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How to get fromMainz to San Simoneby plane, train, bus, train (Trenitalia), car or car train

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There are 9 ways to get from Mainz to San Simone by plane, train, bus, train (Trenitalia), car, or car train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Brindisi Airport, train, line 310 bus

    best
    1. Fly from Frankfurt (FRA) to Brindisi Airport (BDS)planeFRA - BDS
    2. Take the train from Brindisi to Tarantotrain
    3. Take the bus from Taranto Porto Mercantile to San Simonebus
    9h 30m
    €104–271

  2. Bus

    cheapest
    1. Take the bus from Frankfurt central train station to TarantobusN422
    29h 4m
    €91–188

  3. Train

    1. Take the train from Frankfurt to Basel SBBtrain20 / ...
    2. Take the train from Basel SBB to Zürich HBtrainIce / ...
    3. Take the train from Zürich HB to Milan RogoredotrainEc
    4. Take the train from Milan Rogoredo to Napoli Afragolatrain
    5. Take the train from Napoli Afragola to TarantotrainFr
    20h 24m
    €266–604

  4. Train, bus

    1. Take the train from Mainz, Römisches Theater to Ludwigshafen, HauptbahnhoftrainS6
    2. Take the bus from Ludwigshafen to Metapontobus
    3. Take the train from Metaponto to TarantotrainIc
    23h 44m
    €128–165

  5. Drive 1,617.7 km

    1. Drive from Mainz to San Simonecar1,617.7 km
    14h 51m
    €253–365

  6. Fly to Bari Karol Wojtyła Airport, bus, Italobus Connections

    1. Fly from Frankfurt (FRA) to Bari Karol Wojtyła Airport (BRI)planeFRA - BRI
    2. Take the bus from Bari Airport to Matera piazza Matteottibus
    3. Take the bus from Matera to Tarantobus
    10h 39m

  7. Fly to Naples Airport, train

    1. Fly from Frankfurt (FRA) to Naples Airport (NAP)planeFRA - NAP
    2. Take the train from Napoli Centrale to Tarantotrain
    11h 46m
    €125–330

  8. Bus via Durrës

    1. Take the bus from Frankfurt(Main)Hbf to Durrësbus
    2. Take the bus from Durrës to Taranto Portbus
    37h 39m

  9. Drive, car train

    1. Drive from Mainz to Fuldacar
    2. Take the car train from Fulda to Villach Hbfcartrain
    3. Drive from Villach Hbf to San Simonecar
    16h 48m
    €290–1,079

Frankfurt (FRA) to Brindisi Airport (BDS) flights

Calendar8Weekly Planes
Duration3h 7mAverage Duration
Ticket€85Cheapest Price
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Questions & Answers

What companies run services between Mainz, Germany and San Simone, Apulia, Italy?

You can take a train from Mainz, Römisches Theater to San Simone via Frankfurt, Basel SBB, Zürich HB, Milan Rogoredo, Napoli Afragola, and Taranto in around 20h 24m. Alternatively, FlixBus operates a bus from Frankfurt central train station to Taranto once daily. Tickets cost €80–170 and the journey takes 24h 25m.

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