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There are 5 ways to get from Knoxville to Indianapolis by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  4h 42m

  1. Fly from Knoxville (TYS) to Indianapolis (IND) TYS - IND

$209 - $869

Cheapest option

Bus via University of Cincinnati  •  9h 7m

  1. Take the bus from Knoxville, Tn to Cincinnati, Oh 1104 / ...
  2. Take the bus from University of Cincinnati to Indianapolis, IN

$43 - $96

3 alternative options

Bus  •  9h 29m

  1. Take the bus from Knoxville, Tn to Cincinnati, Oh 1104 / ...
  2. Take the bus from Cincinnati, OH to Indianapolis, IN Cincinnati

$47 - $106

Bus via Louisville, KY  •  10h 39m

  1. Take the bus from Knoxville, Tn to Lexington, Ky
  2. Take the bus from Lexington, KY to Louisville, KY
  3. Take the bus from Louisville, KY to Indianapolis, IN

$74 - $198

Drive  •  5h 53m

  1. Drive from Knoxville to Indianapolis 359.2 miles

$35 - $55

Questions & Answers

The cheapest way to get from Knoxville to Indianapolis is to drive which costs $35 - $55 and takes 5h 53m.

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The quickest way to get from Knoxville to Indianapolis is to fly which costs $200 - $900 and takes 4h 42m.

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No, there is no direct bus from Knoxville to Indianapolis. However, there are services departing from Knoxville, Tn and arriving at Indianapolis, IN via Main St & Court St and University of Cincinnati. The journey, including transfers, takes approximately 9h 7m.

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The distance between Knoxville and Indianapolis is 292 miles. The road distance is 359.2 miles.

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The best way to get from Knoxville to Indianapolis without a car is to bus which takes 9h 7m and costs $40 - $100.

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It takes approximately 4h 42m to get from Knoxville to Indianapolis, including transfers.

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Knoxville to Indianapolis bus services, operated by Greyhound USA, depart from Knoxville, Tn station.

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The best way to get from Knoxville to Indianapolis is to fly which takes 4h 42m and costs $200 - $900. Alternatively, you can bus, which costs $40 - $100 and takes 9h 7m.

Mode details

There is no direct flight from Knoxville Airport to Indianapolis Airport. The quickest flight takes 3h 20m and has one stopover.

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Knoxville to Indianapolis bus services, operated by Megabus, arrive at Indianapolis, IN station.

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Map of how to get from Knoxville to Indianapolis.
Launch map view
  • Distance: 291.7 miles
  • Duration: 4h 42m

What companies run services between Knoxville, TN, USA and Indianapolis, IN, USA?

Delta, American Airlines and United Airlines fly from Knoxville to Indianapolis hourly. Alternatively, you can take a bus from Knoxville to Indianapolis via Cincinnati, Oh, Main St & Court St, Jefferson Ave & University Ave, and University of Cincinnati in around 9h 7m.

Airlines
Delta
Website
delta.com
Flights from Knoxville to Indianapolis via Atlanta
Ave. Duration
4h 8m
When
Every day
Estimated price
$150 - $800
Flights from Knoxville to Indianapolis via Detroit
Ave. Duration
4h 31m
When
Every day
Estimated price
$160 - $800
American Airlines
Website
aa.com
Flights from Knoxville to Indianapolis via Charlotte
Ave. Duration
4h 6m
When
Every day
Estimated price
$160 - $800
Flights from Knoxville to Indianapolis via Chicago O'Hare
Ave. Duration
4h 17m
When
Every day
Estimated price
$170 - $850
Flights from Knoxville to Indianapolis via Reagan Washington
Ave. Duration
4h 37m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $850
Flights from Knoxville to Indianapolis via Philadelphia
Ave. Duration
4h 54m
When
Every day
Estimated price
$200 - $900
United Airlines
Website
united.com
Flights from Knoxville to Indianapolis via Chicago O'Hare
Ave. Duration
4h 22m
When
Every day
Estimated price
$180 - $850
Flights from Knoxville to Indianapolis via Washington Dulles
Ave. Duration
4h 21m
When
Every day
Estimated price
$190 - $900
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Knoxville, Tn to Cincinnati, Oh
Ave. Duration
5h 24m
Frequency
4 times a day
Estimated price
$29 - $75
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $75
Bus from Knoxville, Tn to Lexington, Ky
Ave. Duration
3h 49m
Frequency
4 times a day
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Megabus
Hoosier Ride
Phone
800-544-2383
Website
hoosierride.com
Bus from Lexington, KY to Louisville, KY
Ave. Duration
1h 20m
Frequency
4 times a day
Estimated price
$21 - $100
Book at
hoosierride.com
Bus from Louisville, KY to Indianapolis, IN
Ave. Duration
3h 30m
Frequency
Once daily
Estimated price
$30 - $45
Book at
hoosierride.com

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More Questions & Answers

Yes, the driving distance between Knoxville to Indianapolis is 359 miles. It takes approximately 5h 53m to drive from Knoxville to Indianapolis.

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United Airlines, American Airlines and Delta offer flights from Knoxville Airport to Indianapolis Airport.

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There are 262+ hotels available in Indianapolis. Prices start at $67 USD per night.

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The best way to get from Knoxville to Knoxville Airport is to taxi which takes 18m and costs $55 - $70.

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