Travel from Spain to Italy is: Partially open. See details.
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There are 10 ways to get from Madrid to Sicily by plane, train, ferry, bus, bus and ferry, car or car ferry

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Palermo

  1. Fly from Madrid (MAD) to Palermo (PMO)

Cheapest option

Fly to Catania

  1. Fly from Madrid (MAD) to Catania (CTA)

8 alternative options

Fly to Comiso

  1. Fly from Madrid (MAD) to Comiso (CIY)

Fly to Trapani

  1. Fly from Madrid (MAD) to Trapani (TPS)

Train, ferry

  1. Take the train from Madrid-Puerta De Atocha to Barcelona-Sants
  2. Take the ferry from Barcellona to Civitavecchia
  3. Take the ferry from Civitavecchia to Palermo

Train, bus

  1. Take the train from Madrid-Puerta De Atocha to Barcelona-Sants
  2. Take the train from Barcelona-Sants to Lyon Perrache
  3. Take the bus from Lyon Perrache to Frosinone
  4. Take the train from Frosinone to Palermo Centrale

Bus

  1. Take the bus from Madrid to Turin
  2. Take the bus from Turin to Palermo

Bus, train

  1. Take the bus from Madrid to Roma
  2. Take the train from Roma Termini to Palermo Centrale

Bus, bus and ferry

  1. Take the bus from Madrid to Roma
  2. Take the bus and ferry from Roma Tiburtina to Marsala
  3. Take the bus from Marsala to Palermo Centrale

Drive, car ferry

  1. Drive from Madrid to Marseille
  2. Take the car ferry from Marseille to Bejaia
  3. Drive from Bejaia to Tunis
  4. Take the car ferry from Tunis to Palermo

Madrid to Sicily by train, walk, subway, ferry and bus

The journey time between Madrid and Sicily is around 2 days 12h and covers a distance of around 1897 km. This includes an average layover time of around 25h 35m. The fastest journey normally takes 2 days 12h. Operated by Renfe AVE, Tmb, Grimaldi Lines and others, the Madrid to Sicily service departs from Madrid-Puerta De Atocha and arrives in Leonardo Da Vinci - Galilei. Typically only one service runs weekly, although weekend and holiday schedules can vary so check in advance.

Explore all travel options

Average journey times

Time on transportation:
34h 48m
Layover time:
25h 35m
Total time:
2 days 12h

Route information

Fastest journey time:
2 days 12h
Journey distance:
1897 km
Services per week:
1
Cheapest price:
€178
Carbon emissions:
61 kg CO2

First and last service

First service departs at:
19:00
Last service departs at:
19:00

The schedules shown below are for the next available departures.

Madrid to Sicily train, walk, subway, ferry and bus schedules

Spain → Italy
Partially open

Travel safe during COVID-19

International entry into Italy from Spain

  • Entry is partially open for citizens and permanent residents of Spain
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Allowed for: All visitors

Restricted for: Bangladesh, Brazil, India and Sri Lanka

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Conditions of entry into Italy from Spain

  • Negative COVID-19 test issued at most 2 days before arrival or 5 day mandatory self-quarantine
  • Travellers issued with the EU Digital COVID Certificate are exempt from quarantine and COVID-19 testing
  • Passenger Locator Form (PLF) required
This applies to arrivals from Spain
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  • Negative COVID-19 test issued at most 2 days before arrival or 5 day mandatory self-quarantine
This applies to arrivals from EU Schengen Area (EU countries, Iceland, Liechtenstein, Norway, and Switzerland), Andorra, Faroe Islands, Greenland, Guadeloupe, Guyana, Martinique, Monaco, Réunion and United Kingdom
  • 10-day mandatory self-quarantine and COVID-19 test at the end of the isolation period
This doesn't apply to arrivals from: EU Schengen Area (EU countries, Iceland, Liechtenstein, Norway, and Switzerland), Albania, Andorra, Armenia, Australia, Azerbaijan, Bosnia and Herzegovina, Brunei, Canada, Gibraltar, Guadeloupe, Guernsey, Guyana, Hong Kong, Isle of Man, Japan, Jersey, Jordan, Kosovo, Lebanon, Macau, Martinique, Mayotte, Moldova, Monaco, Montenegro, New Zealand, North Macedonia, Qatar, Réunion, San Marino, Saudi Arabia, Serbia, Singapore, South Korea, Taiwan, Ukraine, United Arab Emirates, United Kingdom, United States and Vatican
  • COVID-19 testing required within 72 hours from entering the country
This doesn't apply to arrivals from: EU Schengen Area (EU countries, Iceland, Liechtenstein, Norway, and Switzerland), Andorra, Faroe Islands, Greenland, Guadeloupe, Guyana, Martinique, Mayotte, Monaco, Réunion and United Kingdom unless other countries have been visited within the past 14 days prior to arrival
  • Negative COVID-19 test issued at most 3 days before arrival or 5 day mandatory self-quarantine
This applies to arrivals from Albania, Armenia, Australia, Azerbaijan, Bosnia and Herzegovina, Brunei, Canada, Gibraltar, Guernsey, Hong Kong, Isle of Man, Japan, Jersey, Jordan, Kosovo, Lebanon, Macau, Moldova, Montenegro, New Zealand, North Macedonia, Qatar, Saudi Arabia, Serbia, Singapore, South Korea, Taiwan, Ukraine, United Arab Emirates and United States
  • Travellers issued with the EU Digital COVID Certificate are exempt from quarantine and COVID-19 testing
This applies to arrivals from EU Schengen Area (EU countries, Iceland, Liechtenstein, Norway, and Switzerland), Andorra and Monaco
  • Travellers with the Digital Green Certificate are exempt from the quarantine. Digital Green Certificate is proof that a person has been vaccinated against COVID-19, received a negative test result, or recovered from COVID-19
This applies to arrivals who have visited Canada, Gibraltar, Guernsey, Isle of Man, Israel, Japan, Jersey, United Kingdom and United States in the last 14 days
  • Passenger Locator Form (PLF) required
This doesn't apply to arrivals from: San Marino and Vatican

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Rules to follow in Italy

1.5m

Mandatory

Mandatory

Considerations leaving from Spain

The official advice is to avoid non-essential international travel to high risk countries

Frequently Asked Questions


Yes, but conditions apply when entering Italy from Spain.

Explore options for future travel

Domestic travel is not restricted, but some conditions may apply

  • Face masks are mandatory
  • There is a social distancing requirement of 1.5 metres
  • Observe COVID-19 safety rules
  • Nationwide control measures in place
  • Inter-regional travel is permitted
  • Health pass is required for long-distance travel by plane, train or coach, as well as in some public venues

Explore travel options

The national COVID-19 helpline number in Sicily is 1500.

Wearing a face mask on public transport in Sicily is mandatory.

The social distance requirement in Sicily is 1.5 metres.

Make yourself known to an official member of staff and/or call the national coronavirus helpline number on 1500.

No, but conditions apply when returning to Spain from Italy.

See options for return travel.

Last updated: 15 Sep 2021
Exceptions may apply, for full details: European Union.

We're working around the clock to bring you the latest COVID-19 travel updates.
This information is compiled from official sources. To the best of our knowledge, it is correct as of the last update.
Visit Rome2rio travel advice for general help.

Questions & Answers

The cheapest way to get from Madrid to Sicily is to fly which costs €27 - €130 and takes 6h.

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The quickest way to get from Madrid to Sicily is to fly which costs €27 - €130 and takes 6h.

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No, there is no direct bus from Madrid to Sicily. However, there are services departing from Madrid and arriving at Piazza Boiardo via Turin and Stazione Centrale - Pensilina Esterna. The journey, including transfers, takes approximately 2 days 0h.

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It is approximately 1572 km to get from Madrid to Sicily.

The best way to get from Madrid to Sicily without a car is to train and ferry which takes 37h 35m and costs €170 - €290.

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It takes approximately 6h 7m to get from Madrid to Sicily, including transfers.

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Madrid to Sicily bus services, operated by ALSA, depart from Madrid station.

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The best way to get from Madrid to Sicily is to fly which takes 6h 7m and costs €29 - €170. Alternatively, you can bus, which costs €190 - €260 and takes 2 days 0h.

Mode details

The quickest flight from Madrid Airport to Palermo Airport is the direct flight which takes 2h 25m.

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Madrid to Sicily bus services, operated by FlixBus, arrive at Palermo station.

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Map of how to get from Madrid to Sicily.
Launch map view
  • Distance: 1571.9 km
  • Duration: 6h 7m

What companies run services between Madrid, Spain and Sicily, Italy?

Ryanair, Volotea and six other airlines fly from Madrid to Palermo 3 times a day. Alternatively, you can take a bus from Madrid to Palermo via Turin, Palermo, and Stazione Centrale - Pensilina Esterna in around 2 days 0h.

Airlines
Ryanair
Website
ryanair.com
Flights from Madrid to Palermo
Ave. Duration
2h 25m
When
Tuesday, Wednesday, Thursday, Saturday and Sunday
Estimated price
€19 - €140
Flights from Madrid to Palermo via Bologna
Ave. Duration
5h 10m
When
Sunday
Estimated price
€19 - €140
Flights from Madrid to Palermo via Milan Bergamo
Ave. Duration
5h 15m
When
Thursday
Estimated price
€19 - €140
Flights from Madrid to Catania
Ave. Duration
2h 40m
When
Wednesday and Sunday
Estimated price
€16 - €120
Flights from Madrid to Catania via Naples
Ave. Duration
5h
When
Wednesday and Sunday
Estimated price
€16 - €120
Flights from Madrid to Catania via Milan Bergamo
Ave. Duration
5h 45m
When
Monday, Friday and Sunday
Estimated price
€16 - €120
Flights from Madrid to Comiso via Milan Bergamo
Ave. Duration
10h 20m
When
Monday, Wednesday and Friday
Estimated price
€30 - €55
Flights from Madrid to Comiso via Milan Malpensa
Ave. Duration
12h
When
Wednesday, Friday and Sunday
Estimated price
€60 - €180
Flights from Madrid to Comiso via Marseille, Bari
Ave. Duration
11h 45m
When
Monday
Estimated price
€30 - €55
Flights from Madrid to Comiso via Sevilla, Pisa
Ave. Duration
9h
When
Friday
Estimated price
€30 - €55
Flights from Madrid to Comiso via Ibiza, Pisa
Ave. Duration
9h 20m
When
Monday and Friday
Estimated price
€30 - €55
Flights from Madrid to Comiso via Venice, Bari
Ave. Duration
10h 15m
When
Monday
Estimated price
€100 - €300
Flights from Madrid to Trapani via Rome Ciampino
Ave. Duration
6h 20m
When
Tuesday and Saturday
Estimated price
€30 - €190
Flights from Madrid to Trapani via Milan Bergamo
Ave. Duration
7h 5m
When
Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
€30 - €200
Flights from Madrid to Trapani via Malta
Ave. Duration
8h
When
Sunday
Estimated price
€30 - €190
Flights from Madrid to Trapani via Turin
Ave. Duration
7h 55m
When
Tuesday
Estimated price
€120 - €380
Iberia
Website
iberia.com
Flights from Madrid to Palermo via Barcelona
Ave. Duration
5h
When
Friday
Estimated price
€100 - €280
Flights from Madrid to Catania
Ave. Duration
2h 45m
When
Saturday
Estimated price
€55 - €260
Alba Star
Website
albastar.es
Flights from Madrid to Trapani via Rome
Ave. Duration
6h 48m
When
Monday, Friday and Sunday
Estimated price
€100 - €350
Volotea
Website
volotea.com
Flights from Madrid to Palermo via Bordeaux
Ave. Duration
4h 25m
When
Friday
Estimated price
€50 - €220
Flights from Madrid to Catania via Genoa
Ave. Duration
5h 10m
When
Friday
Estimated price
€50 - €220
easyJet
Website
easyjet.com
Flights from Madrid to Palermo via Milan Malpensa
Ave. Duration
5h 30m
When
Monday
Estimated price
€75 - €280
Flights from Madrid to Catania via Milan Malpensa
Ave. Duration
4h 55m
When
Monday
Estimated price
€75 - €280
Vueling Airlines
Website
vueling.com
Flights from Madrid to Palermo via Barcelona
Ave. Duration
5h
When
Friday
Estimated price
€100 - €280
Alitalia
Website
alitalia.com
Flights from Madrid to Palermo via Rome
Ave. Duration
5h 40m
When
Every day
Estimated price
€180 - €460
Flights from Madrid to Catania via Rome
Ave. Duration
5h 5m
When
Every day
Estimated price
€75 - €230
Blue Air
Website
flyblueair.com
Flights from Madrid to Palermo via Milan Linate
Ave. Duration
5h 25m
When
Tuesday, Thursday, Saturday and Sunday
Estimated price
€40 - €180
Air Europa
Website
aireuropa.com
Flights from Madrid to Palermo via Rome
Ave. Duration
5h 40m
When
Every day
Estimated price
€180 - €460
Tayaran Jet
Website
en.tayaranjet.com
Flights from Madrid to Trapani via Milan Linate
Ave. Duration
5h 15m
When
Every day
Estimated price
€130 - €380
Train operators
Renfe AVE
Rome2rio's guide to Renfe AVE
Contact Details
Website
renfe.com
Train from Madrid-Puerta De Atocha to Barcelona-Sants
Ave. Duration
2h 30m
Frequency
Every 2 hours
Estimated price
€60 - €120
Website
Renfe AVE
Promo
€60 - €80
Promo+
€68 - €73
Flexible
€90 - €120
Renfe SNCF
Trenitalia Intercity

Trenitalia’s Intercity (IC) trains are slower than the high-speed Frecce trains but are still a good way to travel between major cities and towns, with routes including Rome to Naples, Venice to Bologna and Milan to Genoa. Tickets usually open for booking 90 days ahead of travel, and you’ll need make a seat reservation before boarding. All IC trains have 1st and 2nd class carriages as well as a bar buffet car, air conditioning and power sockets. InterCity trains that run at night are called InterCity Notte (ICN).

Contact Details
Phone
+39 06 68475475
Website
trenitalia.com
Train from Frosinone to Palermo Centrale
Ave. Duration
11h 40m
Frequency
3 times a week
Estimated price
€45 - €70
Website
Trenitalia Intercity
2nd Class
€45 - €70
Train from Roma Termini to Palermo Centrale
Ave. Duration
11h 59m
Frequency
Once daily
Estimated price
€50 - €75
Website
Trenitalia Intercity
2nd Class
€50 - €75
Bus operators
FlixBus

One of Europe’s leading bus companies, Flixbus serves 2000+ destinations in 29 countries, including Germany, France, Italy, Austria, the Netherlands and Croatia and into Scandinavia and eastern Europe, as well as some US cities. Coaches have toilets, free WiFi and power outlets, plus snacks and drinks for purchase on board. Flixbus is a good choice for the budget-conscious traveller; purchase tickets in advance for the cheapest fares (note: there is no option to reserve a seat in advance).

Rome2rio's guide to FlixBus
Contact Details
Phone
+49 1807 123 99 123
Email
info@flixbus.de
Website
flixbus.de
Bus from Lyon Perrache to Frosinone
Ave. Duration
16h 40m
Frequency
5 times a week
Estimated price
€55 - €70
Website
flixbus.co.uk
Bus from Turin to Palermo
Ave. Duration
23h 40m
Frequency
Once daily
Estimated price
€75 - €95
Website
flixbus.co.uk
Frequently asked questions
Is there Wi-Fi on FlixBus?
Yes - FlixBus offers free Wi-Fi
Are there power outlets on FlixBus?
Yes
Does FlixBus offer meals or snacks?
Yes - snacks and drinks may be purchased from the driver. Please note, this is not available on all services.
For more information, please visit this page
ALSA

A Spanish subsidiary of National Express, ALSA provides bus and coach services across Spain and neighbouring countries including Portugal, France, Germany, the Netherlands, Italy, Poland and Malta. Founded in 1923, ALSA values service and the customer experience. Buses are equipped with communal TV screens showing movies, individual behind-seat screens, ALSA radio, app for books and music, and free WiFi. ALSA services are accessible to people with disabilities, and guide dogs are welcome on all journeys. There are three types of tickets on offer (Frequent Traveller Pass, Share Pass and ALSA Pass), along with discounts for senior citizens, students and children.

Contact Details
Phone
+34 902 42 22 42
Website
alsa.es
Bus from Madrid to Turin
Ave. Duration
23h
Frequency
Once daily
Estimated price
€120 - €170
Website
alsa.com
Bus from Madrid to Roma
Ave. Duration
2 days 5h
Frequency
Once daily
Estimated price
€210 - €300
Website
alsa.com
Autoservizi Salemi Srl
Phone
(+39) 0923 98.11.20
Website
autoservizisalemi.it
Bus and ferry from Roma Tiburtina to Marsala
Ave. Duration
15h
Frequency
Once daily
Estimated price
€50 - €75
Schedules at
autoservizisalemi.it
Bus from Marsala to Palermo Centrale
Ave. Duration
2h 35m
Frequency
Hourly
Estimated price
€8 - €13
Schedules at
autoservizisalemi.it
Ferry operators
Grimaldi Lines
Phone
+39.081.496.444
Email
info@grimaldi.napoli.it
Website
grimaldi-lines.com
Ferry from Barcellona to Civitavecchia
Ave. Duration
20h
Frequency
6 times a week
Estimated price
€60 - €95
Website
Grimaldi Lines
Car ferry from Tunis to Palermo
Ave. Duration
10h 30m
Frequency
Twice a week
Estimated price
€23 - €35
Website
Grimaldi Lines
Algerie Ferries
Phone
+213 (0)21.63.53.76
Email
drc.entmv@algerieferries.dz
Website
algerieferries.dz
Car ferry from Marseille to Bejaia
Ave. Duration
20h
Frequency
Once a week
Estimated price
€255
Website
Algerie Ferries

Want to know more about travelling around Italy

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

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Air Europa, Alitalia, Volotea and five other airlines offer flights from Madrid Airport to Palermo Airport.

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There are 42+ hotels available in Sicily. Prices start at €87 per night.

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