V-Line operates a bus from Kyabram to Melbourne 6 times a week. Tickets cost $15 - $22 and the journey takes 3 h 15 min.
How to get from Kyabram to Melbourne
From Transit Centre/Union St bus to Southern Cross Coach Terminal/Spencer St. 3 h 15 min $22. From Transit Centre/Union St bus to Murchison East then train to Southern Cross. 3 h 49 min $21. From Kyabram drive to Melbourne. 2 h 26 min $26.