From London Bridge Underground Station Tube to London Marylebone then train to High Wycombe. 53 min £19. From London Bridge Underground Station Tube to Baker Street Underground Station, Tube to Uxbridge, York Road (UB8), then line 740 bus to High Wycombe, High Street (Corporation Street). 1 h 47 min £10. From London Bridge Station taxi to High Wycombe. 47 min £147. From London Bridge Station drive to High Wycombe. 47 min £6.
London Underground (Tube) operates a train from London Bridge Station to High Wycombe every 5 minutes. Tickets cost $3 - $4 and the journey takes 11 min. Chiltern Railways also services this route every 30 minutes.