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How to get fromMainz to Sicilyby plane, car, car ferry, train, night train or bus

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There are 9 ways to get from Mainz to Sicily by plane, car, car ferry, train, night train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Frankfurt to Palermo Airport

    best
    1. Fly from Frankfurt (FRA) to Palermo Airport (PMO)plane plane FRA - PMO
    5h 46m
    €96–289
  2. Bus to Hahn, fly to Catania–Fontanarossa Airport

    cheapest
    1. Take the bus from Mainz Short-term parking lot Am Schlag to Frankfurt Hahn Airportbus bus
    2. Fly from Hahn (HHN) to Catania–Fontanarossa Airport (CTA)plane plane HHN - CTA
    6h 9m
    €68–227
  3. Drive, car ferry

    1. Drive from Mainz to Port of Genoacar car
    2. Take the car ferry from Port of Genoa to Port of Palermocarferry car ferry
    28h 34m
    €219–329
  4. Train, night train

    1. Take the train from Mainz, Hauptbahnhof to Hauptbahnhoftrain train 55 / ...
    2. Take the night train from Stuttgart Hbf to Venezia Mestrenighttrain night train Nj
    3. Take the train from Venezia Mestre to Roma Terminitrain train
    4. Take the train from Roma Termini to Palermo Centraletrain train Ic
    32h 5m
    €231–549
  5. Bus

    1. Take the bus from Mainz central train station to Milanbus bus FlixBus 476
    2. Take the bus from Milano, Autostazione Lampugnano to Palermobus bus N597
    35h 31m
    €114–281
  6. Fly Frankfurt to Catania–Fontanarossa Airport

    1. Fly from Frankfurt (FRA) to Catania–Fontanarossa Airport (CTA)plane plane FRA - CTA
    5h 23m
    €88–304
  7. Bus to Hahn, fly to Palermo Airport

    1. Take the bus from Mainz Short-term parking lot Am Schlag to Frankfurt Hahn Airportbus bus
    2. Fly from Hahn (HHN) to Palermo Airport (PMO)plane plane HHN - PMO
    6h 32m
    €71–252
  8. Train, bus

    1. Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain train S5 / ...
    2. Take the bus from Mannheim central bus station to Milano, Autostazione Lampugnanobus bus N77
    3. Take the bus from Milano, San Donato M3 to Palermo Via Tommaso Fazellobus bus
    36h 20m
    €117–196
  9. Train, car ferry

    1. Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain train S5 / ...
    2. Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain train 20 / ...
    3. Take the train from Basel SBB to Como S. Giovannitrain train Ec
    4. Take the train from Como S.Giovanni to Genova Piazza Principetrain train
    5. Take the car ferry from Port of Genoa to Port of Palermocarferry car ferry
    36h 21m
    €247–588

Mainz to Sicily by bus

Calendar9Weekly Buses
Duration35h 31mAverage Duration
Ticket€114Cheapest Price
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Questions & Answers

What companies run services between Mainz, Germany and Sicily, Italy?

Lufthansa, ITA Airways, and Swiss fly from Frankfurt (FRA) to Palermo Airport (PMO) every 4 hours. Alternatively, you can take a bus from Mainz central train station to Piazza Boiardo via Milano, Autostazione Lampugnano, Palermo, and Stazione Centrale Pensilina Esterna in around 35h 31m.

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