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There are 10 ways to get from Louisville to Cambridge by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Louisville to Boston

  1. Fly from Louisville (SDF) to Boston (BOS)

Cheapest option

Bus to Indianapolis, fly to Boston

  1. Take the bus from Louisville to Indianapolis
  2. Fly from Indianapolis (IND) to Boston (BOS)

8 alternative options

Fly Louisville to Providence, train

  1. Fly from Louisville (SDF) to Providence (PVD)
  2. Take the train from Providence to Back Bay

Bus to Covington, fly to Boston

  1. Take the bus from Louisville to Cincinnati
  2. Fly from Covington (CVG) to Boston (BOS)

Fly Louisville to Manchester, bus

  1. Fly from Louisville (SDF) to Manchester (MHT)
  2. Take the bus from Manchester, NH to Boston, MA

Bus

  1. Take the bus from Louisville to Indianapolis
  2. Take the bus from Indianapolis, IN to New York, NY
  3. Take the bus from New York, NY to Boston, MA

Bus via Columbus

  1. Take the bus from Louisville to Columbus
  2. Take the bus from Columbus, OH to New York, NY
  3. Take the bus from New York to Boston South Buses

Bus, train via Toledo

  1. Take the bus from Louisville to Toledo
  2. Take the train from Toledo to Boston

Bus, train

  1. Take the bus from Louisville to Indianapolis
  2. Take the train from Indianapolis to Ny Moynihan Train Hall At Penn Station
  3. Take the train from Ny Moynihan Train Hall At Penn Station to Boston

Drive

  1. Drive from Louisville to Cambridge
Louisville → Cambridge
Fully open

Travel safe during COVID-19

Rules to follow in United States

2m

Recommended

Recommended

Travel within United States

Domestic border crossings may be subject to approval, testing and quarantine
Observe COVID-19 safety rules

COVID-19 help in United States

If you need help, visit the national COVID-19 website or call the COVID-19 Helpline 800-232-4636

Frequently Asked Questions


Yes, travel within United States is currently allowed.

Explore travel options

Domestic travel is not restricted, but some conditions may apply

  • Face masks are recommended
  • There is a social distancing requirement of 2 metres
  • Domestic border crossings may be subject to approval, testing and quarantine
  • Observe COVID-19 safety rules

Explore travel options

The national COVID-19 helpline number in Cambridge is 800-232-4636.

Wearing a face mask on public transport in Cambridge is recommended.

The social distance requirement in Cambridge is 2 metres.

Make yourself known to an official member of staff and/or call the national coronavirus helpline number on 800-232-4636.

Last updated: 29 Nov 2021
Exceptions may apply, for full details: Centers for Disease control and prevention (CDC).

We're working around the clock to bring you the latest COVID-19 travel updates.
This information is compiled from official sources. To the best of our knowledge, it is correct as of the last update.
Visit Rome2rio travel advice for general help.

Questions & Answers

The cheapest way to get from Louisville to Cambridge is to drive which costs $95 - $140 and takes 16h 17m.

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The quickest way to get from Louisville to Cambridge is to fly which costs $85 - $360 and takes 6h 4m.

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No, there is no direct bus from Louisville to Cambridge. However, there are services departing from Louisville and arriving at Boston South Buses via Columbus, OH and New York. The journey, including transfers, takes approximately 21h 59m.

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The distance between Louisville and Cambridge is 826 miles. The road distance is 970.5 miles.

Get driving directions

The best way to get from Louisville to Cambridge without a car is to bus which takes 19h 50m and costs $120 - $160.

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It takes approximately 6h 4m to get from Louisville to Cambridge, including transfers.

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Louisville to Cambridge bus services, operated by Greyhound USA, depart from Louisville station.

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The best way to get from Louisville to Cambridge is to fly which takes 6h 4m and costs $85 - $360. Alternatively, you can bus, which costs $120 - $160 and takes 19h 50m.

Mode details

There is no direct flight from Louisville Airport to Boston Airport. The quickest flight takes 4h and has one stopover.

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Louisville to Cambridge bus services, operated by Lucky Star Bus, arrive at Boston South Buses station.

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Map of how to get from Louisville to Cambridge.
Launch map view
  • Distance: 826.3 miles
  • Duration: 6h 4m

What companies run services between Louisville, KY, USA and Cambridge, MA, USA?

Southwest Airlines, American Airlines and two other airlines fly from Louisville to Cambridge hourly. Alternatively, you can take a bus from Louisville to Cambridge via Indianapolis, Ctc-R, Lafayette Rd 3750 N, Indianapolis, IN, New York, NY, Canal St, Times Sq-42 St, and New York, NY in around 19h 50m.

Airlines
American Airlines
Website
aa.com
Flights from Louisville to Boston via Reagan Washington
Ave. Duration
4h 18m
When
Every day
Estimated price
$210 - $850
Flights from Louisville to Boston via Philadelphia
Ave. Duration
4h 27m
When
Monday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$210 - $850
Flights from Louisville to Boston via Charlotte
Ave. Duration
4h 52m
When
Every day
Estimated price
$210 - $850
Flights from Louisville to Boston via Chicago O'Hare
Ave. Duration
4h 57m
When
Every day
Estimated price
$210 - $850
Flights from Louisville to Boston via New York La Guardia
Ave. Duration
4h 52m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $850
Flights from Louisville to Providence via Philadelphia
Ave. Duration
4h 5m
When
Tuesday
Estimated price
$130 - $550
Flights from Louisville to Providence via Reagan Washington
Ave. Duration
4h 56m
When
Every day
Estimated price
$130 - $550
Flights from Louisville to Providence via Charlotte
Ave. Duration
5h 49m
When
Every day
Estimated price
$140 - $550
Flights from Covington to Boston
Ave. Duration
1h 59m
When
Every day
Estimated price
$110 - $440
Flights from Covington to Boston via Reagan Washington
Ave. Duration
4h 12m
When
Every day
Estimated price
$110 - $440
Flights from Louisville to Manchester via Reagan Washington
Ave. Duration
4h 11m
When
Every day
Estimated price
$130 - $500
Flights from Louisville to Manchester via Philadelphia
Ave. Duration
4h 38m
When
Every day
Estimated price
$130 - $500
Flights from Louisville to Manchester via Charlotte
Ave. Duration
6h 18m
When
Every day
Estimated price
$130 - $550
Flights from Indianapolis to Boston
Ave. Duration
2h 11m
When
Every day
Estimated price
$100 - $650
Flights from Indianapolis to Boston via Philadelphia
Ave. Duration
4h 6m
When
Saturday
Estimated price
$100 - $650
Flights from Indianapolis to Boston via Reagan Washington
Ave. Duration
4h 15m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$100 - $650
Delta
Website
delta.com
Flights from Louisville to Boston via New York La Guardia
Ave. Duration
4h 37m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$95 - $160
Flights from Louisville to Boston via Detroit
Ave. Duration
4h 44m
When
Saturday
Estimated price
$100 - $170
Flights from Louisville to Boston via Atlanta
Ave. Duration
4h 53m
When
Every day
Estimated price
$110 - $220
Flights from Louisville to Providence via Detroit
Ave. Duration
5h 26m
When
Every day
Estimated price
$130 - $210
Flights from Louisville to Providence via Atlanta
Ave. Duration
4h 56m
When
Every day
Estimated price
$140 - $270
Flights from Covington to Boston
Ave. Duration
2h 12m
When
Every day
Estimated price
$100 - $170
Flights from Covington to Boston via Detroit
Ave. Duration
4h 12m
When
Monday, Thursday, Friday, Saturday and Sunday
Estimated price
$100 - $180
Flights from Covington to Boston via New York La Guardia
Ave. Duration
4h 7m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$100 - $180
Flights from Covington to Boston via Reagan Washington
Ave. Duration
4h 10m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$100 - $180
Flights from Indianapolis to Boston
Ave. Duration
2h 10m
When
Every day
Estimated price
$100 - $180
Flights from Indianapolis to Boston via Detroit
Ave. Duration
3h 59m
When
Monday, Thursday, Friday, Saturday and Sunday
Estimated price
$110 - $180
Southwest Airlines
Website
southwest.com
Flights from Louisville to Boston via Baltimore
Ave. Duration
4h 22m
When
Every day
Estimated price
$90 - $300
Flights from Louisville to Boston via Chicago Midway
Ave. Duration
4h 50m
When
Monday to Friday
Estimated price
$100 - $330
Flights from Louisville to Providence via Baltimore
Ave. Duration
4h 16m
When
Every day
Estimated price
$110 - $380
Flights from Louisville to Providence via Tampa
Ave. Duration
5h 40m
When
Saturday
Estimated price
$170 - $550
Flights from Louisville to Providence via Orlando
Ave. Duration
6h 7m
When
Saturday and Sunday
Estimated price
$160 - $550
Flights from Louisville to Providence via Chicago Midway
Ave. Duration
7h
When
Sunday
Estimated price
$120 - $420
Flights from Covington to Boston via Baltimore
Ave. Duration
4h
When
Sunday
Estimated price
$90 - $320
Flights from Louisville to Manchester via Baltimore
Ave. Duration
5h 8m
When
Every day
Estimated price
$100 - $370
Flights from Louisville to Manchester via Chicago Midway
Ave. Duration
5h 50m
When
Sunday
Estimated price
$120 - $400
Flights from Louisville to Manchester via Orlando
Ave. Duration
8h 10m
When
Saturday
Estimated price
$160 - $500
Flights from Indianapolis to Boston via Baltimore
Ave. Duration
4h 5m
When
Saturday and Sunday
Estimated price
$100 - $340
United Airlines
Website
united.com
Flights from Louisville to Boston via Washington Dulles
Ave. Duration
4h 31m
When
Every day
Estimated price
$160 - $900
Flights from Louisville to Boston via Chicago O'Hare
Ave. Duration
4h 49m
When
Monday to Saturday
Estimated price
$160 - $900
Flights from Louisville to Providence via Newark
Ave. Duration
5h 21m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$130 - $550
Flights from Louisville to Providence via Washington Dulles
Ave. Duration
4h 39m
When
Sunday
Estimated price
$130 - $550
Flights from Covington to Boston via Washington Dulles
Ave. Duration
3h 55m
When
Monday to Saturday
Estimated price
$110 - $450
Flights from Louisville to Manchester via Washington Dulles
Ave. Duration
4h 51m
When
Sunday
Estimated price
$120 - $500
Flights from Louisville to Manchester via Newark
Ave. Duration
8h 3m
When
Monday to Friday
Estimated price
$120 - $500
Flights from Indianapolis to Boston via Washington Dulles
Ave. Duration
4h 4m
When
Every day
Estimated price
$100 - $650
Spirit Airlines
Website
spirit.com
Flights from Louisville to Manchester via Tampa
Ave. Duration
8h 56m
When
Thursday and Sunday
Estimated price
$55 - $430
Allegiant Air
Website
allegiantair.com
Flights from Indianapolis to Boston
Ave. Duration
2h 5m
When
Monday and Friday
Estimated price
$28 - $550
Train operators
MBTA
Phone
+1-617-222-3200
Website
mbta.com
Train from Providence to Back Bay
Ave. Duration
1h 6m
Frequency
Hourly
Estimated price
$0 - $13
Website
MBTA
children 11 and under
$0
Adult
$10 - $13
Amtrak Acela Express

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak Acela Express
Contact Details
Phone
+1 800-872-7245
Website
amtrak.com
Train from Providence to Boston
Ave. Duration
40 min
Frequency
Every 4 hours
Estimated price
$16 - $90
Schedules at
amtrak.com
Book at
amtrak.com
Business Seat - Child 2-12
$16 - $45
Business Seat - Seniors and Active Military
$28 - $85
Business Seat - Adult
$30 - $90
First Class - Child 2-12
$55 - $90
First Class - Senior Citizens and Active Military
$100 - $160
First Class - Adult
$110 - $180
Train from Ny Moynihan Train Hall At Penn Station to Boston
Ave. Duration
3h 38m
Frequency
Every 4 hours
Estimated price
$35 - $250
Schedules at
amtrak.com
Book at
amtrak.com
Business Seat - Child 2-12
$35 - $130
Business Seat - Seniors and Active Military
$65 - $230
Business Seat - Adult
$75 - $250
First Class - Child 2-12
$100 - $200
First Class - Senior Citizens and Active Military
$190 - $350
First Class - Adult
$210 - $390
Amtrak Northeast Regional

Amtrak’s Northeast Regional train service serves the US’ busy northeast corridor from Virginia to Massachusetts; major stops include Boston, Providence, New York City, Philadelphia, Washington DC and Baltimore. Amenities include Wi-Fi, a quiet car, cafe and business-class seating, and travelling with a small dog or cat is permitted. Book at least 14 days in advance for a cheaper Saver Fare.

Rome2rio's guide to Amtrak Northeast Regional
Contact Details
Phone
+1 800-523-6590
Website
amtrak.com
Train from Providence to Boston
Ave. Duration
57 min
Frequency
Every 3 hours
Estimated price
$13 - $75
Schedules at
amtrak.com
Book at
amtrak.com
Child 2-12 with paid adult
$13 - $40
Reserved Coach Seat
$25 - $75
Business Class Seat
$40 - $100
Train from Ny Moynihan Train Hall At Penn Station to Boston
Ave. Duration
5h 13m
Frequency
Every 3 hours
Estimated price
$20 - $130
Schedules at
amtrak.com
Book at
amtrak.com
Child 2-12 with paid adult
$20 - $65
Reserved Coach Seat
$35 - $130
Business Class Seat
$65 - $170
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 800-872-7245
Website
amtrak.com
Train from Toledo to Boston
Ave. Duration
16h 37m
Frequency
Twice daily
Estimated price
$80 - $120
Schedules at
amtrak.com
Book at
amtrak.com
Coach Seat
$80 - $120
Premium
$290 - $410
Flexi Coach Seat
$160 - $240
Business Seat
$170 - $250
Train from Indianapolis to Ny Moynihan Train Hall At Penn Station
Ave. Duration
21h 59m
Frequency
6 times a week
Estimated price
$95 - $140
Schedules at
amtrak.com
Book at
amtrak.com
Coach Seat
$95 - $140
Premium
$320 - $440
Flexi Coach Seat
$190 - $290
Business Seat
$200 - $290
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Louisville to Cincinnati
Ave. Duration
1h 45m
Frequency
Twice daily
Estimated price
$17 - $24
Website
greyhound.com
Economy
$17 - $24
Flexible
$35 - $50
Bus from Louisville to Indianapolis
Ave. Duration
2h
Frequency
Twice daily
Estimated price
$18 - $26
Website
greyhound.com
Economy
$18 - $26
Flexible
$35 - $55
Bus from Louisville to Columbus
Ave. Duration
5h 25m
Frequency
Once daily
Estimated price
$29 - $40
Website
greyhound.com
Economy
$29 - $40
Flexible
$50 - $75
Bus from Louisville to Toledo
Ave. Duration
6h 45m
Frequency
Once daily
Estimated price
$35 - $50
Website
greyhound.com
Economy
$35 - $50
Flexible
$60 - $90
OurBus
Phone
+1 844-800-6828
Email
pr@ourbus.com
Website
ourbus.com
Bus from Manchester, NH to Boston, MA
Ave. Duration
1h 15m
Frequency
4 times a week
Estimated price
$26 - $35
Book at
ourbus.com
Bus from New York, NY to Boston, MA
Ave. Duration
4h 30m
Frequency
5 times a day
Estimated price
$26 - $35
Book at
ourbus.com
Hoosier Ride
Phone
+1 800-544-2383
Website
hoosierride.com
Bus from Louisville, KY to Indianapolis, IN
Ave. Duration
2h 25m
Frequency
Twice daily
Estimated price
$19 - $40
Book at
hoosierride.com
Child Fares
$19 - $27
Amtrak Thruway

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak Thruway
Contact Details
Phone
+1 800-872-7245
Website
amtrak.com
Bus from Louisville, KY to Indianapolis Amtrak Station
Ave. Duration
2h
Frequency
Once daily
Estimated price
$11 - $35
Schedules at
amtrak.com
Child 2-12
$11 - $17
Adult
$23 - $35
Indiana Travel Express
Bus from Indianapolis, IN to New York, NY
Ave. Duration
9h 45m
Frequency
3 times a week
Estimated price
$80
Schedules at
gotobus.com
Book at
gotobus.com
SkyHorse / Jaguar
Phone
+1 917.288.6888
Email
vaseagull@gotobus.com
Website
skyhorsebus.com
Bus from Columbus, OH to New York, NY
Ave. Duration
9h 30m
Frequency
Once daily
Estimated price
$65 - $90
Schedules at
gotobus.com
Lucky Star Bus
Phone
(888) 881-0887 / (617) 269-5468
Email
info@luckystarbus.com
Website
luckystarbus.com
Bus from New York to Boston South Buses
Ave. Duration
5h
Frequency
3 times a day
Estimated price
$35
Schedules at
luckystarbus.com

Want to know more about travelling around United States

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More Questions & Answers

Yes, the driving distance between Louisville to Cambridge is 971 miles. It takes approximately 16h 17m to drive from Louisville to Cambridge.

Get driving directions

United Airlines, Southwest Airlines, Delta and American Airlines offer flights from Louisville Airport to Boston Airport.

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There are 384+ hotels available in Cambridge. Prices start at $100 USD per night.

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The best way to get from Louisville to Louisville Airport is to line 02 bus which takes 27 min and costs $1 - $3.

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