Chiltern Railways operates a train from Maidenhead to Aylesbury every 30 minutes. Tickets cost $24 - $40 and the journey takes 56 min. Alternatively, you can take a bus from Maidenhead to Aylesbury via High Wycombe, Bus Station (Shopping Centre) in around 1 h 59 min.
From Maidenhead train to Paddington Underground Station, Tube to London Marylebone, then train to Aylesbury. 1 h 56 min £35. From Maidenhead Town Centre, Sainsbury's (Cookham Road) line 37 bus to High Wycombe, Bus Station (Shopping Centre) then bus to Aylesbury, Bus Station (Bus Stn Bay 7). 1 h 59 min £5. From Maidenhead taxi to Aylesbury. 38 min £112. From Maidenhead drive to Aylesbury. 38 min £4. From Maidenhead rideshare to Aylesbury. 56 min £3.