There are 4 ways to get from Louisville to Knoxville by bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus  •  5 h 41 min

  1. Take the bus from Louisville, KY to Lexington, KY Evansville / ...
  2. Take the bus from Lexington, Ky to Knoxville, Tn 1109 / ...

$44 - $83

3 alternative options

Drive  •  4 h 3 min

  1. Drive from Louisville to Knoxville 248.6 miles

$24 - $35

Fly from Louisville  •  4 h 54 min

  1. Fly from Louisville (SDF) to Knoxville (TYS) SDF - TYS

$237 - $1,073

Bus to Lexington, fly  •  6 h 32 min

  1. Take the bus from Louisville, KY to Lexington, KY
  2. Fly from Lexington (LEX) to Knoxville (TYS) LEX - TYS

$304 - $1,230

Questions & Answers

The cheapest way to get from Louisville to Knoxville is to drive which costs $24 - $35 and takes 4 h 3 min.

More details

The quickest way to get from Louisville to Knoxville is to drive which costs $24 - $35 and takes 4 h 3 min.

More details

No, there is no direct bus from Louisville to Knoxville. However, there are services departing from Louisville, KY and arriving at Knoxville, Tn via Lexington, Ky. The journey, including transfers, takes approximately 5 h 41 min.

More details

The distance between Louisville and Knoxville is 189 miles. The road distance is 248.6 miles.

Get driving directions

The best way to get from Louisville to Knoxville without a car is to bus which takes 5 h 41 min and costs $40 - $85.

More details

It takes approximately 5 h 41 min to get from Louisville to Knoxville, including transfers.

More details

Louisville to Knoxville bus services, operated by Hoosier Ride, depart from Louisville, KY station.

More details

The best way to get from Louisville to Knoxville is to bus which takes 5 h 41 min and costs $40 - $85. Alternatively, you can fly, which costs $230 - $1,100 and takes 4 h 54 min.

Mode details

Map of how to get from Louisville to Knoxville.
Launch map view
  • Distance: 189.2 miles
  • Duration: 5 h 41 min

What companies run services between Louisville, KY, USA and Knoxville, TN, USA?

You can take a bus from Louisville to Knoxville via Lexington, KY and Lexington, Ky in around 5 h 41 min. Alternatively, Delta, American Airlines and United Airlines fly from Louisville to Knoxville every 30 minutes.

Airlines
Delta
Website
delta.com
Flights from Louisville to Knoxville via Atlanta
Ave. Duration
3 h 53 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $1,000
Flights from Louisville to Knoxville via Detroit
Ave. Duration
5 h 12 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $1,100
Flights from Louisville to Knoxville via New York La Guardia
Ave. Duration
6 h 36 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$250 - $1,200
Flights from Lexington to Knoxville via Atlanta
Ave. Duration
3 h 49 min
When
Every day
Estimated price
$200 - $1,100
Flights from Lexington to Knoxville via Detroit
Ave. Duration
4 h 27 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,200
American Airlines
Website
aa.com
Flights from Louisville to Knoxville via Charlotte
Ave. Duration
3 h 55 min
When
Every day
Estimated price
$200 - $1,000
Flights from Louisville to Knoxville via Reagan Washington
Ave. Duration
4 h 32 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$230 - $1,100
Flights from Louisville to Knoxville via Philadelphia
Ave. Duration
4 h 54 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$250 - $1,100
Flights from Louisville to Knoxville via Chicago O'Hare
Ave. Duration
6 h 12 min
When
Every day
Estimated price
$220 - $1,100
Flights from Lexington to Knoxville via Charlotte
Ave. Duration
4 h 55 min
When
Every day
Estimated price
$210 - $1,100
Flights from Lexington to Knoxville via Chicago O'Hare
Ave. Duration
4 h 40 min
When
Every day
Estimated price
$250 - $1,200
Flights from Lexington to Knoxville via Dallas/Ft.Worth
Ave. Duration
7 h 9 min
When
Every day
Estimated price
$320 - $1,300
United Airlines
Website
united.com
Flights from Louisville to Knoxville via Washington Dulles
Ave. Duration
4 h 8 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$240 - $1,200
Flights from Louisville to Knoxville via Chicago O'Hare
Ave. Duration
5 h 22 min
When
Every day
Estimated price
$230 - $1,100
Flights from Lexington to Knoxville via Newark
Ave. Duration
5 h 16 min
When
Sunday
Estimated price
$300 - $1,300
Flights from Lexington to Knoxville via Chicago O'Hare
Ave. Duration
6 h 9 min
When
Every day
Estimated price
$260 - $1,200
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Lexington, Ky to Knoxville, Tn
Ave. Duration
3 h 45 min
Frequency
Every 30 minutes
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.