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There are 4 ways to get from Louisville to Knoxville by bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus  •  5h 30m

  1. Take the bus from Louisville, KY to Lexington, KY Evansville / ...
  2. Take the bus from Lexington, Ky to Knoxville, Tn 1109 / ...

$44 - $83

3 alternative options

Drive  •  4h 3m

  1. Drive from Louisville to Knoxville 248.6 miles

$24 - $35

Fly from Louisville  •  5h 18m

  1. Fly from Louisville (SDF) to Knoxville (TYS) SDF - TYS

$237 - $1,073

Bus to Lexington, fly  •  6h 46m

  1. Take the bus from Louisville, KY to Lexington, KY
  2. Fly from Lexington (LEX) to Knoxville (TYS) LEX - TYS

$324 - $1,130

Questions & Answers

The cheapest way to get from Louisville to Knoxville is to drive which costs $24 - $35 and takes 4h 3m.

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The quickest way to get from Louisville to Knoxville is to drive which costs $24 - $35 and takes 4h 3m.

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No, there is no direct bus from Louisville to Knoxville. However, there are services departing from Louisville, KY and arriving at Knoxville, Tn via Lexington, Ky. The journey, including transfers, takes approximately 5h 30m.

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The distance between Louisville and Knoxville is 189 miles. The road distance is 248.6 miles.

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The best way to get from Louisville to Knoxville without a car is to bus which takes 5h 30m and costs $40 - $85.

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It takes approximately 5h 30m to get from Louisville to Knoxville, including transfers.

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Louisville to Knoxville bus services, operated by Hoosier Ride, depart from Louisville, KY station.

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The best way to get from Louisville to Knoxville is to bus which takes 5h 30m and costs $40 - $85. Alternatively, you can fly, which costs $230 - $1,100 and takes 5h 18m.

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There is no direct flight from Louisville Airport to Knoxville Airport. The quickest flight takes 3h 33m and has one stopover.

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Louisville to Knoxville bus services, operated by Greyhound USA, arrive at Knoxville, Tn station.

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Map of how to get from Louisville to Knoxville.
Launch map view
  • Distance: 189.2 miles
  • Duration: 5h 30m

What companies run services between Louisville, KY, USA and Knoxville, TN, USA?

You can take a bus from Louisville to Knoxville via Lexington, KY and Lexington, Ky in around 5h 30m. Alternatively, Delta, American Airlines and United Airlines fly from Louisville to Knoxville hourly.

Airlines
Delta
Website
delta.com
Flights from Louisville to Knoxville via Atlanta
Ave. Duration
4h 16m
When
Every day
Estimated price
$180 - $1,000
Flights from Louisville to Knoxville via Detroit
Ave. Duration
5h 1m
When
Every day
Estimated price
$200 - $1,100
Flights from Louisville to Knoxville via Minneapolis
Ave. Duration
5h 59m
When
Monday to Friday
Estimated price
$260 - $1,200
Flights from Lexington to Knoxville via Atlanta
Ave. Duration
4h 4m
When
Every day
Estimated price
$200 - $1,100
Flights from Lexington to Knoxville via Detroit
Ave. Duration
6h 4m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,200
American Airlines
Website
aa.com
Flights from Louisville to Knoxville via Charlotte
Ave. Duration
4h 30m
When
Every day
Estimated price
$200 - $1,000
Flights from Louisville to Knoxville via Chicago O'Hare
Ave. Duration
4h 42m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,100
Flights from Louisville to Knoxville via Reagan Washington
Ave. Duration
5h 39m
When
Monday to Friday
Estimated price
$230 - $1,100
Flights from Louisville to Knoxville via New York La Guardia
Ave. Duration
5h 48m
When
Saturday
Estimated price
$270 - $1,200
Flights from Lexington to Knoxville via Charlotte
Ave. Duration
4h 40m
When
Every day
Estimated price
$210 - $1,100
Flights from Lexington to Knoxville via Chicago O'Hare
Ave. Duration
4h 53m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$250 - $1,200
Flights from Lexington to Knoxville via Philadelphia
Ave. Duration
6h 44m
When
Every day
Estimated price
$270 - $1,200
Flights from Lexington to Knoxville via Dallas/Ft.Worth
Ave. Duration
7h 4m
When
Every day
Estimated price
$320 - $1,300
United Airlines
Website
united.com
Flights from Louisville to Knoxville via Washington Dulles
Ave. Duration
4h 15m
When
Every day
Estimated price
$240 - $1,200
Flights from Louisville to Knoxville via Chicago O'Hare
Ave. Duration
5h 4m
When
Every day
Estimated price
$230 - $1,100
Flights from Lexington to Knoxville via Washington Dulles
Ave. Duration
4h 30m
When
Monday to Friday
Estimated price
$260 - $1,200
Flights from Lexington to Knoxville via Chicago O'Hare
Ave. Duration
5h 50m
When
Every day
Estimated price
$260 - $1,200
Allegiant Air
Website
allegiantair.com
Flights from Lexington to Knoxville via St. Petersburg
Ave. Duration
7h 48m
When
Thursday and Sunday
Estimated price
$220 - $1,000
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Lexington, Ky to Knoxville, Tn
Ave. Duration
2h 50m
Frequency
4 times a day
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Yes, the driving distance between Louisville to Knoxville is 249 miles. It takes approximately 4h 3m to drive from Louisville to Knoxville.

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United Airlines, American Airlines and Delta offer flights from Louisville Airport to Knoxville Airport.

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There are 105+ hotels available in Knoxville. Prices start at $54 USD per night.

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The best way to get from Louisville to Louisville Airport is to line 02 bus which takes 27m and costs $1 - $3.

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