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How to get fromLyon to Iserniaby train (Trenitalia), bus, car, plane or train

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There are 11 ways to get from Lyon to Isernia by train (Trenitalia), bus, car, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Lyon Part Dieu to Milano Centraletrain train Fr
    2. Take the train from Milano Centrale to Roma Terminitrain train Fr / ...
    3. Take the train from Roma Termini to Iserniatrain train Re
    11h 13m
    €117–302
  2. Bus via Lyon Lyon Perrache Bus Station

    cheapest
    1. Take the bus from Lyon Lyon Perrache Bus Station to Roma, Autostazione Tiburtinabus bus Itabus
    2. Take the bus from Roma, Autostazione Tiburtina to Iserniabus bus Rome Tiburtina
    18h 40m
    €38–132
  3. Bus

    1. Take the bus from Lyon to Roma, Autostazione Tiburtinabus bus N521 / ...
    2. Take the bus from Roma, Autostazione Tiburtina to Iserniabus bus Rome Tiburtina
    18h
    €55–98
  4. Drive 1,117.4 km

    1. Drive from Lyon to Iserniacar car 1,117.4 km
    10h 57m
    €172–249
  5. Fly Lyon–Saint Exupéry Airport to Fiumicino International Airport, train

    1. Fly from Lyon–Saint Exupéry Airport (LYS) to Fiumicino International Airport (FCO)plane plane LYS - FCO
    2. Take the train from Roma Termini to Iserniatrain train
    7h 56m
    €76–258
  6. Train via Turin

    1. Take the train from Lyon Part Dieu to Torino Porta Susatrain train Fr
    2. Take the train from Torino Porta Susa to Roma Terminitrain train Fr
    3. Take the train from Roma Termini to Iserniatrain train Re
    11h 44m
    €122–322
  7. Fly Lyon–Saint Exupéry Airport to Naples Airport, train

    1. Fly from Lyon–Saint Exupéry Airport (LYS) to Naples Airport (NAP)plane plane LYS - NAP
    2. Take the train from Napoli Centrale to Iserniatrain train
    7h 40m
    €70–244
  8. Train to Turin Caselle Airport, fly to Naples Airport, train

    1. Take the train from Lyon Part Dieu to Torino Porta Susatrain train
    2. Fly from Turin Caselle Airport (TRN) to Naples Airport (NAP)plane plane TRN - NAP
    3. Take the train from Napoli Centrale to Iserniatrain train
    10h 37m
    €113–280
  9. Train to Geneva International Airport, fly to Fiumicino International Airport, train

    1. Take the train from Lyon Part Dieu to Genevetrain train
    2. Fly from Geneva International Airport (GVA) to Fiumicino International Airport (FCO)plane plane GVA - FCO
    3. Take the train from Roma Termini to Iserniatrain train
    9h 46m
    €90–305
  10. Train to Geneva International Airport, fly to Naples Airport, train

    1. Take the train from Lyon Part Dieu to Genevetrain train
    2. Fly from Geneva International Airport (GVA) to Naples Airport (NAP)plane plane GVA - NAP
    3. Take the train from Napoli Centrale to Iserniatrain train
    9h 25m
    €84–291
  11. Train to Turin Caselle Airport, fly to Abruzzo Airport, bus

    1. Take the train from Lyon Part Dieu to Torino Porta Susatrain train
    2. Fly from Turin Caselle Airport (TRN) to Abruzzo Airport (PSR)plane plane TRN - PSR
    3. Take the bus from Pescara to Iserniabus bus
    11h 49m
    €107–410

Lyon to Isernia by train

Calendar14Weekly Trains
Duration11h 13mAverage Duration
Ticket€117Cheapest Price
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Questions & Answers

What companies run services between Lyon, France and Isernia, Italy?

You can take a train from Lyon Part Dieu to Isernia via Milano Centrale and Roma Termini in around 11h 13m. Alternatively, you can take a bus from Lyon to Isernia via Roma, Autostazione Tiburtina in around 18h.

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