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How to get fromLyon to Iserniaby train (Trenitalia), bus, car, plane, train, or train (Trenitalia, TGV)

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There are 10 ways to get from Lyon to Isernia by train (Trenitalia), bus, car, plane, train, or train (Trenitalia, TGV)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Lyon Part Dieu to Milano Centraletrain train Fr
    2. Take the train from Milano Centrale to Roma Terminitrain train
    3. Take the train from Roma Termini to Iserniatrain train Re
    11h 11m
    €148–269

  2. Bus

    cheapest
    1. Take the bus from Lyon - Gerland Bus Station to Roma, Autostazione Tiburtinabus bus BlaBlaCar Bus
    2. Take the bus from Roma, Autostazione Tiburtina to Iserniabus bus Rome Tiburtina
    17h 50m
    €72–176

  3. Drive 1,117.4 km

    1. Drive from Lyon to Iserniacar car 1,117.4 km
    10h 57m
    €178–256

  4. Fly Lyon–Saint Exupéry Airport to Fiumicino International Airport, train

    1. Fly from Lyon–Saint Exupéry Airport (LYS) to Fiumicino International Airport (FCO)plane plane LYS - FCO
    2. Take the train from Roma Termini to Iserniatrain train
    7h 56m
    €102–233

  5. Train via Turin

    1. Take the train from Lyon Part Dieu to Chambery Challes Les Eauxtrain train Ter
    2. Take the train from Chambery Challes Les Eaux to Torino Porta Susatrain train Tgv
    3. Take the train from Torino Porta Susa to Roma Terminitrain train Fr
    4. Take the train from Roma Termini to Iserniatrain train Re
    12h 48m
    €145–355

  6. Bus via Lyon Lyon Perrache Bus Station

    1. Take the bus from Lyon Lyon Perrache Bus Station to Rome Tiburtina Largo Mazzonibus bus Itabus
    2. Take the bus from Roma, Autostazione Tiburtina to Iserniabus bus Rome Tiburtina
    18h 40m
    €75–144

  7. Fly Lyon–Saint Exupéry Airport to Naples Airport, train

    1. Fly from Lyon–Saint Exupéry Airport (LYS) to Naples Airport (NAP)plane plane LYS - NAP
    2. Take the train from Caserta to Iserniatrain train
    8h 8m
    €89–209

  8. Train to Geneva International Airport, fly to Naples Airport, train

    1. Take the train from Lyon Part Dieu to Genevetrain train
    2. Fly from Geneva International Airport (GVA) to Naples Airport (NAP)plane plane GVA - NAP
    3. Take the train from Caserta to Iserniatrain train
    9h 58m
    €118–306

  9. Train to Geneva International Airport, fly to Fiumicino International Airport, train

    1. Take the train from Lyon Part Dieu to Genevetrain train
    2. Fly from Geneva International Airport (GVA) to Fiumicino International Airport (FCO)plane plane GVA - FCO
    3. Take the train from Roma Termini to Iserniatrain train
    9h 45m
    €116–300

  10. Train, train to Turin Caselle Airport, fly to Naples Airport

    1. Take the train from Lyon Part Dieu to Chambery Challes Les Eauxtrain train
    2. Take the train from Chambery Challes Les Eaux to Torino Porta Susatrain train
    3. Fly from Turin Caselle Airport (TRN) to Naples Airport (NAP)plane plane TRN - NAP
    4. Take the train from Caserta to Iserniatrain train
    11h 55m
    €92–272

Lyon to Isernia by train

Calendar28Weekly Trains
Duration11h 11mAverage Duration
Ticket€148Cheapest Price
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Questions & Answers

Map of how to get from Lyon to Isernia.ExpandLaunch map view
  • Distance: 1,212.4 km
  • Duration: 11h 11m

What companies run services between Lyon, France and Isernia, Italy?

You can take a train from Lyon Part Dieu to Isernia via Milano Centrale and Roma Termini in around 11h 11m. Alternatively, you can take a bus from Lyon - Gerland Bus Station to Isernia via Roma, Autostazione Tiburtina in around 17h 50m.

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