There are 2 ways to get from Knoxville to Greenville by bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus  •  4 h 45 min

  1. Take the bus from Knoxville, Tn to Asheville, Nc 4840
  2. Take the bus from Asheville to Greenville

$35 - $65

1 alternative option

Drive  •  3 h 8 min

  1. Drive from Knoxville to Greenville 170 miles

$16 - $24

Questions & Answers

The cheapest way to get from Knoxville to Greenville is to drive which costs $16 - $24 and takes 3 h 8 min.

More details

The quickest way to get from Knoxville to Greenville is to drive which costs $16 - $24 and takes 3 h 8 min.

More details

The distance between Knoxville and Greenville is 116 miles. The road distance is 170 miles.

Get driving directions

It takes approximately 4 h 45 min to get from Knoxville to Greenville, including transfers.

More details

No, there is no direct bus from Knoxville to Greenville. However, there are services departing from Knoxville, Tn and arriving at Greenville via Asheville. The journey, including transfers, takes approximately 4 h 45 min.

More details

What companies run services between Knoxville, TN, USA and Greenville, SC, USA?

You can take a bus from Knoxville to Greenville via Asheville, Nc and Asheville in around 4 h 45 min.

Bus operators
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Knoxville, Tn to Asheville, Nc
Ave. Duration
2 h 20 min
Frequency
Every 2 hours
Estimated price
$17 - $40
Website
greyhound.com
Economy
$17 - $26
Flexible
$30 - $40

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