Travel from Louisville to Knoxville

Bus or fly from Louisville to Knoxville?

Hoosier Ride operates a bus from Louisville to Knoxville twice daily. Tickets cost $21 - $28 and the journey takes 1 h 40 min. Greyhound USA also services this route once daily. Alternatively, Delta, American Airlines and United Airlines fly from Louisville to Knoxville hourly.

Travel Guides

Need to know: GreyhoundRome2rio’s guide on the bus operator has all the information you need

How to get from Louisville to Knoxville

From Louisville, KY bus to Lexington, KY then bus to Knoxville, TN. 6 h 25 min $67. From Louisville, KY bus to Lexington, KY then bus to Knoxville, TN. 7 h 40 min $65. From Louisville drive to Knoxville. 4 h 3 min $29. From S 1st @ W Broadway line 02 bus to Louisville airport, fly to Knoxville airport, then taxi to Knoxville. 5 h 1 min $622. From Louisville, KY bus to Lexington, KY, taxi to Lexington airport, fly to Knoxville airport, then taxi to Knoxville. 6 h 45 min $679.

Operators from Louisville to Knoxville

OperatorPhoneWebsite
Hoosier RideHoosier Ride
Greyhound USA+1 214-849-8100Greyhound USA
Transit Authority of River CityTransit Authority of River City
DeltaDelta
American AirlinesAmerican Airlines
United AirlinesUnited Airlines
Allegiant AirAllegiant Air
Close Print Itinerary
  1. Here are 5 options to get from
    Louisville to Knoxville:

    1. Trip:
      1 Bus
      • One-Way approx: USD $44 - $83
      • Duration: 6 h 25 min
      Open +
      • Trip:
        1 Bus
        • One-Way approx: USD $44 - $83
        • Duration: 6 h 25 min
        Close x
    2. Trip:
      2 Bus via Louisville, KY
      • One-Way approx: USD $44 - $83
      • Duration: 7 h 40 min
      Open +
      • Trip:
        2 Bus via Louisville, KY
        • One-Way approx: USD $44 - $83
        • Duration: 7 h 40 min
        Close x
    3. Trip:
      3 Drive
      • One-Way approx: USD $24 - $35
      • Duration: 4 h 3 min
      Open +
      • Trip:
        3 Drive
        • One-Way approx: USD $24 - $35
        • Duration: 4 h 3 min
        Close x
    4. Trip:
      4 Fly from Louisville
      • One-Way approx: USD $237 - $1,073
      • Duration: 5 h 1 min
      Open +
      • Trip:
        4 Fly from Louisville
        • One-Way approx: USD $237 - $1,073
        • Duration: 5 h 1 min
        Close x
    5. Trip:
      5 Bus to Lexington, fly
      • One-Way approx: USD $324 - $1,130
      • Duration: 6 h 45 min
      Open +
      • Trip:
        5 Bus to Lexington, fly
        • One-Way approx: USD $324 - $1,130
        • Duration: 6 h 45 min
        Close x