There are 5 ways to get from Madrid to Santa María de Cayón by train, bus, car or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Recommended option
Train
-
Take the train from Madrid-Chamartin to Santander
4 alternative options
Bus
-
Take the bus from Madrid to Santander
Drive
-
Drive from Madrid to Santa María de Cayón
Fly to Santander, bus
-
Fly from Madrid (MAD) to Santander (SDR)
-
Take the bus from Santander to Santa Maria De Cayon
Fly to Bilbao, bus
-
Fly from Madrid (MAD) to Bilbao (BIO)
-
Take the bus from Bilbao to Santander
-
Take the bus from Santander to Santa Maria De Cayon
Madrid to Santa María de Cayón by subway, train and bus
Questions & Answers
The most affordable way to get from Madrid to Santa María de Cayón is to train, which costs €35 - €60 and takes 7h 8m.
The quickest way to get from Madrid to Santa María de Cayón is to drive which costs €75 - €110 and takes 4h 18m.
No, there is no direct bus from Madrid to Santa María de Cayón. However, there are services departing from Madrid and arriving at Santa Maria De Cayon via Santander. The journey, including transfers, takes approximately 7h 20m.
The distance between Madrid and Santa María de Cayón is 322 km. The road distance is 443.3 km.
The best way to get from Madrid to Santa María de Cayón without a car is to train which takes 7h 8m and costs €35 - €60.
It takes approximately 7h 8m to get from Madrid to Santa María de Cayón, including transfers.
Madrid to Santa María de Cayón bus services, operated by ALSA, depart from Madrid station.
The best way to get from Madrid to Santa María de Cayón is to train which takes 7h 8m and costs €35 - €60. Alternatively, you can bus, which costs €65 - €110 and takes 7h 20m.
The quickest flight from Madrid Airport to Santander Airport is the direct flight which takes 1h 5m.
Madrid to Santa María de Cayón bus services, operated by ALSA, arrive at Santander station.

- Distance: 322 km
- Duration: 7h 8m
What companies run services between Madrid, Spain and Santa María de Cayón, Spain?
Renfe Viajeros operates a train from Madrid-Chamartin to Santander 3 times a day. Tickets cost €35 - €50 and the journey takes 4h 14m. Alternatively, ALSA operates a bus from Madrid to Santander every 4 hours. Tickets cost €65 - €95 and the journey takes 5h 45m.

- Website
- iberia.com
Flights from Madrid to Santander
- Ave. Duration
- 1h 8m
- When
- Every day
- Estimated price
- €40 - €320
Flights from Madrid to Bilbao
- Ave. Duration
- 1h 2m
- When
- Every day
- Estimated price
- €35 - €250

- Website
- aireuropa.com
Flights from Madrid to Bilbao
- Ave. Duration
- 1h
- When
- Every day
- Estimated price
- €30 - €180

Rome2Rio's guide to Renfe Viajeros
Contact Details
- Phone
- +34 91 232 03 20
- Website
- renfe.com
Train from Madrid-Chamartin to Santander
- Ave. Duration
- 4h 14m
- Frequency
- 3 times a day
- Estimated price
- €35 - €50
- Website
- https://www.renfe.com/es/en

- Phone
- +34 910 207 007
- alsa@alsa.es
- Website
- alsa.es
Bus from Madrid to Santander
- Ave. Duration
- 5h 45m
- Frequency
- Every 4 hours
- Estimated price
- €65 - €95
- Website
- https://www.alsa.com/en/web/bus/home
Bus from Santander to Santa Maria De Cayon
- Ave. Duration
- 35 min
- Frequency
- Every 4 hours
- Estimated price
- €3 - €6
- Website
- https://www.alsa.com/en/web/bus/home
Bus from Bilbao to Santander
- Ave. Duration
- 1h 20m
- Frequency
- Hourly
- Estimated price
- €14 - €22
- Website
- https://www.alsa.com/en/web/bus/home

Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.de
Bus from Bilbao to Santander
- Ave. Duration
- 1h 10m
- Frequency
- Once daily
- Estimated price
- €10 - €14
- Website
- https://www.flixbus.co.uk
- Book at
- https://shop.global.flixbus.com/
Frequently asked questions

- Phone
- +33 1 71 53 01 80
- Website
- blablacar.fr
Bus from Bilbao to Santander
- Ave. Duration
- 2h 5m
- Frequency
- 4 times a week
- Estimated price
- €6 - €10
- Website
- https://www.blablacar.co.uk/
Want to know more about travelling around Spain
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Read the travel guideMore Questions & Answers
Yes, the driving distance between Madrid to Santa María de Cayón is 443 km. It takes approximately 4h 18m to drive from Madrid to Santa María de Cayón.
Iberia offers flights from Madrid Airport to Santander Airport.
Book your Madrid to Santa María de Cayón bus tickets online with Omio and Busbud.
There are 1666+ hotels available in Santa María de Cayón. Prices start at €87 per night.
The best way to get from Madrid to Madrid Airport is to train which takes 26 min and costs €2 - €3.