There are 6 ways to get from La Crosse to Chicago by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Chicago O'Hare  •  2 h 9 min

  1. Fly from La Crosse (LSE) to Chicago O'Hare (ORD) LSE - ORD

$166 - $671

Cheapest option

Train  •  5 h 8 min

  1. Take the train from La Crosse Amtrak to Chicago Union Station Amtrak Empire Builder

$50 - $130

4 alternative options

Fly to Chicago Midway  •  5 h 21 min

  1. Fly from La Crosse (LSE) to Chicago Midway (MDW) LSE - MDW

$226 - $1,120

Bus Jefferson Lines  •  6 h 30 min

  1. Take the bus from La Crosse to Milwaukee 965
  2. Take the bus from Milwaukee, Wi to Chicago, Il 4727 / ...

$59 - $95

Bus Vangalder Bus  •  7 h

  1. Take the bus from La Crosse, WI - UW La Crosse - Sanford Hall to Madison, WI - Chazen UW Madison College Connection
  2. Take the bus from Madison, WI-Langdon & Park St to Chicago, IL - Amtrak

$68

Drive  •  4 h 44 min

  1. Drive from La Crosse to Chicago 284.4 miles

$27 - $40

Questions & Answers

The cheapest way to get from La Crosse to Chicago is to drive which costs $27 - $40 and takes 4 h 44 min.

More details

The quickest way to get from La Crosse to Chicago is to fly which takes 2 h 9 min and costs $160 - $700.

More details

The distance between La Crosse and Chicago is 364 km. The road distance is 455 km.

Get driving directions

It takes approximately 2 h 9 min to get from La Crosse to Chicago, including transfers.

More details

No, there is no direct bus from La Crosse to Chicago. However, there are services departing from La Crosse and arriving at Chicago, Il via Milwaukee, Wi. The journey, including transfers, takes approximately 6 h 30 min.

More details

Yes, there is a direct train departing from La Crosse Amtrak and arriving at Chicago Union Station Amtrak. Services depart three times a day, and operate every day. The journey takes approximately 5 h 8 min.

More details

What companies run services between La Crosse, WI, USA and Chicago, IL, USA?

American Airlines flies from La Crosse to Chicago 4 times a day. Alternatively, Amtrak operates a train from La Crosse to Chicago 3 times a day. Tickets cost $50 - $130 and the journey takes 5 h 8 min.

Airlines
American Airlines
Website
aa.com
Flights from La Crosse to Chicago O'Hare
Ave. Duration
1 h 15 min
When
Every day
Estimated price
$260 - $850
Delta
Website
delta.com
Flights from La Crosse to Chicago Midway via Minneapolis
Ave. Duration
5 h 30 min
When
Every day
Estimated price
$210 - $1,100
Flights from La Crosse to Chicago Midway via Minneapolis, Detroit
Ave. Duration
9 h
When
Every day
Estimated price
$250 - $1,200
Train operators
Amtrak
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from La Crosse Amtrak to Chicago Union Station Amtrak
Ave. Duration
5 h 8 min
Frequency
3 times a day
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Bus operators
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from La Crosse to Milwaukee
Ave. Duration
4 h 20 min
Frequency
Every 3 hours
Estimated price
$40 - $65
Schedules at
jeffersonlines.com
Greyhound USA
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Milwaukee, Wi to Chicago, Il
Ave. Duration
1 h 55 min
Frequency
Every 30 minutes
Estimated price
$15 - $35
Website
greyhound.com
Economy
$15 - $23
Flexible
$27 - $35
Badger Bus
Website
badgerbus.com
Bus from La Crosse, WI - UW La Crosse - Sanford Hall to Madison, WI - Chazen UW Madison
Ave. Duration
2 h 45 min
Frequency
Every 4 hours
Estimated price
$38
Schedules at
badgerbus.com
Book at
badgerbus.com
Vangalder Bus
Phone
+1 608-752-5407
Email
vangalder@coachusa.com
Bus from Madison, WI-Langdon & Park St to Chicago, IL - Amtrak
Ave. Duration
3 h 15 min
Frequency
Hourly
Estimated price
$30
Schedules at
vangalderbus.com
Book at
govangalder.com

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