There are 8 ways to get from Louisville to Chicago Loop by plane, subway, bus (Greyhound, Amtrak, Flixbus), bus, train, car, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Louisville International Airport to Chicago Midway International Airport, subway
best- Fly from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW)plane SDF - MDW
- Take the subway from Midway to Washington/Wellssubway
3h 27m$59–398Bus
cheapest- Take the bus from Louisville Bus Station to Chicago Bus Stationbus Greyhound US0100
6h$40–75Bus, train
- Take the bus from Louisville Bus Station to Indianapolis Union Stationbus Greyhound US0100 / ...
- Take the train from Indianapolis to Chicago Union Stationtrain Cardinal
7h 55m$73–164Drive 295.2 mi
- Drive from Louisville to Chicago Loopcar 295.2 mi
5h 4m$54–78Fly Louisville International Airport to Chicago O'Hare International Airport
- Fly from Louisville International Airport (SDF) to Chicago O'Hare International Airport (ORD)plane SDF - ORD
3h 42m$54–338Drive to Blue Grass Airport, fly to Chicago O'Hare International Airport
- Drive from Louisville to Lexington-Airport-LEXcar
- Fly from Blue Grass Airport (LEX) to Chicago O'Hare International Airport (ORD)plane LEX - ORD
3h 43m$55–284Bus to Covington, fly to Chicago O'Hare International Airport
- Take the bus from Louisville to Cincinnatibus
- Fly from Covington (CVG) to Chicago O'Hare International Airport (ORD)plane CVG - ORD
5h 42m$164–850Bus via Bloomington (Flixbus)
- Take the bus from Louisville Bus Station to Bloomingtonbus FlixBus 2512
- Take the bus from Bloomington to Chicago Bus Stationbus FlixBus 2515 / ...
8h$44–75
Louisville to Chicago Loop by bus
Comparing Your Travel Options
The cheapest way to get from Louisville to Chicago Loop is to bus which costs $40 - $75 and takes 6h.
The fastest way to get from Louisville to Chicago Loop is to fly and subway which takes 3h 27m and costs $55 - $400.
Yes, there is a direct bus departing from Louisville Bus Station station and arriving at Chicago Bus Station station. Services depart four times a day, and operate every day. The journey takes approximately 6h.
The distance between Louisville and Chicago Loop is 290 miles. The road distance is 297 miles.
The best way to get from Louisville to Chicago Loop without a car is to bus which takes 6h and costs $40 - $75.
It takes approximately 3h 27m to get from Louisville to Chicago Loop, including transfers.
Louisville to Chicago Loop bus services, operated by Greyhound USA, depart from Louisville Bus Station.
The best way to get from Louisville to Chicago Loop is to bus which takes 6h and costs $40 - $75. Alternatively, you can fly, which costs $50 - $340 and takes 3h 42m.
Louisville to Chicago Loop bus services, operated by Greyhound USA, arrive at Chicago Bus Station.
Chicago Loop is 1h behind Louisville. It is currently 3:42 AM in Louisville and 2:42 AM in Chicago Loop.
What companies run services between Louisville, KY, USA and Chicago Loop, IL, USA?
Greyhound USA operates a bus from Louisville Bus Station to Chicago Bus Station 4 times a day. Tickets cost $45–75 and the journey takes 6h. Two other operators also service this route. Alternatively, American Airlines, United Airlines, and Delta fly from Louisville International Airport (SDF) to Chicago O'Hare International Airport (ORD) every 2 hours.
- Website
- aa.com
Flights from Louisville International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 41m
- When
- Every day
- Estimated price
- $50–330
Flights from Blue Grass Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 48m
- When
- Every day
- Estimated price
- $40–260
Flights from Covington to Chicago O'Hare International Airport
- Ave. Duration
- 1h 34m
- When
- Every day
- Estimated price
- $50–350
- Phone
- +1 888-968-7282
- Website
- Chicago Transit Authority
Subway from Midway to Washington/Wells
- Ave. Duration
- 28 min
- Frequency
- Every 15 minutes
- Estimated price
- $2–5
- Website
- Chicago Transit Authority
- Schedules at
- Chicago Transit Authority Schedules & Routes
- Adult
- $2–5
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Louisville Bus Station to Chicago Bus Station
- Ave. Duration
- 6h
- Frequency
- 4 times a day
- Estimated price
- $45–75
- Website
- Greyhound
Bus from Louisville Bus Station to Indianapolis Union Station
- Ave. Duration
- 1h 55m
- Frequency
- 5 times a day
- Estimated price
- $17–28
- Website
- Greyhound
Want to know more about travelling around United States
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Booking & Getting There
Yes, the driving distance between Louisville to Chicago Loop is 297 miles. It takes approximately 5h 4m to drive from Louisville to Chicago Loop.
Book your Louisville to Chicago Loop bus tickets online with Omio and FlixBus.
There are 1290+ hotels available in Chicago Loop.