There are 10 ways to get from Madison to Lexington by plane, car, bus (Flixbus, Greyhound), bus, train, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Dane County Regional Airport-Truax Field to Louisville International Airport, drive
best- Fly from Dane County Regional Airport-Truax Field (MSN) to Louisville International Airport (SDF)MSN - SDF
- Drive from Louisville-Airport-SDF to Lexington
6h 53m$116–623Bus
cheapest- Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton StVan Galder
- Take the bus from Chicago Bus Station to Lexington Bus StopGreyhound US0120
15h 5m$86–229Bus via Indianapolis
- Take the bus from Madison to IndianapolisFlixBus 2514
- Take the bus from Indianapolis Union Station to Lexington Bus StopGreyhound US0120
12h 31m$105–255Bus, train via Milwaukee
- Take the bus from Madison, WI-Lake St. to Milwaukee, WI - Amtrak
- Take the train from Milwaukee to Chicago Union Station
- Take the train from Chicago Union Station to Indianapolis
- Take the bus from Indianapolis Union Station to Lexington Bus Stop
15h$116–286Drive 508.3 mi
- Drive from Madison to Lexington508.3 mi
8h 55m$93–134Fly Dane County Regional Airport-Truax Field to Blue Grass Airport
- Fly from Dane County Regional Airport-Truax Field (MSN) to Blue Grass Airport (LEX)MSN - LEX
7h 32m$164–1,004Bus to Chicago O'Hare International Airport, fly to Louisville International Airport, drive
- Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departures
- Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)ORD - SDF
- Drive from Louisville-Airport-SDF to Lexington
6h 59m$234–611Bus to Chicago O'Hare International Airport, fly to Blue Grass Airport
- Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departures
- Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)ORD - LEX
7h 49m$122–692Bus to Chicago Midway International Airport, fly to Louisville International Airport, drive
- Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departures
- Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)MDW - SDF
- Drive from Louisville-Airport-SDF to Lexington
8h 8m$108–531Bus, train
- Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton St
- Take the train from Chicago Union Station to Indianapolis
- Take the bus from Indianapolis Union Station to Lexington Bus Stop
14h 56m$109–228
Dane County Regional Airport-Truax Field (MSN) to Louisville International Airport (SDF) flights
Questions & Answers
The cheapest way to get from Madison to Lexington is to drive which costs $90 - $140 and takes 8h 55m.
The fastest way to get from Madison to Lexington is to fly and drive which takes 6h 53m and costs $110 - $650.
The distance between Madison and Lexington is 480 miles. The road distance is 511.3 miles.
The best way to get from Madison to Lexington without a car is to bus via Indianapolis which takes 12h 31m and costs $100 - $260.
It takes approximately 6h 53m to get from Madison to Lexington, including transfers.
The best way to get from Madison to Lexington is to bus via Indianapolis which takes 12h 31m and costs $100 - $260. Alternatively, you can fly, which costs $160 - $1,000 and takes 7h 32m.
Lexington is 1h ahead of Madison. It is currently 7:51 PM in Madison and 8:51 PM in Lexington.
Yes, the driving distance between Madison to Lexington is 511 miles. It takes approximately 8h 55m to drive from Madison to Lexington.
There are 137+ hotels available in Lexington.
What companies run services between Madison, WI, USA and Lexington, KY, USA?
You can take a bus from Madison to Lexington via Indianapolis, Indianapolis Union Station, and Lexington Bus Stop in around 12h 31m. Alternatively, United Airlines, American Airlines, and Delta fly from Dane County Regional Airport-Truax Field (MSN) to Blue Grass Airport (LEX) hourly.
- Website
- aa.com
Flights from Dane County Regional Airport-Truax Field to Louisville International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 6h 4m
- When
- Every day
- Estimated price
- $100–600
Flights from Dane County Regional Airport-Truax Field to Louisville International Airport via Charlotte
- Ave. Duration
- 6h 21m
- When
- Every day
- Estimated price
- $170–850
Flights from Dane County Regional Airport-Truax Field to Louisville International Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 40m
- When
- Every day
- Estimated price
- $220–1,000
Flights from Dane County Regional Airport-Truax Field to Louisville International Airport via Philadelphia
- Ave. Duration
- 7h 11m
- When
- Every day
- Estimated price
- $200–950
Flights from Dane County Regional Airport-Truax Field to Blue Grass Airport via Chicago O'Hare International Airport
- Ave. Duration
- 5h 46m
- When
- Every day
- Estimated price
- $160–1,000
Flights from Dane County Regional Airport-Truax Field to Blue Grass Airport via Charlotte
- Ave. Duration
- 5h 43m
- When
- Every day
- Estimated price
- $260–1,300
Flights from Dane County Regional Airport-Truax Field to Blue Grass Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 1m
- When
- Every day
- Estimated price
- $370–1,700
Flights from Chicago O'Hare International Airport to Louisville International Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- $60–380
Flights from Chicago O'Hare International Airport to Blue Grass Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- $100–650
- Website
- united.com
Flights from Dane County Regional Airport-Truax Field to Louisville International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 4h 14m
- When
- Every day
- Estimated price
- $100–600
Flights from Dane County Regional Airport-Truax Field to Blue Grass Airport via Chicago O'Hare International Airport
- Ave. Duration
- 4h
- When
- Every day
- Estimated price
- $160–1,000
Flights from Chicago O'Hare International Airport to Louisville International Airport
- Ave. Duration
- 1h 37m
- When
- Every day
- Estimated price
- $60–380
Flights from Chicago O'Hare International Airport to Blue Grass Airport
- Ave. Duration
- 1h 39m
- When
- Every day
- Estimated price
- $100–650
- Website
- delta.com
Flights from Dane County Regional Airport-Truax Field to Louisville International Airport via Atlanta
- Ave. Duration
- 5h 22m
- When
- Monday, Tuesday, Friday, Saturday, and Sunday
- Estimated price
- $170–850
Flights from Dane County Regional Airport-Truax Field to Louisville International Airport via Detroit
- Ave. Duration
- 5h 36m
- When
- Every day
- Estimated price
- $120–700
Flights from Dane County Regional Airport-Truax Field to Louisville International Airport via Minneapolis
- Ave. Duration
- 6h 45m
- When
- Monday, Tuesday, Friday, Saturday, and Sunday
- Estimated price
- $140–750
Flights from Dane County Regional Airport-Truax Field to Blue Grass Airport via Reagan Washington
- Ave. Duration
- 4h 43m
- When
- Sunday
- Estimated price
- $280–1,400
Flights from Dane County Regional Airport-Truax Field to Blue Grass Airport via Atlanta
- Ave. Duration
- 5h 10m
- When
- Every day
- Estimated price
- $260–1,300
Flights from Dane County Regional Airport-Truax Field to Blue Grass Airport via Detroit
- Ave. Duration
- 5h 43m
- When
- Every day
- Estimated price
- $190–1,100
Flights from Dane County Regional Airport-Truax Field to Blue Grass Airport via New York La Guardia
- Ave. Duration
- 5h 58m
- When
- Saturday
- Estimated price
- $330–1,600
- Website
- southwest.com
Flights from Chicago O'Hare International Airport to Louisville International Airport via Nashville
- Ave. Duration
- 3h 40m
- When
- Monday, Tuesday, Friday, and Sunday
- Estimated price
- $80–440
Flights from Chicago Midway International Airport to Louisville International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- $70–460
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Milwaukee to Chicago Union Station
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $22–45
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Indianapolis
- Ave. Duration
- 4h 54m
- Frequency
- 3 times a week
- Estimated price
- $30–75
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Madison to Indianapolis
- Ave. Duration
- 7h 15m
- Frequency
- 6 times a week
- Estimated price
- $45–150
- Schedules at
- flixbus.com
Bus from Madison, WI-Lake St. to Milwaukee, WI - Amtrak
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $20–40
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Indianapolis Union Station to Lexington Bus Stop
- Ave. Duration
- 3h 50m
- Frequency
- Once daily
- Estimated price
- $30–80
- Website
- https://www.greyhound.com/
Bus from Chicago Bus Station to Lexington Bus Stop
- Ave. Duration
- 8h 55m
- Frequency
- Once daily
- Estimated price
- $50–170
- Website
- https://www.greyhound.com/
- Phone
- +1 414-266-4409
- ticketinfo@badgerbus.com
- Website
- badgerbus.com
Bus from Madison, WI-Lake St. to Milwaukee, WI - Amtrak
- Ave. Duration
- 1h 35m
- Frequency
- 5 times a day
- Estimated price
- $23–30
- Website
- https://badgerbus.com
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Madison, WI-Lake St. to Milwaukee, WI - Amtrak
- Ave. Duration
- 1h 25m
- Frequency
- Once daily
- Estimated price
- $7–55
- Book at
- https://www.jeffersonlines.com
- Phone
- +1 800-236-1240
- Website
- golamers.com
Bus from Madison, WI-Lake St. to Milwaukee, WI - Amtrak
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Estimated price
- $21–50
- Website
- https://www.golamers.com/
- Schedules at
- https://www.golamers.com/
- Phone
- +1 608-752-5407
- vangalder@coachusa.com
- Website
- coachusa.com
Bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departures
- Ave. Duration
- 3h
- Frequency
- Hourly
- Estimated price
- $20–40
- Website
- https://www.coachusa.com/van-galder-bus-company
Bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton St
- Ave. Duration
- 4h
- Frequency
- Hourly
- Estimated price
- $22–45
- Website
- https://www.coachusa.com/van-galder-bus-company
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide














