There are 5 ways to get from Lexington to Tupelo by plane, car, bus (Greyhound), or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Blue Grass Airport to Golden Triangle Regional Airport, drive
best- Fly from Blue Grass Airport (LEX) to Golden Triangle Regional Airport (GTR)plane LEX - GTR
- Drive from Golden Triangle Regional Airport (GTR) to Tupelocar
8h 14m$98–499Drive 411.5 mi
cheapest- Drive from Lexington to Tupelocar 411.5 mi
8h 1m$76–109Bus (Greyhound)
- Take the bus from Lexington Bus Stop to Atlanta Bus Stationbus Greyhound US0110
- Take the bus from Atlanta Bus Station to Tupelobus Greyhound US0610
14h 50m$147–283Drive to Louisville International Airport, fly to Tupelo Regional Airport
- Drive from Lexington to Louisville-Airport-SDFcar
- Fly from Louisville International Airport (SDF) to Tupelo Regional Airport (TUP)plane SDF - TUP
7h 10m$160–691Fly Blue Grass Airport to Memphis, bus
- Fly from Blue Grass Airport (LEX) to Memphis (MEM)plane LEX - MEM
- Take the bus from Memphis Bus Station to Tupelobus
11h 18m$165–830
Blue Grass Airport (LEX) to Golden Triangle Regional Airport (GTR) flights
Questions & Answers
The cheapest way to get from Lexington to Tupelo is to drive which costs $75 - $110 and takes 8h 1m.
The fastest way to get from Lexington to Tupelo is to drive and fly which takes 7h 10m and costs $160 - $700.
The distance between Lexington and Tupelo is 468 miles. The road distance is 413.9 miles.
The best way to get from Lexington to Tupelo without a car is to bus which takes 14h 50m and costs $140 - $290.
It takes approximately 8h 14m to get from Lexington to Tupelo, including transfers.
Tupelo is 1h behind Lexington. It is currently 2:27 PM in Lexington and 1:27 PM in Tupelo.
Yes, the driving distance between Lexington to Tupelo is 414 miles. It takes approximately 8h 1m to drive from Lexington to Tupelo.
There are 33+ hotels available in Tupelo.
What companies run services between Lexington, KY, USA and Tupelo, MS, USA?
You can take a vehicle from Lexington to Tupelo via Lexington Bus Stop, Atlanta Bus Station, and Tupelo in around 14h 50m.
- Website
- delta.com
Flights from Blue Grass Airport to Golden Triangle Regional Airport via Atlanta
- Ave. Duration
- 6h 9m
- When
- Every day
- Estimated price
- $85–480
Flights from Blue Grass Airport to Golden Triangle Regional Airport via Reagan Washington, Atlanta
- Ave. Duration
- 7h 38m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $130–650
Flights from Blue Grass Airport to Memphis via Atlanta
- Ave. Duration
- 4h 51m
- When
- Every day
- Estimated price
- $130–750
Flights from Blue Grass Airport to Memphis via Detroit
- Ave. Duration
- 4h 55m
- When
- Every day
- Estimated price
- $170–850
- Website
- aa.com
Flights from Blue Grass Airport to Golden Triangle Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 8h 56m
- When
- Every day
- Estimated price
- $140–700
Flights from Blue Grass Airport to Memphis via Charlotte
- Ave. Duration
- 4h 54m
- When
- Every day
- Estimated price
- $150–850
Flights from Blue Grass Airport to Memphis via Chicago O'Hare
- Ave. Duration
- 5h 58m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $160–850
- Website
- contouraviation.com
Flights from Louisville International Airport to Tupelo Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 38m
- When
- Every day
- Estimated price
- $180–900
Flights from Louisville International Airport to Tupelo Regional Airport via Nashville
- Ave. Duration
- 8h 5m
- When
- Sunday
- Estimated price
- $130–650
Flights from Louisville International Airport to Tupelo Regional Airport via Chicago Midway, Nashville
- Ave. Duration
- 6h 35m
- When
- Monday to Friday
- Estimated price
- $140–750
Flights from Louisville International Airport to Tupelo Regional Airport via Charlotte, Nashville
- Ave. Duration
- 7h 55m
- When
- Every day
- Estimated price
- $140–750
Flights from Louisville International Airport to Tupelo Regional Airport via Atlanta, Nashville
- Ave. Duration
- 7h 23m
- When
- Sunday
- Estimated price
- $130–700
- Website
- united.com
Flights from Blue Grass Airport to Memphis via Chicago O'Hare
- Ave. Duration
- 5h 18m
- When
- Every day
- Estimated price
- $160–850
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Lexington Bus Stop to Atlanta Bus Station
- Ave. Duration
- 7h 50m
- Frequency
- Once daily
- Estimated price
- $50–110
- Website
- https://www.greyhound.com/
Bus from Atlanta Bus Station to Tupelo
- Ave. Duration
- 5h 45m
- Frequency
- Twice daily
- Estimated price
- $60–130
- Website
- https://www.greyhound.com/
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $22–65
- Website
- https://www.greyhound.com/
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide


