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How to get fromLexington to Saint Charlesby car, plane or bus (Greyhound)

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There are 4 ways to get from Lexington to Saint Charles by car, plane, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Louisville International Airport, fly

    best
    1. Drive from Lexington to Louisville-Airport-SDFcar
    2. Fly from Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL)planeSDF - STL
    6h 2m
    $128–725

  2. Drive 358.6 mi

    cheapest
    1. Drive from Lexington to Saint Charlescar358.6 mi
    6h 6m
    $66–95

  3. Bus (Greyhound)

    1. Take the bus from Lexington Bus Stop to Cincinnati Bus Stationbus
    2. Take the bus from Cincinnati Bus Station to Indianapolis Union Stationbus
    3. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus
    11h 10m
    $106–230

  4. Fly from Blue Grass Airport

    1. Fly from Blue Grass Airport (LEX) to Lambert–St. Louis International Airport (STL)planeLEX - STL
    8h 9m
    $166–906

Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL) flights

Calendar79Weekly Planes
Duration4h 58mAverage Duration
Ticket$113Cheapest Price
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Questions & Answers

What companies run services between Lexington, KY, USA and Saint Charles, MO, USA?

You can take a vehicle from Lexington to 4375 Rider Trail North Sb via Lexington Bus Stop, Cincinnati Bus Station, Indianapolis Union Station, St Louis Bus Station, CIVIC CENTER station, NORTH HANLEY station, and North Hanley Transit Center in around 11h 10m. Alternatively, Delta, American Airlines, and United Airlines fly from Blue Grass Airport (LEX) to Lambert–St. Louis International Airport (STL) every 2 hours.

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