There are 3 ways to get from Knoxville to St. Louis by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  4 h 39 min

  1. Fly from Knoxville (TYS) to St. Louis (STL) TYS - STL

$220 - $920

Cheapest option

Bus  •  14 h 43 min

  1. Take the bus from Knoxville, Tn to Lexington, Ky
  2. Take the bus from Lexington, KY to Louisville, KY
  3. Take the bus from Louisville, KY to Evansville
  4. Take the bus from Evansville, In to St Louis, Mo

$101 - $253

1 alternative option

Drive  •  7 h 57 min

  1. Drive from Knoxville to St. Louis 488.7 miles

$45 - $70

Questions & Answers

No, there is no direct bus from Knoxville to St. Louis. However, there are services departing from Knoxville, Tn and arriving at St Louis, Mo via Lexington, KY, Louisville, KY and Evansville, In. The journey, including transfers, takes approximately 14 h 43 min.

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The distance between Knoxville and St. Louis is 393 miles. The road distance is 488.7 miles.

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The best way to get from Knoxville to St. Louis without a car is to bus which takes 14 h 43 min and costs .

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It takes approximately 4 h 39 min to get from Knoxville to St. Louis, including transfers.

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Knoxville to St. Louis bus services, operated by Greyhound USA, depart from Knoxville, Tn station.

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The best way to get from Knoxville to St. Louis is to fly which takes 4 h 39 min and costs . Alternatively, you can bus, which costs and takes 14 h 43 min.

Mode details

There is no direct flight from Knoxville Airport to St. Louis Airport. The quickest flight takes 3 h 40 min and has one stopover.

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Knoxville to St. Louis bus services, operated by Greyhound USA, arrive at St Louis, Mo station.

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St. Louis is 1 h behind Knoxville. It is currently 2:37 AM in Knoxville and 1:37 AM in St. Louis.

Yes, the driving distance between Knoxville to St. Louis is 489 miles. It takes approximately 7 h 57 min to drive from Knoxville to St. Louis.

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Map of how to get from Knoxville to St. Louis.
Launch map view
  • Distance: 393.3 miles
  • Duration: 4 h 39 min

What companies run services between Knoxville, TN, USA and St. Louis, MO, USA?

Delta, American Airlines and United Airlines fly from Knoxville to St. Louis hourly. Alternatively, you can take a bus from Knoxville to St. Louis via Lexington, Ky, Lexington, KY, Louisville, KY, Evansville, and Evansville, In in around 14 h 43 min.

Airlines
Delta
Website
delta.com
Flights from Knoxville to St. Louis via Atlanta
Ave. Duration
4 h 3 min
When
Every day
Estimated price
$160 - $850
Flights from Knoxville to St. Louis via Detroit
Ave. Duration
4 h 26 min
When
Every day
Estimated price
$180 - $900
American Airlines
Website
aa.com
Flights from Knoxville to St. Louis via Chicago O'Hare
Ave. Duration
4 h 39 min
When
Monday to Saturday
Estimated price
$180 - $900
Flights from Knoxville to St. Louis via Charlotte
Ave. Duration
4 h 19 min
When
Every day
Estimated price
$180 - $900
Flights from Knoxville to St. Louis via Dallas/Ft.Worth
Ave. Duration
5 h 1 min
When
Every day
Estimated price
$230 - $950
Flights from Knoxville to St. Louis via Reagan Washington
Ave. Duration
5 h 2 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $950
Flights from Knoxville to St. Louis via Philadelphia
Ave. Duration
5 h 27 min
When
Every day
Estimated price
$230 - $950
United Airlines
Website
united.com
Flights from Knoxville to St. Louis via Chicago O'Hare
Ave. Duration
4 h 28 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $950
Flights from Knoxville to St. Louis via Washington Dulles
Ave. Duration
4 h 56 min
When
Every day
Estimated price
$220 - $1,000
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Knoxville, Tn to Lexington, Ky
Ave. Duration
3 h 49 min
Frequency
Every 30 minutes
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Bus from Evansville, In to St Louis, Mo
Ave. Duration
3 h 55 min
Frequency
Hourly
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Hoosier Ride
Phone
800-544-2383
Website
hoosierride.com
Bus from Lexington, KY to Louisville, KY
Ave. Duration
1 h 20 min
Frequency
4 times a day
Estimated price
$21 - $100
Book at
hoosierride.com
Bus from Louisville, KY to Evansville
Ave. Duration
3 h 5 min
Frequency
Twice daily
Estimated price
$35 - $45
Book at
hoosierride.com

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More Questions & Answers

United Airlines, American Airlines and Delta offer flights from Knoxville Airport to St. Louis Airport.

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There are 193+ hotels available in St. Louis. Prices start at $70 USD per night.

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The best way to get from Knoxville to Knoxville Airport is to taxi which takes 18 min and costs .

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