There are 6 ways to get from Lowell to Florida Keys by plane, train, bus, car, or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Boston Logan Airport to Key West International Airport
best- Fly from Boston Logan Airport (BOS) to Key West International Airport (EYW)plane BOS - EYW
9h 4m$189–591Train, bus
- Take the train from Lowell to North Stationtrain
- Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain
- Take the train from Ny Moynihan Train Hall At Penn Station to Miami Amtrak Stationtrain
- Take the bus from Miami Airport Station to Big Pine Keybus
41h 16m$244–1,265Drive 1,626.6 mi
- Drive from Lowell to Florida Keyscar 1,626.6 mi
28h 34m$297–429Fly Boston Logan Airport to Miami International Airport, shuttle
- Fly from Boston Logan Airport (BOS) to Miami International Airport (MIA)plane BOS - MIA
- Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FL
11h 23m$234–621Fly Boston Logan Airport to Fort Lauderdale–Hollywood International Airport, shuttle
- Fly from Boston Logan Airport (BOS) to Fort Lauderdale–Hollywood International Airport (FLL)plane BOS - FLL
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
11h 45m$254–571Train, bus to Manchester Airport, fly to Key West International Airport
- Take the train from Lowell to North Stationtrain
- Take the bus from Boston to Boston Manchester Airportbus
- Fly from Manchester Airport (MHT) to Key West International Airport (EYW)plane MHT - EYW
12h 51m$267–976
Boston Logan Airport (BOS) to Key West International Airport (EYW) flights
Questions & Answers
The cheapest way to get from Lowell to Florida Keys is to drive which costs $290 - $430 and takes 28h 34m.
The fastest way to get from Lowell to Florida Keys is to fly which takes 9h 4m and costs $180 - $600.
The distance between Lowell and Florida Keys is 1433 miles. The road distance is 1636.1 miles.
The best way to get from Lowell to Florida Keys without a car is to train and bus which takes 41h 16m and costs $240 - $1,300.
It takes approximately 9h 4m to get from Lowell to Florida Keys, including transfers.
Yes, the driving distance between Lowell to Florida Keys is 1636 miles. It takes approximately 28h 34m to drive from Lowell to Florida Keys.
There are 943+ hotels available in Florida Keys.
What companies run services between Lowell, MA, USA and Florida Keys, FL, USA?
American Airlines, JetBlue Airways, and Spirit Airlines fly from Boston Logan Airport (BOS) to Key West International Airport (EYW) 5 times a day.
- Website
- jetblue.com
Flights from Boston Logan Airport to Key West International Airport
- Ave. Duration
- 3h 58m
- When
- Every day
- Estimated price
- $130–650
Flights from Boston Logan Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 3h 33m
- When
- Every day
- Estimated price
- $70–340
Flights from Boston Logan Airport to Fort Lauderdale–Hollywood International Airport via Raleigh/Durham
- Ave. Duration
- 5h 25m
- When
- Thursday and Friday
- Estimated price
- $70–350
- Website
- aa.com
Flights from Boston Logan Airport to Key West International Airport
- Ave. Duration
- 3h 58m
- When
- Saturday and Sunday
- Estimated price
- $130–650
Flights from Boston Logan Airport to Key West International Airport via Miami International Airport
- Ave. Duration
- 6h 10m
- When
- Every day
- Estimated price
- $130–650
Flights from Boston Logan Airport to Miami International Airport
- Ave. Duration
- 3h 44m
- When
- Every day
- Estimated price
- $90–450
Flights from Manchester Airport to Key West International Airport via Reagan Washington
- Ave. Duration
- 5h 53m
- When
- Monday to Saturday
- Estimated price
- $180–850
Flights from Manchester Airport to Key West International Airport via Philadelphia
- Ave. Duration
- 6h 18m
- When
- Every day
- Estimated price
- $170–850
Flights from Manchester Airport to Key West International Airport via Charlotte
- Ave. Duration
- 7h 26m
- When
- Every day
- Estimated price
- $180–850
- Website
- spirit.com
Flights from Boston Logan Airport to Key West International Airport via Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 8h 3m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $100–480
Flights from Boston Logan Airport to Miami International Airport
- Ave. Duration
- 3h 40m
- When
- Every day
- Estimated price
- $70–410
Flights from Boston Logan Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 3h 36m
- When
- Every day
- Estimated price
- $70–350
- Website
- delta.com
Flights from Boston Logan Airport to Miami International Airport
- Ave. Duration
- 3h 47m
- When
- Every day
- Estimated price
- $90–450
Flights from Boston Logan Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 3h 37m
- When
- Every day
- Estimated price
- $70–340
- Website
- flybreeze.com
Flights from Manchester Airport to Key West International Airport via Orlando
- Ave. Duration
- 5h 56m
- When
- Monday and Friday
- Estimated price
- $170–850
- Phone
- +1-617-222-3200
- Website
- mbta.com
Train from Lowell to North Station
- Ave. Duration
- 45 min
- Frequency
- Hourly
- Estimated price
- $4–11
- Website
- https://www.mbta.com
- Adult
- $4–11
Rome2Rio's guide to Amtrak Northeast Regional
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Boston to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 3h 57m
- Frequency
- Every 3 hours
- Estimated price
- $30–300
- Website
- https://www.amtrak.com/home
- Schedules at
- https://www.amtrak.com/northeast-regional-train
- Coach
- $30–300
- Business Class
- $95–360
Rome2Rio's guide to Amtrak Acela
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Boston to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 3h 36m
- Frequency
- Every 4 hours
- Estimated price
- $50–750
- Schedules at
- https://www.amtrak.com/acela-train
- Website
- https://www.amtrak.com/home.html
- Business Class
- $50–490
- First Class
- $200–750
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Ny Moynihan Train Hall At Penn Station to Miami Amtrak Station
- Ave. Duration
- 28h 29m
- Frequency
- Once daily
- Estimated price
- $160–440
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 35m
- Frequency
- 3 times a day
- Estimated price
- $21–29
- Website
- https://www.greyhound.com/
Bus from Boston to Boston Manchester Airport
- Ave. Duration
- 1h 5m
- Frequency
- Twice daily
- Estimated price
- $13–19
- Website
- https://www.greyhound.com/
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- keysshuttle.com
Shuttle from Miami, FL - International Airport to Big Pine Key, FL
- Ave. Duration
- 3h
- Frequency
- 3 times a day
- Estimated price
- $150–180
- Website
- https://www.keysshuttle.com
Shuttle from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $170–200
- Website
- https://www.keysshuttle.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide












