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How to get fromLisle to St. Louisby train (Amtrak), bus (Flixbus), car, train, plane or subway

Find Transport to St. Louis

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There are 5 ways to get from Lisle to St. Louis by train (Amtrak), bus (Flixbus), car, train, plane, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    6h 44m
    $35–116

  2. Bus

    1. Take the bus from Oakbrook Mall to Illinois Terminalbus bus Chicago to Champaign via shopping SB / ...
    2. Take the bus from Champaign Intermodal Trans Ctr to St Louis Bus Stationbus bus FlixBus N2521 / ...
    8h 47m
    $77–104

  3. Drive 275.9 mi

    1. Drive from Lisle to St. Louiscar car 275.9 mi
    4h 37m
    $51–73

  4. Train to Chicago O'Hare International Airport, fly

    1. Take the train from Lisle to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    4h 59m
    $250–514

  5. Train, subway to Chicago Midway International Airport, fly

    1. Take the train from Lisle to Chicago Union Stationtrain train
    2. Take the subway from LaSalle/Van Buren to Midwaysubway subway
    3. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    4h 51m
    $100–664

Lisle to St. Louis by train (Amtrak)

Calendar38Weekly Trains
Duration6h 44mAverage Duration
Ticket$35Cheapest Price
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Questions & Answers

What companies run services between Lisle, IL, USA and St. Louis, MO, USA?

Amtrak operates a train from Chicago Union Station to St. Louis 5 times a day. Tickets cost $30–110 and the journey takes 4h 46m. Alternatively, you can take a bus from Ogden Ave / Spencer Ave to St Louis Bus Station via Yorktown Center, Oakbrook Mall, Illinois Terminal, and Champaign Intermodal Trans Ctr in around 8h 47m.

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