There are 6 ways to get from Knoxville to Indianapolis by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Knoxville  •  4 h 57 min

  1. Fly from Knoxville (TYS) to Indianapolis (IND) TYS - IND

$209 - $869

Cheapest option

Bus  •  8 h 32 min

  1. Take the bus from Knoxville, Tn to Cincinnati, Oh 1104 / ...
  2. Take the bus from University of Cincinnati to Indianapolis, IN

$43 - $96

4 alternative options

Bus to Atlanta, fly  •  8 h 21 min

  1. Take the bus from Knoxville, Tn to Atlanta, Ga
  2. Fly from Atlanta (ATL) to Indianapolis (IND) ATL - IND

$126 - $347

Bus via Louisville, KY  •  9 h 39 min

  1. Take the bus from Knoxville, Tn to Lexington, Ky
  2. Take the bus from Lexington, KY to Louisville, KY
  3. Take the bus from Louisville, KY to Indianapolis, IN - Amtrak

$72 - $121

Bus #2  •  9 h 42 min

  1. Take the bus from Knoxville, Tn to Cincinnati, Oh 1104 / ...
  2. Take the bus from Cincinnati, OH to Indianapolis, IN Schedules 0014 and 0015

$47 - $106

Drive  •  5 h 53 min

  1. Drive from Knoxville to Indianapolis 359.2 miles

$35 - $55

What companies run services between Knoxville, TN, USA and Indianapolis, IN, USA?

American Airlines, United Airlines and Delta fly from Knoxville to Indianapolis hourly. Alternatively, you can take a bus from Knoxville to Indianapolis via Cincinnati, Oh, Main St & Court St, Jefferson Ave & University Ave, and University of Cincinnati in around 8 h 32 min.

Airlines
Delta
Website
delta.com
Flights from Knoxville to Indianapolis via Detroit
Ave. Duration
4 h 8 min
When
Every day
Estimated price
$160 - $800
Flights from Knoxville to Indianapolis via Atlanta
Ave. Duration
4 h 15 min
When
Every day
Estimated price
$150 - $800
Flights from Atlanta to Indianapolis
Ave. Duration
1 h 30 min
When
Every day
Estimated price
$95 - $280
American Airlines
Website
aa.com
Flights from Knoxville to Indianapolis via Charlotte
Ave. Duration
3 h 55 min
When
Every day
Estimated price
$160 - $800
Flights from Knoxville to Indianapolis via Chicago O'Hare
Ave. Duration
4 h 13 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$170 - $850
Flights from Knoxville to Indianapolis via Reagan Washington
Ave. Duration
4 h 38 min
When
Every day
Estimated price
$190 - $850
Flights from Atlanta to Indianapolis via Charlotte
Ave. Duration
3 h 52 min
When
Monday and Friday
Estimated price
$130 - $370
Southwest Airlines
Website
southwest.com
Flights from Atlanta to Indianapolis
Ave. Duration
1 h 32 min
When
Every day
Estimated price
$170 - $340
Flights from Atlanta to Indianapolis via Chicago Midway
Ave. Duration
3 h 50 min
When
Monday to Friday
Estimated price
$170 - $340
United Airlines
Website
united.com
Flights from Knoxville to Indianapolis via Chicago O'Hare
Ave. Duration
3 h 55 min
When
Every day
Estimated price
$180 - $850
Flights from Knoxville to Indianapolis via Washington Dulles
Ave. Duration
4 h 15 min
When
Every day
Estimated price
$190 - $900
Bus operators
Greyhound USA
Phone
+1 214-849-8100
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Knoxville, Tn to Atlanta, Ga
Ave. Duration
4 h 30 min
Frequency
Every 30 minutes
Estimated price
$26 - $65
Website
greyhound.com
Economy
$26 - $45
Flexible
$45 - $65
Bus from Knoxville, Tn to Cincinnati, Oh
Ave. Duration
5 h 24 min
Frequency
Every 30 minutes
Estimated price
$29 - $75
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $75
Bus from Knoxville, Tn to Lexington, Ky
Ave. Duration
3 h 49 min
Frequency
Every 30 minutes
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from University of Cincinnati to Indianapolis, IN
Ave. Duration
1 h 35 min
Frequency
4 times a day
Estimated price
$12 - $22
Schedules at
us.megabus.com
Hoosier Ride
Website
hoosierride.com
Bus from Lexington, KY to Louisville, KY
Ave. Duration
1 h 40 min
Frequency
Once daily
Estimated price
$21 - $28
Schedules at
hoosierride.com
Bus from Louisville, KY to Indianapolis, IN
Ave. Duration
4 h 5 min
Frequency
Once daily
Estimated price
$28 - $40
Schedules at
hoosierride.com
Book at
hos.tdstickets.com

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Questions & Answers

The distance between Knoxville and Indianapolis is 467 km. The road distance is 575 km.

The cheapest way to get from Knoxville to Indianapolis is to drive which costs $35 - $55 and takes 5 h 53 min.

The quickest way to get from Knoxville to Indianapolis is to fly which takes 4 h 57 min and costs $200 - $900.

No, there is no direct bus from Knoxville to Indianapolis. However, there are services departing from Knoxville, Tn and arriving at Indianapolis, IN via Main St & Court St and University of Cincinnati. The journey, including transfers, takes approximately 8 h 32 min.

It takes approximately 4 h 57 min to get from Knoxville to Indianapolis, including transfers.