From Los Angeles, CA bus to Santa Ana, CA. 45 min $19. From Los Angeles Union Station Amtrak train to Santa Ana Regional Transportation Center Amtrak. 46 min $28. From 5th / Spring bus to Harbor-East Shuttle Area then line 83 bus to Mortimer-6Th. 2 h 44 min $3. From Los Angeles taxi to Santa Ana. 36 min $206. From Los Angeles drive to Santa Ana. 36 min $3.