There are 11 ways to get from Mainz to Comiso by plane, bus, car, car ferry, train (Trenitalia), or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Frankfurt to Catania–Fontanarossa Airport, bus
best- Fly from Frankfurt (FRA) to Catania–Fontanarossa Airport (CTA)plane FRA - CTA
- Take the bus from Catania Fontanarossa Airport Bus Stop to Gela Bus Stationbus
8h 52m€81–298Drive, car ferry
- Drive from Mainz to Port of Genoacar
- Take the car ferry from Port of Genoa to Port of Palermocarferry
- Drive from Port of Palermo to Comisocar
31h 40m€245–370Train
- Take the train from Frankfurt to Como S. Giovannitrain Ec
- Take the train from Como S.Giovanni to Milano Porta Garibalditrain S11
- Take the train from Milano P.Garibaldi to Siracusatrain
- Take the train from Siracusa to Comisotrain Re
35h 58m€419–1,023Bus
- Take the bus from Mainz central train station to Milanbus FlixBus 476
- Take the bus from Milano, Autostazione Lampugnano to Gela Bus Stationbus Autoservizi Salemi S121 / ...
36h 20m€107–171Fly Frankfurt to Vincenzo Magliocco Airport
- Fly from Frankfurt (FRA) to Vincenzo Magliocco Airport (CIY)plane FRA - CIY
6h 27m€114–398Fly Frankfurt to Palermo Airport, train
- Fly from Frankfurt (FRA) to Palermo Airport (PMO)plane FRA - PMO
- Take the train from Palermo Centrale to Caltanissetta Xirbitrain
- Take the train from Caltanissetta Xirbi to Comisotrain
11h 46m€129–341Train to Stuttgart Airport, fly to Catania–Fontanarossa Airport, bus
- Take the train from Mainz, Hauptbahnhof to Hauptbahnhoftrain
- Fly from Stuttgart Airport (STR) to Catania–Fontanarossa Airport (CTA)plane STR - CTA
- Take the bus from Catania Fontanarossa Airport Bus Stop to Gela Bus Stationbus
10h 26m€117–329Bus to Hahn, fly to Catania–Fontanarossa Airport, bus
- Take the bus from Mainz Short-term parking lot Am Schlag to Frankfurt Hahn Airportbus
- Fly from Hahn (HHN) to Catania–Fontanarossa Airport (CTA)plane HHN - CTA
- Take the bus from Catania Fontanarossa Airport Bus Stop to Gela Bus Stationbus
9h 38m€108–311Train to Düsseldorf International Airport, fly to Catania–Fontanarossa Airport, bus
- Take the train from Frankfurt to Düsseldorf Hbftrain
- Fly from Düsseldorf International Airport (DUS) to Catania–Fontanarossa Airport (CTA)plane DUS - CTA
- Take the bus from Catania Fontanarossa Airport Bus Stop to Gela Bus Stationbus
10h 57m€118–336Train via Como
- Take the train from Frankfurt to Chiassotrain Ec
- Take the train from Chiasso to Milano Lambratetrain Ec
- Take the train from Milano Lambrate to Siracusatrain
- Take the train from Siracusa to Comisotrain Re
37h 4m€433–1,033Train, bus
- Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain S5 / ...
- Take the bus from Mannheim central bus station to Milanbus
- Take the bus from Milan Malpensa Terminal 2 Arrivals to Catania Fontanarossa Airport Bus Stopbus
- Take the bus from Aeroporto Vincenzo Bellini/Fontanarossa to Ragusa Bus Terminalbus
37h 35m€145–268
Mainz to Comiso by train
Questions & Answers
The cheapest way to get from Mainz to Comiso is to bus which costs €100 - €180 and takes 36h 20m.
The fastest way to get from Mainz to Comiso is to fly which takes 6h 27m and costs €110 - €400.
No, there is no direct bus from Mainz station to Comiso. However, there are services departing from Mainz central train station and arriving at Comiso via Milano, Autostazione Lampugnano and Gela. The journey, including transfers, takes approximately 36h 20m.
No, there is no direct train from Mainz to Comiso. However, there are services departing from Mainz, Römisches Theater and arriving at Comiso via Frankfurt, Como S.Giovanni, Milano P.Garibaldi and Siracusa. The journey, including transfers, takes approximately 35h 58m.
The distance between Mainz and Comiso is 1653 km.
The best way to get from Mainz to Comiso without a car is to train which takes 35h 58m and costs €410 - €1100.
It takes approximately 8h 52m to get from Mainz to Comiso, including transfers.
Mainz to Comiso bus services, operated by FlixBus, depart from Mainz central train station.
Mainz to Comiso train services, operated by Swiss Federal Railways (SBB CFF FFS), depart from Frankfurt station.
The best way to get from Mainz to Comiso is to train which takes 35h 58m and costs €410 - €1100. Alternatively, you can bus, which costs €100 - €180 and takes 36h 20m, you could also fly, which costs €110 - €400 and takes 6h 27m.
What companies run services between Mainz, Germany and Comiso, Italy?
You can take a train from Mainz, Römisches Theater to Comiso via Frankfurt, Como S.Giovanni, Milano P.Garibaldi, and Siracusa in around 35h 58m. Alternatively, you can take a bus from Mainz central train station to Comiso via Milano, Autostazione Lampugnano and Gela in around 36h 20m.
- Website
- lufthansa.com
Flights from Frankfurt to Catania–Fontanarossa Airport
- Ave. Duration
- 2h 30m
- When
- Every day
- Estimated price
- €95–370
Flights from Frankfurt to Catania–Fontanarossa Airport via Munich
- Ave. Duration
- 4h 13m
- When
- Every day
- Estimated price
- €65–370
Flights from Frankfurt to Palermo Airport
- Ave. Duration
- 2h 20m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €100–400
Flights from Frankfurt to Palermo Airport via Munich
- Ave. Duration
- 3h 55m
- When
- Every day
- Estimated price
- €100–400
Flights from Stuttgart Airport to Catania–Fontanarossa Airport via Munich
- Ave. Duration
- 4h 45m
- When
- Every day
- Estimated price
- €70–400
- Website
- ita-airways.com
Flights from Frankfurt to Catania–Fontanarossa Airport
- Ave. Duration
- 2h 30m
- When
- Every day
- Estimated price
- €95–370
Flights from Frankfurt to Catania–Fontanarossa Airport via Milan Linate
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- €90–320
Flights from Frankfurt to Palermo Airport via Milan Linate
- Ave. Duration
- 4h 22m
- When
- Every day
- Estimated price
- €85–240
Flights from Stuttgart Airport to Catania–Fontanarossa Airport via Rome
- Ave. Duration
- 4h 23m
- When
- Thursday, Tuesday, Sunday, Monday, Wednesday, and Friday
- Estimated price
- €75–220
- Website
- eurowings.com
Flights from Stuttgart Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 2h 15m
- When
- Every day
- Estimated price
- €75–220
Flights from Düsseldorf International Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 2h 40m
- When
- Every day
- Estimated price
- €80–210
- Website
- aeroitalia.com
Flights from Frankfurt to Vincenzo Magliocco Airport via Milan Linate
- Ave. Duration
- 3h 55m
- When
- Every day
- Estimated price
- €95–370
Flights from Frankfurt to Vincenzo Magliocco Airport via Turin
- Ave. Duration
- 4h 45m
- When
- Monday and Friday
- Estimated price
- €160–1,000
Flights from Frankfurt to Vincenzo Magliocco Airport via Bologna
- Ave. Duration
- 5h 40m
- When
- Monday and Friday
- Estimated price
- €95–370
Flights from Frankfurt to Vincenzo Magliocco Airport via Rome
- Ave. Duration
- 6h 15m
- When
- Every day
- Estimated price
- €130–500
- Website
- flexflight.dk
Flights from Frankfurt to Vincenzo Magliocco Airport via Milan Linate
- Ave. Duration
- 3h 55m
- When
- Every day
- Estimated price
- €95–370
Flights from Frankfurt to Vincenzo Magliocco Airport via Turin
- Ave. Duration
- 4h 45m
- When
- Monday and Friday
- Estimated price
- €160–1,000
Flights from Frankfurt to Vincenzo Magliocco Airport via Bologna
- Ave. Duration
- 5h 40m
- When
- Monday and Friday
- Estimated price
- €95–370
Flights from Frankfurt to Vincenzo Magliocco Airport via Rome
- Ave. Duration
- 6h 15m
- When
- Every day
- Estimated price
- €130–500
- Website
- swiss.com
Flights from Frankfurt to Palermo Airport via Zurich
- Ave. Duration
- 5h 10m
- When
- Every day
- Estimated price
- €95–360
- Website
- neosair.it
Flights from Frankfurt to Vincenzo Magliocco Airport via Verona
- Ave. Duration
- 7h 30m
- When
- Sunday
- Estimated price
- €340–700
- Website
- ryanair.com
Flights from Hahn to Catania–Fontanarossa Airport
- Ave. Duration
- 2h 25m
- When
- Tuesday, Friday, and Saturday
- Estimated price
- €50–200
- Phone
- +41 848 446 688
- Website
- sbb.ch
Train from Frankfurt to Como S. Giovanni
- Ave. Duration
- 7h 2m
- Frequency
- 6 times a week
- Estimated price
- €220–650
- Website
- https://www.sbb.ch/en
Train from Como S.Giovanni to Milano Porta Garibaldi
- Ave. Duration
- 1h 2m
- Frequency
- Once daily
- Estimated price
- €17–50
- Website
- https://www.sbb.ch/en
Train from Frankfurt to Chiasso
- Ave. Duration
- 6h 49m
- Frequency
- 6 times a week
- Estimated price
- €220–650
- Website
- https://www.sbb.ch/en
Train from Chiasso to Milano Lambrate
- Ave. Duration
- 53 min
- Frequency
- Twice a week
- Estimated price
- €18–55
- Website
- https://www.sbb.ch/en
- Phone
- +39 02 7249 4494
- my-link@trenord.it
- Website
- trenord.it
Train from Como S.Giovanni to Milano Porta Garibaldi
- Ave. Duration
- 1h 1m
- Frequency
- Every 30 minutes
- Estimated price
- €4–6
- Website
- https://www.trenord.it/en/
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Milano P.Garibaldi to Siracusa
- Ave. Duration
- 21h 26m
- Frequency
- Once a week
- Estimated price
- €170–280
- Website
- https://www.trenitalia.com/en.html
Train from Siracusa to Comiso
- Ave. Duration
- 2h 34m
- Frequency
- 3 times a day
- Estimated price
- €17–29
- Website
- https://www.trenitalia.com/en.html
Train from Palermo Centrale to Caltanissetta Xirbi
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- €15–26
- Website
- https://www.trenitalia.com/en.html
Train from Caltanissetta Xirbi to Comiso
- Ave. Duration
- 2h 12m
- Frequency
- Twice daily
- Estimated price
- €19–35
- Website
- https://www.trenitalia.com/en.html
Train from Milano Lambrate to Siracusa
- Ave. Duration
- 22h 9m
- Frequency
- Once a week
- Estimated price
- €170–280
- Website
- https://www.trenitalia.com/en.html
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from Mainz, Hauptbahnhof to Hauptbahnhof
- Ave. Duration
- 1h 37m
- Frequency
- Every 3 hours
- Estimated price
- €30–80
- Website
- https://int.bahn.de/en
Train from Frankfurt to Düsseldorf Hbf
- Ave. Duration
- 1h 12m
- Frequency
- Every 30 minutes
- Estimated price
- €35–90
- Website
- https://int.bahn.de/en
- Phone
- +31 30 751 5155
- Website
- ns.nl
Train from Frankfurt to Düsseldorf Hbf
- Ave. Duration
- 1h 22m
- Frequency
- Every 3 hours
- Estimated price
- €22–50
- Website
- https://www.ns.nl/en
- Phone
- +39 06 68475475
- ufficiogruppi@trenitalia.it
- Website
- trenitalia.com
Train from Chiasso to Milano Lambrate
- Ave. Duration
- 53 min
- Frequency
- Once daily
- Estimated price
- €19–60
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €40–60
- 2nd Class
- €19–25
- Phone
- +49 30 2970
- Website
- bahn.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 1h 17m
- Frequency
- Hourly
- Estimated price
- €14–22
- Website
- https://int.bahn.de/en
- Phone
- 0621 8301200
- Website
- suewex.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 53 min
- Frequency
- Once daily
- Estimated price
- €14–20
- Schedules at
- suewex.de
- Phone
- +39 06 164160
- info@etnatrasporti.it
- Website
- etnatrasporti.it
Bus from Catania Fontanarossa Airport Bus Stop to Gela Bus Station
- Ave. Duration
- 1h 35m
- Frequency
- Hourly
- Estimated price
- €6–8
- Schedules at
- etnatrasporti.it
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- https://www.flixbus.fr
Bus from Mainz central train station to Milan
- Ave. Duration
- 12h 5m
- Frequency
- Once daily
- Estimated price
- €50–90
- Website
- https://www.flixbus.co.uk
Bus from Mannheim central bus station to Milan
- Ave. Duration
- 9h 15m
- Frequency
- Once daily
- Estimated price
- €40–75
- Website
- https://www.flixbus.co.uk
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Milano, Autostazione Lampugnano to Gela Bus Station
- Ave. Duration
- 21h 15m
- Frequency
- 5 times a week
- Estimated price
- €55–85
- Schedules at
- autoservizisalemi.it
- info@flibco.com
- Website
- flibco.com
Bus from Mainz Short-term parking lot Am Schlag to Frankfurt Hahn Airport
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Estimated price
- €17–35
- Website
- https://www.flibco.com/en
- Phone
- +39 06 88 93 82 32
- Website
- itabus.it
Bus from Milan Malpensa Terminal 2 Arrivals to Catania Fontanarossa Airport Bus Stop
- Ave. Duration
- 21h 5m
- Frequency
- Twice daily
- Estimated price
- €85–160
- Website
- https://www.itabus.it/en/home
- Phone
- +39 0935 22 460
- Website
- interbus.it
Bus from Aeroporto Vincenzo Bellini/Fontanarossa to Ragusa Bus Terminal
- Ave. Duration
- 1h 40m
- Frequency
- Hourly
- Estimated price
- €6–12
- Schedules at
- interbus.it
- Phone
- +39 010 209 4591
- booking@gnv.it
- Website
- gnv.it
Car ferry from Port of Genoa to Port of Palermo
- Ave. Duration
- 20h 45m
- Frequency
- Once daily
- Estimated price
- €90–140
- Website
- https://www.gnv.it/en
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More Questions & Answers
Mainz to Comiso bus services, operated by FlixBus, arrive at Milan station.
Mainz to Comiso train services, operated by Swiss Federal Railways (SBB CFF FFS), arrive at Como S. Giovanni station.
Book your Mainz to Comiso train tickets online with Omio.
There are 1995+ hotels available in Comiso.






























































