Rome2Rio

How to get fromKnoxville to Key Largoby plane, shuttle, bus, train, bus (Flixbus, Greyhound) or car

Find Transport to Key Largo

See all options

There are 9 ways to get from Knoxville to Key Largo by plane, shuttle, bus, train, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Mcghee Tyson Airport to Miami International Airport, shuttle

    best
    1. Fly from Mcghee Tyson Airport (TYS) to Miami International Airport (MIA)plane plane TYS - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    4h 41m
    $257–797

  2. Drive 900.8 mi

    cheapest
    1. Drive from Knoxville to Key Largocar car 900.8 mi
    15h 55m
    $165–238

  3. Bus, train

    1. Take the bus from Knoxville to New York Citybus bus
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Hollywood Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    46h 16m
    $301–578

  4. Bus

    1. Take the bus from Knoxville to New York Citybus bus
    2. Take the bus from New York City Chinatown to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    2d 4h
    $231–453

  5. Fly Mcghee Tyson Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Mcghee Tyson Airport (TYS) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane TYS - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FLshuttle bus
    5h 5m
    $252–647

  6. Fly Mcghee Tyson Airport to Key West International Airport, bus

    1. Fly from Mcghee Tyson Airport (TYS) to Key West International Airport (EYW)plane plane TYS - EYW
    2. Take the bus from Key West Airport to Key Largo Bus Stopbus bus
    6h 8m
    $228–893

  7. Drive to Asheville Regional Airport, fly to Miami International Airport, shuttle

    1. Drive from Knoxville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Miami International Airport (MIA)plane plane AVL - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    6h 29m
    $182–512

  8. Drive to Asheville Regional Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Drive from Knoxville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane AVL - FLL
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FLshuttle bus
    6h 55m
    $187–452

  9. Bus, train via Farragut

    1. Take the bus from Knoxville to New Yorkbus bus
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Hollywood Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    46h 17m
    $363–673

Knoxville to Key Largo by bus and foot

Calendar3Weekly Services
Duration2d 4hAverage Duration
Ticket$231Cheapest Price
See schedules

Questions & Answers

What companies run services between Knoxville, TN, USA and Key Largo, FL, USA?

You can take a bus from Knoxville Station Bay H to Key Largo Bus Stop via Fountain City Superstop, Walmart, Knoxville, New York City Chinatown, Atlanta Bus Station, and Miami Airport Station in around 2d 4h.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Trips from Knoxville

Trips to Key Largo

Popular routes