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How to get fromMainz to Sienaby plane, train, bus, night train, train (Trenitalia), or car

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There are 13 ways to get from Mainz to Siena by plane, train, bus, night train, train (Trenitalia), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Peretola Airport, train

    best
    1. Fly from Frankfurt (FRA) to Florence Peretola Airport (FLR)plane plane FRA - FLR
    2. Take the train from Firenze Rifredi to Sienatrain train
    6h 46m
    €137–343

  2. Fly to Milan Linate Airport, train, bus

    cheapest
    1. Fly from Frankfurt (FRA) to Milan Linate Airport (LIN)plane plane FRA - LIN
    2. Take the train from Milano Rogoredo to Firenze S.M.N.train train
    3. Take the bus from Firenze Autostazione to Siena-V Le V.Veneto N.5bus bus
    7h 59m
    €81–313

  3. Train, bus

    1. Take the train from Mainz, Hauptbahnhof to Mannheim, Hauptbahnhoftrain train 55 / ...
    2. Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain train 12 / ...
    3. Take the train from Basel SBB to Luganotrain train Ec
    4. Take the train from Lugano to Milano Centraletrain train
    5. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    6. Take the bus from Firenze Autostazione to Siena-V Le V.Veneto N.5bus bus 131
    13h 17m
    €118–623

  4. Train, bus via Zurich

    1. Take the train from Mainz Hbf to Zürich HBtrain train
    2. Take the bus from Zürich Bus Station to San Donato Milanesebus bus 36
    3. Take the bus from Milan to Siena Central Train Stationbus bus
    19h 52m
    €91–192

  5. Train, night train, bus

    1. Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain train S5 / ...
    2. Take the train from Mannheim, Hauptbahnhof to Hauptbahnhoftrain train 22 / ...
    3. Take the night train from Stuttgart Hbf to Verona Porta Nuovanighttrain night train Nj
    4. Take the train from Verona Porta Nuova to Firenze S.M.N.train train Fr
    5. Take the bus from Firenze Autostazione to Siena-Via Tozzibus bus 131
    19h 52m
    €105–276

  6. Fly to Pisa International Airport, train

    1. Fly from Frankfurt (FRA) to Pisa International Airport (PSA)plane plane FRA - PSA
    2. Take the train from Pisa Centrale to Empolitrain train
    3. Take the train from Empoli to Sienatrain train
    6h 30m
    €122–302

  7. Fly to Bologna Guglielmo Marconi Airport, train, bus

    1. Fly from Frankfurt (FRA) to Bologna Guglielmo Marconi Airport (BLQ)plane plane FRA - BLQ
    2. Take the train from Bologna Centrale to Firenze S.M.N.train train
    3. Take the bus from Firenze Autostazione to Siena-V Le V.Veneto N.5bus bus
    6h 32m
    €118–338

  8. Fly to Venice Marco Polo Airport, train, bus

    1. Fly from Frankfurt (FRA) to Venice Marco Polo Airport (VCE)plane plane FRA - VCE
    2. Take the train from Venezia Mestre to Firenze S.M.N.train train
    3. Take the bus from Firenze Autostazione to Siena-V Le V.Veneto N.5bus bus
    8h 30m
    €106–357

  9. Fly to Verona Villafranca Airport, train, bus

    1. Fly from Frankfurt (FRA) to Verona Villafranca Airport (VRN)plane plane FRA - VRN
    2. Take the train from Verona Porta Nuova to Firenze S.M.N.train train
    3. Take the bus from Firenze Autostazione to Siena-V Le V.Veneto N.5bus bus
    8h 17m
    €165–364

  10. Fly to Fiumicino International Airport, train, bus

    1. Fly from Frankfurt (FRA) to Fiumicino International Airport (FCO)plane plane FRA - FCO
    2. Take the train from Roma Termini to Firenze S.M.N.train train
    3. Take the bus from Firenze Autostazione to Siena-V Le V.Veneto N.5bus bus
    8h 23m
    €89–270

  11. Train

    1. Take the train from Frankfurt to Chiassotrain train Ec
    2. Take the train from Chiasso to Milano Centraletrain train S11
    3. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    4. Take the train from Firenze S.M.N. to Sienatrain train Re
    14h 44m
    €287–828

  12. Bus

    1. Take the bus from Frankfurt central train station to Florence Villa Constanza Bus Stationbus bus N77 / ...
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus N528 / ...
    20h 11m
    €82–142

  13. Drive 1,023.6 km

    1. Drive from Mainz to Sienacar car 1,023.6 km
    9h 48m
    €163–235

Mainz to Siena by train and bus

Calendar76Weekly Services
Duration13h 17mAverage Duration
Ticket€118Cheapest Price
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Questions & Answers

Map of how to get from Mainz to Siena.ExpandLaunch map view
  • Distance: 843.9 km
  • Duration: 6h 46m

What companies run services between Mainz, Germany and Siena, Italy?

You can take a train from Mainz, Römisches Theater to Siena via Frankfurt, Chiasso, Milano Centrale, and Firenze S.M.N. in around 14h 44m. Alternatively, you can take a bus from Mainz central train station to Siena via Frankfurt central train station and Florence Villa Constanza Bus Station in around 20h 11m.

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