Travel within Spain is: Partially open. See details.
Rome2rio uses cookies to help personalize content and show you personalised ads. By proceeding, you accept the use of cookies in accordance with our privacy policy. You may opt out of personalised ads at any time. OK

Need a hotel room in Santa María de Cayón?

Book now

There are 5 ways to get from Madrid to Santa María de Cayón by train, bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Train

  1. Take the train from Madrid-Chamartin to Santander

4 alternative options

Bus

  1. Take the bus from Madrid to Santander

Drive

  1. Drive from Madrid to Santa María de Cayón

Fly to Santander, bus

  1. Fly from Madrid (MAD) to Santander (SDR)
  2. Take the bus from Santander to Santa Maria De Cayon

Fly to Bilbao, bus

  1. Fly from Madrid (MAD) to Bilbao (BIO)
  2. Take the bus from Bilbao to Santander
  3. Take the bus from Santander to Santa Maria De Cayon

Madrid to Santa María de Cayón by train and bus

21 Weekly Services
6h 49m Average Duration
€36 Cheapest Price
See schedules
Madrid → Santa María de Cayón
Partially open

Travel safe during COVID-19

Rules to follow in Spain

1.5m

Mandatory

Mandatory

Travel within Spain

Observe COVID-19 safety rules

COVID-19 help in Spain

If you need help, visit the national COVID-19 website or call the COVID-19 Helpline 112

Frequently Asked Questions


There are currently travel restrictions within Spain.

Explore options for future travel

Domestic travel is not restricted, but some conditions may apply

  • Face masks are mandatory
  • There is a social distancing requirement of 1.5 metres
  • Observe COVID-19 safety rules

Explore travel options

The national COVID-19 helpline number in Santa María de Cayón is 112.

Wearing a face mask on public transport in Santa María de Cayón is mandatory.

The social distance requirement in Santa María de Cayón is 1.5 metres.

Make yourself known to an official member of staff and/or call the national coronavirus helpline number on 112.

Last updated: 28 Jul 2022
Exceptions may apply, for full details: European Union.

We're working around the clock to bring you the latest COVID-19 travel updates.
This information is compiled from official sources. To the best of our knowledge, it is correct as of the last update.
Visit Rome2rio travel advice for general help.

Questions & Answers

The most affordable way to get from Madrid to Santa María de Cayón is to train, which costs €35 - €50 and takes 6h 49m.

More details

The quickest way to get from Madrid to Santa María de Cayón is to drive which costs €80 - €120 and takes 4h 18m.

More details

No, there is no direct bus from Madrid to Santa María de Cayón. However, there are services departing from Madrid and arriving at Santa Maria De Cayon via Santander. The journey, including transfers, takes approximately 7h 20m.

More details

The distance between Madrid and Santa María de Cayón is 322 km. The road distance is 443.3 km.

Get driving directions

The best way to get from Madrid to Santa María de Cayón without a car is to train which takes 6h 49m and costs €35 - €50.

More details

It takes approximately 6h 49m to get from Madrid to Santa María de Cayón, including transfers.

More details

Madrid to Santa María de Cayón bus services, operated by ALSA, depart from Madrid station.

More details

The best way to get from Madrid to Santa María de Cayón is to train which takes 6h 49m and costs €35 - €50. Alternatively, you can bus, which costs €35 - €55 and takes 7h 20m.

Mode details

The quickest flight from Madrid Airport to Santander Airport is the direct flight which takes 1h 5m.

Search flights

Madrid to Santa María de Cayón bus services, operated by ALSA, arrive at Santander station.

More details

Map of how to get from Madrid to Santa María de Cayón.
Launch map view
  • Distance: 322 km
  • Duration: 6h 49m

What companies run services between Madrid, Spain and Santa María de Cayón, Spain?

Renfe Viajeros operates a train from Madrid-Chamartin to Santander 3 times a day. Tickets cost €28 - €35 and the journey takes 4h 4m. Alternatively, ALSA operates a bus from Madrid to Santander every 4 hours. Tickets cost €35 - €50 and the journey takes 5h 45m.

Airlines
Iberia
Website
iberia.com
Flights from Madrid to Santander
Ave. Duration
1h 9m
When
Every day
Estimated price
€40 - €240
Flights from Madrid to Bilbao
Ave. Duration
1h 3m
When
Every day
Estimated price
€45 - €190
Air Europa
Website
aireuropa.com
Flights from Madrid to Bilbao
Ave. Duration
58 min
When
Every day
Estimated price
€35 - €170
Train operators
Renfe Viajeros

Spain's excellent and extensive rail system connects cities across Spain and into neighbouring countries. Renfe's high-speed AVE trains can reach speeds of up to 350km/h, making travel between major cities very efficient. All medium- and long-distance trains require a seat reservation; ticket sales for these trains usually open 30-60 days before travel. Most Renfe trains have two classes: Turista (2nd class) and Preferente (1st class), although some AVE trains offer Turista Plus. There is free WiFi for Preferente passengers and for those with a +Renfe loyalty card.

Rome2rio's guide to Renfe Viajeros
Contact Details
Phone
+34 91 232 03 20
Email
comunicacion@renfe.es
Website
renfe.com
Train from Madrid-Chamartin to Santander
Ave. Duration
4h 4m
Frequency
3 times a day
Estimated price
€28 - €35
Website
Renfe Viajeros
Bus operators
ALSA

A Spanish subsidiary of National Express, ALSA provides bus and coach services across Spain and neighbouring countries including Portugal, France, Germany, the Netherlands, Italy, Poland and Malta. Founded in 1923, ALSA values service and the customer experience. Buses are equipped with communal TV screens showing movies, individual behind-seat screens, ALSA radio, app for books and music, and free WiFi. ALSA services are accessible to people with disabilities, and guide dogs are welcome on all journeys. There are three types of tickets on offer (Frequent Traveller Pass, Share Pass and ALSA Pass), along with discounts for senior citizens, students and children.

Contact Details
Phone
+34 902 42 22 42
Email
alsa@alsa.es
Website
alsa.es
Bus from Madrid to Santander
Ave. Duration
5h 45m
Frequency
Every 4 hours
Estimated price
€35 - €50
Website
ALSA
Bus from Santander to Santa Maria De Cayon
Ave. Duration
35 min
Frequency
Every 4 hours
Estimated price
€3 - €5
Website
ALSA
Bus from Bilbao to Santander
Ave. Duration
1h 20m
Frequency
Hourly
Estimated price
€9 - €13
Website
ALSA
FlixBus

One of Europe’s leading bus companies, Flixbus serves 2000+ destinations in 29 countries, including Germany, France, Italy, Austria, the Netherlands and Croatia and into Scandinavia and eastern Europe, as well as some US cities. Coaches have toilets, free WiFi and power outlets, plus snacks and drinks for purchase on board. Flixbus is a good choice for the budget-conscious traveller; purchase tickets in advance for the cheapest fares (note: there is no option to reserve a seat in advance).

Rome2rio's guide to FlixBus
Contact Details
Phone
+49 30 300 137 300
Email
service@flixbus.com
Website
flixbus.de
Bus from Bilbao to Santander
Ave. Duration
1h 10m
Frequency
Once daily
Estimated price
€8 - €10
Website
flixbus.co.uk
Frequently asked questions
Is there Wi-Fi on FlixBus?
Yes - FlixBus offers free Wi-Fi
Are there power outlets on FlixBus?
Yes
Does FlixBus offer meals or snacks?
Yes - snacks and drinks may be purchased from the driver. Please note, this is not available on all services.
For more information, please visit this page

Want to know more about travelling around Spain

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Yes, the driving distance between Madrid to Santa María de Cayón is 443 km. It takes approximately 4h 18m to drive from Madrid to Santa María de Cayón.

Get driving directions

Iberia offers flights from Madrid Airport to Santander Airport.

Search flights

Book your Madrid to Santa María de Cayón bus tickets online with Omio and Busbud.

Search and book

There are 184+ hotels available in Santa María de Cayón. Prices start at €100 per night.

More details

ticket