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How to get fromLucerne to Sienaby train (Trenitalia), bus, car, train, or plane

Find Transport to Siena

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There are 6 ways to get from Lucerne to Siena by train (Trenitalia), bus, car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Luzern to Luganotrain train Ec / ...
    2. Take the train from Lugano to Milano Centraletrain train
    3. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    4. Take the train from Firenze S.M.N. to Sienatrain train Re
    7h 50m
    €110–195

  2. Bus

    cheapest
    1. Take the bus from Luzern to Milanbus bus FlixBus N401 / ...
    2. Take the bus from Milano, Autostazione Lampugnano to Sienabus bus N528 / ...
    9h 15m
    €45–80

  3. Bus via Florence

    1. Take the bus from Luzern, Bahnhof to Comobus bus
    2. Take the bus from Como to Florence Villa Constanza Bus Stationbus bus
    3. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 443 / ...
    8h 32m
    €73–106

  4. Drive  604.5 km

    1. Drive from Lucerne to Sienacar car 604.5 km
    6h 14m
    €109–158

  5. Train, fly to Florence Peretola Airport

    1. Take the train from Luzern to Zürich Flughafentrain train
    2. Fly from Zurich Airport (ZRH) to Florence Peretola Airport (FLR)plane plane ZRH - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    6h 37m
    €120–307

  6. Train, fly to Bologna Guglielmo Marconi Airport

    1. Take the train from Luzern to Zürich Flughafentrain train
    2. Fly from Zurich Airport (ZRH) to Bologna Guglielmo Marconi Airport (BLQ)plane plane ZRH - BLQ
    3. Take the train from Bologna Centrale to Firenze S.M.N.train train
    4. Take the train from Firenze S.M.N. to Sienatrain train
    7h 7m
    €112–347

Lucerne to Siena by train

Calendar70Weekly Trains
Duration7h 50mAverage Duration
Ticket€110Cheapest Price
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Comparing Your Travel Options

Map of how to get from Lucerne to Siena.ExpandLaunch map view
  • Distance: 633.5 km
  • Duration: 7h 50m

What companies run services between Lucerne, Switzerland and Siena, Italy?

You can take a train from Luzern to Siena via Lugano, Milano Centrale, and Firenze S.M.N. in around 7h 50m. Alternatively, you can take a bus from Luzern, Bahnhof to Siena via Como, Como Stazione Lago, Como - S. Zenone, Como, and Florence Villa Constanza Bus Station in around 8h 32m.

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