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There are 5 ways to get from Knoxville to St. Louis by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  4h 49m

  1. Fly from Knoxville (TYS) to St. Louis (STL) TYS - STL

$220 - $920

Cheapest option

Bus  •  35h 7m

  1. Take the bus from Knoxville to New York, NY
  2. Take the bus from New York, NY to Columbus, OH
  3. Take the bus from Columbus, Oh to St Louis, Mo

$146 - $256

3 alternative options

Bus, train  •  37h 11m

  1. Take the bus from Knoxville to New York, NY
  2. Take the bus from New York to Chicago, IL
  3. Take the train from Chicago Union Station to St. Louis Gateway Station

$178 - $274

Bus, train via New York  •  42h 43m

  1. Take the bus from Knoxville to New York, NY
  2. Take the train from New York Penn Station to Chicago Union Station
  3. Take the train from Chicago Union Station to St. Louis Gateway Station

$182 - $322

Drive  •  7h 57m

  1. Drive from Knoxville to St. Louis 487.4 miles

$45 - $70

Questions & Answers

The cheapest way to get from Knoxville to St. Louis is to drive which costs $45 - $70 and takes 7h 57m.

More details

The quickest way to get from Knoxville to St. Louis is to fly which costs $220 - $950 and takes 4h 49m.

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No, there is no direct bus from Knoxville to St. Louis. However, there are services departing from Cumberland Ave WB @ Locust St and arriving at St Louis, Mo via Knoxville, New York, NY and Columbus, Oh. The journey, including transfers, takes approximately 35h 7m.

More details

The distance between Knoxville and St. Louis is 393 miles. The road distance is 487.4 miles.

Get driving directions

The best way to get from Knoxville to St. Louis without a car is to bus which takes 35h 7m and costs $140 - $260.

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It takes approximately 4h 49m to get from Knoxville to St. Louis, including transfers.

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Knoxville to St. Louis bus services, operated by Wanda Coach, depart from Knoxville station.

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The best way to get from Knoxville to St. Louis is to fly which takes 4h 49m and costs $220 - $950. Alternatively, you can bus, which costs $140 - $260 and takes 35h 7m.

Mode details

There is no direct flight from Knoxville Airport to St. Louis Airport. The quickest flight takes 3h 50m and has one stopover.

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Knoxville to St. Louis bus services, operated by Greyhound USA, arrive at St Louis, Mo station.

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Map of how to get from Knoxville to St. Louis.
Launch map view
  • Distance: 393.3 miles
  • Duration: 4h 49m

What companies run services between Knoxville, TN, USA and St. Louis, MO, USA?

American Airlines, Delta and United Airlines fly from Knoxville to St. Louis hourly. Alternatively, you can take a bus from Knoxville to St. Louis via Walmart, Knoxville, New York, NY, Columbus, OH, and Columbus, Oh in around 35h 7m.

Airlines
Delta
Website
delta.com
Flights from Knoxville to St. Louis via Atlanta
Ave. Duration
4h 26m
When
Every day
Estimated price
$160 - $850
Flights from Knoxville to St. Louis via Detroit
Ave. Duration
4h 29m
When
Every day
Estimated price
$180 - $900
American Airlines
Website
aa.com
Flights from Knoxville to St. Louis via Chicago O'Hare
Ave. Duration
4h 2m
When
Every day
Estimated price
$180 - $900
Flights from Knoxville to St. Louis via Charlotte
Ave. Duration
4h 22m
When
Every day
Estimated price
$180 - $900
Flights from Knoxville to St. Louis via Dallas/Ft.Worth
Ave. Duration
5h 15m
When
Every day
Estimated price
$230 - $950
United Airlines
Website
united.com
Flights from Knoxville to St. Louis via Chicago O'Hare
Ave. Duration
4h 24m
When
Every day
Estimated price
$190 - $950
Flights from Knoxville to St. Louis via Washington Dulles
Ave. Duration
4h 55m
When
Every day
Estimated price
$220 - $1,000
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Chicago Union Station to St. Louis Gateway Station
Ave. Duration
5h 30m
Frequency
5 times a day
Estimated price
$40 - $60
Website
amtrak.com
Coach Seat
$40 - $60
Premium
$210 - $300
Flexi Coach Seat
$75 - $110
Business Seat
$75 - $110
Train from New York Penn Station to Chicago Union Station
Ave. Duration
19h 10m
Frequency
Once daily
Estimated price
$95 - $140
Website
amtrak.com
Coach Seat
$95 - $140
Premium
$320 - $440
Flexi Coach Seat
$190 - $290
Business Seat
$210 - $300
Bus operators
Wanda Coach
Phone
646-630-7186
Email
help@wandacoach.com
Website
wandacoach.com
Bus from Knoxville to New York, NY
Ave. Duration
13h
Frequency
6 times a week
Estimated price
$45 - $70
Book at
GoTo Bus
NYTN Bus
Phone
+1 615-939-8887
Email
tennesseetravel@gotobus.com
Website
nytnbus.com
Bus from Knoxville to New York, NY
Ave. Duration
12h
Frequency
Twice a week
Estimated price
$70 - $120
Schedules at
nytnbus.com
Book at
gotobus.com
SkyHorse / Jaguar
Phone
+1 917.288.6888
Email
vaseagull@gotobus.com
Website
skyhorsebus.com
Bus from New York, NY to Columbus, OH
Ave. Duration
9h
Frequency
Twice daily
Estimated price
$55 - $70
Schedules at
gotobus.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Columbus, Oh to St Louis, Mo
Ave. Duration
9h 10m
Frequency
5 times a day
Estimated price
$45 - $65
Website
greyhound.com
Economy
$45 - $65
Flexible
$75 - $110
D&J Bus
Bus from New York to Chicago, IL
Ave. Duration
14h
Frequency
Once daily
Estimated price
$90
Schedules at
gotobus.com
Book at
gotobus.com

Want to know more about travelling around United States

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More Questions & Answers

St. Louis is 1h behind Knoxville. It is currently 1:34 AM in Knoxville and 12:34 AM in St. Louis.

Yes, the driving distance between Knoxville to St. Louis is 487 miles. It takes approximately 7h 57m to drive from Knoxville to St. Louis.

Get driving directions

United Airlines, American Airlines and Delta offer flights from Knoxville Airport to St. Louis Airport.

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There are 250+ hotels available in St. Louis. Prices start at $72 USD per night.

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The best way to get from Knoxville to Knoxville Airport is to taxi which takes 18m and costs $55 - $70.

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