There are 5 ways to get from Louisville to Knoxville by bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus  •  5 h 41 min

  1. Take the bus from Louisville, KY to Lexington, KY 0360
  2. Take the bus from Lexington, Ky to Knoxville, Tn 1109 / ...

$44 - $83

4 alternative options

Bus via Louisville, KY  •  6 h 56 min

  1. Take the bus from Louisville, KY to Lexington, KY 0364
  2. Take the bus from Lexington, Ky to Knoxville, Tn 1109 / ...

$44 - $83

Drive  •  4 h 3 min

  1. Drive from Louisville to Knoxville 248.6 miles

$24 - $35

Fly from Louisville  •  5 h 3 min

  1. Fly from Louisville (SDF) to Knoxville (TYS) SDF - TYS

$237 - $1,073

Bus to Lexington, fly  •  6 h 25 min

  1. Take the bus from Louisville, KY to Lexington, KY
  2. Fly from Lexington (LEX) to Knoxville (TYS) LEX - TYS

$324 - $1,080

What companies run services between Louisville, KY, USA and Knoxville, TN, USA?

You can take a bus from Louisville to Knoxville via Lexington, KY and Lexington, Ky in around 5 h 41 min. Alternatively, Delta, American Airlines and United Airlines fly from Louisville to Knoxville hourly.

Airlines
Delta
Website
delta.com
Flights from Louisville to Knoxville via Atlanta
Ave. Duration
4 h
When
Every day
Estimated price
$180 - $1,000
Flights from Louisville to Knoxville via Detroit
Ave. Duration
4 h 51 min
When
Every day
Estimated price
$200 - $1,100
Flights from Lexington to Knoxville via Atlanta
Ave. Duration
3 h 57 min
When
Every day
Estimated price
$200 - $1,100
Flights from Lexington to Knoxville via Detroit
Ave. Duration
5 h 34 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,200
American Airlines
Website
aa.com
Flights from Louisville to Knoxville via Charlotte
Ave. Duration
3 h 48 min
When
Every day
Estimated price
$200 - $1,000
Flights from Louisville to Knoxville via Chicago O'Hare
Ave. Duration
5 h 57 min
When
Every day
Estimated price
$220 - $1,100
Flights from Louisville to Knoxville via Dallas/Ft.Worth
Ave. Duration
5 h 39 min
When
Every day
Estimated price
$290 - $1,200
Flights from Louisville to Knoxville via Philadelphia
Ave. Duration
6 h 39 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$250 - $1,100
Flights from Lexington to Knoxville via Charlotte
Ave. Duration
3 h 54 min
When
Every day
Estimated price
$210 - $1,100
Flights from Lexington to Knoxville via Chicago O'Hare
Ave. Duration
6 h 33 min
When
Every day
Estimated price
$250 - $1,200
United Airlines
Website
united.com
Flights from Louisville to Knoxville via Washington Dulles
Ave. Duration
4 h 30 min
When
Every day
Estimated price
$240 - $1,200
Flights from Louisville to Knoxville via Chicago O'Hare
Ave. Duration
6 h 9 min
When
Every day
Estimated price
$230 - $1,100
Flights from Lexington to Knoxville via Chicago O'Hare
Ave. Duration
5 h 47 min
When
Every day
Estimated price
$260 - $1,200
Flights from Lexington to Knoxville via Newark
Ave. Duration
5 h 27 min
When
Every day
Estimated price
$300 - $1,300
Allegiant Air
Website
allegiantair.com
Flights from Lexington to Knoxville via Orlando Sanford
Ave. Duration
6 h 24 min
When
Thursday and Sunday
Estimated price
$220 - $950
Bus operators
Greyhound USA
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Lexington, Ky to Knoxville, Tn
Ave. Duration
3 h 45 min
Frequency
Every 30 minutes
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55

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Questions & Answers

The distance between Louisville and Knoxville is 303 km. The road distance is 398 km.

The cheapest way to get from Louisville to Knoxville is to drive which costs $24 - $35 and takes 4 h 3 min.

The quickest way to get from Louisville to Knoxville is to drive which takes 4 h 3 min and costs $24 - $35.

No, there is no direct bus from Louisville to Knoxville. However, there are services departing from Louisville, KY and arriving at Knoxville, Tn via Lexington, Ky. The journey, including transfers, takes approximately 5 h 41 min.

It takes approximately 5 h 41 min to get from Louisville to Knoxville, including transfers.