There are 4 ways to get from La Serena to Santa Cruz by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  10 h 7 min

  1. Fly from La Serena (LSC) to Santa Cruz (VVI) LSC - VVI

$220 - $862

Cheapest option

Bus via Calama  •  47 h 22 min

  1. Take the bus from Serena to Calama Santiago
  2. Take the bus from Calama to Santa Cruz de la Sierra

$60 - $137

2 alternative options

Bus  •  38 h 10 min

  1. Take the bus from La Serena to Antofagasta Valparaíso / ...
  2. Take the bus from Antofagasta to Santa Cruz

$73 - $127

Drive  •  32 h 34 min

  1. Drive from La Serena to Santa Cruz de la Sierra 1609 miles

$260 - $390

Questions & Answers

The cheapest way to get from La Serena to Santa Cruz is to bus which costs $70 - $130 and takes 38 h 10 min.

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The quickest way to get from La Serena to Santa Cruz is to fly which costs $220 - $900 and takes 10 h 7 min.

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No, there is no direct bus from La Serena to Santa Cruz. However, there are services departing from Serena and arriving at Santa Cruz - Ex Terminal via Calama and Santa Cruz Airport - El Trompillo. The journey, including transfers, takes approximately 47 h 22 min.

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The distance between La Serena and Santa Cruz is 1713 km. The road distance is 2574.4 km.

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The best way to get from La Serena to Santa Cruz without a car is to bus which takes 38 h 10 min and costs $70 - $130.

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It takes approximately 10 h 7 min to get from La Serena to Santa Cruz, including transfers.

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La Serena to Santa Cruz bus services, operated by Turbus, depart from Serena station.

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The best way to get from La Serena to Santa Cruz is to fly which takes 10 h 7 min and costs $220 - $900. Alternatively, you can bus, which costs $70 - $130 and takes 38 h 10 min.

Mode details

There is no direct flight from La Serena Airport to Santa Cruz Airport. The quickest flight takes 7 h 28 min and has one stopover.

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La Serena to Santa Cruz bus services, operated by Trans Salvador, arrive at Santa Cruz de la Sierra station.

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Map of how to get from La Serena to Santa Cruz.
Launch map view
  • Distance: 1070.5 miles
  • Duration: 10 h 7 min

What companies run services between La Serena, Chile and Santa Cruz, Bolivia?

LATAM Chile and Sky Airline fly from La Serena to Warnes twice daily. Alternatively, you can take a bus from La Serena to Santa Cruz de la Sierra via Antofagasta and Santa Cruz in around 38 h 10 min.

Airlines
LATAM Chile
Website
latam.com
Flights from La Serena to Santa Cruz via Santiago
Ave. Duration
8 h 16 min
When
Tuesday, Thursday and Sunday
Estimated price
$210 - $850
Flights from La Serena to Santa Cruz via Calama, Santiago
Ave. Duration
10 h 21 min
When
Thursday
Estimated price
$280 - $1,000
Flights from La Serena to Santa Cruz via Santiago, Lima
Ave. Duration
10 h 39 min
When
Wednesday
Estimated price
$300 - $1,100
Flights from La Serena to Santa Cruz via Antofagasta, Santiago
Ave. Duration
14 h 52 min
When
Thursday
Estimated price
$270 - $1,000
Bus operators
Pullman Bus
Phone
600 320 3200
Website
pullman.cl
Bus from La Serena to Antofagasta
Ave. Duration
10 h 30 min
Frequency
Twice daily
Estimated price
$30 - $50
Schedules at
pullman.cl
Buses Evans
Website
busesevans.com
Bus from La Serena to Antofagasta
Ave. Duration
9 h 32 min
Frequency
Once daily
Schedules at
busesevans.com
Trans Salvador
Phone
+56 58 222 8547
Email
central@trans-salvador.com
Website
trans-salvador.com
Bus from Antofagasta to Santa Cruz
Ave. Duration
25 h
Frequency
Twice daily
Estimated price
$40 - $75
Book at
ticketsbolivia.com.bo
Semi Bed
$40 - $55
Premium
$55 - $70
Bus from Calama to Santa Cruz de la Sierra
Ave. Duration
31 h 30 min
Frequency
3 times a week
Estimated price
$35 - $65
Schedules at
trans-salvador.com
Book at
ticketsbolivia.com.bo
Semi Bed
$35 - $50
Premium
$50 - $60
Turbus
Phone
+56 22 822 7500
Email
atencion_clientes@turbus.cl
Website
turbus.cl
Bus from Serena to Calama
Ave. Duration
14 h 30 min
Frequency
4 times a day
Estimated price
$24 - $75
Schedules at
turbus.cl
2nd Class
$24 - $50
Premium
$50 - $75
1st Class
$60 - $90

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More Questions & Answers

Yes, the driving distance between La Serena to Santa Cruz is 2574 km. It takes approximately 32 h 34 min to drive from La Serena to Santa Cruz.

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Sky Airline and LATAM Chile offer flights from La Serena Airport to Santa Cruz Airport.

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The best way to get from La Serena to La Serena Airport is to line 883 bus which takes 16 min and costs $1.

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