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How to get fromLouisville to Iowaby plane, bus (Amtrak, Greyhound), car, bus, train or bus (Flixbus, Greyhound)

Find Transport to Iowa

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There are 9 ways to get from Louisville to Iowa by plane, bus (Amtrak, Greyhound), car, bus, train, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Des Moines

    best
    1. Fly from Louisville International Airport (SDF) to Des Moines (DSM)plane plane SDF - DSM
    5h 39m
    $189–1,124

  2. Fly to Quad City International Airport

    cheapest
    1. Fly from Louisville International Airport (SDF) to Quad City International Airport (MLI)plane plane SDF - MLI
    7h 19m
    $69–425

  3. Bus

    1. Take the bus from Louisville, KY to Chicago Union Stationbus bus
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0155S
    15h 39m
    $118–178

  4. Drive 580.9 mi

    1. Drive from Louisville to Des Moinescar car 580.9 mi
    9h 45m
    $106–154

  5. Fly to Omaha

    1. Fly from Louisville International Airport (SDF) to Omaha (OMA)plane plane SDF - OMA
    5h 53m
    $247–1,333

  6. Fly to Waterloo Municipal Airport

    1. Fly from Louisville International Airport (SDF) to Waterloo Municipal Airport (ALO)plane plane SDF - ALO
    7h 15m
    $89–464

  7. Fly to The Eastern Iowa Airport, bus

    1. Fly from Louisville International Airport (SDF) to The Eastern Iowa Airport (CID)plane plane SDF - CID
    2. Take the bus from GTC Bay 9 to Court St Transportation Centerbus bus
    8h 14m

  8. Bus, train

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    17h 59m
    $141–285

  9. Bus via Speedway

    1. Take the bus from El Mercadito Grocery - Clarksville, IN to Indianapolisbus bus
    2. Take the bus from Indianapolis to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    18h 32m
    $135–306

Louisville International Airport (SDF) to Des Moines (DSM) flights

Calendar89Weekly Planes
Duration5h 34mAverage Duration
Ticket$175Cheapest Price
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Questions & Answers

What companies run services between Louisville, KY, USA and Iowa, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Louisville International Airport (SDF) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Louisville, KY to Des Moines via Chicago Union Station, Chicago Bus Station, and Des Moines in around 15h 39m.

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