There are 6 ways to get from Louisville to Mebane by plane, bus, bus (Greyhound), train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Louisville International Airport to Raleigh-Durham International Airport, bus
best- Fly from Louisville International Airport (SDF) to Raleigh-Durham International Airport (RDU)plane SDF - RDU
- Take the bus from Durham Station Gate G to E Washington St at S 5th Stbus
6h 18m$142–416Bus
cheapest- Take the bus from Louisville, KY Bus Station to Columbus - Downtown - Mound Stbus
- Take the bus from Columbus to Winston Salem(Trans Center)bus
- Take the bus from Coble Transportation Center to Mebane Cone Health Park & Ridebus 4
18h 56m$77–175Bus, train (Amtrak)
- Take the bus from Louisville, KY to Indianapolis Union Stationbus
- Take the train from Indianapolis to Charlottesvilletrain
- Take the train from Charlottesville to Greensborotrain
24h 49m$167–301Drive 475.8 mi
- Drive from Louisville to Mebanecar 475.8 mi
9h 11m$87–126Fly Louisville International Airport to Piedmont Triad International Airport, bus
- Fly from Louisville International Airport (SDF) to Piedmont Triad International Airport (GSO)plane SDF - GSO
- Take the bus from Coble Transportation Center to Mebane Cone Health Park & Ridebus
9h 50m$108–709Bus to Covington, fly to Raleigh-Durham International Airport, bus
- Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus
- Fly from Covington (CVG) to Raleigh-Durham International Airport (RDU)plane CVG - RDU
- Take the bus from Durham Station Gate G to E Washington St at S 5th Stbus
8h 47m$102–648
Louisville International Airport (SDF) to Raleigh-Durham International Airport (RDU) flights
Questions & Answers
The cheapest way to get from Louisville to Mebane is to drive which costs $85 - $130 and takes 9h 11m.
The fastest way to get from Louisville to Mebane is to fly and bus which takes 6h 18m and costs $140 - $420.
No, there is no direct bus from Louisville station to Mebane. However, there are services departing from Louisville, KY Bus Station and arriving at E Washington St at S 5th St via Columbus, Winston-Salem Transportation Center, Coble Transportation Center and Mebane Cone Health Park-and-Ride. The journey, including transfers, takes approximately 18h 56m.
The distance between Louisville and Mebane is 467 miles. The road distance is 478.6 miles.
The best way to get from Louisville to Mebane without a car is to bus which takes 18h 56m and costs $75 - $180.
It takes approximately 6h 18m to get from Louisville to Mebane, including transfers.
Louisville to Mebane bus services, operated by Barons Bus, depart from Louisville, KY Bus Station.
Louisville to Mebane bus services, operated by Barons Bus, arrive at Columbus - Downtown - Mound St station.
Yes, the driving distance between Louisville to Mebane is 479 miles. It takes approximately 9h 11m to drive from Louisville to Mebane.
There are 58+ hotels available in Mebane.
What companies run services between Louisville, KY, USA and Mebane, NC, USA?
You can take a bus from Louisville, KY Bus Station to E Washington St at S 5th St via Columbus, Winston Salem(Trans Center), Winston-Salem Transportation Center, Coble Transportation Center, and Mebane Cone Health Park-and-Ride in around 18h 56m.
- Website
- aa.com
Flights from Louisville International Airport to Raleigh-Durham International Airport via Charlotte
- Ave. Duration
- 3h 36m
- When
- Every day
- Estimated price
- $75–480
Flights from Louisville International Airport to Piedmont Triad International Airport via Charlotte
- Ave. Duration
- 3h 44m
- When
- Every day
- Estimated price
- $100–700
Flights from Louisville International Airport to Piedmont Triad International Airport via Reagan Washington
- Ave. Duration
- 4h 6m
- When
- Saturday
- Estimated price
- $140–800
Flights from Louisville International Airport to Piedmont Triad International Airport via Chicago O'Hare
- Ave. Duration
- 4h 56m
- When
- Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $150–850
Flights from Louisville International Airport to Piedmont Triad International Airport via Philadelphia
- Ave. Duration
- 5h 8m
- When
- Every day
- Estimated price
- $160–900
Flights from Covington to Raleigh-Durham International Airport via Charlotte
- Ave. Duration
- 3h 35m
- When
- Every day
- Estimated price
- $100–650
- Website
- delta.com
Flights from Louisville International Airport to Piedmont Triad International Airport via Atlanta
- Ave. Duration
- 4h 9m
- When
- Every day
- Estimated price
- $130–750
Flights from Louisville International Airport to Piedmont Triad International Airport via Detroit
- Ave. Duration
- 4h 21m
- When
- Monday and Sunday
- Estimated price
- $140–800
Flights from Covington to Raleigh-Durham International Airport
- Ave. Duration
- 1h 26m
- When
- Monday to Friday
- Estimated price
- $90–600
- Website
- united.com
Flights from Louisville International Airport to Piedmont Triad International Airport via Washington Dulles
- Ave. Duration
- 4h 18m
- When
- Every day
- Estimated price
- $130–800
Flights from Louisville International Airport to Piedmont Triad International Airport via Chicago O'Hare
- Ave. Duration
- 5h 28m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $150–850
Flights from Covington to Raleigh-Durham International Airport via Washington Dulles
- Ave. Duration
- 3h 44m
- When
- Wednesday to Friday
- Estimated price
- $110–700
- Website
- flybreeze.com
Flights from Louisville International Airport to Raleigh-Durham International Airport
- Ave. Duration
- 1h 23m
- When
- Thursday and Sunday
- Estimated price
- $190–1,100
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Indianapolis to Charlottesville
- Ave. Duration
- 15h 20m
- Frequency
- 3 times a week
- Estimated price
- $60–130
- Website
- https://www.amtrak.com/home.html
Train from Charlottesville to Greensboro
- Ave. Duration
- 3h 33m
- Frequency
- Once daily
- Estimated price
- $50–85
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 919 485 7433
- customerservice@gotriangle.org
- Website
- gotriangle.org
Bus from Durham Station Gate G to E Washington St at S 5th St
- Ave. Duration
- 50 min
- Frequency
- Once daily
- Website
- https://gotriangle.org/
- Schedules at
- https://gotriangle.org/maps-schedules/gotriangle
- Phone
- +1 888-378-3823
- info@baronsbus.com
- Website
- baronsbus.com
Bus from Louisville, KY Bus Station to Columbus - Downtown - Mound St
- Ave. Duration
- 4h 2m
- Frequency
- Once daily
- Estimated price
- $21–60
- Website
- https://baronsbus.com
Bus from Louisville, KY Bus Station to Cincinnati - Downtown
- Ave. Duration
- 1h 52m
- Frequency
- Once daily
- Estimated price
- $9–45
- Website
- https://baronsbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Columbus to Winston Salem(Trans Center)
- Ave. Duration
- 9h 25m
- Frequency
- Once daily
- Estimated price
- $50–110
- Website
- https://www.greyhound.com/
- Phone
- +1 336-662-0002
- Website
- partnc.org
Bus from Coble Transportation Center to Mebane Cone Health Park & Ride
- Ave. Duration
- 1h 27m
- Frequency
- Twice daily
- Estimated price
- $2–3
- Schedules at
- partnc.org
Rome2Rio's guide to Amtrak Thruway
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Louisville, KY to Indianapolis Union Station
- Ave. Duration
- 2h 20m
- Frequency
- Twice daily
- Estimated price
- $22–45
- Website
- https://www.amtrak.com/home.html
- Adult
- $22–45
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide













