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How to get fromMainz to Mendrisioby train, bus, car or plane

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There are 8 ways to get from Mainz to Mendrisio by train, bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Mainz, Römisches Theater to Mannheim, HauptbahnhoftrainS5 / ...
    2. Take the train from Mannheim, Hauptbahnhof to Basel SBBtrain20 / ...
    3. Take the train from Basel SBB to LuganotrainEc
    8h 20m
    CHF 61–260
  2. Bus

    cheapest
    1. Take the bus from Frankfurt central train station to LuganobusN474
    11h 17m
    CHF 40–82
  3. Drive 604.8 km

    1. Drive from Mainz to Mendrisiocar604.8 km
    5h 34m
    CHF 98–141
  4. Fly to Milano Malpensa Airport, train

    1. Fly from Frankfurt (FRA) to Milano Malpensa Airport (MXP)planeFRA - MXP
    2. Take the train from Malpensa Aeroporto T1 to Mendrisiotrain
    5h 1m
    CHF 61–148
  5. Train via Zurich

    1. Take the train from Mainz Hbf to Zürich HBtrainNightjet
    2. Take the train from Zürich HB to ChiassotrainEcm
    10h 24m
    CHF 82–245
  6. Fly to Zurich Airport, train

    1. Fly from Frankfurt (FRA) to Zurich Airport (ZRH)planeFRA - ZRH
    2. Take the train from Zürich HB to Luganotrain
    5h 17m
    CHF 121–267
  7. Fly to Milan Linate Airport, train

    1. Fly from Frankfurt (FRA) to Milan Linate Airport (LIN)planeFRA - LIN
    2. Take the train from Monza to Mendrisiotrain
    5h 50m
    CHF 42–141
  8. Fly to Basel, train

    1. Fly from Frankfurt (FRA) to Basel (BSL)planeFRA - BSL
    2. Take the train from Basel SBB to Luganotrain
    7h 3m
    CHF 139–369

Mainz to Mendrisio by train

Calendar84Weekly Trains
Duration8h 20mAverage Duration
TicketCHF 61Cheapest Price
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Questions & Answers

What companies run services between Mainz, Germany and Mendrisio, Switzerland?

You can take a train from Mainz, Römisches Theater to Mendrisio via Mannheim, Hauptbahnhof, Basel SBB, and Lugano in around 8h 20m. Alternatively, FlixBus operates a bus from Frankfurt central train station to Lugano once daily. Tickets cost CHF 30–60 and the journey takes 8h 50m.

Transport is disrupted due to the Russia-Ukraine war. Read more

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