There are 5 ways to get from La Serena to Cusco by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  10 h 28 min

  1. Fly from La Serena (LSC) to Cuzco (CUZ) LSC - CUZ

$329 - $1,193

Cheapest option

Bus via Arequipa  •  41 h 42 min

  1. Take the bus from La Serena to Iquique
  2. Take the bus from Iquique to Arica
  3. Take the bus from Arica to Tacna
  4. Take the bus from Tacna to Arequipa
  5. Take the bus from Arequipa to Cusco

$78 - $176

3 alternative options

Bus Expreso Norte  •  42 h 20 min

  1. Take the bus from La Serena to Arica
  2. Take the bus from Arica to Tacna
  3. Take the bus from Tacna to Cusco

$87 - $136

Bus, train  •  44 h 50 min

  1. Take the bus from La Serena to Arica
  2. Take the train from Arica to Tacna
  3. Take the bus from Tacna to Puno
  4. Take the train from Puno to Cusco - Wanchaq

Drive  •  32 h 1 min

  1. Drive from La Serena to Cusco 1511.7 miles

$250 - $370

What companies run services between La Serena, Chile and Cusco, Peru?

LATAM Chile, Sky Airline and JetSMART fly from La Serena to Cusco hourly. Alternatively, you can take a bus from La Serena to Cusco via Iquique, Arica, Tacna, and Arequipa in around 41 h 42 min.

Airlines
LATAM Chile
Website
latam.com
Flights from La Serena to Cuzco via Santiago, Lima
Ave. Duration
10 h 31 min
When
Every day
Estimated price
$320 - $1,200
Flights from La Serena to Cuzco via Santiago, Santa Cruz, Lima
Ave. Duration
15 h 1 min
When
Tuesday, Thursday and Sunday
Estimated price
$380 - $1,400
Flights from La Serena to Cuzco via Santiago, Buenos Aires Ministro Pistarini, Lima
Ave. Duration
15 h 1 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$420 - $1,400
Train operators
Ferrocarril Tacna-Arica
Phone
(+51) 52 611824
Website
facebook.com
Train from Arica to Tacna
Ave. Duration
1 h 15 min
Frequency
Twice daily
Estimated price
$6
Schedules at
facebook.com
PeruRail
Phone
51-84-581414
Email
reservas@perurail.com
Website
perurail.com
Train from Puno to Cusco - Wanchaq
Ave. Duration
10 h 20 min
Frequency
3 times a week
Estimated price
$210 - $3,100
Schedules at
perurail.com
Book at
pax1.perurail.com
VIP
$210 - $3,100
Regular
$330 - $460
Bus operators
Ciktur
Phone
951690977
Email
servicioalcliente@ciktur.cl
Website
ciktur.cl
Bus from La Serena to Iquique
Ave. Duration
18 h 22 min
Frequency
3 times a day
Estimated price
$68
Schedules at
ciktur.cl
Book at
altanetpasajes.cl
Pullman Bus
Phone
600 320 3200
Website
pullman.cl
Bus from La Serena to Iquique
Ave. Duration
18 h 13 min
Frequency
Twice daily
Estimated price
$35 - $65
Schedules at
pullman.cl
Bus from Iquique to Arica
Ave. Duration
3 h 12 min
Frequency
Twice daily
Estimated price
$12 - $16
Schedules at
pullman.cl
Bus from La Serena to Arica
Ave. Duration
21 h 25 min
Frequency
Twice daily
Estimated price
$45 - $75
Schedules at
pullman.cl
Frontera del Norte
Phone
+56 065-280 999 / 9 6633 7480
Website
facebook.com
Bus from Iquique to Arica
Ave. Duration
3 h 59 min
Frequency
Twice daily
Schedules at
recorrido.cl
Terminal Internacional ASEVERTRANS Ltda
Phone
(58) 241 390
Website
terminaldebuses.com
Bus from Arica to Tacna
Ave. Duration
2 h
Frequency
Every 30 minutes
Estimated price
$7
Schedules at
terminaldebuses.com
Oltursa
Website
oltursa.pe
Bus from Tacna to Arequipa
Ave. Duration
5 h 30 min
Frequency
Once daily
Estimated price
$10 - $26
Schedules at
oltursa.pe
Bus from Arequipa to Cusco
Ave. Duration
10 h 15 min
Frequency
Twice daily
Estimated price
$15 - $35
Schedules at
oltursa.pe
Transportes Reyna
Phone
+51 54 429339
Email
transreyna@reyna.com.pe
Website
reyna.com.pe
Bus from Arequipa to Cusco
Ave. Duration
8 h 30 min
Frequency
Twice daily
Estimated price
$19
Schedules at
reyna.com.pe
Movil Tours
Transzela
Phone
+51 51 353822
Bus from Arequipa to Cusco
Ave. Duration
10 h 15 min
Frequency
Once daily
Estimated price
$22
Schedules at
redbus.pe
Book at
redbus.pe
Turbus
Website
turbus.cl
Bus from La Serena to Arica
Ave. Duration
21 h 35 min
Frequency
Once daily
Estimated price
$50 - $80
Schedules at
turbus.cl
2nd Class
$50 - $75
1st Class
$95 - $140
Semi Cama
$80
Expreso Turismo San Martin Nobleza
Phone
+51 951977185
Website
facebook.com
Bus from Tacna to Puno
Ave. Duration
8 h
Frequency
4 times a day
Schedules at
facebook.com

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Questions & Answers

How far is it from La Serena to Cusco?

The distance between La Serena and Cusco is 1823 km. The road distance is 2419 km.

What is the cheapest way to get from La Serena to Cusco?

The cheapest way to get from La Serena to Cusco is to bus which costs $85 - $140 and takes 42 h 20 min.

What is the fastest way to get from La Serena to Cusco?

The quickest way to get from La Serena to Cusco is to fly which takes 10 h 28 min and costs $320 - $1,200.

Is there a direct bus between La Serena and Cusco?

No, there is no direct bus from La Serena to Cusco. However, there are services departing from La Serena and arriving at Cusco via Iquique, Arica, Tacna and Arequipa. The journey, including transfers, takes approximately 41 h 42 min.

How long does it take to get from La Serena to Cusco?

It takes approximately 10 h 28 min to get from La Serena to Cusco, including transfers.