There are 11 ways to get from Lyon to Isernia by train (Trenitalia), bus, car, plane, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train
best- Take the train from Lyon Part Dieu to Milano Centraletrain Fr
- Take the train from Milano Centrale to Roma Terminitrain Fr / ...
- Take the train from Roma Termini to Iserniatrain Re
11h 13m€117–302Bus via Lyon Lyon Perrache Bus Station
cheapest- Take the bus from Lyon Lyon Perrache Bus Station to Roma, Autostazione Tiburtinabus Itabus
- Take the bus from Roma, Autostazione Tiburtina to Iserniabus Rome Tiburtina
18h 40m€38–132Bus
- Take the bus from Lyon to Roma, Autostazione Tiburtinabus N521 / ...
- Take the bus from Roma, Autostazione Tiburtina to Iserniabus Rome Tiburtina
18h€55–98Drive 1,117.4 km
- Drive from Lyon to Iserniacar 1,117.4 km
10h 57m€172–249Fly Lyon–Saint Exupéry Airport to Fiumicino International Airport, train
- Fly from Lyon–Saint Exupéry Airport (LYS) to Fiumicino International Airport (FCO)plane LYS - FCO
- Take the train from Roma Termini to Iserniatrain
7h 56m€76–258Train via Turin
- Take the train from Lyon Part Dieu to Torino Porta Susatrain Fr
- Take the train from Torino Porta Susa to Roma Terminitrain Fr
- Take the train from Roma Termini to Iserniatrain Re
11h 44m€122–322Fly Lyon–Saint Exupéry Airport to Naples Airport, train
- Fly from Lyon–Saint Exupéry Airport (LYS) to Naples Airport (NAP)plane LYS - NAP
- Take the train from Napoli Centrale to Iserniatrain
7h 40m€70–244Train to Turin Caselle Airport, fly to Naples Airport, train
- Take the train from Lyon Part Dieu to Torino Porta Susatrain
- Fly from Turin Caselle Airport (TRN) to Naples Airport (NAP)plane TRN - NAP
- Take the train from Napoli Centrale to Iserniatrain
10h 37m€113–280Train to Geneva International Airport, fly to Fiumicino International Airport, train
- Take the train from Lyon Part Dieu to Genevetrain
- Fly from Geneva International Airport (GVA) to Fiumicino International Airport (FCO)plane GVA - FCO
- Take the train from Roma Termini to Iserniatrain
9h 46m€90–305Train to Geneva International Airport, fly to Naples Airport, train
- Take the train from Lyon Part Dieu to Genevetrain
- Fly from Geneva International Airport (GVA) to Naples Airport (NAP)plane GVA - NAP
- Take the train from Napoli Centrale to Iserniatrain
9h 25m€84–291Train to Turin Caselle Airport, fly to Abruzzo Airport, bus
- Take the train from Lyon Part Dieu to Torino Porta Susatrain
- Fly from Turin Caselle Airport (TRN) to Abruzzo Airport (PSR)plane TRN - PSR
- Take the bus from Pescara to Iserniabus
11h 49m€107–410
Lyon to Isernia by train
Questions & Answers
The cheapest way to get from Lyon to Isernia is to bus which costs €55 - €100 and takes 18h.
The fastest way to get from Lyon to Isernia is to fly and train which takes 7h 40m and costs €65 - €250.
No, there is no direct bus from Lyon to Isernia. However, there are services departing from Lyon and arriving at Isernia via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 18h.
No, there is no direct train from Lyon to Isernia. However, there are services departing from Lyon Part Dieu and arriving at Isernia via Milano Centrale and Roma Termini. The journey, including transfers, takes approximately 11h 13m.
The distance between Lyon and Isernia is 1192 km. The road distance is 1117.4 km.
The best way to get from Lyon to Isernia without a car is to train which takes 11h 13m and costs €110 - €310.
It takes approximately 11h 13m to get from Lyon to Isernia, including transfers.
Lyon to Isernia bus services, operated by FlixBus, depart from Lyon station.
Lyon to Isernia train services, operated by Trenitalia, depart from Lyon Part Dieu station.
The best way to get from Lyon to Isernia is to train which takes 11h 13m and costs €110 - €310. Alternatively, you can bus, which costs €55 - €100 and takes 18h.
What companies run services between Lyon, France and Isernia, Italy?
You can take a train from Lyon Part Dieu to Isernia via Milano Centrale and Roma Termini in around 11h 13m. Alternatively, you can take a bus from Lyon to Isernia via Roma, Autostazione Tiburtina in around 18h.
- Website
- easyjet.com
Flights from Lyon–Saint Exupéry Airport to Fiumicino International Airport
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- €30–150
Flights from Lyon–Saint Exupéry Airport to Naples Airport
- Ave. Duration
- 1h 40m
- When
- Tuesday, Thursday, and Sunday
- Estimated price
- €35–160
Flights from Geneva International Airport to Fiumicino International Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €35–150
Flights from Geneva International Airport to Fiumicino International Airport via Nice
- Ave. Duration
- 4h
- When
- Sunday
- Estimated price
- €35–150
Flights from Geneva International Airport to Naples Airport
- Ave. Duration
- 1h 40m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €30–180
- Website
- ryanair.com
Flights from Turin Caselle Airport to Naples Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €40–120
Flights from Turin Caselle Airport to Abruzzo Airport
- Ave. Duration
- 1h 20m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €30–200
- Website
- ita-airways.com
Flights from Turin Caselle Airport to Naples Airport via Fiumicino International Airport
- Ave. Duration
- 3h 28m
- When
- Every day
- Estimated price
- €50–120
Flights from Geneva International Airport to Fiumicino International Airport
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- €60–170
- Website
- swiss.com
Flights from Turin Caselle Airport to Naples Airport via Fiumicino International Airport
- Ave. Duration
- 3h 40m
- When
- Monday, Wednesday, Friday, Saturday, and Sunday
- Estimated price
- €50–120
Flights from Geneva International Airport to Fiumicino International Airport
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- €60–170
Flights from Geneva International Airport to Fiumicino International Airport via Zurich
- Ave. Duration
- 3h 40m
- When
- Every day
- Estimated price
- €130–180
- Website
- ethiopianairlines.com
Flights from Geneva International Airport to Fiumicino International Airport
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- €60–390
- Website
- volotea.com
Flights from Turin Caselle Airport to Naples Airport
- Ave. Duration
- 1h 30m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- €26–150
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Lyon Part Dieu to Milano Centrale
- Ave. Duration
- 4h 44m
- Frequency
- Twice daily
- Estimated price
- €55–140
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €13–55
- Website
- https://www.trenitalia.com/en.html
Train from Lyon Part Dieu to Torino Porta Susa
- Ave. Duration
- 3h 57m
- Frequency
- Twice daily
- Estimated price
- €55–140
- Website
- https://www.trenitalia.com/en.html
Train from Napoli Centrale to Isernia
- Ave. Duration
- 2h 3m
- Frequency
- 4 times a day
- Estimated price
- €9–14
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 12m
- Frequency
- Every 30 minutes
- Estimated price
- €50–110
- Schedules at
- trenitalia.com
Train from Torino Porta Susa to Roma Termini
- Ave. Duration
- 4h 15m
- Frequency
- Hourly
- Estimated price
- €55–120
- Schedules at
- trenitalia.com
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Milano Centrale to Roma Termini
- Ave. Duration
- 3h 39m
- Frequency
- Hourly
- Estimated price
- €45–100
- Website
- https://www.italotreno.it/en
Train from Torino Porta Susa to Roma Termini
- Ave. Duration
- 4h 50m
- Frequency
- Every 2 hours
- Estimated price
- €50–130
- Website
- https://www.italotreno.it/en
- Phone
- +33 1 84 94 36 35
- Website
- track.effiliation.com
Train from Lyon Part Dieu to Geneve
- Ave. Duration
- 1h 57m
- Frequency
- Every 3 hours
- Estimated price
- €25–35
- Website
- https://track.effiliation.com/servlet/effi.redir?id_compteur=23007591&url=https%3A%2F%2Fwww.sncf-connect.com%2Fen-en%2F
- Phone
- +33 1 84 94 36 35
- Website
- sncf-connect.com
Train from Lyon Part Dieu to Geneve
- Ave. Duration
- 1h 50m
- Frequency
- 5 times a week
- Estimated price
- €30–70
- Website
- https://www.sncf-connect.com/en-en
- 2nd Class
- €30–45
- 1st Class
- €55–70
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Lyon to Roma, Autostazione Tiburtina
- Ave. Duration
- 14h 50m
- Frequency
- Twice daily
- Estimated price
- €45–80
- Website
- https://www.flixbus.co.uk
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- €8–21
- Website
- https://www.flixbus.co.uk
Bus from Pescara to Isernia
- Ave. Duration
- 2h 29m
- Frequency
- Once daily
- Estimated price
- €13–27
- Website
- https://www.flixbus.co.uk
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Bus from Pescara to Isernia
- Ave. Duration
- 2h 15m
- Frequency
- Twice daily
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
- Phone
- +39 06 88 93 82 32
- Website
- itabus.it
Bus from Lyon Lyon Perrache Bus Station to Roma, Autostazione Tiburtina
- Ave. Duration
- 15h 30m
- Frequency
- Twice daily
- Estimated price
- €30–120
- Website
- https://www.itabus.it/en/home
- Phone
- +3-389-268-0068
- Website
- blablacar.co.uk
Bus from Lyon Lyon Perrache Bus Station to Roma, Autostazione Tiburtina
- Ave. Duration
- 14h 45m
- Frequency
- 4 times a week
- Estimated price
- €65–90
- Website
- https://www.blablacar.co.uk/bus
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More Questions & Answers
Lyon to Isernia bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Lyon to Isernia train services, operated by Trenitalia, arrive at Milano Centrale station.
Yes, the driving distance between Lyon to Isernia is 1117 km. It takes approximately 10h 57m to drive from Lyon to Isernia.
Book your Lyon to Isernia train tickets online with Omio.
Book your Lyon to Isernia bus tickets online with Omio and FlixBus.
There are 435+ hotels available in Isernia.








































