Rome2Rio

How to get fromKnoxville to Murrells Inletby plane, car, shuttle, bus or taxi

Find Transport to Murrells Inlet

See all options

There are 5 ways to get from Knoxville to Murrells Inlet by plane, car, shuttle, bus, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Myrtle Beach (MYR)plane plane TYS - MYR
    4h
    $172–617
  2. Drive 409.1 mi

    cheapest
    1. Drive from Knoxville to Murrells Inletcar car 409.1 mi
    7h 49m
    $75–108
  3. Drive, shuttle, bus

    1. Drive from Knoxville to Hot Springs, NCcar car
    2. Take a shuttle bus from Hot Springs, NC to Black Bear Resortshuttle bus
    3. Take a shuttle bus from Black Bear Resort to Booneshuttle bus
    4. Take the bus from ASU Peacock Hall Boone to Charlotte Airportbus bus
    5. Take the bus from Charlotte Bus Station to Florence Bus Stationbus bus
    6. Take the bus from Florence to Myrtle Beach, SCbus bus
    14h 3m
    $453–593
  4. Drive, shuttle, taxi, bus

    1. Drive from Knoxville to Hot Springs, NCcar car
    2. Take a shuttle bus from Hot Springs, NC to Black Bear Resortshuttle bus
    3. Take the taxi from Black Bear Resort to ASU Peacock Hall Boonetaxi taxi
    4. Take the bus from ASU Peacock Hall Boone to Charlotte Airportbus bus
    5. Take the bus from Charlotte Bus Station to Florence Bus Stationbus bus
    6. Take the bus from Florence to Myrtle Beach, SCbus bus
    14h 42m
    $422–576
  5. Drive, shuttle, taxi, bus via Chilhowee at Holston

    1. Drive from Chilhowee at Holston to Hot Springs, NCcar car
    2. Take a shuttle bus from Hot Springs, NC to Black Bear Resortshuttle bus
    3. Take the taxi from Black Bear Resort to ASU Peacock Hall Boonetaxi taxi
    4. Take the bus from ASU Peacock Hall Boone to Charlotte Airportbus bus
    5. Take the bus from Charlotte Bus Station to Florence Bus Stationbus bus
    6. Take the bus from Florence to Myrtle Beach, SCbus bus
    15h
    $454–616

Mcghee Tyson Airport (TYS) to Myrtle Beach (MYR) flights

Calendar65Weekly Planes
Duration4h 14mAverage Duration
Ticket$77Cheapest Price
See schedules

Questions & Answers

What companies run services between Knoxville, TN, USA and Murrells Inlet, SC, USA?

Delta and American Airlines fly from Mcghee Tyson Airport (TYS) to Myrtle Beach (MYR) every 3 hours.

Airlines
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound