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How to get fromMainz to Sicilyby plane, car, car ferry, bus, train, or night train

Find Transport to Sicily

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There are 11 ways to get from Mainz to Sicily by plane, car, car ferry, bus, train, or night train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Frankfurt to Catania–Fontanarossa Airport

    best
    1. Fly from Frankfurt (FRA) to Catania–Fontanarossa Airport (CTA)plane plane FRA - CTA
    5h 10m
    €94–244

  2. Bus to Hahn, fly to Palermo Airport

    cheapest
    1. Take the bus from Mainz, Hauptbahnhof to Hahnbus bus
    2. Fly from Hahn (HHN) to Palermo Airport (PMO)plane plane HHN - PMO
    6h 28m
    €67–241

  3. Drive, car ferry

    1. Drive from Mainz to Port of Genoacar car
    2. Take the carferry from Port of Genoa to Port of Palermocarferry car ferry
    28h 34m
    €230–338

  4. Bus

    1. Take the bus from Mühlheim am Main to Palermo Piazza Cairolibus bus
    31h 1m
    €266–376

  5. Train, night train

    1. Take the train from Mainz, Hauptbahnhof to Hauptbahnhoftrain train 55 / ...
    2. Take the nighttrain from Stuttgart Hbf to Venezia Mestrenighttrain night train Nj
    3. Take the train from Venezia Mestre to Roma Terminitrain train
    4. Take the train from Roma Termini to Palermo Centraletrain train Ic
    31h 49m
    €227–469

  6. Fly Frankfurt to Palermo Airport

    1. Fly from Frankfurt (FRA) to Palermo Airport (PMO)plane plane FRA - PMO
    5h 36m
    €88–235

  7. Bus to Hahn, fly to Catania–Fontanarossa Airport

    1. Take the bus from Mainz, Hauptbahnhof to Hahnbus bus
    2. Fly from Hahn (HHN) to Catania–Fontanarossa Airport (CTA)plane plane HHN - CTA
    6h 12m
    €138–340

  8. Train to Stuttgart Airport, fly to Catania–Fontanarossa Airport

    1. Take the train from Mainz, Hauptbahnhof to Hauptbahnhoftrain train
    2. Fly from Stuttgart Airport (STR) to Catania–Fontanarossa Airport (CTA)plane plane STR - CTA
    6h 54m
    €108–326

  9. Train to Cologne Bonn Airport, fly to Palermo Airport

    1. Take the train from Frankfurt to Siegburg Bftrain train
    2. Fly from Cologne Bonn Airport (CGN) to Palermo Airport (PMO)plane plane CGN - PMO
    7h 20m
    €90–413

  10. Bus via Milan

    1. Take the bus from Mainz central train station to Milanbus bus FlixBus 476
    2. Take the bus from Milano, Autostazione Lampugnano to Palermobus bus N597
    35h 31m
    €208–309

  11. Bus #2

    1. Take the bus from Wiesbaden Gartenfeldstraße P+R to Palermo Piazza Cairolibus bus
    38h 32m
    €293–411

Mainz to Sicily by bus

Calendar7Weekly Buses
Duration35h 31mAverage Duration
Ticket€208Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mainz to Sicily.ExpandLaunch map view
  • Distance: 1,521.8 km
  • Duration: 5h 10m

What companies run services between Mainz, Germany and Sicily, Italy?

Lufthansa, ITA Airways, and Edelweiss Air fly from Frankfurt (FRA) to Catania–Fontanarossa Airport (CTA) 3 times a day. Alternatively, Onebus operates a bus from Mühlheim am Main to Palermo Piazza Cairoli once a week. Tickets cost €250–350 and the journey takes 28h 19m.

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