There are 5 ways to get from Knoxville to St. Louis by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Knoxville  •  4 h 53 min

  1. Fly from Knoxville (TYS) to St. Louis (STL) TYS - STL

$220 - $920

Cheapest option

Megabus, bus  •  14 h 44 min

  1. Take the Megabus from Knoxville to Chattanooga
  2. Take the bus from Chattanooga to Nashville, TN
  3. Take the bus from Nashville, Tn to St Louis, Mo

$65 - $136

3 alternative options

Bus to Atlanta, fly  •  8 h 4 min

  1. Take the bus from Knoxville, Tn to Atlanta, Ga
  2. Fly from Atlanta (ATL) to St. Louis (STL) ATL - STL

$152 - $438

Bus  •  14 h 48 min

  1. Take the bus from Knoxville, Tn to Lexington, Ky
  2. Take the bus from Lexington, KY to Evansville
  3. Take the bus from Evansville, In to St Louis, Mo

$90 - $173

Drive  •  7 h 57 min

  1. Drive from Knoxville to St. Louis 488.7 miles

$45 - $70

Questions & Answers

The cheapest way to get from Knoxville to St. Louis is to drive which costs $45 - $70 and takes 7 h 57 min.

More details

The quickest way to get from Knoxville to St. Louis is to fly which costs $220 - $950 and takes 4 h 53 min.

More details

The distance between Knoxville and St. Louis is 393 miles. The road distance is 488.7 miles.

Get driving directions

It takes approximately 4 h 53 min to get from Knoxville to St. Louis, including transfers.

More details

No, there is no direct bus from Knoxville to St. Louis. However, there are services departing from Knoxville and arriving at St Louis, Mo via Chattanooga, Nashville, TN and Nashville, Tn. The journey, including transfers, takes approximately 14 h 44 min.

More details

What companies run services between Knoxville, TN, USA and St. Louis, MO, USA?

Delta, American Airlines and United Airlines fly from Knoxville to St. Louis hourly. Alternatively, you can take a bus from Knoxville to St. Louis via Chattanooga, Nashville, TN, Nashville, TN, and Nashville, Tn in around 14 h 44 min.

Airlines
Delta
Website
delta.com
Flights from Knoxville to St. Louis via Atlanta
Ave. Duration
4 h 27 min
When
Every day
Estimated price
$160 - $850
Flights from Knoxville to St. Louis via Detroit
Ave. Duration
4 h 25 min
When
Every day
Estimated price
$180 - $900
Flights from Atlanta to St. Louis
Ave. Duration
1 h 42 min
When
Every day
Estimated price
$240 - $600
Southwest Airlines
Website
southwest.com
Flights from Atlanta to St. Louis
Ave. Duration
1 h 42 min
When
Every day
Estimated price
$290 - $500
American Airlines
Website
aa.com
Flights from Knoxville to St. Louis via Charlotte
Ave. Duration
4 h 11 min
When
Every day
Estimated price
$180 - $900
Flights from Knoxville to St. Louis via Chicago O'Hare
Ave. Duration
4 h 15 min
When
Every day
Estimated price
$180 - $900
Flights from Knoxville to St. Louis via Reagan Washington
Ave. Duration
4 h 55 min
When
Every day
Estimated price
$210 - $950
Flights from Knoxville to St. Louis via Dallas/Ft.Worth
Ave. Duration
5 h 17 min
When
Every day
Estimated price
$230 - $950
Flights from Knoxville to St. Louis via Philadelphia
Ave. Duration
5 h 26 min
When
Every day
Estimated price
$230 - $950
United Airlines
Website
united.com
Flights from Knoxville to St. Louis via Chicago O'Hare
Ave. Duration
4 h 47 min
When
Every day
Estimated price
$190 - $950
Flights from Knoxville to St. Louis via Washington Dulles
Ave. Duration
4 h 45 min
When
Every day
Estimated price
$220 - $1,000
Air Choice One
Website
airchoiceone.com
Flights from Atlanta to St. Louis via Jackson
Ave. Duration
3 h 30 min
When
Monday to Friday
Estimated price
$210 - $300
Bus operators
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Knoxville, Tn to Atlanta, Ga
Ave. Duration
4 h 30 min
Frequency
Every 30 minutes
Estimated price
$26 - $65
Website
greyhound.com
Economy
$26 - $45
Flexible
$45 - $65
Bus from Nashville, Tn to St Louis, Mo
Ave. Duration
7 h 35 min
Frequency
Every 30 minutes
Estimated price
$35 - $85
Website
greyhound.com
Economy
$35 - $55
Flexible
$65 - $85
Bus from Knoxville, Tn to Lexington, Ky
Ave. Duration
3 h 49 min
Frequency
Every 30 minutes
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Bus from Evansville, In to St Louis, Mo
Ave. Duration
3 h 55 min
Frequency
Hourly
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Knoxville to Chattanooga
Ave. Duration
2 h
Frequency
3 times a day
Estimated price
$12 - $22
Schedules at
us.megabus.com
Bus from Chattanooga to Nashville, TN
Ave. Duration
2 h 37 min
Frequency
Twice daily
Estimated price
$14 - $25
Schedules at
us.megabus.com

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