
    20h 39m
    €69–135
  7. Drive 1,023.2 km

    1. Drive from Mainz to Sienacar car 1,023.2 km
    9h 45m
    €158–228
  8. Drive, car train

    1. Drive from Mainz to Fuldacar car
    2. Take the car train from Fulda to München Ostcartrain train
    3. Drive from München Ost to Sienacar car
    10h 28m
    €215–299

Mainz to Siena by train

Calendar8Weekly Trains
Duration14h 36mAverage Duration
Ticket€170Cheapest Price
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Questions & Answers

What companies run services between Mainz, Germany and Siena, Italy?

You can take a train from Mainz, Römisches Theater to Siena via Mannheim, Hauptbahnhof, Basel SBB, Zürich HB, Milano Centrale, and Firenze S.M.N. in around 14h 36m. Alternatively, you can take a bus from Mainz central train station to Siena via Frankfurt central train station and Florence Villa Constanza Bus Station in around 19h 52m.

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