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How to get fromLouisville to Chicago Loopby plane, subway, bus (Amtrak), bus, train, car, or bus (Amtrak, Greyhound)

Find Transport to Chicago Loop

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There are 9 ways to get from Louisville to Chicago Loop by plane, subway, bus (Amtrak), bus, train, car, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Chicago Midway International Airport, subway

    best
    1. Fly from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW)plane plane SDF - MDW
    2. Take the subway from Midway to Washington/Wellssubway subway
    3h 27m
    $59–398

  2. Fly Louisville International Airport to Chicago O'Hare International Airport

    cheapest
    1. Fly from Louisville International Airport (SDF) to Chicago O'Hare International Airport (ORD)plane plane SDF - ORD
    3h 51m
    $49–318

  3. Bus (Amtrak)

    1. Take the bus from Louisville, KY to Chicago Union Stationbus bus Nashville
    6h
    $50–60

  4. Bus, train (Amtrak)

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus Nashville
    2. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    8h 20m
    $123–214

  5. Drive  295.2 mi

    1. Drive from Louisville to Chicago Loopcar car 295.2 mi
    5h 4m
    $54–78

  6. Drive to Blue Grass Airport, fly to Chicago O'Hare International Airport

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Chicago O'Hare International Airport (ORD)plane plane LEX - ORD
    3h 42m
    $50–274

  7. Drive to Covington, fly to Chicago O'Hare International Airport

    1. Drive from Louisville to Covington (CVG)car car
    2. Fly from Covington (CVG) to Chicago O'Hare International Airport (ORD)plane plane CVG - ORD
    3h 50m
    $169–780

  8. Drive to Covington, fly to Chicago Midway International Airport

    1. Drive from Louisville to Covington (CVG)car car
    2. Fly from Covington (CVG) to Chicago Midway International Airport (MDW)plane plane CVG - MDW
    3h 33m
    $179–330

  9. Bus via Indianapolis

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus Nashville
    2. Take the bus from Indianapolis Union Station to Chicago Bus Stationbus bus Greyhound US0100 / ...
    7h 7m
    $56–97

Louisville to Chicago Loop by bus (Amtrak)

Calendar14Weekly Buses
Duration6hAverage Duration
Ticket$50Cheapest Price
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Comparing Your Travel Options

Map of how to get from Louisville to Chicago Loop.ExpandLaunch map view
  • Distance: 288.6 mi
  • Duration: 3h 27m

What companies run services between Louisville, KY, USA and Chicago Loop, IL, USA?

Amtrak Thruway operates a bus from Louisville, KY to Chicago Union Station twice daily. Tickets cost $50–60 and the journey takes 6h. Alternatively, American Airlines, United Airlines, and Delta fly from Louisville International Airport (SDF) to Chicago O'Hare International Airport (ORD) hourly.

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Bus operators

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Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

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